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PRICKLE1 prickle homolog 1 (Drosophila) [Homo sapiens (human)]


RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_001144881 Homo sapiens prickle homolog 1 (Drosophila) (PRICKLE1), transcript variant 2, mRNA. GenEZ ORF Cloning In-stock $809.00 $760.00 15
NM_001144882 Homo sapiens prickle homolog 1 (Drosophila) (PRICKLE1), transcript variant 3, mRNA. GenEZ ORF Cloning In-stock $809.00 $760.00 15
NM_001144883 Homo sapiens prickle homolog 1 (Drosophila) (PRICKLE1), transcript variant 4, mRNA. GenEZ ORF Cloning In-stock $809.00 $760.00 15
NM_153026 Homo sapiens prickle homolog 1 (Drosophila) (PRICKLE1), transcript variant 1, mRNA. GenEZ ORF Cloning In-stock $809.00 $760.00 15

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Related Services

Gene Symbol PRICKLE1
Entrez Gene ID 144165
Full Name prickle homolog 1 (Drosophila)
Synonyms EPM1B, RILP
General protein information
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

12

12q12

Summary This gene encodes a nuclear receptor that may be a negative regulator of the Wnt/beta-catenin signaling pathway. The encoded protein localizes to the nuclear membrane and has been implicated in the nuclear trafficking of the transcription repressors REST/NRSF and REST4. Mutations in this gene have been linked to progressive myoclonus epilepsy. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 3. [provided by RefSeq, Sep 2009].
Disorder

MIM: 608500

Epilepsy, progressive myoclonic 1B, 612437 (3)

mRNA Protein Product Sequence Price Select
NM_001144881, 222136679 NP_001138353, 222136680 prickle-like protein 1 ORF Sequence $660.00
NM_001144882, 222136681 NP_001138354, 222136682 prickle-like protein 1 ORF Sequence $660.00
NM_001144883, 222136683 NP_001138355, 222136684 prickle-like protein 1 ORF Sequence $660.00
NM_153026, 222136677 NP_694571, 222136678 prickle-like protein 1 ORF Sequence $660.00
KEGG
hsa04310Wnt signaling pathway
Reactome
REACT_11045Signaling by Wnt
REACT_111102Signal Transduction
REACT_172694beta-catenin independent WNT signaling
REACT_172638Asymmetric localization of PCP proteins
REACT_172581PCP/CE pathway
Homo sapiens (human)PRICKLE1NP_001138355.1
Pan troglodytes (chimpanzee)PRICKLE1XP_001166831.1
Macaca mulatta (Rhesus monkey)PRICKLE1XP_002798581.1
Canis lupus familiaris (dog)PRICKLE1XP_005637023.1
Bos taurus (cattle)PRICKLE1NP_001096004.1
Mus musculus (house mouse)Prickle1NP_001028389.1
Rattus norvegicus (Norway rat)Prickle1NP_955428.1
Gallus gallus (chicken)PRICKLE1XP_416036.2
Danio rerio (zebrafish)prickle1aNP_899185.2
Xenopus (Silurana) tropicalis (western clawed frog)prickle1NP_001016939.1
Process
IDNameEvidence
GO:0001843neural tube closureIMP
GO:0006606protein import into nucleusIDA
GO:0006606protein import into nucleusIMP
GO:0031398positive regulation of protein ubiquitinationIDA
GO:0032436positive regulation of proteasomal ubiquitin-dependent protein catabolic processIDA
GO:0045892negative regulation of transcription, DNA-templatedIDA
GO:0090090negative regulation of canonical Wnt signaling pathwayIDA
GO:2000691negative regulation of cardiac muscle cell myoblast differentiationIDA
Component
IDNameEvidence
GO:0005634nucleusIDA
GO:0005829cytosolIDA
GO:0005829cytosolTAS
GO:0031965nuclear membraneIDA
Function
IDNameEvidence
GO:0005515protein bindingIPI
GO:0008270zinc ion bindingIEA
GeneCards PRICKLE1
UniProt B3KVG3, B3KVG6, Q96MT3
Vega OTTHUMG00000169443
MIM 608500
Ensembl ENSG00000139174
HGNC 17019
HPRD 16341

GeneRIFs: Gene References Into Functions What's a GeneRIF?

What is the normal function of the PRICKLE1 gene?

The PRICKLE1 gene provides instructions for making a protein called prickle-like 1. The function of this protein is unclear, although it appears to play an important role in the development of the nervous system. Prickle-like 1 is likely part of a chemical signaling pathway known as noncanonical WNT signaling. During development before birth, noncanonical WNT signaling helps to determine the position of various components within cells (cell polarity). This pathway also regulates the movement of nerve cells (neurons) in the developing nervous system.

Studies suggest that prickle-like 1 interacts with other proteins, including RE1-silencing transcription factor (REST). The REST protein regulates several critical genes in neurons by turning off (suppressing) their activity. To regulate these genes, REST must enter the nucleus and attach (bind) to particular regions of DNA. Researchers believe that prickle-like 1 controls REST by transporting it out of the nucleus, which prevents it from binding to DNA and suppressing gene activity. It remains unclear how the interaction between prickle-like 1 and REST contributes to the normal development of the nervous system.

Interactant

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