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CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa [Homo sapiens (human)]


Clone ID RefSeq Accession Definition Vector Stock Status *Turnaround time Price Order
OHu17197 NM_001098209 Homo sapiens catenin (cadherin-associated protein), beta 1, 88kDa (CTNNB1), transcript variant 2, mRNA. pcDNA3.1+-DYK In-stock 5-7 $99.00
OHu17197 NM_001098210 Homo sapiens catenin (cadherin-associated protein), beta 1, 88kDa (CTNNB1), transcript variant 3, mRNA. pcDNA3.1+-DYK In-stock 5-7 $99.00
OHu17197 NM_001904 Homo sapiens catenin (cadherin-associated protein), beta 1, 88kDa (CTNNB1), transcript variant 1, mRNA. pcDNA3.1+-DYK In-stock 5-7 $99.00
OHu17197 XM_005264886 PREDICTED: Homo sapiens catenin (cadherin-associated protein), beta 1, 88kDa (CTNNB1), transcript variant X1, mRNA. pcDNA3.1+-DYK On-demand 12-14 $279.00
OHu36978 XM_006712983 PREDICTED: Homo sapiens catenin (cadherin-associated protein), beta 1, 88kDa (CTNNB1), transcript variant X2, mRNA. pcDNA3.1+-DYK On-demand 12-14 $279.00
OHu36978 XM_006712984 PREDICTED: Homo sapiens catenin (cadherin-associated protein), beta 1, 88kDa (CTNNB1), transcript variant X3, mRNA. pcDNA3.1+-DYK On-demand 12-14 $279.00
OHu36979 XM_006712985 PREDICTED: Homo sapiens catenin (cadherin-associated protein), beta 1, 88kDa (CTNNB1), transcript variant X4, mRNA. pcDNA3.1+-DYK On-demand 12-14 $279.00
OHu17197C NM_001098209 Homo sapiens catenin (cadherin-associated protein), beta 1, 88kDa (CTNNB1), transcript variant 2, mRNA. Customized vector In-stock 5-7 $149.00
OHu17197C NM_001098210 Homo sapiens catenin (cadherin-associated protein), beta 1, 88kDa (CTNNB1), transcript variant 3, mRNA. Customized vector In-stock 5-7 $149.00
OHu17197C NM_001904 Homo sapiens catenin (cadherin-associated protein), beta 1, 88kDa (CTNNB1), transcript variant 1, mRNA. Customized vector In-stock 5-7 $149.00
OHu17197C XM_005264886 PREDICTED: Homo sapiens catenin (cadherin-associated protein), beta 1, 88kDa (CTNNB1), transcript variant X1, mRNA. Customized vector On-demand 12-14 $329.00
OHu36978C XM_006712983 PREDICTED: Homo sapiens catenin (cadherin-associated protein), beta 1, 88kDa (CTNNB1), transcript variant X2, mRNA. Customized vector On-demand 12-14 $329.00
OHu36978C XM_006712984 PREDICTED: Homo sapiens catenin (cadherin-associated protein), beta 1, 88kDa (CTNNB1), transcript variant X3, mRNA. Customized vector On-demand 12-14 $329.00
OHu36979C XM_006712985 PREDICTED: Homo sapiens catenin (cadherin-associated protein), beta 1, 88kDa (CTNNB1), transcript variant X4, mRNA. Customized vector On-demand 12-14 $329.00

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Gene Symbol CTNNB1
Entrez Gene ID 1499
Full Name catenin (cadherin-associated protein), beta 1, 88kDa
Synonyms CTNNB, MRD19, armadillo
General protein information
Preferred Names
catenin beta-1
Names
catenin beta-1
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

3

3p21

Summary The protein encoded by this gene is part of a complex of proteins that constitute adherens junctions (AJs). AJs are necessary for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells. The encoded protein also anchors the actin cytoskeleton and may be responsible for transmitting the contact inhibition signal that causes cells to stop dividing once the epithelial sheet is complete. Finally, this protein binds to the product of the APC gene, which is mutated in adenomatous polyposis of the colon. Mutations in this gene are a cause of colorectal cancer (CRC), pilomatrixoma (PTR), medulloblastoma (MDB), and ovarian cancer. Three transcript variants encoding the same protein have been found for this gene.[provided by RefSeq, Oct 2009].
Disorder

