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ADSL adenylosuccinate lyase [Homo sapiens (human)]

RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_000026 Homo sapiens adenylosuccinate lyase (ADSL), transcript variant 1, mRNA. GenEZ ORF Cloning In-stock $509.00 $460.00 12
NM_001123378 Homo sapiens adenylosuccinate lyase (ADSL), transcript variant 2, mRNA. GenEZ ORF Cloning On-demand $699.00 18

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Gene Symbol ADSL
Entrez Gene ID 158
Full Name adenylosuccinate lyase
Gene Type protein-coding
Organism Homo sapiens (human)



Summary Adenylsuccinate lyase is involved in both de novo synthesis of purines and formation of adenosine monophosphate from inosine monophosphate. It catalyzes two reactions in AMP biosynthesis: the removal of a fumarate from succinylaminoimidazole carboxamide (SAICA) ribotide to give aminoimidazole carboxamide ribotide (AICA) and removal of fumarate from adenylosuccinate to give AMP. Adenylosuccinase deficiency results in succinylpurinemic autism, psychomotor retardation, and , in some cases, growth retardation associated with muscle wasting and epilepsy. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].

MIM: 608222

Adenylosuccinase deficiency, 103050 (3)

mRNA Protein Product Sequence Price Select
NM_000026, 183227686 NP_000017, 4557269 adenylosuccinate lyase isoform a ORF Sequence $360.00
NM_001123378, 183227687 NP_001116850, 183227688 adenylosuccinate lyase isoform b ORF Sequence $550.00
hsa_M00049Adenine ribonucleotide biosynthesis, IMP => ADP,ATP
hsa_M00048Inosine monophosphate biosynthesis, PRPP + glutamine => IMP
hsa00250Alanine, aspartate and glutamate metabolism
hsa00230Purine metabolism
WP404Nucleotide Metabolism
REACT_1776Purine ribonucleoside monophosphate biosynthesis
REACT_1698Metabolism of nucleotides
REACT_522Purine metabolism
Homo sapiens (human)ADSLNP_000017.1
Pan troglodytes (chimpanzee)ADSLXP_003317301.1
Canis lupus familiaris (dog)ADSLXP_531727.3
Bos taurus (cattle)ADSLNP_001095847.1
Mus musculus (house mouse)AdslNP_033764.2
Rattus norvegicus (Norway rat)AdslNP_001123975.1
Gallus gallus (chicken)ADSLNP_990860.1
Danio rerio (zebrafish)adslNP_956193.1
Drosophila melanogaster (fruit fly)CG3590NP_650586.2
GeneCards ADSL
PDB 2VD6, 4FLC, 2J91, 4FFX
UniProt P30566
MIM 608222
Ensembl ENSG00000239900
HGNC 291
HPRD 00049

GeneRIFs: Gene References Into Functions What's a GeneRIF?

General protein information


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