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Sequence in raw or FASTA format:

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CYLD cylindromatosis (turban tumor syndrome) [Homo sapiens (human)]


RefSeq Accession Definition Services Price Order
NM_001042355 Homo sapiens cylindromatosis (turban tumor syndrome) (CYLD), transcript variant 2, mRNA. ORF Sequence $829.98
Peptide Services
Antibody Services
Protein Services
NM_001042412 Homo sapiens cylindromatosis (turban tumor syndrome) (CYLD), transcript variant 3, mRNA. ORF Sequence $829.98
Peptide Services
Antibody Services
Protein Services
NM_015247 Homo sapiens cylindromatosis (turban tumor syndrome) (CYLD), transcript variant 1, mRNA. ORF Sequence $832.59
Peptide Services
Antibody Services
Protein Services


Gene Symbol CYLD
Entrez Gene ID 1540
Full Name cylindromatosis (turban tumor syndrome)
Synonyms CDMT, CYLD1, CYLDI, EAC, FLJ20180, FLJ31664, FLJ78684, KIAA0849, MFT, MFT1, SBS, TEM, USPL2
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

16

16q12.1

Summary This gene is encodes a cytoplasmic protein with three cytoskeletal-associated protein-glycine-conserved (CAP-GLY) domains that functions as a deubiquitinating enzyme. Mutations in this gene have been associated with cylindromatosis, multiple familial trichoepithelioma, and Brooke-Spiegler syndrome. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008].
Disorder

MIM: 605018

Cylindromatosis, familial, 132700 (3); Brooke-Spiegler syndrome,

mRNA Protein Product Sequence Price Select
NM_001042355, 109637773 NP_001035814, 109637774 ubiquitin carboxyl-terminal hydrolase CYLD isoform 2 Full Length $0.00
ORF Sequence $829.98
NM_001042412, 109637775 NP_001035877, 109637776 ubiquitin carboxyl-terminal hydrolase CYLD isoform 2 Full Length $0.00
ORF Sequence $829.98
NM_015247, 109637772 NP_056062, 14165258 ubiquitin carboxyl-terminal hydrolase CYLD isoform 1 Full Length $0.00
ORF Sequence $832.59
KEGG
hsa04380Osteoclast differentiation
hsa04622RIG-I-like receptor signaling pathway
WikiPathways
WP231TNF-alpha/NF-kB Signaling Pathway
Pathway Interaction Database
tnfpathwayTNF receptor signaling pathway
nfkappabcanonicalpathwayCanonical NF-kappaB pathway
Reactome
REACT_6900Immune System
REACT_25271Negative regulators of RIG-I/MDA5 signaling
REACT_6802Innate Immune System
REACT_75776NOD1/2 Signaling Pathway
REACT_25359RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
REACT_75913Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
Homo sapiens (human)CYLDNP_056062.1
Pan troglodytes (chimpanzee)CYLDXP_001164783.2
Macaca mulatta (Rhesus monkey)CYLDXP_002802521.1
Canis lupus familiaris (dog)CYLDXP_854436.1
Bos taurus (cattle)CYLDNP_001039882.1
Mus musculus (house mouse)CyldNP_001121641.1
Rattus norvegicus (Norway rat)CyldNP_001017380.1
Gallus gallus (chicken)CYLDXP_414091.2
Danio rerio (zebrafish)cyldaXP_684817.3
Drosophila melanogaster (fruit fly)CYLDNP_723556.1
GeneCards CYLD
PDB 1WHM, 2VHF, 1IXD, 1WHL
UniProt Q9NQC7
MIM 605018
Ensembl ENSG00000083799
HGNC 2584
HPRD 05427

GeneRIFs: Gene References Into Functions What's a GeneRIF?

General protein information

Preferred Names
ubiquitin carboxyl-terminal hydrolase CYLD
Names
ubiquitin carboxyl-terminal hydrolase CYLD
ubiquitin thioesterase CYLD
deubiquitinating enzyme CYLD
ubiquitin thiolesterase CYLD
ubiquitin specific peptidase like 2
ubiquitin-specific-processing protease CYLD
probable ubiquitin carboxyl-terminal hydrolase CYLD
NP_001035814.1
NP_001035877.1
NP_056062.1

Interactant

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