MIM: 116806

Colorectal cancer (3); Hepatoblastoma (3); Pilomatricoma, 132600 (3);

mRNA Protein Product Sequence Price Select
NM_001098209, 148233337 NP_001091679, 148233338 catenin beta-1 ORF Sequence $660.00
NM_001098210, 148227671 NP_001091680, 148227672 catenin beta-1 ORF Sequence $660.00
NM_001904, 148228165 NP_001895, 4503131 catenin beta-1 ORF Sequence $660.00
XM_005264886, 578805672 XP_005264943, 530371928 catenin beta-1 isoform X1 ORF Sequence $750.00
XM_006712983, 578805673 XP_006713046, 578805674 catenin beta-1 isoform X2 ORF Sequence $750.00
XM_006712984, 578805675 XP_006713047, 578805676 catenin beta-1 isoform X3 ORF Sequence $750.00
XM_006712985, 578805677 XP_006713048, 578805678 catenin beta-1 isoform X4 ORF Sequence $700.00
KEGG
hsa04510Focal adhesion
hsa04310Wnt signaling pathway
hsa04520Adherens junction
hsa04530Tight junction
hsa04670Leukocyte transendothelial migration
hsa05217Basal cell carcinoma
hsa04916Melanogenesis
hsa05130Pathogenic Escherichia coli infection
hsa05213Endometrial cancer
hsa05215Prostate cancer
hsa05200Pathways in cancer
hsa05210Colorectal cancer
hsa05216Thyroid cancer
hsa05412Arrhythmogenic right ventricular cardiomyopathy (ARVC)
hsa05100Bacterial invasion of epithelial cells
hsa05166HTLV-I infection
hsa04390Hippo signaling pathway
hsa05205Proteoglycans in cancer
hsa04919Thyroid hormone signaling pathway
hsa04015Rap1 signaling pathway
WikiPathways
WP127IL-5 Signaling Pathway
WP138Androgen receptor signaling pathway
WP1984Integrated Breast Cancer Pathway
WP1544MicroRNAs in cardiomyocyte hypertrophy
WP1591Heart Development
WP428Wnt Signaling Pathway
WP366TGF-beta Receptor Signaling Pathway
WP560TGF Beta Signaling Pathway
WP363Wnt Signaling Pathway NetPath
WP399Wnt Signaling Pathway and Pluripotency
WP710DNA damage response (only ATM dependent)
WP236Adipogenesis
WP23B Cell Receptor Signaling Pathway
WP706SIDS Susceptibility Pathways
WP53Id Signaling Pathway
WP2377Integrated Pancreatic Cancer Pathway
WP2380BDNF signaling pathway
WP2036TWEAK Signaling Pathway
WP2118Arrhythmogenic right ventricular cardiomyopathy
WP2064Neural Crest Differentiation
WP2272Pathogenic Escherichia coli infection
WP2363Gastric cancer network 2
WP2355Corticotropin-releasing hormone
Pathway Interaction Database
ps1pathwayPresenilin action in Notch and Wnt signaling
vegfr1_2_pathwaySignaling events mediated by VEGFR1 and VEGFR2
met_pathwaySignaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
ecadherin_stabilization_pathwayStabilization and expansion of the E-cadherin adherens junction
arf6_traffickingpathwayArf6 trafficking events
cdc42_pathwayCDC42 signaling events
foxopathwayFoxO family signaling
ncadherinpathwayN-cadherin signaling events
ecadherin_1_pathwayE-cadherin signaling events
wnt_canonical_pathwayCanonical Wnt signaling pathway
tgfbrpathwayTGF-beta receptor signaling
nectin_pathwayNectin adhesion pathway
ecadherin_nascentaj_pathwayE-cadherin signaling in the nascent adherens junction
ar_pathwayCoregulation of Androgen receptor activity
wnt_beta_catenin_pathwayRegulation of Wnt-mediated beta catenin signaling and target gene transcription
rac1_pathwayRAC1 signaling pathway
Reactome
REACT_578Apoptosis
REACT_107Apoptotic cleavage of cellular proteins
REACT_13579Apoptotic cleavage of cell adhesion proteins
REACT_995Apoptotic execution phase
REACT_19331Cell-cell junction organization
REACT_19195Adherens junctions interactions
REACT_17015Metabolism of proteins
REACT_6900Immune System
REACT_6802Innate Immune System
REACT_11045Signaling by Wnt
REACT_11065Beta-catenin phosphorylation cascade
