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CYLD cylindromatosis (turban tumor syndrome) [Homo sapiens (human)]


Clone ID RefSeq Accession Definition Vector Stock Status *Turnaround time Price Order
OHu25318 NM_001042355 Homo sapiens cylindromatosis (turban tumor syndrome) (CYLD), transcript variant 2, mRNA. pcDNA3.1+-DYK On-demand 12-14 $279.00
OHu25318 NM_001042412 Homo sapiens cylindromatosis (turban tumor syndrome) (CYLD), transcript variant 3, mRNA. pcDNA3.1+-DYK On-demand 12-14 $279.00
OHu25529 NM_015247 Homo sapiens cylindromatosis (turban tumor syndrome) (CYLD), transcript variant 1, mRNA. pcDNA3.1+-DYK On-demand 12-14 $279.00
OHu25318 XM_006721148 PREDICTED: Homo sapiens cylindromatosis (turban tumor syndrome) (CYLD), transcript variant X3, mRNA. pcDNA3.1+-DYK On-demand 12-14 $279.00
OHu25318 XM_005255812 PREDICTED: Homo sapiens cylindromatosis (turban tumor syndrome) (CYLD), transcript variant X2, mRNA. pcDNA3.1+-DYK On-demand 12-14 $279.00
OHu25318 XM_006721149 PREDICTED: Homo sapiens cylindromatosis (turban tumor syndrome) (CYLD), transcript variant X4, mRNA. pcDNA3.1+-DYK On-demand 12-14 $279.00
OHu25318 XM_006721150 PREDICTED: Homo sapiens cylindromatosis (turban tumor syndrome) (CYLD), transcript variant X5, mRNA. pcDNA3.1+-DYK On-demand 12-14 $279.00
OHu25318 XM_006721151 PREDICTED: Homo sapiens cylindromatosis (turban tumor syndrome) (CYLD), transcript variant X6, mRNA. pcDNA3.1+-DYK On-demand 12-14 $279.00
OHu49281 XM_006721152 PREDICTED: Homo sapiens cylindromatosis (turban tumor syndrome) (CYLD), transcript variant X7, mRNA. pcDNA3.1+-DYK On-demand 12-14 $279.00
OHu25318C NM_001042355 Homo sapiens cylindromatosis (turban tumor syndrome) (CYLD), transcript variant 2, mRNA. Customized vector On-demand 12-14 $329.00
OHu25318C NM_001042412 Homo sapiens cylindromatosis (turban tumor syndrome) (CYLD), transcript variant 3, mRNA. Customized vector On-demand 12-14 $329.00
OHu25529C NM_015247 Homo sapiens cylindromatosis (turban tumor syndrome) (CYLD), transcript variant 1, mRNA. Customized vector On-demand 12-14 $329.00
OHu25318C XM_006721148 PREDICTED: Homo sapiens cylindromatosis (turban tumor syndrome) (CYLD), transcript variant X3, mRNA. Customized vector On-demand 12-14 $329.00
OHu25318C XM_005255812 PREDICTED: Homo sapiens cylindromatosis (turban tumor syndrome) (CYLD), transcript variant X2, mRNA. Customized vector On-demand 12-14 $329.00
OHu25318C XM_006721149 PREDICTED: Homo sapiens cylindromatosis (turban tumor syndrome) (CYLD), transcript variant X4, mRNA. Customized vector On-demand 12-14 $329.00
OHu25318C XM_006721150 PREDICTED: Homo sapiens cylindromatosis (turban tumor syndrome) (CYLD), transcript variant X5, mRNA. Customized vector On-demand 12-14 $329.00
OHu25318C XM_006721151 PREDICTED: Homo sapiens cylindromatosis (turban tumor syndrome) (CYLD), transcript variant X6, mRNA. Customized vector On-demand 12-14 $329.00
OHu49281C XM_006721152 PREDICTED: Homo sapiens cylindromatosis (turban tumor syndrome) (CYLD), transcript variant X7, mRNA. Customized vector On-demand 12-14 $329.00

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Gene Symbol CYLD
Entrez Gene ID 1540
Full Name cylindromatosis (turban tumor syndrome)
Synonyms BRSS, CDMT, CYLD1, CYLDI, EAC, MFT, MFT1, SBS, TEM, USPL2
General protein information
Preferred Names
ubiquitin carboxyl-terminal hydrolase CYLD
Names
ubiquitin carboxyl-terminal hydrolase CYLD
ubiquitin thioesterase CYLD
deubiquitinating enzyme CYLD
ubiquitin thiolesterase CYLD
ubiquitin specific peptidase like 2
ubiquitin-specific-processing protease CYLD
probable ubiquitin carboxyl-terminal hydrolase CYLD
NP_001035814.1
NP_001035877.1
NP_056062.1
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

16

16q12.1

Summary This gene is encodes a cytoplasmic protein with three cytoskeletal-associated protein-glycine-conserved (CAP-GLY) domains that functions as a deubiquitinating enzyme. Mutations in this gene have been associated with cylindromatosis, multiple familial trichoepithelioma, and Brooke-Spiegler syndrome. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008].
Disorder

