GSC goosecoid homeobox [Homo sapiens (human)]
| Gene Symbol | GSC |
| Entrez Gene ID | 145258 |
| Full Name | goosecoid homeobox |
| Synonyms | |
| Gene Type | protein-coding |
| Organism | Homo sapiens (human) |
| Genome |
14 14q32.1 |
| Summary | This gene encodes a member of the bicoid subfamily of the paired (PRD) homeobox family of proteins. The encoded protein acts as a transcription factor and may be autoregulatory. A similar protein in mice plays a role in craniofacial and rib cage development during embryogenesis. [provided by RefSeq]. |
| Disorder | MIM: 138890 |
| mRNA | NM_173849, 29171761 |
| Protein | NP_776248, 27777663 |
| Product | homeobox protein goosecoid |
| RefSeq Status | REVIEWED |
| smad2_3nuclearpathway | Regulation of nuclear SMAD2/3 signaling |
| rb_1pathway | Regulation of retinoblastoma protein |
| Homo sapiens (human) | GSC | NP_776248.1 |
| Pan troglodytes (chimpanzee) | GSC | XP_522943.2 |
| Bos taurus (cattle) | GSC | XP_592774.2 |
| Mus musculus (house mouse) | Gsc | NP_034481.1 |
| Rattus norvegicus (Norway rat) | Gsc | XP_343102.3 |
| Gallus gallus (chicken) | GSC | NP_990662.1 |
| Danio rerio (zebrafish) | gsc | NP_571092.1 |
| ID | Name | Evidence |
| GO:0000122 | negative regulation of transcription from RNA polymerase II promoter | IEA |
| GO:0006355 | regulation of transcription, DNA-dependent | IEA |
| GO:0007275 | multicellular organismal development | IEA |
| GO:0007369 | gastrulation | NAS |
| GO:0009653 | anatomical structure morphogenesis | IEA |
| GO:0021904 | dorsal/ventral neural tube patterning | IEA |
| GO:0030178 | negative regulation of Wnt receptor signaling pathway | IEA |
| GO:0030900 | forebrain development | IEA |
| GO:0042474 | middle ear morphogenesis | ISS |
| GO:0043583 | ear development | IEA |
| GO:0048644 | muscle organ morphogenesis | IEA |
| GO:0048704 | embryonic skeletal system morphogenesis | IEA |
Component
| ID | Name | Evidence |
| GO:0005634 | nucleus | NAS |
| GO:0005667 | transcription factor complex | IEA |
Function
| ID | Name | Evidence |
| GO:0003677 | DNA binding | NAS |
| GO:0003700 | sequence-specific DNA binding transcription factor activity | IEA |
| GO:0043565 | sequence-specific DNA binding | IEA |
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