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CYBB cytochrome b-245, beta polypeptide [Homo sapiens (human)]


RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_000397 Homo sapiens cytochrome b-245, beta polypeptide (CYBB), mRNA. GenEZ ORF Cloning In-stock $639.00 $590.00 15

*Business Day

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Gene Symbol CYBB
Entrez Gene ID 1536
Full Name cytochrome b-245, beta polypeptide
Synonyms AMCBX2, CGD, GP91-1, GP91-PHOX, GP91PHOX, NOX2, p91-PHOX
General protein information
Preferred Names
cytochrome b-245 heavy chain
Names
cytochrome b-245 heavy chain
CGD91-phox
NADPH oxidase 2
p22 phagocyte B-cytochrome
cytochrome b558 subunit beta
cytochrome b(558) subunit beta
neutrophil cytochrome b 91 kDa polypeptide
heme-binding membrane glycoprotein gp91phox
superoxide-generating NADPH oxidase heavy chain subunit
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

X

Xp21.1

Summary Cytochrome b (-245) is composed of cytochrome b alpha (CYBA) and beta (CYBB) chain. It has been proposed as a primary component of the microbicidal oxidase system of phagocytes. CYBB deficiency is one of five described biochemical defects associated with chronic granulomatous disease (CGD). In this disorder, there is decreased activity of phagocyte NADPH oxidase; neutrophils are able to phagocytize bacteria but cannot kill them in the phagocytic vacuoles. The cause of the killing defect is an inability to increase the cell's respiration and consequent failure to deliver activated oxygen into the phagocytic vacuole. [provided by RefSeq, Jul 2008].
Disorder

MIM: 300481

Chronic granulomatous disease, X-linked, 306400 (3)

mRNA Protein Product Sequence Price Select
NM_000397, 163854302 NP_000388, 6996021 cytochrome b-245 heavy chain ORF Sequence $490.00
KEGG
hsa04670Leukocyte transendothelial migration
hsa04145Phagosome
hsa04380Osteoclast differentiation
hsa04066HIF-1 signaling pathway
WikiPathways
WP619Type II interferon signaling (IFNG)
Pathway Interaction Database
rac1_pathwayRAC1 signaling pathway
Reactome
REACT_6900Immune System
REACT_75774Adaptive Immune System
REACT_75820Class I MHC mediated antigen processing & presentation
REACT_111119Antigen processing-Cross presentation
REACT_111174Cross-presentation of particulate exogenous antigens (phagosomes)
REACT_116125Disease
REACT_121256Phagosomal maturation (early endosomal stage)
REACT_121237Latent infection of Homo sapiens with Mycobacterium tuberculosis
Homo sapiens (human)CYBBNP_000388.2
Pan troglodytes (chimpanzee)LOC465566XP_521002.2
Macaca mulatta (Rhesus monkey)CYBBXP_001083654.1
Canis lupus familiaris (dog)CYBBNP_001093761.1
Bos taurus (cattle)CYBBNP_776460.1
Mus musculus (house mouse)CybbNP_031833.3
Rattus norvegicus (Norway rat)CybbNP_076455.1
Gallus gallus (chicken)CYBBNP_001093756.1
Danio rerio (zebrafish)cybbNP_956708.1
Arabidopsis thaliana (thale cress)AT1G19230NP_173357.1
Xenopus (Silurana) tropicalis (western clawed frog)cybbNP_001025689.1
Process
IDNameEvidence
GO:0002474antigen processing and presentation of peptide antigen via MHC class ITAS
GO:0002479antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependentTAS
GO:0006801superoxide metabolic processIDA
GO:0006801superoxide metabolic processTAS
GO:0006811ion transportIEA
GO:0006954inflammatory responseISS
GO:0007584response to nutrientIEA
GO:0034765regulation of ion transmembrane transportIEA
GO:0042493response to drugIEA
GO:0042554superoxide anion generationIDA
GO:0042554superoxide anion generationTAS
GO:0042590antigen processing and presentation of exogenous peptide antigen via MHC class ITAS
GO:0045087innate immune responseIMP
GO:0045087innate immune responseTAS
GO:0045730respiratory burstIMP
GO:0045730respiratory burstTAS
GO:0050665hydrogen peroxide biosynthetic processIEA
GO:0051701interaction with hostTAS
GO:0055114oxidation-reduction processIDA
GO:0055114oxidation-reduction processTAS
GO:0090382phagosome maturationTAS
Component
IDNameEvidence
GO:0005739mitochondrionIEA
GO:0005791rough endoplasmic reticulumIEA
GO:0005794Golgi apparatusIEA
GO:0005887integral component of plasma membraneIDA
GO:0030425dendriteIEA
GO:0030670phagocytic vesicle membraneTAS
GO:0043020NADPH oxidase complexIDA
GO:0043020NADPH oxidase complexTAS
GO:0043025neuronal cell bodyIEA
Function
IDNameEvidence
GO:0005244voltage-gated ion channel activityIEA
GO:0005515protein bindingIPI
GO:0009055electron carrier activityIDA
GO:0016175superoxide-generating NADPH oxidase activityIDA
GO:0016175superoxide-generating NADPH oxidase activityTAS
GO:0020037heme bindingIMP
GO:0046872metal ion bindingIEA
GO:0046982protein heterodimerization activityIPI
GO:0050660flavin adenine dinucleotide bindingIMP
GeneCards CYBB
PDB 3A1F
UniProt P04839
Vega OTTHUMG00000033175
MIM 300481
Ensembl ENSG00000165168
HGNC 2578
HPRD 02382

GeneRIFs: Gene References Into Functions What's a GeneRIF?

What is the normal function of the CYBB gene?

The CYBB gene provides instructions for making a protein called cytochrome b-245, beta subunit (also known as p91-phox). This protein is one part (subunit) of a group of proteins that forms an enzyme complex called NADPH oxidase, which plays an essential role in the immune system. Within this complex, the cytochrome b-245, beta subunit has an alpha subunit partner (produced from the CYBA gene). Both alpha and beta subunits are required for either to function and the NADPH oxidase complex requires both subunits in order to be functional. NADPH oxidase is primarily active in immune system cells called phagocytes. These cells catch and destroy foreign invaders such as bacteria and fungi. NADPH oxidase is also thought to regulate the activity of immune cells called neutrophils. These cells play a role in adjusting the inflammatory response to optimize healing and reduce injury to the body.

The presence of foreign invaders stimulates phagocytes and triggers the assembly of NADPH oxidase. This enzyme participates in a chemical reaction that converts oxygen to a toxic molecule called superoxide. Superoxide is used to generate several other compounds, including hydrogen peroxide (a strong disinfectant) and hypochlorous acid (the active ingredient in bleach). These highly reactive, toxic substances are known as reactive oxygen species. Phagocytes use these substances to kill foreign invaders, preventing them from reproducing in the body and causing illness.

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