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ADRA2A adrenergic, alpha-2A-, receptor [Homo sapiens (human)]


RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_000681 Homo sapiens adrenoceptor alpha 2A (ADRA2A), mRNA. GenEZ ORF Cloning On-demand TBD TBD

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Gene Symbol ADRA2A
Entrez Gene ID 150
Full Name adrenergic, alpha-2A-, receptor
Synonyms ADRA2, ADRA2R, ADRAR, ALPHA2AAR, ZNF32
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

10

10q24-q26

Summary Alpha-2-adrenergic receptors are members of the G protein-coupled receptor superfamily. They include 3 highly homologous subtypes: alpha2A, alpha2B, and alpha2C. These receptors have a critical role in regulating neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. Studies in mouse revealed that both the alpha2A and alpha2C subtypes were required for normal presynaptic control of transmitter release from sympathetic nerves in the heart and from central noradrenergic neurons; the alpha2A subtype inhibited transmitter release at high stimulation frequencies, whereas the alpha2C subtype modulated neurotransmission at lower levels of nerve activity. This gene encodes alpha2A subtype and it contains no introns in either its coding or untranslated sequences. [provided by RefSeq, Jul 2008].
Disorder

MIM: 104210

mRNA Protein Product Sequence Price Select
NM_000681, 194353969 NP_000672, 194353970 alpha-2A adrenergic receptor ORF Sequence $550.00
KEGG
hsa04080Neuroactive ligand-receptor interaction
WikiPathways
WP58Monoamine GPCRs
WP455GPCRs, Class A Rhodopsin-like
Reactome
REACT_278Platelet Aggregation (Plug Formation)
REACT_798Platelet activation, signaling and aggregation
REACT_111217Metabolism
REACT_19184GPCR downstream signaling
REACT_1505Integration of energy metabolism
REACT_21340GPCR ligand binding
REACT_16983Amine ligand-binding receptors
REACT_14797Signaling by GPCR
REACT_604Hemostasis
REACT_19180Adrenaline signalling through Alpha-2 adrenergic receptor
REACT_18325Regulation of Insulin Secretion
REACT_16927Adrenoceptors
REACT_19333G alpha (z) signalling events
REACT_14828Class A/1 (Rhodopsin-like receptors)
REACT_19231G alpha (i) signalling events
REACT_111102Signal Transduction
REACT_18339Inhibition of Insulin Secretion by Adrenaline/Noradrenaline
Homo sapiens (human)ADRA2ANP_000672.3
Pan troglodytes (chimpanzee)ADRA2AXP_003312813.1
Macaca mulatta (Rhesus monkey)ADRA2AXP_001087738.2
Canis lupus familiaris (dog)ADRA2AXP_544018.3
Bos taurus (cattle)ADRA2ANP_776924.1
Mus musculus (house mouse)Adra2aNP_031443.4
Gallus gallus (chicken)ADRA2AXP_426537.3
Danio rerio (zebrafish)adra2aNP_997520.2
GeneCards ADRA2A
PDB 1HOF, 1HO9, 1HOD, 1HLL
UniProt P08913
MIM 104210
Ensembl ENSG00000150594
HGNC 281
HPRD 00078

GeneRIFs: Gene References Into Functions What's a GeneRIF?

General protein information

Interactant



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