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PRICKLE1 prickle homolog 1 (Drosophila) [Homo sapiens (human)]


Clone ID RefSeq Accession Definition Vector Stock Status *Turnaround time Price Order
OHu22315 NM_001144883 Homo sapiens prickle homolog 1 (Drosophila) (PRICKLE1), transcript variant 4, mRNA. pcDNA3.1+-DYK In-stock 5-7 $99.00
OHu22315 NM_153026 Homo sapiens prickle homolog 1 (Drosophila) (PRICKLE1), transcript variant 1, mRNA. pcDNA3.1+-DYK In-stock 5-7 $99.00
OHu22315 NM_001144881 Homo sapiens prickle homolog 1 (Drosophila) (PRICKLE1), transcript variant 2, mRNA. pcDNA3.1+-DYK In-stock 5-7 $99.00
OHu22315 NM_001144882 Homo sapiens prickle homolog 1 (Drosophila) (PRICKLE1), transcript variant 3, mRNA. pcDNA3.1+-DYK In-stock 5-7 $99.00
OHu22315C NM_001144883 Homo sapiens prickle homolog 1 (Drosophila) (PRICKLE1), transcript variant 4, mRNA. Customized vector In-stock 5-7 $149.00
OHu22315C NM_153026 Homo sapiens prickle homolog 1 (Drosophila) (PRICKLE1), transcript variant 1, mRNA. Customized vector In-stock 5-7 $149.00
OHu22315C NM_001144881 Homo sapiens prickle homolog 1 (Drosophila) (PRICKLE1), transcript variant 2, mRNA. Customized vector In-stock 5-7 $149.00
OHu22315C NM_001144882 Homo sapiens prickle homolog 1 (Drosophila) (PRICKLE1), transcript variant 3, mRNA. Customized vector In-stock 5-7 $149.00

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Gene Symbol PRICKLE1
Entrez Gene ID 144165
Full Name prickle homolog 1 (Drosophila)
Synonyms EPM1B, RILP
General protein information
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

12

12q12

Summary This gene encodes a nuclear receptor that may be a negative regulator of the Wnt/beta-catenin signaling pathway. The encoded protein localizes to the nuclear membrane and has been implicated in the nuclear trafficking of the transcription repressors REST/NRSF and REST4. Mutations in this gene have been linked to progressive myoclonus epilepsy. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 3. [provided by RefSeq, Sep 2009].
Disorder

MIM: 608500

Epilepsy, progressive myoclonic 1B, 612437 (3)

mRNA Protein Product Sequence Price Select
NM_001144881, 222136679 NP_001138353, 222136680 prickle-like protein 1 ORF Sequence $660.00
NM_001144882, 222136681 NP_001138354, 222136682 prickle-like protein 1 ORF Sequence $660.00
NM_001144883, 222136683 NP_001138355, 222136684 prickle-like protein 1 ORF Sequence $660.00
NM_153026, 222136677 NP_694571, 222136678 prickle-like protein 1 ORF Sequence $660.00
KEGG
hsa04310Wnt signaling pathway
Reactome
REACT_11045Signaling by Wnt
REACT_111102Signal Transduction
REACT_172694beta-catenin independent WNT signaling
REACT_172638Asymmetric localization of PCP proteins
REACT_172581PCP/CE pathway
Homo sapiens (human)PRICKLE1NP_001138355.1
Pan troglodytes (chimpanzee)PRICKLE1XP_001166831.1
Macaca mulatta (Rhesus monkey)PRICKLE1XP_002798581.1
Canis lupus familiaris (dog)PRICKLE1XP_005637023.1
Bos taurus (cattle)PRICKLE1NP_001096004.1
Mus musculus (house mouse)Prickle1NP_001028389.1
Rattus norvegicus (Norway rat)Prickle1NP_955428.1
Gallus gallus (chicken)PRICKLE1XP_416036.2
Danio rerio (zebrafish)prickle1aNP_899185.2
Xenopus (Silurana) tropicalis (western clawed frog)prickle1NP_001016939.1
Process
IDNameEvidence
GO:0001843neural tube closureIMP
GO:0006606protein import into nucleusIDA
GO:0006606protein import into nucleusIMP
GO:0031398positive regulation of protein ubiquitinationIDA
GO:0032436positive regulation of proteasomal ubiquitin-dependent protein catabolic processIDA
GO:0045892negative regulation of transcription, DNA-templatedIDA
GO:0090090negative regulation of canonical Wnt signaling pathwayIDA
GO:2000691negative regulation of cardiac muscle cell myoblast differentiationIDA
Component
IDNameEvidence
GO:0005634nucleusIDA
GO:0005829cytosolIDA
GO:0005829cytosolTAS
GO:0031965nuclear membraneIDA
Function
IDNameEvidence
GO:0005515protein bindingIPI
GO:0008270zinc ion bindingIEA
GeneCards PRICKLE1
UniProt B3KVG3, B3KVG6, Q96MT3
Vega OTTHUMG00000169443
MIM 608500
Ensembl ENSG00000139174
HGNC 17019
HPRD 16341

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Interactant

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