REACT_11063Degradation of beta-catenin by the destruction complex
REACT_20676Cell junction organization
REACT_21303Myogenesis
REACT_21402CDO in myogenesis
REACT_24019Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)
REACT_23974Incretin synthesis, secretion, and inactivation
REACT_111102Signal Transduction
REACT_111045Developmental Biology
REACT_111155Cell-Cell communication
REACT_118823Cytosolic sensors of pathogen-associated DNA
REACT_163743LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production
REACT_160078Peptide hormone metabolism
REACT_200731deactivation of the beta-catenin transactivating complex
REACT_200777TCF dependent signaling in response to WNT
REACT_200799binding of TCF/LEF:CTNNB1 to target gene promoters
REACT_200610disassembly of the destruction complex and recruitment of AXIN to the membrane
REACT_200753formation of the beta-catenin:TCF transactivating complex
REACT_172761Ca2+ pathway
REACT_172694beta-catenin independent WNT signaling
Homo sapiens (human)CTNNB1NP_001091679.1
Pan troglodytes (chimpanzee)CTNNB1XP_001138023.1
Macaca mulatta (Rhesus monkey)CTNNB1XP_002802886.1
Canis lupus familiaris (dog)CTNNB1NP_001131124.1
Bos taurus (cattle)CTNNB1NP_001069609.1
Mus musculus (house mouse)Ctnnb1NP_001159374.1
Rattus norvegicus (Norway rat)Ctnnb1NP_445809.2
Gallus gallus (chicken)CTNNB1NP_990412.1
Danio rerio (zebrafish)ctnnb1NP_571134.2
Drosophila melanogaster (fruit fly)armNP_996328.1
Caenorhabditis eleganshmp-2NP_001252426.1
Xenopus (Silurana) tropicalis (western clawed frog)ctnnb1NP_001016958.1
Process
IDNameEvidence
GO:0000122negative regulation of transcription from RNA polymerase II promoterIBA
GO:0000578embryonic axis specificationIBA
GO:0001569patterning of blood vesselsIBA
GO:0001569patterning of blood vesselsIC
GO:0001658branching involved in ureteric bud morphogenesisIBA
GO:0001701in utero embryonic developmentIEA
GO:0001702gastrulation with mouth forming secondIBA
GO:0001708cell fate specificationIEA
GO:0001711endodermal cell fate commitmentIBA
GO:0001764neuron migrationIEA
GO:0001837epithelial to mesenchymal transitionTAS
GO:0001840neural plate developmentIEA
GO:0001889liver developmentIBA
GO:0002052positive regulation of neuroblast proliferationIEA
GO:0002053positive regulation of mesenchymal cell proliferationIEA
GO:0002089lens morphogenesis in camera-type eyeIEA
GO:0003136negative regulation of heart induction by canonical Wnt signaling pathwayIBA
GO:0003266regulation of secondary heart field cardioblast proliferationIEA
GO:0003337mesenchymal to epithelial transition involved in metanephros morphogenesisIBA
GO:0006351transcription, DNA-templatedIEA
GO:0006915apoptotic processTAS
GO:0006921cellular component disassembly involved in execution phase of apoptosisTAS
GO:0007016cytoskeletal anchoring at plasma membraneIBA
GO:0007155cell adhesionIMP
GO:0007160cell-matrix adhesionIBA
GO:0007398ectoderm developmentIBA
GO:0007403glial cell fate determinationIBA
GO:0007494midgut developmentIEA
GO:0008285negative regulation of cell proliferationIDA
GO:0009948anterior/posterior axis specificationIEA
GO:0009950dorsal/ventral axis specificationIBA
GO:0009954proximal/distal pattern formationIBA
GO:0010718positive regulation of epithelial to mesenchymal transitionIGI
GO:0010909positive regulation of heparan sulfate proteoglycan biosynthetic processIMP
GO:0014010Schwann cell proliferationIBA
GO:0016055Wnt signaling pathwayIDA
GO:0016337single organismal cell-cell adhesionIMP
GO:0021819layer formation in cerebral cortexIEA
GO:0022009central nervous system vasculogenesisIBA
GO:0030316osteoclast differentiationIEA
GO:0030326embryonic limb morphogenesisIBA
