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CST3 cystatin C [Homo sapiens (human)]

RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_000099 Homo sapiens cystatin C (CST3), mRNA. GenEZ ORF Cloning In-stock $248.00 $199.00 10

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Gene Symbol CST3
Entrez Gene ID 1471
Full Name cystatin C
Synonyms ARMD11, MGC117328
Gene Type protein-coding
Organism Homo sapiens (human)



Summary The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and the kininogens. The type 2 cystatin proteins are a class of cysteine proteinase inhibitors found in a variety of human fluids and secretions, where they appear to provide protective functions. The cystatin locus on chromosome 20 contains the majority of the type 2 cystatin genes and pseudogenes. This gene is located in the cystatin locus and encodes the most abundant extracellular inhibitor of cysteine proteases, which is found in high concentrations in biological fluids and is expressed in virtually all organs of the body. A mutation in this gene has been associated with amyloid angiopathy. Expression of this protein in vascular wall smooth muscle cells is severely reduced in both atherosclerotic and aneurysmal aortic lesions, establishing its role in vascular disease. [provided by RefSeq, Jul 2008].

MIM: 604312

Cerebral amyloid angiopathy, 105150 (3); Macular degeneration,

mRNA Protein Product Sequence Price Select
NM_000099, 19882253 NP_000090, 4503107 cystatin-C precursor ORF Sequence $99.00
hsa04970Salivary secretion
WP2377Integrated Pancreatic Cancer Pathway
WP2256Integrated Pancreatic Cancer Pathway
Homo sapiens (human)CST3NP_000090.1
Macaca mulatta (Rhesus monkey)CST3NP_001028096.1
Canis lupus familiaris (dog)LOC607874XP_003639869.1
Bos taurus (cattle)CST3NP_776454.1
Mus musculus (house mouse)Cst3NP_034106.2
Rattus norvegicus (Norway rat)Cst3NP_036969.1
Gallus gallus (chicken)CST3NP_990831.2
GeneCards CST3
PDB 1G96, 3NX0, 1TIJ, 3S67, 3PS8, 3QRD, 3GAX, 3SVA, 1R4C
UniProt P01034
MIM 604312
Ensembl ENSG00000101439
HGNC 2475
HPRD 05056

GeneRIFs: Gene References Into Functions What's a GeneRIF?

General protein information

Preferred Names
cystatin 3
bA218C14.4 (cystatin C)
neuroendocrine basic polypeptide


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