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CYP2E1 cytochrome P450, family 2, subfamily E, polypeptide 1 [Homo sapiens (human)]


Clone ID RefSeq Accession Definition Vector Stock Status *Turnaround time Price Order
OHu25425 NM_000773 Homo sapiens cytochrome P450, family 2, subfamily E, polypeptide 1 (CYP2E1), mRNA. pcDNA3.1+-DYK In-stock 5-7 $99.00
OHu25425C NM_000773 Homo sapiens cytochrome P450, family 2, subfamily E, polypeptide 1 (CYP2E1), mRNA. Customized vector In-stock 5-7 $149.00

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Gene Symbol CYP2E1
Entrez Gene ID 1571
Full Name cytochrome P450, family 2, subfamily E, polypeptide 1
Synonyms CPE1, CYP2E, P450-J, P450C2E
General protein information
Preferred Names
cytochrome P450 2E1
Names
cytochrome P450 2E1
CYPIIE1
cytochrome P450-J
microsomal monooxygenase
xenobiotic monooxygenase
4-nitrophenol 2-hydroxylase
flavoprotein-linked monooxygenase
cytochrome P450, subfamily IIE (ethanol-inducible), polypeptide 1
NP_000764.1
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

10

10q26.3

Summary This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is induced by ethanol, the diabetic state, and starvation. The enzyme metabolizes both endogenous substrates, such as ethanol, acetone, and acetal, as well as exogenous substrates including benzene, carbon tetrachloride, ethylene glycol, and nitrosamines which are premutagens found in cigarette smoke. Due to its many substrates, this enzyme may be involved in such varied processes as gluconeogenesis, hepatic cirrhosis, diabetes, and cancer. [provided by RefSeq, Jul 2008].
Disorder

MIM: 124040

mRNA Protein Product Sequence Price Select
NM_000773, 75709190 NP_000764, 10834998 cytochrome P450 2E1 precursor ORF Sequence $360.00
KEGG
hsa00140Steroid hormone biosynthesis
hsa00980Metabolism of xenobiotics by cytochrome P450
hsa00591Linoleic acid metabolism
hsa00590Arachidonic acid metabolism
hsa00982Drug metabolism - cytochrome P450
hsa05204Chemical carcinogenesis
hsa04932Non-alcoholic fatty liver disease (NAFLD)
WikiPathways
WP691Tamoxifen metabolism
WP43cytochrome P450
WP702metapathway biotransformation
WP716Vitamin A and carotenoid metabolism
WP465Tryptophan metabolism
WP299Nuclear receptors in lipid metabolism and toxicity
WP206Fatty Acid Omega Oxidation
WP1589Folate-Alcohol and Cancer Pathway
BIOCYC
META_PWY66-161ethanol degradation III (oxidative)
META_PWY-5453methylglyoxal degradation III
HUMAN_PWY66-161oxidative ethanol degradation III
HUMAN_PWY-5453methylglyoxal degradation III
HUMAN_PWY-5451acetone degradation I (to methylglyoxal)
Reactome
REACT_13433Biological oxidations
REACT_13567Cytochrome P450 - arranged by substrate type
REACT_13543Xenobiotics
REACT_13797CYP2E1 reactions
REACT_13705Phase 1 - Functionalization of compounds
REACT_111217Metabolism
Homo sapiens (human)CYP2E1NP_000764.1
Pan troglodytes (chimpanzee)LOC450857XP_508139.3
Macaca mulatta (Rhesus monkey)CYP2E1NP_001035303.1
Canis lupus familiaris (dog)CYP2E1NP_001003339.1
Bos taurus (cattle)CYP2E1NP_776955.2
Mus musculus (house mouse)Cyp2e1NP_067257.1
Rattus norvegicus (Norway rat)Cyp2e1NP_113731.1
Process
IDNameEvidence
GO:0006641triglyceride metabolic processIEA
GO:0006805xenobiotic metabolic processTAS
GO:0008202steroid metabolic processIMP
GO:0010193response to ozoneIEA
GO:0010243response to organonitrogen compoundIEA
GO:0016098monoterpenoid metabolic processIDA
GO:0017144drug metabolic processIDA
GO:0017144drug metabolic processIMP
GO:0042493response to drugIEA
GO:0044281small molecule metabolic processTAS
GO:0045471response to ethanolIEA
GO:0046483heterocycle metabolic processIDA
GO:0055114oxidation-reduction processIDA
Component
IDNameEvidence
GO:0000139Golgi membraneIEA
GO:0005739mitochondrionIEA
GO:0005789endoplasmic reticulum membraneTAS
GO:0031227intrinsic component of endoplasmic reticulum membraneIEA
Function
IDNameEvidence
GO:0004497monooxygenase activityIDA
GO:0005506iron ion bindingIEA
GO:0016491oxidoreductase activityIDA
GO:0016709oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygenTAS
GO:0016712oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygenIEA
GO:0019825oxygen bindingTAS
GO:0019899enzyme bindingIPI
GO:0020037heme bindingIDA
GeneCards CYP2E1
PDB 3GPH, 3T3Z, 3E6I, 3KOH, 3E4E, 3LC4
UniProt P05181
Vega OTTHUMG00000019322
MIM 124040
Ensembl ENSG00000130649
HGNC 2631
HPRD 11813

GeneRIFs: Gene References Into Functions What's a GeneRIF?

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