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CRYAB crystallin, alpha B [Homo sapiens (human)]

Clone ID RefSeq Accession Definition Vector Stock Status *Turnaround time Price Order
OHu16676 NM_001289807 Homo sapiens crystallin, alpha B (CRYAB), transcript variant 2, mRNA. pcDNA3.1+-DYK In-stock 5-7 $99.00
OHu16676 NM_001885 Homo sapiens crystallin, alpha B (CRYAB), transcript variant 1, mRNA. pcDNA3.1+-DYK In-stock 5-7 $99.00
OHu16676 NM_001289808 Homo sapiens crystallin, alpha B (CRYAB), transcript variant 3, mRNA. pcDNA3.1+-DYK In-stock 5-7 $99.00
OHu16676C NM_001289807 Homo sapiens crystallin, alpha B (CRYAB), transcript variant 2, mRNA. Customized vector In-stock 5-7 $149.00
OHu16676C NM_001885 Homo sapiens crystallin, alpha B (CRYAB), transcript variant 1, mRNA. Customized vector In-stock 5-7 $149.00
OHu16676C NM_001289808 Homo sapiens crystallin, alpha B (CRYAB), transcript variant 3, mRNA. Customized vector In-stock 5-7 $149.00

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Gene Symbol CRYAB
Entrez Gene ID 1410
Full Name crystallin, alpha B
Synonyms CMD1II, CRYA2, CTPP2, CTRCT16, HEL-S-101, HSPB5, MFM2
General protein information
Preferred Names
alpha-crystallin B chain
alpha-crystallin B chain
heat shock protein beta-5
rosenthal fiber component
heat-shock 20 kD like-protein
renal carcinoma antigen NY-REN-27
Gene Type protein-coding
Organism Homo sapiens (human)



Summary Mammalian lens crystallins are divided into alpha, beta, and gamma families. Alpha crystallins are composed of two gene products: alpha-A and alpha-B, for acidic and basic, respectively. Alpha crystallins can be induced by heat shock and are members of the small heat shock protein (HSP20) family. They act as molecular chaperones although they do not renature proteins and release them in the fashion of a true chaperone; instead they hold them in large soluble aggregates. Post-translational modifications decrease the ability to chaperone. These heterogeneous aggregates consist of 30-40 subunits; the alpha-A and alpha-B subunits have a 3:1 ratio, respectively. Two additional functions of alpha crystallins are an autokinase activity and participation in the intracellular architecture. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Alpha-A and alpha-B gene products are differentially expressed; alpha-A is preferentially restricted to the lens and alpha-B is expressed widely in many tissues and organs. Elevated expression of alpha-B crystallin occurs in many neurological diseases; a missense mutation cosegregated in a family with a desmin-related myopathy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014].

MIM: 123590

Myopathy, cardioskeletal, desmin-related, with cataract, 608810 (3);

mRNA Protein Product Sequence Price Select
NM_001289807, 577019570 NP_001276736, 577019571 alpha-crystallin B chain ORF Sequence $250.00
NM_001289808, 577019572 NP_001276737, 577019573 alpha-crystallin B chain ORF Sequence $250.00
NM_001885, 577019569 NP_001876, 4503057 alpha-crystallin B chain ORF Sequence $159.00
hsa04141Protein processing in endoplasmic reticulum
Homo sapiens (human)CRYABNP_001876.1
Pan troglodytes (chimpanzee)CRYABXP_508752.2
Macaca mulatta (Rhesus monkey)CRYABXP_002799808.1
Canis lupus familiaris (dog)CRYABXP_862258.2
Bos taurus (cattle)CRYABNP_776715.1
Mus musculus (house mouse)CryabNP_034094.1
Rattus norvegicus (Norway rat)CryabNP_037067.1
Gallus gallus (chicken)CRYABNP_990507.1
Danio rerio (zebrafish)cryabbNP_001002670.1
Drosophila melanogaster (fruit fly)l(2)eflNP_523827.1
Xenopus (Silurana) tropicalis (western clawed frog)cryabXP_002932964.1
GO:0001666response to hypoxiaIEA
GO:0002088lens development in camera-type eyeIEA
GO:0006006glucose metabolic processIEA
GO:0006457protein foldingIEA
GO:0006936muscle contractionTAS
GO:0007021tubulin complex assemblyIEA
GO:0007517muscle organ developmentIEA
GO:0010629negative regulation of gene expressionIEA
GO:0010941regulation of cell deathIMP
GO:0030308negative regulation of cell growthIEA
GO:0031109microtubule polymerization or depolymerizationIEA
GO:0032355response to estradiolIEA
GO:0032387negative regulation of intracellular transportIDA
GO:0042542response to hydrogen peroxideIEA
GO:0043066negative regulation of apoptotic processIDA
GO:0043154negative regulation of cysteine-type endopeptidase activity involved in apoptotic processIEA
GO:0051260protein homooligomerizationIDA
GO:0051403stress-activated MAPK cascadeIEA
GO:0060561apoptotic process involved in morphogenesisIEA
GO:0071480cellular response to gamma radiationIMP
GO:2000378negative regulation of reactive oxygen species metabolic processIEA
GO:0005794Golgi apparatusIEA
GO:0005886plasma membraneIEA
GO:0009986cell surfaceIEA
GO:0015630microtubule cytoskeletonIEA
GO:0030018Z discIEA
GO:0032432actin filament bundleIEA
GO:0070062extracellular vesicular exosomeIDA
GO:0005212structural constituent of eye lensIEA
GO:0005515protein bindingIPI
GO:0008017microtubule bindingIEA
GO:0042802identical protein bindingIPI
GO:0042803protein homodimerization activityIPI
GO:0046872metal ion bindingIEA
GO:0051082unfolded protein bindingIPI
GeneCards CRYAB
PDB 3SGN, 2WJ7, 3SGR, 2Y22, 2Y1Z, 2KLR, 3SGM, 3SGP, 3SGS, 3L1G, 2Y1Y, 4M5T, 4M5S, 2YGD, 3SGO
UniProt V9HW27, P02511
Vega OTTHUMG00000166885
MIM 123590
Ensembl ENSG00000109846
HGNC 2389
HPRD 00428

GeneRIFs: Gene References Into Functions What's a GeneRIF?

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