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CRYGD crystallin, gamma D [Homo sapiens (human)]


RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_006891 Homo sapiens crystallin, gamma D (CRYGD), mRNA. GenEZ ORF Cloning On-demand $399.00 14

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Gene Symbol CRYGD
Entrez Gene ID 1421
Full Name crystallin, gamma D
Synonyms CACA, CCA3, CCP, CRYG4, cry-g-D
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

2

2q33-q35

Summary Crystallins are separated into two classes: taxon-specific, or enzyme, and ubiquitous. The latter class constitutes the major proteins of vertebrate eye lens and maintains the transparency and refractive index of the lens. Since lens central fiber cells lose their nuclei during development, these crystallins are made and then retained throughout life, making them extremely stable proteins. Mammalian lens crystallins are divided into alpha, beta, and gamma families; beta and gamma crystallins are also considered as a superfamily. Alpha and beta families are further divided into acidic and basic groups. Seven protein regions exist in crystallins: four homologous motifs, a connecting peptide, and N- and C-terminal extensions. Gamma-crystallins are a homogeneous group of highly symmetrical, monomeric proteins typically lacking connecting peptides and terminal extensions. They are differentially regulated after early development. Four gamma-crystallin genes (gamma-A through gamma-D) and three pseudogenes (gamma-E, gamma-F, gamma-G) are tandemly organized in a genomic segment as a gene cluster. Whether due to aging or mutations in specific genes, gamma-crystallins have been involved in cataract formation. [provided by RefSeq, Jul 2008].
Disorder

MIM: 123690

Cataracts, punctate, progressive juvenile-onset (3); Cataract,

mRNA Protein Product Sequence Price Select
NM_006891, 171906614 NP_008822, 13377002 gamma-crystallin D ORF Sequence $250.00
Homo sapiens (human)CRYGDNP_008822.2
Pan troglodytes (chimpanzee)CRYGDNP_001129137.1
Macaca mulatta (Rhesus monkey)CRYGDXP_001100337.2
Canis lupus familiaris (dog)CRYGDNP_001106640.1
Bos taurus (cattle)CRYGDNP_776716.1
Mus musculus (house mouse)CrygdNP_031802.2
Rattus norvegicus (Norway rat)CrygdNP_149086.1
GeneCards CRYGD
PDB 1LD0, 4GR7, 2KFB, 2G98, 2KLJ, 1H4A, 1HK0
UniProt P07320
MIM 123690
Ensembl ENSG00000118231
HGNC 2411
HPRD 00436

GeneRIFs: Gene References Into Functions What's a GeneRIF?

General protein information

Preferred Names
gamma-crystallin D
Names
gamma-crystallin D
gamma crystallin 4
gamma-D-crystallin
gamma-crystallin 4

Interactant



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