CYBA cytochrome b-245, alpha polypeptide [Homo sapiens (human)]

Gene Symbol	CYBA
Entrez Gene ID	1535
Full Name	cytochrome b-245, alpha polypeptide
Synonyms	p22-PHOX
Gene Type	protein-coding
Organism	Homo sapiens (human)
Genome	Chromosome:16 Map Location:16q24
Summary	Cytochrome b is comprised of a light chain (alpha) and a heavy chain (beta). This gene encodes the light, alpha subunit which has been proposed as a primary component of the microbicidal oxidase system of phagocytes. Mutations in this gene are associated with autosomal recessive chronic granulomatous disease (CGD), that is characterized by the failure of activated phagocytes to generate superoxide, which is important for the microbicidal activity of these cells. [provided by RefSeq].
Disorder	MIM: 608508 Chronic granulomatous disease, autosomal, due to deficiency of CYBA,

KEGG

hsa04670	Leukocyte transendothelial migration
hsa04380	Osteoclast differentiation
hsa04145	Phagosome
hsa05140	Leishmaniasis

WikiPathways

WP408

Oxidative Stress

Pathway Interaction Database

rac1_pathway

RAC1 signaling pathway

Homo sapiens (human)	CYBA	NP_000092.2
Pan troglodytes (chimpanzee)	LOC468068	XP_523459.1
Canis lupus familiaris (dog)	CYBA	XP_546784.2
Bos taurus (cattle)	CYBA	NP_776459.1
Mus musculus (house mouse)	Cyba	NP_031832.1
Rattus norvegicus (Norway rat)	Cyba	NP_077074.1
Danio rerio (zebrafish)	cyba	NP_956873.1

Process

ID	Name	Evidence
GO:0001938	positive regulation of endothelial cell proliferation	IEA
GO:0003106	negative regulation of glomerular filtration by angiotensin	IEA
GO:0006801	superoxide metabolic process	IMP
GO:0006810	transport	IEA
GO:0006954	inflammatory response	IMP
GO:0008217	regulation of blood pressure	IEA
GO:0014895	smooth muscle hypertrophy	ISS
GO:0017004	cytochrome complex assembly	IDA
GO:0022900	electron transport chain	IEA
GO:0030307	positive regulation of cell growth	IEA
GO:0031667	response to nutrient levels	IEA
GO:0042554	superoxide anion generation	IMP
GO:0045087	innate immune response	IMP
GO:0045730	respiratory burst	IMP
GO:0050665	hydrogen peroxide biosynthetic process	ISS
GO:0055114	oxidation-reduction process	IMP
GO:0070555	response to interleukin-1	IEA
GO:0071230	cellular response to amino acid stimulus	IEA
GO:0071260	cellular response to mechanical stimulus	IEA
GO:0071333	cellular response to glucose stimulus	IEA
GO:0071356	cellular response to tumor necrosis factor	IEA
GO:0071407	cellular response to organic cyclic compound	IEA
GO:0071480	cellular response to gamma radiation	IEA

Component

Function

ID	Name	Evidence
GO:0005515	protein binding	IPI
GO:0009055	electron carrier activity	IDA
GO:0009055	electron carrier activity	TAS
GO:0016175	superoxide-generating NADPH oxidase activity	IMP
GO:0016491	oxidoreductase activity	IEA
GO:0017124	SH3 domain binding	IPI
GO:0020037	heme binding	IEA
GO:0046872	metal ion binding	IEA
GO:0046982	protein heterodimerization activity	IPI

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RefSeq Accession	Definition	Sequence	Price	Select
NM_000101	Homo sapiens cytochrome b-245, alpha polypeptide (CYBA), mRNA.	Full Length	$215.47
NM_000101		ORF Sequence	$170.52