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CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1 [Homo sapiens (human)]


Clone ID RefSeq Accession Definition Vector Stock Status *Turnaround time Price Order
OHu26754 NM_000499 Homo sapiens cytochrome P450, family 1, subfamily A, polypeptide 1 (CYP1A1), mRNA. pcDNA3.1+-DYK In-stock 5-7 $99.00
OHu26754 XM_005254185 PREDICTED: Homo sapiens cytochrome P450, family 1, subfamily A, polypeptide 1 (CYP1A1), transcript variant X1, mRNA. pcDNA3.1+-DYK On-demand 7-9 $219.00
OHu26754C NM_000499 Homo sapiens cytochrome P450, family 1, subfamily A, polypeptide 1 (CYP1A1), mRNA. Customized vector In-stock 5-7 $149.00
OHu26754C XM_005254185 PREDICTED: Homo sapiens cytochrome P450, family 1, subfamily A, polypeptide 1 (CYP1A1), transcript variant X1, mRNA. Customized vector On-demand 7-9 $269.00

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Gene Symbol CYP1A1
Entrez Gene ID 1543
Full Name cytochrome P450, family 1, subfamily A, polypeptide 1
Synonyms AHH, AHRR, CP11, CYP1, P1-450, P450-C, P450DX
General protein information
Preferred Names
cytochrome P450 1A1
Names
cytochrome P450 1A1
CYPIA1
cytochrome P450-C
cytochrome P450-P1
cytochrome P450 form 6
xenobiotic monooxygenase
aryl hydrocarbon hydroxylase
flavoprotein-linked monooxygenase
cytochrome P1-450, dioxin-inducible
cytochrome P450, subfamily I (aromatic compound-inducible), polypeptide 1
NP_000490.1
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

15

15q24.1

Summary This gene, CYP1A1, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by some polycyclic aromatic hydrocarbons (PAHs), some of which are found in cigarette smoke. The enzyme's endogenous substrate is unknown; however, it is able to metabolize some PAHs to carcinogenic intermediates. The gene has been associated with lung cancer risk. A related family member, CYP1A2, is located approximately 25 kb away from CYP1A1 on chromosome 15. [provided by RefSeq, Jul 2008].
Disorder

MIM: 108330

mRNA Protein Product Sequence Price Select
NM_000499, 189339226 NP_000490, 4503199 cytochrome P450 1A1 ORF Sequence $360.00
XM_005254185, 530405436 XP_005254242, 530405437 cytochrome P450 1A1 isoform X1 ORF Sequence $550.00
KEGG
hsa00140Steroid hormone biosynthesis
hsa00980Metabolism of xenobiotics by cytochrome P450
hsa00830Retinol metabolism
hsa00380Tryptophan metabolism
hsa05204Chemical carcinogenesis
hsa04913Ovarian steroidogenesis
WikiPathways
WP691Tamoxifen metabolism
WP43cytochrome P450
WP702metapathway biotransformation
WP465Tryptophan metabolism
WP697Estrogen metabolism
WP408Oxidative Stress
WP696Benzo(a)pyrene metabolism
WP206Fatty Acid Omega Oxidation
WP2100AhR pathway
Reactome
REACT_13433Biological oxidations
REACT_13567Cytochrome P450 - arranged by substrate type
REACT_13543Xenobiotics
REACT_13705Phase 1 - Functionalization of compounds
REACT_19241Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
REACT_22279Fatty acid, triacylglycerol, and ketone body metabolism
REACT_22258Metabolism of lipids and lipoproteins
REACT_111217Metabolism
REACT_147851Arachidonic acid metabolism
REACT_116145PPARA activates gene expression
REACT_150417Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET)
REACT_150134Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE)
Homo sapiens (human)CYP1A1NP_000490.1
Pan troglodytes (chimpanzee)LOC453744XP_001137654.1
Macaca mulatta (Rhesus monkey)CYP1A1NP_001035328.1
Canis lupus familiaris (dog)CYP1A1XP_003433938.1
Bos taurus (cattle)CYP1A1XP_005222075.1
Mus musculus (house mouse)Cyp1a1NP_001129531.1
Rattus norvegicus (Norway rat)Cyp1a1NP_036672.2
Gallus gallus (chicken)CYP1A1NP_990477.1
Gallus gallus (chicken)CYP1A4NP_990478.1
Danio rerio (zebrafish)cyp1aNP_571954.1
Arabidopsis thaliana (thale cress)CYP93D1NP_196307.1
Xenopus (Silurana) tropicalis (western clawed frog)cyp1a1NP_001090813.1
Process
IDNameEvidence
GO:0001666response to hypoxiaIEA
GO:0006778porphyrin-containing compound metabolic processIEA
GO:0006805xenobiotic metabolic processTAS
GO:0007568agingIEA
GO:0008283cell proliferationIEA
GO:0009308amine metabolic processIEA
GO:0009611response to woundingIEA
GO:0009615response to virusIEA
GO:0009624response to nematodeIEA
GO:0009635response to herbicideIEA
GO:0009792embryo development ending in birth or egg hatchingIEA
GO:0009804coumarin metabolic processIEA
GO:0009812flavonoid metabolic processIEA
GO:0010041response to iron(III) ionIEA
GO:0017143insecticide metabolic processIEA
GO:0017144drug metabolic processIDA
GO:0019341dibenzo-p-dioxin catabolic processIEA
GO:0019369arachidonic acid metabolic processTAS
GO:0019373epoxygenase P450 pathwayTAS
GO:0032094response to foodIEA
GO:0032496response to lipopolysaccharideIEA
GO:0033189response to vitamin AIEA
GO:0042359vitamin D metabolic processIC
GO:0042493response to drugIEA
GO:00429049-cis-retinoic acid biosynthetic processIEA
GO:0043010camera-type eye developmentIEA
GO:0044255cellular lipid metabolic processTAS
GO:0044281small molecule metabolic processTAS
GO:0046677response to antibioticIEA
GO:0046685response to arsenic-containing substanceIEA
GO:0048565digestive tract developmentIEA
GO:0050665hydrogen peroxide biosynthetic processIEA
GO:0055093response to hyperoxiaIEA
GO:0055114oxidation-reduction processIDA
GO:0060137maternal process involved in parturitionIEA
GO:0070365hepatocyte differentiationIEA
GO:0070988demethylationIEA
GO:0071407cellular response to organic cyclic compoundIDA
GO:0097267omega-hydroxylase P450 pathwayTAS
GO:1900087positive regulation of G1/S transition of mitotic cell cycleIEA
Component
IDNameEvidence
GO:0005739mitochondrionIEA
GO:0005789endoplasmic reticulum membraneTAS
Function
IDNameEvidence
GO:0005506iron ion bindingIEA
GO:0008395steroid hydroxylase activityIEA
GO:0016491oxidoreductase activityIDA
GO:0016679oxidoreductase activity, acting on diphenols and related substances as donorsIEA
GO:0016711flavonoid 3'-monooxygenase activityIEA
GO:0019825oxygen bindingTAS
GO:0019899enzyme bindingIEA
GO:0020037heme bindingIEA
GO:0032451demethylase activityIEA
GO:0070330aromatase activityIEA
GO:0070576vitamin D 24-hydroxylase activityIDA
GeneCards CYP1A1
UniProt P04798, A0N0X8
Vega OTTHUMG00000142812
MIM 108330
Ensembl ENSG00000140465
HGNC 2595
HPRD 00148

GeneRIFs: Gene References Into Functions What's a GeneRIF?

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