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CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1 [Homo sapiens (human)]


RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_000499 Homo sapiens cytochrome P450, family 1, subfamily A, polypeptide 1 (CYP1A1), mRNA. GenEZ ORF Cloning In-stock $509.00 $460.00 12

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Related Services

Gene Symbol CYP1A1
Entrez Gene ID 1543
Full Name cytochrome P450, family 1, subfamily A, polypeptide 1
Synonyms AHH, AHRR, CP11, CYP1, P1-450, P450-C, P450DX
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

15

15q24.1

Summary This gene, CYP1A1, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by some polycyclic aromatic hydrocarbons (PAHs), some of which are found in cigarette smoke. The enzyme's endogenous substrate is unknown; however, it is able to metabolize some PAHs to carcinogenic intermediates. The gene has been associated with lung cancer risk. A related family member, CYP1A2, is located approximately 25 kb away from CYP1A1 on chromosome 15. [provided by RefSeq, Jul 2008].
Disorder

MIM: 108330

mRNA Protein Product Sequence Price Select
NM_000499, 189339226 NP_000490, 4503199 cytochrome P450 1A1 ORF Sequence $360.00
KEGG
hsa00980Metabolism of xenobiotics by cytochrome P450
hsa00140Steroid hormone biosynthesis
hsa00380Tryptophan metabolism
hsa00830Retinol metabolism
hsa05204Chemical carcinogenesis
WikiPathways
WP43cytochrome P450
WP206Fatty Acid Omega Oxidation
WP697Estrogen metabolism
WP696Benzo(a)pyrene metabolism
WP691Tamoxifen metabolism
WP408Oxidative Stress
WP465Tryptophan metabolism
WP702metapathway biotransformation
Reactome
REACT_116145PPARA Activates Gene Expression
REACT_111217Metabolism
REACT_13543Xenobiotics
REACT_22258Metabolism of lipids and lipoproteins
REACT_13567Cytochrome P450 - arranged by substrate type
REACT_13433Biological oxidations
REACT_22279Fatty acid, triacylglycerol, and ketone body metabolism
REACT_13705Phase 1 - Functionalization of compounds
REACT_19241Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
Homo sapiens (human)CYP1A1NP_000490.1
Pan troglodytes (chimpanzee)LOC453744XP_001137654.1
Macaca mulatta (Rhesus monkey)CYP1A1NP_001035328.1
Canis lupus familiaris (dog)CYP1A1XP_003433938.1
Bos taurus (cattle)CYP1A1XP_002696681.1
Mus musculus (house mouse)Cyp1a1NP_001129531.1
Rattus norvegicus (Norway rat)Cyp1a1NP_036672.2
Gallus gallus (chicken)CYP1A1NP_990477.1
Gallus gallus (chicken)CYP1A4NP_990478.1
Danio rerio (zebrafish)cyp1aNP_571954.1
Arabidopsis thaliana (thale cress)CYP93D1NP_196307.1
GeneCards CYP1A1
PDB 4I8V
UniProt P04798, A0N0X8
MIM 108330
Ensembl ENSG00000140465
HGNC 2595
HPRD 00148

GeneRIFs: Gene References Into Functions What's a GeneRIF?

General protein information

Preferred Names
cytochrome P450 1A1
Names
cytochrome P450 1A1
CYPIA1
cytochrome P450-C
cytochrome P450-P1
cytochrome P450 form 6
xenobiotic monooxygenase
aryl hydrocarbon hydroxylase
flavoprotein-linked monooxygenase
cytochrome P1-450, dioxin-inducible
cytochrome P450, subfamily I (aromatic compound-inducible), polypeptide 1
NP_000490.1

Interactant



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