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CYP2E1 cytochrome P450, family 2, subfamily E, polypeptide 1 [Homo sapiens (human)]


RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_000773 Homo sapiens cytochrome P450, family 2, subfamily E, polypeptide 1 (CYP2E1), mRNA. GenEZ ORF Cloning In-stock $509.00 $460.00 12

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Gene Symbol CYP2E1
Entrez Gene ID 1571
Full Name cytochrome P450, family 2, subfamily E, polypeptide 1
Synonyms CPE1, CYP2E, P450-J, P450C2E
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

10

10q24.3-qter

Summary This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is induced by ethanol, the diabetic state, and starvation. The enzyme metabolizes both endogenous substrates, such as ethanol, acetone, and acetal, as well as exogenous substrates including benzene, carbon tetrachloride, ethylene glycol, and nitrosamines which are premutagens found in cigarette smoke. Due to its many substrates, this enzyme may be involved in such varied processes as gluconeogenesis, hepatic cirrhosis, diabetes, and cancer. [provided by RefSeq, Jul 2008].
Disorder

MIM: 124040

mRNA Protein Product Sequence Price Select
NM_000773, 75709190 NP_000764, 10834998 cytochrome P450 2E1 ORF Sequence $360.00
KEGG
hsa00591Linoleic acid metabolism
hsa05204Chemical carcinogenesis
hsa00980Metabolism of xenobiotics by cytochrome P450
hsa00982Drug metabolism - cytochrome P450
hsa00590Arachidonic acid metabolism
WikiPathways
WP206Fatty Acid Omega Oxidation
WP702metapathway biotransformation
WP716Vitamin A and carotenoid metabolism
WP691Tamoxifen metabolism
WP299Nuclear receptors in lipid metabolism and toxicity
WP465Tryptophan metabolism
WP43cytochrome P450
BIOCYC
HUMAN_PWY66-161oxidative ethanol degradation III
HUMAN_PWY-5451acetone degradation I (to methylglyoxal)
HUMAN_PWY-5453methylglyoxal degradation III
META_PWY66-161oxidative ethanol degradation III
META_PWY-5453methylglyoxal degradation III
Reactome
REACT_13567Cytochrome P450 - arranged by substrate type
REACT_13797CYP2E1 reactions
REACT_13433Biological oxidations
REACT_13705Phase 1 - Functionalization of compounds
REACT_111217Metabolism
REACT_13543Xenobiotics
Homo sapiens (human)CYP2E1NP_000764.1
Pan troglodytes (chimpanzee)LOC450857XP_508139.3
Macaca mulatta (Rhesus monkey)CYP2E1NP_001035303.1
Canis lupus familiaris (dog)CYP2E1NP_001003339.1
Bos taurus (cattle)CYP2E1NP_776955.2
Mus musculus (house mouse)Cyp2e1NP_067257.1
Rattus norvegicus (Norway rat)Cyp2e1NP_113731.1
GeneCards CYP2E1
PDB 3GPH, 3T3Z, 3E6I, 3KOH, 3E4E, 3LC4
UniProt P05181
MIM 124040
Ensembl ENSG00000130649
HGNC 2631
HPRD 11813

GeneRIFs: Gene References Into Functions What's a GeneRIF?

General protein information

Preferred Names
cytochrome P450 2E1
Names
cytochrome P450 2E1
CYPIIE1
cytochrome P450-J
microsomal monooxygenase
xenobiotic monooxygenase
4-nitrophenol 2-hydroxylase
flavoprotein-linked monooxygenase
cytochrome P450, subfamily IIE (ethanol-inducible), polypeptide 1
NP_000764.1

Interactant



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