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CYBA cytochrome b-245, alpha polypeptide [Homo sapiens (human)]


RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_000101 Homo sapiens cytochrome b-245, alpha polypeptide (CYBA), mRNA. GenEZ ORF Cloning On-demand $399.00 14

*Business Day

Related Services

Gene Symbol CYBA
Entrez Gene ID 1535
Full Name cytochrome b-245, alpha polypeptide
Synonyms p22-PHOX
General protein information
Preferred Names
cytochrome b-245 light chain
Names
cytochrome b-245 light chain
p22phox
cytochrome b light chain
p22 phagocyte B-cytochrome
cytochrome b(558) alpha chain
cytochrome b558 subunit alpha
cytochrome b(558) alpha-subunit
cytochrome b, alpha polypeptide
flavocytochrome b-558 alpha polypeptide
neutrophil cytochrome b 22 kDa polypeptide
superoxide-generating NADPH oxidase light chain subunit
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

16

16q24

Summary Cytochrome b is comprised of a light chain (alpha) and a heavy chain (beta). This gene encodes the light, alpha subunit which has been proposed as a primary component of the microbicidal oxidase system of phagocytes. Mutations in this gene are associated with autosomal recessive chronic granulomatous disease (CGD), that is characterized by the failure of activated phagocytes to generate superoxide, which is important for the microbicidal activity of these cells. [provided by RefSeq, Jul 2008].
Disorder

MIM: 608508

Chronic granulomatous disease, autosomal, due to deficiency of CYBA,

mRNA Protein Product Sequence Price Select
NM_000101, 371941004 NP_000092, 68509914 cytochrome b-245 light chain ORF Sequence $250.00
KEGG
hsa04670Leukocyte transendothelial migration
hsa05140Leishmaniasis
hsa04145Phagosome
hsa04380Osteoclast differentiation
WikiPathways
WP408Oxidative Stress
Pathway Interaction Database
rac1_pathwayRAC1 signaling pathway
Reactome
REACT_6900Immune System
REACT_75774Adaptive Immune System
REACT_75820Class I MHC mediated antigen processing & presentation
REACT_111119Antigen processing-Cross presentation
REACT_111174Cross-presentation of particulate exogenous antigens (phagosomes)
REACT_116125Disease
REACT_121256Phagosomal maturation (early endosomal stage)
REACT_121237Latent infection of Homo sapiens with Mycobacterium tuberculosis
Homo sapiens (human)CYBANP_000092.2
Pan troglodytes (chimpanzee)CYBAXP_523459.1
Macaca mulatta (Rhesus monkey)LOC696748XP_001089060.1
Canis lupus familiaris (dog)CYBANP_001093760.1
Bos taurus (cattle)CYBANP_776459.1
Mus musculus (house mouse)CybaNP_031832.2
Rattus norvegicus (Norway rat)CybaNP_077074.1
Danio rerio (zebrafish)cybaNP_956873.1
Xenopus (Silurana) tropicalis (western clawed frog)cybaNP_001016480.1
Process
IDNameEvidence
GO:0001938positive regulation of endothelial cell proliferationIEA
GO:0002474antigen processing and presentation of peptide antigen via MHC class ITAS
GO:0002479antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependentTAS
GO:0003106negative regulation of glomerular filtration by angiotensinIEA
GO:0006801superoxide metabolic processIMP
GO:0006954inflammatory responseIMP
GO:0014895smooth muscle hypertrophyISS
GO:0017004cytochrome complex assemblyIDA
GO:0030307positive regulation of cell growthIEA
GO:0031667response to nutrient levelsIEA
GO:0042493response to drugIEA
GO:0042554superoxide anion generationIMP
GO:0042590antigen processing and presentation of exogenous peptide antigen via MHC class ITAS
GO:0045087innate immune responseIMP
GO:0045730respiratory burstIMP
GO:0050665hydrogen peroxide biosynthetic processISS
GO:0051701interaction with hostTAS
GO:0055114oxidation-reduction processIMP
GO:0070555response to interleukin-1IEA
GO:0071230cellular response to amino acid stimulusIEA
GO:0071260cellular response to mechanical stimulusIEA
GO:0071333cellular response to glucose stimulusIEA
GO:0071356cellular response to tumor necrosis factorIEA
GO:0071407cellular response to organic cyclic compoundIEA
GO:0071480cellular response to gamma radiationIEA
GO:0090382phagosome maturationTAS
Component
IDNameEvidence
GO:0005739mitochondrionIEA
GO:0005794Golgi apparatusIEA
GO:0016020membraneIDA
GO:0016324apical plasma membraneIEA
GO:0030141secretory granuleTAS
GO:0030425dendriteIEA
GO:0030670phagocytic vesicle membraneTAS
GO:0043020NADPH oxidase complexIDA
GO:0043020NADPH oxidase complexIMP
GO:0043025neuronal cell bodyIEA
Function
IDNameEvidence
GO:0005515protein bindingIPI
GO:0009055electron carrier activityIDA
GO:0009055electron carrier activityTAS
GO:0016175superoxide-generating NADPH oxidase activityIMP
GO:0017124SH3 domain bindingIPI
GO:0020037heme bindingIEA
GO:0046872metal ion bindingIEA
GO:0046982protein heterodimerization activityIPI
GeneCards CYBA
PDB 1WLP
UniProt P13498, B4DT46
Vega OTTHUMG00000173320
MIM 608508
Ensembl ENSG00000051523
HGNC 2577
HPRD 01989

GeneRIFs: Gene References Into Functions What's a GeneRIF?

What is the normal function of the CYBA gene?

The CYBA gene provides instructions for making a protein called cytochrome b-245, alpha subunit (also known as p22-phox). This protein is one part (subunit) of a group of proteins that forms an enzyme complex called NADPH oxidase, which plays an essential role in the immune system. Within this complex, the cytochrome b-245, alpha subunit has a beta subunit partner (produced from the CYBB gene). Both alpha and beta subunits are required for either to function and the NADPH oxidase complex requires both subunits in order to be functional. NADPH oxidase is primarily active in immune system cells called phagocytes. These cells catch and destroy foreign invaders such as bacteria and fungi. NADPH oxidase is also thought to regulate the activity of immune cells called neutrophils. These cells play a role in adjusting the inflammatory response to optimize healing and reduce injury to the body.

The presence of foreign invaders stimulates phagocytes and triggers the assembly of NADPH oxidase. This enzyme participates in a chemical reaction that converts oxygen to a toxic molecule called superoxide. Superoxide is used to generate several other compounds, including hydrogen peroxide (a strong disinfectant) and hypochlorous acid (the active ingredient in bleach). These highly reactive, toxic substances are known as reactive oxygen species. Phagocytes use these substances to kill foreign invaders, preventing them from reproducing in the body and causing illness.

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