CYLD cylindromatosis (turban tumor syndrome) [Homo sapiens (human)]

Gene Symbol	CYLD
Entrez Gene ID	1540
Full Name	cylindromatosis (turban tumor syndrome)
Synonyms	CDMT, CYLD1, CYLDI, EAC, FLJ20180, FLJ31664, FLJ78684, KIAA0849, MFT, MFT1, SBS, TEM, USPL2
Gene Type	protein-coding
Organism	Homo sapiens (human)
Genome	Chromosome:16 Map Location:16q12.1
Summary	This gene is encodes a cytoplasmic protein with three cytoskeletal-associated protein-glycine-conserved (CAP-GLY) domains that functions as a deubiquitinating enzyme. Mutations in this gene have been associated with cylindromatosis, multiple familial trichoepithelioma, and Brooke-Spiegler syndrome. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq].
Disorder	MIM: 605018 Cylindromatosis, familial, 132700 (3); Brooke-Spiegler syndrome,

mRNA	NM_001042412, 109637775
Protein	NP_001035877, 109637776
Product	ubiquitin carboxyl-terminal hydrolase CYLD isoform 2
RefSeq Status	REVIEWED
mRNA	NM_001042355, 109637773
Protein	NP_001035814, 109637774
Product	ubiquitin carboxyl-terminal hydrolase CYLD isoform 2
RefSeq Status	REVIEWED
mRNA	NM_015247, 109637772
Protein	NP_056062, 14165258
Product	ubiquitin carboxyl-terminal hydrolase CYLD isoform 1
RefSeq Status	REVIEWED

KEGG

hsa04622	RIG-I-like receptor signaling pathway
hsa04380	Osteoclast differentiation

Pathway Interaction Database

nfkappabcanonicalpathway	Canonical NF-kappaB pathway
tnfpathway	TNF receptor signaling pathway

WikiPathways

WP231

TNF-alpha/NF-kB Signaling Pathway

Reactome

REACT_6900	Signaling in Immune system
REACT_25359	RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
REACT_25271	Negative regulators of RIG-I/MDA5 signaling

Homo sapiens (human)	CYLD	NP_056062.1
Pan troglodytes (chimpanzee)	CYLD	XP_520635.2
Canis lupus familiaris (dog)	CYLD	XP_854436.1
Bos taurus (cattle)	CYLD	NP_001039882.1
Mus musculus (house mouse)	Cyld	NP_775545.1
Rattus norvegicus (Norway rat)	Cyld	XP_001058247.1
Gallus gallus (chicken)	CYLD	XP_001233097.1
Danio rerio (zebrafish)	cylda	XP_684817.3
Drosophila melanogaster (fruit fly)	CYLD	NP_723556.1

Process

ID	Name	Evidence
GO:0006412	translation	IEA
GO:0006511	ubiquitin-dependent protein catabolic process	IEA
GO:0007049	cell cycle	IEA
GO:0007346	regulation of mitotic cell cycle	IMP
GO:0016055	Wnt receptor signaling pathway	IEA
GO:0032088	negative regulation of NF-kappaB transcription factor activity	IDA
GO:0032480	negative regulation of type I interferon production	TAS
GO:0042347	negative regulation of NF-kappaB import into nucleus	IDA
GO:0070507	regulation of microtubule cytoskeleton organization	IMP
GO:0070536	protein K63-linked deubiquitination	IDA
GO:0090090	negative regulation of canonical Wnt receptor signaling pathway	IMP

Component

ID	Name	Evidence
GO:0005622	intracellular	IEA
GO:0005737	cytoplasm	IEA
GO:0005829	cytosol	IDA
GO:0005840	ribosome	IEA
GO:0005856	cytoskeleton	IEA
GO:0005881	cytoplasmic microtubule	IDA
GO:0005886	plasma membrane	IEA
GO:0030496	midbody	IDA
GO:0031234	extrinsic to internal side of plasma membrane	IDA
GO:0048471	perinuclear region of cytoplasm	IEA

Function

ID	Name	Evidence
GO:0003735	structural constituent of ribosome	IEA
GO:0004221	ubiquitin thiolesterase activity	IEA
GO:0004843	ubiquitin-specific protease activity	IDA
GO:0005515	protein binding	IPI
GO:0008233	peptidase activity	IEA
GO:0008234	cysteine-type peptidase activity	IEA
GO:0008270	zinc ion binding	IDA
GO:0019901	protein kinase binding	IPI
GO:0046872	metal ion binding	IEA
GO:0070064	proline-rich region binding	IPI

Our customer service representatives are available 24 hours a day, Monday through Friday; please contact us anytime for assistance.

RefSeq Accession	Definition	Sequence	Price	Select
NM_001042412	Homo sapiens cylindromatosis (turban tumor syndrome) (CYLD), transcript variant 3, mRNA.	Full Length	Quote
NM_001042412		ORF Sequence	$829.98
NM_001042355	Homo sapiens cylindromatosis (turban tumor syndrome) (CYLD), transcript variant 2, mRNA.	Full Length	Quote
NM_001042355		ORF Sequence	$829.98
NM_015247	Homo sapiens cylindromatosis (turban tumor syndrome) (CYLD), transcript variant 1, mRNA.	Full Length	Quote
NM_015247		ORF Sequence	$832.59

Sequence in raw or FASTA format: