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CYP2E1 cytochrome P450, family 2, subfamily E, polypeptide 1 [Homo sapiens (human)]


RefSeq Accession Definition Sequence Price Select
NM_000773 Homo sapiens cytochrome P450, family 2, subfamily E, polypeptide 1 (CYP2E1), mRNA. Full Length $483.43
ORF Sequence $429.78


Gene Symbol CYP2E1
Entrez Gene ID 1571
Full Name cytochrome P450, family 2, subfamily E, polypeptide 1
Synonyms CPE1, CYP2E, P450-J, P450C2E
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

10

10q24.3-qter
Summary This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is induced by ethanol, the diabetic state, and starvation. The enzyme metabolizes both endogenous substrates, such as ethanol, acetone, and acetal, as well as exogenous substrates including benzene, carbon tetrachloride, ethylene glycol, and nitrosamines which are premutagens found in cigarette smoke. Due to its many substrates, this enzyme may be involved in such varied processes as gluconeogenesis, hepatic cirrhosis, diabetes, and cancer. [provided by RefSeq].
Disorder

MIM: 124040
mRNA NM_000773, 75709190
Protein NP_000764, 10834998
Product cytochrome P450 2E1
RefSeq Status REVIEWED
KEGG
hsa01100Metabolic pathways
hsa00980Metabolism of xenobiotics by cytochrome P450
hsa00982Drug metabolism - cytochrome P450
hsa00590Arachidonic acid metabolism
hsa00591Linoleic acid metabolism
WikiPathways
WP299Nuclear receptors in lipid metabolism and toxicity
WP716Vitamin A and carotenoid metabolism
WP465Tryptophan metabolism
WP206Fatty Acid Omega Oxidation
BIOCYC
META_PWY66-161oxidative ethanol degradation II (MEOS)
META_PWY-5453methylglyoxal degradation III
META_PWY-5451acetone degradation I (to methylglyoxal)
Reactome
REACT_13705Phase 1 - Functionalization of compounds
REACT_13543Xenobiotics
REACT_13433Biological oxidations
REACT_13797CYP2E1 reactions
REACT_13567Cytochrome P450 - arranged by substrate type
Homo sapiens (human)CYP2E1NP_000764.1
Pan troglodytes (chimpanzee)LOC450857XP_508139.2
Canis lupus familiaris (dog)CYP2E1NP_001003339.1
Bos taurus (cattle)CYP2E1NP_776955.2
Mus musculus (house mouse)Cyp2e1NP_067257.1
Rattus norvegicus (Norway rat)Cyp2e1NP_113731.1
Process
IDNameEvidence
GO:0006805xenobiotic metabolic processTAS
GO:0008202steroid metabolic processIMP
GO:0016098monoterpenoid metabolic processIDA
GO:0017144drug metabolic processIDA
GO:0017144drug metabolic processIMP
GO:0046483heterocycle metabolic processIDA
GO:0055114oxidation-reduction processIDA
Component
IDNameEvidence
GO:0005783endoplasmic reticulumIEA
GO:0005789endoplasmic reticulum membraneEXP
GO:0005789endoplasmic reticulum membraneTAS
GO:0005792microsomeIDA
GO:0016020membraneIEA
Function
IDNameEvidence
GO:0004497monooxygenase activityIDA
GO:0009055electron carrier activityIEA
GO:0016491oxidoreductase activityIDA
GO:0016709oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygenTAS
GO:0016712oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygenIEA
GO:0019825oxygen bindingEXP
GO:0019825oxygen bindingTAS
GO:0019899enzyme bindingIPI
GO:0020037heme bindingIDA
GO:0046872metal ion bindingIEA
GeneCards CYP2E1
PDB 3GPH, 3E6I, 3KOH, 3E4E, 3LC4
UniProt P05181
MIM 124040
Ensembl ENSG00000130649
HGNC 2631
HPRD 11813

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