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CTLA4 cytotoxic T-lymphocyte-associated protein 4 [Homo sapiens (human)]


RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_001037631 Homo sapiens cytotoxic T-lymphocyte-associated protein 4 (CTLA4), transcript variant 2, mRNA. GenEZ ORF Cloning On-demand $399.00 14
NM_005214 Homo sapiens cytotoxic T-lymphocyte-associated protein 4 (CTLA4), transcript variant 1, mRNA. GenEZ ORF Cloning On-demand $399.00 14

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Related Services

Gene Symbol CTLA4
Entrez Gene ID 1493
Full Name cytotoxic T-lymphocyte-associated protein 4
Synonyms CD, CD152, CELIAC3, CTLA-4, GRD4, GSE, ICOS, IDDM12
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

2

2q33

Summary This gene is a member of the immunoglobulin superfamily and encodes a protein which transmits an inhibitory signal to T cells. The protein contains a V domain, a transmembrane domain, and a cytoplasmic tail. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. The membrane-bound isoform functions as a homodimer interconnected by a disulfide bond, while the soluble isoform functions as a monomer. Mutations in this gene have been associated with insulin-dependent diabetes mellitus, Graves disease, Hashimoto thyroiditis, celiac disease, systemic lupus erythematosus, thyroid-associated orbitopathy, and other autoimmune diseases. [provided by RefSeq, Jul 2008].
Disorder

MIM: 123890

{Graves disease, susceptibility to, 4} (3); {Hypothyroidism,

mRNA Protein Product Sequence Price Select
NM_001037631, 339276050 NP_001032720, 83700231 cytotoxic T-lymphocyte protein 4 isoform CTLA-4delTM precursor ORF Sequence $250.00
NM_005214, 339276048 NP_005205, 21361212 cytotoxic T-lymphocyte protein 4 isoform CTLA4-TM precursor ORF Sequence $250.00
KEGG
hsa04660T cell receptor signaling pathway
hsa05320Autoimmune thyroid disease
hsa04514Cell adhesion molecules (CAMs)
hsa05323Rheumatoid arthritis
Pathway Interaction Database
nfat_tfpathwayCalcineurin-regulated NFAT-dependent transcription in lymphocytes
Reactome
REACT_6900Immune System
REACT_19405CTLA4 inhibitory signaling
REACT_19344Costimulation by the CD28 family
REACT_75774Adaptive Immune System
Homo sapiens (human)CTLA4NP_005205.2
Pan troglodytes (chimpanzee)CTLA4XP_526000.1
Macaca mulatta (Rhesus monkey)CTLA4NP_001038204.1
Canis lupus familiaris (dog)CTLA4NP_001003106.1
Bos taurus (cattle)CTLA4NP_776722.1
Mus musculus (house mouse)Ctla4NP_033973.2
Rattus norvegicus (Norway rat)Ctla4NP_113862.1
Gallus gallus (chicken)CTLA4NP_001035180.1
GeneCards CTLA4
PDB 2X44, 3BX7, 1H6E, 1AH1, 1I8L, 1I85, 3OSK
UniProt P16410
MIM 123890
Ensembl ENSG00000163599
HGNC 2505
HPRD 00474

GeneRIFs: Gene References Into Functions What's a GeneRIF?

General protein information

Preferred Names
cytotoxic T-lymphocyte protein 4
Names
cytotoxic T-lymphocyte protein 4
CD152 isoform
celiac disease 3
cytotoxic T-lymphocyte antigen 4
cytotoxic T-lymphocyte-associated antigen 4
cytotoxic T-lymphocyte-associated serine esterase-4
cytotoxic T lymphocyte associated antigen 4 short spliced form
ligand and transmembrane spliced cytotoxic T lymphocyte associated antigen 4

Interactant



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