MIM: 605018

Cylindromatosis, familial, 132700 (3); Brooke-Spiegler syndrome,

mRNA Protein Product Sequence Price Select
NM_001042355, 109637773 NP_001035814, 109637774 ubiquitin carboxyl-terminal hydrolase CYLD isoform 2 ORF Sequence $750.00
NM_001042412, 109637775 NP_001035877, 109637776 ubiquitin carboxyl-terminal hydrolase CYLD isoform 2 ORF Sequence $750.00
NM_015247, 109637772 NP_056062, 14165258 ubiquitin carboxyl-terminal hydrolase CYLD isoform 1 ORF Sequence $750.00
XM_005255812, 578828862 XP_005255869, 530423617 ubiquitin carboxyl-terminal hydrolase CYLD isoform X2 ORF Sequence $750.00
XM_006721148, 578828860 XP_006721211, 578828861 ubiquitin carboxyl-terminal hydrolase CYLD isoform X3 ORF Sequence $750.00
XM_006721149, 578828863 XP_006721212, 578828864 ubiquitin carboxyl-terminal hydrolase CYLD isoform X4 ORF Sequence $750.00
XM_006721150, 578828865 XP_006721213, 578828866 ubiquitin carboxyl-terminal hydrolase CYLD isoform X5 ORF Sequence $750.00
XM_006721151, 578828867 XP_006721214, 578828868 ubiquitin carboxyl-terminal hydrolase CYLD isoform X6 ORF Sequence $750.00
XM_006721152, 578828870 XP_006721215, 578828871 ubiquitin carboxyl-terminal hydrolase CYLD isoform X7 ORF Sequence $750.00
KEGG
hsa04622RIG-I-like receptor signaling pathway
hsa04380Osteoclast differentiation
WikiPathways
WP231TNF-alpha/NF-kB Signaling Pathway
Pathway Interaction Database
nfkappabcanonicalpathwayCanonical NF-kappaB pathway
tnfpathwayTNF receptor signaling pathway
Reactome
REACT_6900Immune System
REACT_6802Innate Immune System
REACT_75776NOD1/2 Signaling Pathway
REACT_75913Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
REACT_25271Negative regulators of RIG-I/MDA5 signaling
REACT_25359RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
Homo sapiens (human)CYLDNP_056062.1
Pan troglodytes (chimpanzee)CYLDXP_001164783.2
Macaca mulatta (Rhesus monkey)CYLDXP_002802521.1
Canis lupus familiaris (dog)CYLDXP_854436.1
Bos taurus (cattle)CYLDNP_001039882.1
Mus musculus (house mouse)CyldNP_001121642.1
Rattus norvegicus (Norway rat)CyldNP_001017380.1
Gallus gallus (chicken)CYLDXP_004944232.1
Danio rerio (zebrafish)cyldaXP_684817.3
Drosophila melanogaster (fruit fly)CYLDNP_723556.1
Xenopus (Silurana) tropicalis (western clawed frog)cyldNP_001116960.1
Process
IDNameEvidence
GO:0002181cytoplasmic translationIBA
GO:0006511ubiquitin-dependent protein catabolic processIEA
GO:0007049cell cycleIEA
GO:0007346regulation of mitotic cell cycleIMP
GO:0016055Wnt signaling pathwayIEA
GO:0032088negative regulation of NF-kappaB transcription factor activityIDA
GO:0032480negative regulation of type I interferon productionTAS
GO:0035872nucleotide-binding domain, leucine rich repeat containing receptor signaling pathwayTAS
GO:0042347negative regulation of NF-kappaB import into nucleusIDA
GO:0045087innate immune responseTAS
GO:0070266necroptotic processIBA
GO:0070423nucleotide-binding oligomerization domain containing signaling pathwayTAS
GO:0070507regulation of microtubule cytoskeleton organizationIMP
GO:0070536protein K63-linked deubiquitinationIDA
GO:0090090negative regulation of canonical Wnt signaling pathwayIMP
GO:2001238positive regulation of extrinsic apoptotic signaling pathwayIMP
GO:2001242regulation of intrinsic apoptotic signaling pathwayIMP
Component
IDNameEvidence
GO:0005634nucleusIDA
GO:0005730nucleolusIDA
GO:0005813centrosomeIDA
GO:0005829cytosolIDA
GO:0005829cytosolTAS
GO:0005881cytoplasmic microtubuleIDA
GO:0030496midbodyIDA
GO:0031234extrinsic component of cytoplasmic side of plasma membraneIDA
GO:0048471perinuclear region of cytoplasmIEA
Function
IDNameEvidence
GO:0003735structural constituent of ribosomeIBA
GO:0004843ubiquitin-specific protease activityIDA
GO:0005515protein bindingIPI
GO:0008270zinc ion bindingIDA
GO:0019901protein kinase bindingIPI
GO:0061578Lys63-specific deubiquitinase activityIDA
GO:0070064proline-rich region bindingIPI
GeneCards CYLD
UniProt Q9NQC7
Vega OTTHUMG00000173404
MIM 605018
Ensembl ENSG00000083799
HGNC 2584
HPRD 05427

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Interactant

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