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CYP11B1 cytochrome P450, family 11, subfamily B, polypeptide 1 [Homo sapiens (human)]


RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_000497 Homo sapiens cytochrome P450, family 11, subfamily B, polypeptide 1 (CYP11B1), nuclear gene encoding mitochondrial protein, transcript variant 1, mRNA. GenEZ ORF Cloning In-stock $509.00 $460.00 12
NM_001026213 Homo sapiens cytochrome P450, family 11, subfamily B, polypeptide 1 (CYP11B1), nuclear gene encoding mitochondrial protein, transcript variant 2, mRNA. GenEZ ORF Cloning On-demand $699.00 18

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Gene Symbol CYP11B1
Entrez Gene ID 1584
Full Name cytochrome P450, family 11, subfamily B, polypeptide 1
Synonyms CPN1, CYP11B, DKFZp686B05283, FHI, FLJ36771, P450C11
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

8

8q21

Summary This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the mitochondrial inner membrane and is involved in the conversion of progesterone to cortisol in the adrenal cortex. Mutations in this gene cause congenital adrenal hyperplasia due to 11-beta-hydroxylase deficiency. Transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Jul 2008].
Disorder

MIM: 610613

Adrenal hyperplasia, congenital, due to 11-beta-hydroxylase

mRNA Protein Product Sequence Price Select
NM_000497, 61743917 NP_000488, 61743918 cytochrome P450 11B1, mitochondrial isoform 1 precursor ORF Sequence $360.00
NM_001026213, 71067342 NP_001021384, 71067343 cytochrome P450 11B1, mitochondrial isoform 2 precursor ORF Sequence $550.00
KEGG
hsa00140Steroid hormone biosynthesis
hsa_M00108C21-Steroid hormone biosynthesis, progesterone => corticosterone/aldosterone
hsa_M00109C21-Steroid hormone biosynthesis, progesterone => cortisol/cortisone
WikiPathways
WP702metapathway biotransformation
WP43cytochrome P450
BIOCYC
HUMAN_PWY66-381glucocorticoid biosynthesis
HUMAN_PWY66-382mineralocorticoid biosynthesis
Reactome
REACT_11057Metabolism of steroid hormones and vitamins A and D
REACT_13433Biological oxidations
REACT_11036Glucocorticoid biosynthesis
REACT_13567Cytochrome P450 - arranged by substrate type
REACT_111217Metabolism
REACT_22258Metabolism of lipids and lipoproteins
REACT_13705Phase 1 - Functionalization of compounds
REACT_13812Endogenous sterols
REACT_11047Mineralocorticoid biosynthesis
Homo sapiens (human)CYP11B1NP_000488.3
Pan troglodytes (chimpanzee)LOC464437XP_519994.3
Macaca mulatta (Rhesus monkey)CYP11B1XP_001084565.1
Mus musculus (house mouse)Cyp11b2NP_034121.3
Rattus norvegicus (Norway rat)Cyp11b2NP_036670.2
GeneCards CYP11B1
UniProt P15538, Q8TDD0
MIM 610613
Ensembl ENSG00000160882
HGNC 2591
HPRD 01943

GeneRIFs: Gene References Into Functions What's a GeneRIF?

General protein information

Preferred Names
cytochrome P450 11B1, mitochondrial
Names
cytochrome P450 11B1, mitochondrial
CYPXIB1
cytochrome P450C11
cytochrome P-450c11
cytochrome p450 XIB1
steroid 11-beta-hydroxylase
steroid 11-beta-monooxygenase
cytochrome P450, subfamily XIB (steroid 11-beta-hydroxylase), polypeptide 1
NP_000488.3
NP_001021384.1

Interactant



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