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ADRA2A adrenoceptor alpha 2A [Homo sapiens (human)]


RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_000681 Homo sapiens adrenoceptor alpha 2A (ADRA2A), mRNA. GenEZ ORF Cloning On-demand TBD TBD

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Gene Symbol ADRA2A
Entrez Gene ID 150
Full Name adrenoceptor alpha 2A
Synonyms ADRA2, ADRA2R, ADRAR, ALPHA2AAR, ZNF32
General protein information
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

10

10q25.2

Summary Alpha-2-adrenergic receptors are members of the G protein-coupled receptor superfamily. They include 3 highly homologous subtypes: alpha2A, alpha2B, and alpha2C. These receptors have a critical role in regulating neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. Studies in mouse revealed that both the alpha2A and alpha2C subtypes were required for normal presynaptic control of transmitter release from sympathetic nerves in the heart and from central noradrenergic neurons; the alpha2A subtype inhibited transmitter release at high stimulation frequencies, whereas the alpha2C subtype modulated neurotransmission at lower levels of nerve activity. This gene encodes alpha2A subtype and it contains no introns in either its coding or untranslated sequences. [provided by RefSeq, Jul 2008].
Disorder

MIM: 104210

mRNA Protein Product Sequence Price Select
NM_000681, 194353969 NP_000672, 194353970 alpha-2A adrenergic receptor ORF Sequence $550.00
KEGG
hsa04080Neuroactive ligand-receptor interaction
hsa04022cGMP-PKG signaling pathway
WikiPathways
WP58Monoamine GPCRs
WP455GPCRs, Class A Rhodopsin-like
Reactome
REACT_19180Adrenaline signalling through Alpha-2 adrenergic receptor
REACT_19184GPCR downstream signaling
REACT_19231G alpha (i) signalling events
REACT_19333G alpha (z) signalling events
REACT_18339Adrenaline,noradrenaline inhibits insulin secretion
REACT_18325Regulation of insulin secretion
REACT_798Platelet activation, signaling and aggregation
REACT_604Hemostasis
REACT_278Platelet Aggregation (Plug Formation)
REACT_1505Integration of energy metabolism
REACT_14828Class A/1 (Rhodopsin-like receptors)
REACT_14797Signaling by GPCR
REACT_16927Adrenoceptors
REACT_16983Amine ligand-binding receptors
REACT_21340GPCR ligand binding
REACT_111102Signal Transduction
REACT_111217Metabolism
Homo sapiens (human)ADRA2ANP_000672.3
Pan troglodytes (chimpanzee)ADRA2AXP_003312813.1
Macaca mulatta (Rhesus monkey)ADRA2AXP_001087738.2
Bos taurus (cattle)ADRA2ANP_776924.1
Mus musculus (house mouse)Adra2aNP_031443.4
Rattus norvegicus (Norway rat)Adra2aNP_036871.3
Gallus gallus (chicken)ADRA2AXP_004942333.1
Danio rerio (zebrafish)adra2aNP_997520.2
Drosophila melanogaster (fruit fly)CG18208NP_001262714.1
Caenorhabditis elegansoctr-1NP_001024569.1
Process
IDNameEvidence
GO:0001819positive regulation of cytokine productionIDA
GO:0002526acute inflammatory responseIEA
GO:0006112energy reserve metabolic processTAS
GO:0006260DNA replicationIEA
GO:0006928cellular component movementTAS
GO:0007165signal transductionTAS
GO:0007186G-protein coupled receptor signaling pathwayISS
GO:0007194negative regulation of adenylate cyclase activityISS
GO:0007265Ras protein signal transductionTAS
GO:0007266Rho protein signal transductionTAS
GO:0007565female pregnancyIEA
GO:0007596blood coagulationTAS
GO:0008284positive regulation of cell proliferationTAS
GO:0010700negative regulation of norepinephrine secretionNAS
GO:0010700negative regulation of norepinephrine secretionTAS
GO:0019229regulation of vasoconstrictionIEA
GO:0030036actin cytoskeleton organizationTAS
GO:0030168platelet activationTAS
GO:0030335positive regulation of cell migrationIMP
GO:0030818negative regulation of cAMP biosynthetic processIDA
GO:0030818negative regulation of cAMP biosynthetic processISS
GO:0032147activation of protein kinase activityIDA
GO:0032148activation of protein kinase B activityIDA
GO:0032811negative regulation of epinephrine secretionNAS
GO:0032870cellular response to hormone stimulusIGI
GO:0035625epidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathwayIDA
GO:0042593glucose homeostasisIMP
GO:0042596fear responseIEA
GO:0043268positive regulation of potassium ion transportISS
GO:0043406positive regulation of MAP kinase activityIDA
GO:0044281small molecule metabolic processTAS
GO:0045741positive regulation of epidermal growth factor-activated receptor activityIDA
GO:0045909positive regulation of vasodilationIEA
GO:0045955negative regulation of calcium ion-dependent exocytosisIC
GO:0046676negative regulation of insulin secretionIMP
GO:0050796regulation of insulin secretionTAS
GO:0050892intestinal absorptionTAS
GO:0050955thermoceptionIEA
GO:0050995negative regulation of lipid catabolic processIGI
GO:0051044positive regulation of membrane protein ectodomain proteolysisIDA
GO:0051926negative regulation of calcium ion transportISS
GO:0061179negative regulation of insulin secretion involved in cellular response to glucose stimulusIMP
GO:0070473negative regulation of uterine smooth muscle contractionIEA
GO:0071878negative regulation of adrenergic receptor signaling pathwayISS
GO:0071881adenylate cyclase-inhibiting adrenergic receptor signaling pathwayIDA
GO:0071882phospholipase C-activating adrenergic receptor signaling pathwayIDA
GO:0071883activation of MAPK activity by adrenergic receptor signaling pathwayIDA
GO:0090303positive regulation of wound healingIMP
GO:1901020negative regulation of calcium ion transmembrane transporter activityISS
Component
IDNameEvidence
GO:0005737cytoplasmIDA
GO:0005886plasma membraneTAS
GO:0005887integral component of plasma membraneIDA
GO:0016323basolateral plasma membraneTAS
GO:0043235receptor complexIDA
GO:0045202synapseIEA
Function
IDNameEvidence
GO:0004938alpha2-adrenergic receptor activityIDA
GO:0004938alpha2-adrenergic receptor activityISS
GO:0005515protein bindingIPI
GO:0019901protein kinase bindingIPI
GO:0031692alpha-1B adrenergic receptor bindingISS
GO:0031696alpha-2C adrenergic receptor bindingIPI
GO:0031996thioesterase bindingIPI
GO:0032795heterotrimeric G-protein bindingIDA
GO:0042803protein homodimerization activityIDA
GO:0046982protein heterodimerization activityIPI
GO:0046982protein heterodimerization activityISS
GO:0051379epinephrine bindingIDA
GO:0051380norepinephrine bindingIDA
GeneCards ADRA2A
PDB 1HOF, 1HO9, 1HOD, 1HLL
UniProt P08913
Vega OTTHUMG00000019050
MIM 104210
Ensembl ENSG00000150594
HGNC 281
HPRD 00078

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