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CSF1R colony stimulating factor 1 receptor [Homo sapiens (human)]


Clone ID RefSeq Accession Definition Vector Stock Status *Turnaround time Price Order
OHu24034 NM_001288705 Homo sapiens colony stimulating factor 1 receptor (CSF1R), transcript variant 2, mRNA. pcDNA3.1+-DYK On-demand 12-14 $279.00
OHu24034 NM_005211 Homo sapiens colony stimulating factor 1 receptor (CSF1R), transcript variant 1, mRNA. pcDNA3.1+-DYK On-demand 12-14 $279.00
OHu24034C NM_001288705 Homo sapiens colony stimulating factor 1 receptor (CSF1R), transcript variant 2, mRNA. Customized vector On-demand 12-14 $329.00
OHu24034C NM_005211 Homo sapiens colony stimulating factor 1 receptor (CSF1R), transcript variant 1, mRNA. Customized vector On-demand 12-14 $329.00

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Gene Symbol CSF1R
Entrez Gene ID 1436
Full Name colony stimulating factor 1 receptor
Synonyms C-FMS, CD115, CSF-1R, CSFR, FIM2, FMS, HDLS, M-CSF-R
General protein information
Preferred Names
macrophage colony-stimulating factor 1 receptor
Names
macrophage colony-stimulating factor 1 receptor
CD115 antigen
CSF-1 receptor
FMS proto-oncogene
proto-oncogene c-Fms
macrophage colony stimulating factor I receptor
McDonough feline sarcoma viral (v-fms) oncogene homolog
NP_005202.2
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

5

5q32

Summary The protein encoded by this gene is the receptor for colony stimulating factor 1, a cytokine which controls the production, differentiation, and function of macrophages. This receptor mediates most if not all of the biological effects of this cytokine. Ligand binding activates the receptor kinase through a process of oligomerization and transphosphorylation. The encoded protein is a tyrosine kinase transmembrane receptor and member of the CSF1/PDGF receptor family of tyrosine-protein kinases. Mutations in this gene have been associated with a predisposition to myeloid malignancy. The first intron of this gene contains a transcriptionally inactive ribosomal protein L7 processed pseudogene oriented in the opposite direction. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013].
Disorder

MIM: 164770

Myeloid malignancy, predisposition to (3)

mRNA Protein Product Sequence Price Select
NM_001288705, 569026719 NP_001275634, 569026720 macrophage colony-stimulating factor 1 receptor precursor ORF Sequence $750.00
NM_005211, 195947380 NP_005202, 27262659 macrophage colony-stimulating factor 1 receptor precursor ORF Sequence $750.00
KEGG
hsa04060Cytokine-cytokine receptor interaction
hsa04640Hematopoietic cell lineage
hsa05200Pathways in cancer
hsa04144Endocytosis
hsa04380Osteoclast differentiation
hsa04151PI3K-Akt signaling pathway
hsa05202Transcriptional misregulation in cancer
hsa04014Ras signaling pathway
hsa04015Rap1 signaling pathway
Pathway Interaction Database
avb3_integrin_pathwayIntegrins in angiogenesis
ptp1bpathwaySignaling events mediated by PTP1B
cmyb_pathwayC-MYB transcription factor network
tcptp_pathwaySignaling events mediated by TCPTP
Homo sapiens (human)CSF1RNP_005202.2
Pan troglodytes (chimpanzee)CSF1RXP_003310972.1
Macaca mulatta (Rhesus monkey)CSF1RXP_001107711.2
Canis lupus familiaris (dog)CSF1RXP_546306.2
Bos taurus (cattle)CSF1RNP_001068871.2
Mus musculus (house mouse)Csf1rNP_001032948.2
Rattus norvegicus (Norway rat)Csf1rNP_001025072.1
Danio rerio (zebrafish)csf1raNP_571747.1
Danio rerio (zebrafish)csf1rbXP_001919824.4
Xenopus (Silurana) tropicalis (western clawed frog)csf1rNP_001008181.1
Process
IDNameEvidence
GO:0001934positive regulation of protein phosphorylationIMP
GO:0006954inflammatory responseTAS
GO:0007165signal transductionTAS
GO:0007169transmembrane receptor protein tyrosine kinase signaling pathwayISS
GO:0007275multicellular organismal developmentTAS
GO:0008283cell proliferationIMP
GO:0008284positive regulation of cell proliferationIMP
GO:0008360regulation of cell shapeIMP
GO:0018108peptidyl-tyrosine phosphorylationIDA
GO:0019221cytokine-mediated signaling pathwayIMP
GO:0030097hemopoiesisIMP
GO:0030224monocyte differentiationTAS
GO:0030225macrophage differentiationTAS
GO:0030316osteoclast differentiationISS
GO:0030335positive regulation of cell migrationISS
GO:0031529ruffle organizationISS
GO:0036006cellular response to macrophage colony-stimulating factor stimulusIMP
GO:0038145macrophage colony-stimulating factor signaling pathwayIEA
GO:0038145macrophage colony-stimulating factor signaling pathwayIMP
GO:0038145macrophage colony-stimulating factor signaling pathwayTAS
GO:0042517positive regulation of tyrosine phosphorylation of Stat3 proteinISS
GO:0045087innate immune responseIEA
GO:0045124regulation of bone resorptionISS
GO:0045217cell-cell junction maintenanceIMP
GO:0046488phosphatidylinositol metabolic processISS
GO:0046777protein autophosphorylationIDA
GO:0048015phosphatidylinositol-mediated signalingISS
GO:0060603mammary gland duct morphogenesisTAS
GO:0061098positive regulation of protein tyrosine kinase activityIMP
GO:0070374positive regulation of ERK1 and ERK2 cascadeISS
GO:0071345cellular response to cytokine stimulusISS
GO:0071902positive regulation of protein serine/threonine kinase activityISS
GO:0090197positive regulation of chemokine secretionIMP
GO:2000147positive regulation of cell motilityIMP
GO:2000249regulation of actin cytoskeleton reorganizationISS
Component
IDNameEvidence
GO:0005886plasma membraneTAS
GO:0005887integral component of plasma membraneTAS
GO:0009986cell surfaceISS
GO:0043235receptor complexISS
Function
IDNameEvidence
GO:0005011macrophage colony-stimulating factor receptor activityIMP
GO:0005524ATP bindingIEA
GO:0019903protein phosphatase bindingIEA
GO:0019955cytokine bindingIDA
GO:0019955cytokine bindingISS
GO:0042803protein homodimerization activityISS
GeneCards CSF1R
UniProt P07333, A2VDG3
Vega OTTHUMG00000130050
MIM 164770
Ensembl ENSG00000182578
HGNC 2433
HPRD 01269

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Interactant

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