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CYBB cytochrome b-245, beta polypeptide [Homo sapiens (human)]

RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_000397 Homo sapiens cytochrome b-245, beta polypeptide (CYBB), mRNA. GenEZ ORF Cloning In-stock $639.00 $590.00 15

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Gene Symbol CYBB
Entrez Gene ID 1536
Full Name cytochrome b-245, beta polypeptide
Synonyms CGD, GP91-1, GP91-PHOX, GP91PHOX, NOX2, p91-PHOX
Gene Type protein-coding
Organism Homo sapiens (human)



Summary Cytochrome b (-245) is composed of cytochrome b alpha (CYBA) and beta (CYBB) chain. It has been proposed as a primary component of the microbicidal oxidase system of phagocytes. CYBB deficiency is one of five described biochemical defects associated with chronic granulomatous disease (CGD). In this disorder, there is decreased activity of phagocyte NADPH oxidase; neutrophils are able to phagocytize bacteria but cannot kill them in the phagocytic vacuoles. The cause of the killing defect is an inability to increase the cell's respiration and consequent failure to deliver activated oxygen into the phagocytic vacuole. [provided by RefSeq, Jul 2008].

MIM: 300481

Chronic granulomatous disease, X-linked, 306400 (3)

mRNA Protein Product Sequence Price Select
NM_000397, 163854302 NP_000388, 6996021 cytochrome b-245 heavy chain ORF Sequence $490.00
hsa04066HIF-1 signaling pathway
hsa04670Leukocyte transendothelial migration
hsa04380Osteoclast differentiation
Pathway Interaction Database
rac1_pathwayRAC1 signaling pathway
WP619Type II interferon signaling (IFNG)
REACT_111119Antigen processing-Cross presentation
REACT_6900Immune System
REACT_75820Class I MHC mediated antigen processing & presentation
REACT_121237Latent infection of Homo sapiens with Mycobacterium tuberculosis
REACT_75774Adaptive Immune System
REACT_111174Cross-presentation of particulate exogenous antigens (phagosomes)
REACT_121256Phagosomal maturation (early endosomal stage)
Homo sapiens (human)CYBBNP_000388.2
Pan troglodytes (chimpanzee)LOC465566XP_521002.2
Macaca mulatta (Rhesus monkey)CYBBXP_001083654.1
Canis lupus familiaris (dog)CYBBNP_001093761.1
Bos taurus (cattle)CYBBNP_776460.1
Mus musculus (house mouse)CybbNP_031833.3
Rattus norvegicus (Norway rat)CybbNP_076455.1
Gallus gallus (chicken)CYBBNP_001093756.1
Danio rerio (zebrafish)cybbNP_956708.1
Arabidopsis thaliana (thale cress)AT1G19230NP_173357.1
GeneCards CYBB
UniProt P04839
MIM 300481
Ensembl ENSG00000165168
HGNC 2578
HPRD 02382

GeneRIFs: Gene References Into Functions What's a GeneRIF?

General protein information

Preferred Names
cytochrome b-245 heavy chain
cytochrome b-245 heavy chain
NADPH oxidase 2
p22 phagocyte B-cytochrome
cytochrome b558 subunit beta
cytochrome b(558) subunit beta
neutrophil cytochrome b 91 kDa polypeptide
heme-binding membrane glycoprotein gp91phox
superoxide-generating NADPH oxidase heavy chain subunit


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