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CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa [Homo sapiens (human)]


RefSeq Accession Definition Services Price Order
NM_001098209 Homo sapiens catenin (cadherin-associated protein), beta 1, 88kDa (CTNNB1), transcript variant 2, mRNA. ORF Sequence $680.34
Peptide Services
Antibody Services
Protein Services
NM_001098210 Homo sapiens catenin (cadherin-associated protein), beta 1, 88kDa (CTNNB1), transcript variant 3, mRNA. ORF Sequence $680.34
Peptide Services
Antibody Services
Protein Services
NM_001904 Homo sapiens catenin (cadherin-associated protein), beta 1, 88kDa (CTNNB1), transcript variant 1, mRNA. ORF Sequence $680.34
Peptide Services
Antibody Services
Protein Services


Gene Symbol CTNNB1
Entrez Gene ID 1499
Full Name catenin (cadherin-associated protein), beta 1, 88kDa
Synonyms CTNNB, DKFZp686D02253, FLJ25606, FLJ37923
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

3

3p21

Summary The protein encoded by this gene is part of a complex of proteins that constitute adherens junctions (AJs). AJs are necessary for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells. The encoded protein also anchors the actin cytoskeleton and may be responsible for transmitting the contact inhibition signal that causes cells to stop dividing once the epithelial sheet is complete. Finally, this protein binds to the product of the APC gene, which is mutated in adenomatous polyposis of the colon. Mutations in this gene are a cause of colorectal cancer (CRC), pilomatrixoma (PTR), medulloblastoma (MDB), and ovarian cancer. Three transcript variants encoding the same protein have been found for this gene.[provided by RefSeq, Oct 2009].
Disorder

MIM: 116806

Colorectal cancer (3); Hepatoblastoma (3); Pilomatricoma, 132600 (3);

mRNA Protein Product Sequence Price Select
NM_001098209, 148233337 NP_001091679, 148233338 catenin beta-1 Full Length $1195.25
ORF Sequence $680.34
NM_001098210, 148227671 NP_001091680, 148227672 catenin beta-1 Full Length $1139.60
ORF Sequence $680.34
NM_001904, 148228165 NP_001895, 4503131 catenin beta-1 Full Length $1302.00
ORF Sequence $680.34
KEGG
hsa05100Bacterial invasion of epithelial cells
hsa04510Focal adhesion
hsa05412Arrhythmogenic right ventricular cardiomyopathy (ARVC)
hsa05200Pathways in cancer
hsa04670Leukocyte transendothelial migration
hsa05130Pathogenic Escherichia coli infection
hsa04916Melanogenesis
hsa05213Endometrial cancer
hsa05166HTLV-I infection
hsa05216Thyroid cancer
hsa04530Tight junction
hsa04520Adherens junction
hsa05217Basal cell carcinoma
hsa04310Wnt signaling pathway
hsa05210Colorectal cancer
hsa05215Prostate cancer
Pathway Interaction Database
ar_pathwayCoregulation of Androgen receptor activity
ncadherinpathwayN-cadherin signaling events
ps1pathwayPresenilin action in Notch and Wnt signaling
ecadherin_1_pathwayE-cadherin signaling events
wnt_beta_catenin_pathwayRegulation of Wnt-mediated beta catenin signaling and target gene transcription
cdc42_pathwayCDC42 signaling events
ecadherin_stabilization_pathwayStabilization and expansion of the E-cadherin adherens junction
met_pathwaySignaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
tgfbrpathwayTGF-beta receptor signaling
foxopathwayFoxO family signaling
wnt_canonical_pathwayCanonical Wnt signaling pathway
rac1_pathwayRAC1 signaling pathway
ecadherin_nascentaj_pathwayE-cadherin signaling in the nascent adherens junction
vegfr1_2_pathwaySignaling events mediated by VEGFR1 and VEGFR2
nectin_pathwayNectin adhesion pathway
arf6_traffickingpathwayArf6 trafficking events
WikiPathways
WP560TGF Beta Signaling Pathway
WP2272Pathogenic Escherichia coli infection
WP1984Integrated Breast Cancer Pathway
WP428Wnt Signaling Pathway
WP366TGF-beta Receptor Signaling Pathway
WP23B Cell Receptor Signaling Pathway
WP710DNA damage response (only ATM dependent)
WP1544MicroRNAs in cardiomyocyte hypertrophy
WP2064Neural Crest Differentiation
WP1591Heart Development
WP363Wnt Signaling Pathway NetPath
WP53Id Signaling Pathway
WP706SIDS Susceptibility Pathways
WP236Adipogenesis
WP127IL-5 Signaling Pathway
WP2256Integrated Pancreatic Cancer Pathway
WP2377Integrated Pancreatic Cancer Pathway
WP2036TWEAK Signaling Pathway
WP399Wnt Signaling Pathway and Pluripotency
WP2118Arrhythmogenic right ventricular cardiomyopathy
WP138Androgen receptor signaling pathway
Reactome
REACT_11065Beta-catenin phosphorylation cascade
REACT_111102Signal Transduction
REACT_107Apoptotic cleavage of cellular proteins
REACT_24019Synthesis, Secretion, and Inactivation of Glucagon-like Peptide-1 (GLP-1)
REACT_1505Integration of energy metabolism
REACT_13579Apoptotic cleavage of cell adhesion proteins
REACT_111045Developmental Biology
REACT_19331Cell-cell junction organization
REACT_111155Cell-Cell communication
REACT_21303Myogenesis
REACT_23974Incretin Synthesis, Secretion, and Inactivation
REACT_21402CDO in myogenesis
REACT_995Apoptotic execution phase
REACT_19195Adherens junctions interactions
REACT_111217Metabolism
REACT_11045Signaling by Wnt
REACT_18325Regulation of Insulin Secretion
REACT_11063Degradation of beta-catenin by the destruction complex
REACT_20676Cell junction organization
REACT_578Apoptosis
Homo sapiens (human)CTNNB1NP_001091679.1
Pan troglodytes (chimpanzee)CTNNB1XP_001138023.1
Macaca mulatta (Rhesus monkey)CTNNB1XP_002802884.1
Canis lupus familiaris (dog)CTNNB1NP_001131124.1
Bos taurus (cattle)CTNNB1NP_001069609.1
Mus musculus (house mouse)Ctnnb1NP_001159374.1
Rattus norvegicus (Norway rat)Ctnnb1NP_445809.2
Gallus gallus (chicken)CTNNB1NP_990412.1
Danio rerio (zebrafish)ctnnb1NP_571134.2
Drosophila melanogaster (fruit fly)armNP_996328.1
Caenorhabditis eleganshmp-2NP_493566.1
GeneCards CTNNB1
PDB 3TX7, 2Z6H, 1T08, 1QZ7, 3FQN, 1JPW, 3SLA, 2GL7, 1P22, 2G57, 3SL9, 1G3J, 1JDH, 1TH1, 3DIW, 4DJS, 1LUJ, 3FQR
UniProt P35222
MIM 116806
Ensembl ENSG00000168036
HGNC 2514
HPRD 00286

GeneRIFs: Gene References Into Functions What's a GeneRIF?

General protein information

Preferred Names
catenin beta-1
Names
catenin beta-1

Interactant

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