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Sequence in raw or FASTA format:


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CYBA cytochrome b-245, alpha polypeptide [Homo sapiens (human)]

RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_000101 Homo sapiens cytochrome b-245, alpha polypeptide (CYBA), mRNA. GenEZ ORF Cloning On-demand $399.00 14

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Gene Symbol CYBA
Entrez Gene ID 1535
Full Name cytochrome b-245, alpha polypeptide
Synonyms p22-PHOX
Gene Type protein-coding
Organism Homo sapiens (human)



Summary Cytochrome b is comprised of a light chain (alpha) and a heavy chain (beta). This gene encodes the light, alpha subunit which has been proposed as a primary component of the microbicidal oxidase system of phagocytes. Mutations in this gene are associated with autosomal recessive chronic granulomatous disease (CGD), that is characterized by the failure of activated phagocytes to generate superoxide, which is important for the microbicidal activity of these cells. [provided by RefSeq, Jul 2008].

MIM: 608508

Chronic granulomatous disease, autosomal, due to deficiency of CYBA,

mRNA Protein Product Sequence Price Select
NM_000101, 371941004 NP_000092, 68509914 cytochrome b-245 light chain ORF Sequence $250.00
hsa04670Leukocyte transendothelial migration
hsa04380Osteoclast differentiation
Pathway Interaction Database
rac1_pathwayRAC1 signaling pathway
WP408Oxidative Stress
REACT_75820Class I MHC mediated antigen processing & presentation
REACT_6900Immune System
REACT_121256Phagosomal maturation (early endosomal stage)
REACT_111119Antigen processing-Cross presentation
REACT_111174Cross-presentation of particulate exogenous antigens (phagosomes)
REACT_75774Adaptive Immune System
REACT_121237Latent infection of Homo sapiens with Mycobacterium tuberculosis
Homo sapiens (human)CYBANP_000092.2
Pan troglodytes (chimpanzee)LOC468068XP_523459.1
Macaca mulatta (Rhesus monkey)LOC696748XP_001089060.1
Canis lupus familiaris (dog)CYBANP_001093760.1
Bos taurus (cattle)CYBANP_776459.1
Mus musculus (house mouse)CybaNP_031832.2
Rattus norvegicus (Norway rat)CybaNP_077074.1
Danio rerio (zebrafish)cybaNP_956873.1
GeneCards CYBA
UniProt P13498, B4DT46
MIM 608508
Ensembl ENSG00000051523
HGNC 2577
HPRD 01989

GeneRIFs: Gene References Into Functions What's a GeneRIF?

General protein information

Preferred Names
cytochrome b-245 light chain
cytochrome b-245 light chain
cytochrome b light chain
p22 phagocyte B-cytochrome
cytochrome b(558) alpha chain
cytochrome b558 subunit alpha
cytochrome b(558) alpha-subunit
cytochrome b, alpha polypeptide
flavocytochrome b-558 alpha polypeptide
neutrophil cytochrome b 22 kDa polypeptide
superoxide-generating NADPH oxidase light chain subunit


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