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CSF1R colony stimulating factor 1 receptor [Homo sapiens (human)]


RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_005211 Homo sapiens colony stimulating factor 1 receptor (CSF1R), mRNA. GenEZ ORF Cloning On-demand $899.00 20

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Gene Symbol CSF1R
Entrez Gene ID 1436
Full Name colony stimulating factor 1 receptor
Synonyms C-FMS, CD115, CSFR, FIM2, FMS
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

5

5q32

Summary The protein encoded by this gene is the receptor for colony stimulating factor 1, a cytokine which controls the production, differentiation, and function of macrophages. This receptor mediates most if not all of the biological effects of this cytokine. Ligand binding activates the receptor kinase through a process of oligomerization and transphosphorylation. The encoded protein is a tyrosine kinase transmembrane receptor and member of the CSF1/PDGF receptor family of tyrosine-protein kinases. Mutations in this gene have been associated with a predisposition to myeloid malignancy. The first intron of this gene contains a transcriptionally inactive ribosomal protein L7 processed pseudogene oriented in the opposite direction. [provided by RefSeq, Jul 2008].
Disorder

MIM: 164770

Myeloid malignancy, predisposition to (3)

mRNA Protein Product Sequence Price Select
NM_005211, 195947380 NP_005202, 27262659 macrophage colony-stimulating factor 1 receptor precursor ORF Sequence $750.00
KEGG
hsa04380Osteoclast differentiation
hsa04060Cytokine-cytokine receptor interaction
hsa05202Transcriptional misregulation in cancer
hsa04640Hematopoietic cell lineage
hsa04144Endocytosis
hsa05200Pathways in cancer
hsa04151PI3K-Akt signaling pathway
Pathway Interaction Database
avb3_integrin_pathwayIntegrins in angiogenesis
ptp1bpathwaySignaling events mediated by PTP1B
tcptp_pathwaySignaling events mediated by TCPTP
cmyb_pathwayC-MYB transcription factor network
Homo sapiens (human)CSF1RNP_005202.2
Pan troglodytes (chimpanzee)CSF1RXP_003310972.1
Macaca mulatta (Rhesus monkey)CSF1RXP_001107711.2
Canis lupus familiaris (dog)CSF1RXP_546306.2
Bos taurus (cattle)CSF1RNP_001068871.2
Mus musculus (house mouse)Csf1rNP_001032948.2
Rattus norvegicus (Norway rat)Csf1rNP_001025072.1
Gallus gallus (chicken)CSF1RXP_414597.2
Danio rerio (zebrafish)csf1raNP_571747.1
Danio rerio (zebrafish)LOC568405XP_001919824.3
GeneCards CSF1R
PDB 2OGV, 2I1M, 2I0Y, 3BEA, 3LCO, 3KRL, 4DKD, 2I0V, 3LCD, 3KRJ, 3DPK
UniProt P07333
MIM 164770
Ensembl ENSG00000182578
HGNC 2433
HPRD 01269

GeneRIFs: Gene References Into Functions What's a GeneRIF?

General protein information

Preferred Names
macrophage colony-stimulating factor 1 receptor
Names
macrophage colony-stimulating factor 1 receptor
CD115 antigen
CSF-1 receptor
FMS proto-oncogene
proto-oncogene c-Fms
macrophage colony stimulating factor I receptor
McDonough feline sarcoma viral (v-fms) oncogene homolog
NP_005202.2

Interactant



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