Sequence in raw or FASTA format:
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1 [Homo sapiens (human)]
| Gene Symbol | CYP1A1 |
| Entrez Gene ID | 1543 |
| Full Name | cytochrome P450, family 1, subfamily A, polypeptide 1 |
| Synonyms | AHH, AHRR, CP11, CYP1, P1-450, P450-C, P450DX |
| Gene Type | protein-coding |
| Organism | Homo sapiens (human) |
| Genome |
15 15q24.1 |
| Summary | This gene, CYP1A1, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by some polycyclic aromatic hydrocarbons (PAHs), some of which are found in cigarette smoke. The enzyme's endogenous substrate is unknown; however, it is able to metabolize some PAHs to carcinogenic intermediates. The gene has been associated with lung cancer risk. A related family member, CYP1A2, is located approximately 25 kb away from CYP1A1 on chromosome 15. [provided by RefSeq]. |
| Disorder | MIM: 108330 |
| mRNA | NM_000499, 189339226 |
| Protein | NP_000490, 4503199 |
| Product | cytochrome P450 1A1 |
| RefSeq Status | REVIEWED |
| hsa00140 | Steroid hormone biosynthesis |
| hsa00830 | Retinol metabolism |
| hsa01100 | Metabolic pathways |
| hsa00380 | Tryptophan metabolism |
| hsa00980 | Metabolism of xenobiotics by cytochrome P450 |
WikiPathways
| WP465 | Tryptophan metabolism |
| WP408 | Oxidative Stress |
| WP206 | Fatty Acid Omega Oxidation |
Reactome
| REACT_13567 | Cytochrome P450 - arranged by substrate type |
| REACT_22279 | Fatty acid, triacylglycerol, and ketone body metabolism |
| REACT_13705 | Phase 1 - Functionalization of compounds |
| REACT_19241 | Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) |
| REACT_13543 | Xenobiotics |
| REACT_13433 | Biological oxidations |
| REACT_22258 | Metabolism of lipids and lipoproteins |
| Homo sapiens (human) | CYP1A1 | NP_000490.1 |
| Pan troglodytes (chimpanzee) | LOC453744 | XP_001137654.1 |
| Bos taurus (cattle) | CYP1A1 | XP_588298.2 |
| Mus musculus (house mouse) | Cyp1a1 | NP_034122.1 |
| Rattus norvegicus (Norway rat) | Cyp1a1 | NP_036672.2 |
| Gallus gallus (chicken) | CYP1A1 | NP_990477.1 |
| Gallus gallus (chicken) | CYP1A4 | NP_990478.1 |
| Danio rerio (zebrafish) | cyp1a | NP_571954.1 |
| Arabidopsis thaliana (thale cress) | CYP93D1 | NP_196307.1 |
| ID | Name | Evidence |
| GO:0006805 | xenobiotic metabolic process | TAS |
| GO:0009308 | amine metabolic process | IEA |
| GO:0009404 | toxin metabolic process | IEA |
| GO:0009636 | response to toxin | IEA |
| GO:0017144 | drug metabolic process | IDA |
| GO:0042359 | vitamin D metabolic process | IC |
| GO:0044255 | cellular lipid metabolic process | TAS |
| GO:0046483 | heterocycle metabolic process | IEA |
| GO:0050665 | hydrogen peroxide biosynthetic process | IEA |
| GO:0055114 | oxidation-reduction process | IDA |
Component
| ID | Name | Evidence |
| GO:0005783 | endoplasmic reticulum | IEA |
| GO:0005789 | endoplasmic reticulum membrane | TAS |
| GO:0005792 | microsome | IDA |
| GO:0016020 | membrane | IEA |
Function
| ID | Name | Evidence |
| GO:0009055 | electron carrier activity | IEA |
| GO:0016491 | oxidoreductase activity | IDA |
| GO:0019825 | oxygen binding | TAS |
| GO:0020037 | heme binding | IEA |
| GO:0046872 | metal ion binding | IEA |
| GO:0070330 | aromatase activity | IEA |
| GO:0070576 | vitamin D 24-hydroxylase activity | IDA |
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