GO:0030521androgen receptor signaling pathwayNAS
GO:0030539male genitalia developmentIBA
GO:0030902hindbrain developmentIBA
GO:0030997regulation of centriole-centriole cohesionIDA
GO:0031016pancreas developmentIBA
GO:0031069hair follicle morphogenesisIBA
GO:0031641regulation of myelinationIEA
GO:0032331negative regulation of chondrocyte differentiationIBA
GO:0032355response to estradiolIDA
GO:0032481positive regulation of type I interferon productionTAS
GO:0033077T cell differentiation in thymusIBA
GO:0033234negative regulation of protein sumoylationIDA
GO:0034097response to cytokineIEA
GO:0034333adherens junction assemblyIMP
GO:0034394protein localization to cell surfaceIMP
GO:0035050embryonic heart tube developmentIEA
GO:0035112genitalia morphogenesisIEA
GO:0035115embryonic forelimb morphogenesisIEA
GO:0035116embryonic hindlimb morphogenesisIEA
GO:0035315hair cell differentiationTAS
GO:0036023embryonic skeletal limb joint morphogenesisISS
GO:0042129regulation of T cell proliferationIBA
GO:0042475odontogenesis of dentin-containing toothIBA
GO:0042493response to drugIEP
GO:0042692muscle cell differentiationTAS
GO:0042733embryonic digit morphogenesisIEA
GO:0043065positive regulation of apoptotic processIDA
GO:0043123positive regulation of I-kappaB kinase/NF-kappaB signalingIBA
GO:0043410positive regulation of MAPK cascadeIBA
GO:0043587tongue morphogenesisIBA
GO:0044334canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transitionIMP
GO:0044336canonical Wnt signaling pathway involved in negative regulation of apoptotic processIMP
GO:0045087innate immune responseTAS
GO:0045445myoblast differentiationIEA
GO:0045453bone resorptionIEA
GO:0045603positive regulation of endothelial cell differentiationIEA
GO:0045669positive regulation of osteoblast differentiationIBA
GO:0045671negative regulation of osteoclast differentiationIBA
GO:0045743positive regulation of fibroblast growth factor receptor signaling pathwayIBA
GO:0045765regulation of angiogenesisTAS
GO:0045892negative regulation of transcription, DNA-templatedIMP
GO:0045893positive regulation of transcription, DNA-templatedIDA
GO:0045893positive regulation of transcription, DNA-templatedIMP
GO:0045944positive regulation of transcription from RNA polymerase II promoterIDA
GO:0045944positive regulation of transcription from RNA polymerase II promoterIMP
GO:0046686response to cadmium ionIEA
GO:0048145regulation of fibroblast proliferationTAS
GO:0048262determination of dorsal/ventral asymmetryIBA
GO:0048469cell maturationIEA
GO:0048489synaptic vesicle transportIBA
GO:0048538thymus developmentIBA
GO:0048599oocyte developmentIBA
GO:0048617embryonic foregut morphogenesisIBA
GO:0048660regulation of smooth muscle cell proliferationIMP
GO:0048715negative regulation of oligodendrocyte differentiationIEA
GO:0050808synapse organizationIBA
GO:0051145smooth muscle cell differentiationIBA
GO:0051149positive regulation of muscle cell differentiationTAS
GO:0051291protein heterooligomerizationIEA
GO:0060066oviduct developmentIEA
GO:0060070canonical Wnt signaling pathwayIDA
GO:0060440trachea formationIBA
GO:0060441epithelial tube branching involved in lung morphogenesisIEA
GO:0060479lung cell differentiationIBA
GO:0060484lung-associated mesenchyme developmentIBA
GO:0060492lung inductionIBA
GO:0060742epithelial cell differentiation involved in prostate gland developmentIEA
GO:0060769positive regulation of epithelial cell proliferation involved in prostate gland developmentIBA
GO:0060789hair follicle placode formationIBA
GO:0060916mesenchymal cell proliferation involved in lung developmentIBA
GO:0061047positive regulation of branching involved in lung morphogenesisIBA
GO:0061154endothelial tube morphogenesisIMP
GO:0061198fungiform papilla formationIEA
GO:0061324canonical Wnt signaling pathway involved in positive regulation of cardiac outflow tract cell proliferationISS
GO:0070602regulation of centromeric sister chromatid cohesionIMP
GO:0071260cellular response to mechanical stimulusIEA
GO:0071363cellular response to growth factor stimulusIMP
GO:0071681cellular response to indole-3-methanolIDA
GO:0072033renal vesicle formationIBA
GO:0072053renal inner medulla developmentIBA
GO:0072054renal outer medulla developmentIBA
GO:0072079nephron tubule formationIBA
GO:0072182regulation of nephron tubule epithelial cell differentiationISS
GO:0090279regulation of calcium ion importIDA
GO:2000008regulation of protein localization to cell surfaceIDA
GO:2000017positive regulation of determination of dorsal identityIEA
GO:2001234negative regulation of apoptotic signaling pathwayIEA
Component
IDNameEvidence
GO:0000922spindle poleIEA
GO:0005634nucleusIDA
GO:0005654nucleoplasmTAS
GO:0005667transcription factor complexIDA
GO:0005737cytoplasmIDA
GO:0005813centrosomeIDA
GO:0005829cytosolIDA
GO:0005829cytosolTAS
GO:0005886plasma membraneIDA
GO:0005911cell-cell junctionIDA
GO:0005912adherens junctionIDA
GO:0005913cell-cell adherens junctionIDA
GO:0005915zonula adherensIBA
GO:0005916fascia adherensIBA
GO:0005938cell cortexIDA
GO:0009898cytoplasmic side of plasma membraneIBA
GO:0016020membraneISS
GO:0016323basolateral plasma membraneIEA
GO:0016328lateral plasma membraneIDA
GO:0016342catenin complexIDA
GO:0030018Z discIBA
GO:0030027lamellipodiumIBA
GO:0030054cell junctionIDA
GO:0030054cell junctionTAS
GO:0030057desmosomeIBA
GO:0030877beta-catenin destruction complexIDA
GO:0031528microvillus membraneIBA
GO:0032993protein-DNA complexIDA
GO:0034750Scrib-APC-beta-catenin complexIEA
GO:0043198dendritic shaftIBA
GO:0045177apical part of cellIEA
GO:0045202synapseIBA
GO:0048471perinuclear region of cytoplasmIDA
GO:0070062extracellular vesicular exosomeIDA
GO:0070369beta-catenin-TCF7L2 complexIDA
GO:0071944cell peripheryIDA
Function
IDNameEvidence
GO:0001102RNA polymerase II activating transcription factor bindingIPI
GO:0003682chromatin bindingIEA
GO:0003690double-stranded DNA bindingIEA
GO:0003700sequence-specific DNA binding transcription factor activityIEA
GO:0003713transcription coactivator activityIDA
GO:0003713transcription coactivator activityIMP
GO:0004871signal transducer activityNAS
GO:0005198structural molecule activityIBA
GO:0005515protein bindingIPI
GO:0008022protein C-terminus bindingIPI
GO:0008134transcription factor bindingIPI
GO:0008134transcription factor bindingTAS
GO:0019899enzyme bindingIPI
GO:0019900kinase bindingIPI
GO:0019901protein kinase bindingIBA
GO:0019903protein phosphatase bindingIPI
GO:0030331estrogen receptor bindingIPI
GO:0032403protein complex bindingIEA
GO:0035255ionotropic glutamate receptor bindingIEA
GO:0035257nuclear hormone receptor bindingIPI
GO:0035257nuclear hormone receptor bindingTAS
GO:0044212transcription regulatory region DNA bindingIDA
GO:0044325ion channel bindingIPI
GO:0045294alpha-catenin bindingIPI
GO:0045296cadherin bindingIPI
GO:0046332SMAD bindingIPI
GO:0050681androgen receptor bindingNAS
GO:0070411I-SMAD bindingIPI
GO:0070412R-SMAD bindingIPI
GO:0070491repressing transcription factor bindingIEA
GeneCards CTNNB1
UniProt P35222, B4DGU4
Vega OTTHUMG00000131393
MIM 116806
Ensembl ENSG00000168036
HGNC 2514
HPRD 00286

GeneRIFs: Gene References Into Functions What's a GeneRIF?

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