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CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1 [Homo sapiens (human)]


RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_000782 Homo sapiens cytochrome P450, family 24, subfamily A, polypeptide 1 (CYP24A1), transcript variant 1, mRNA. GenEZ ORF Cloning On-demand $699.00 18
NM_001128915 Homo sapiens cytochrome P450, family 24, subfamily A, polypeptide 1 (CYP24A1), transcript variant 2, mRNA. GenEZ ORF Cloning On-demand $699.00 18
XM_005260304 PREDICTED: Homo sapiens cytochrome P450, family 24, subfamily A, polypeptide 1 (CYP24A1), transcript variant X1, mRNA. GenEZ ORF Cloning On-demand $699.00 18

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Related Services

Gene Symbol CYP24A1
Entrez Gene ID 1591
Full Name cytochrome P450, family 24, subfamily A, polypeptide 1
Synonyms CP24, CYP24, HCAI, P450-CC24
General protein information
Preferred Names
1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial
Names
1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial
24-OHase
cytochrome P450 24A1
cytochrome P450-CC24
vitamin D 24-hydroxylase
exo-mitochondrial protein
vitamin D(3) 24-hydroxylase
1,25-@dihydroxyvitamin D3 24-hydroxylase
cytochrome P450, subfamily XXIV (vitamin D 24-hydroxylase)
NP_000773.2
NP_001122387.1
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

20

20q13

Summary This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This mitochondrial protein initiates the degradation of 1,25-dihydroxyvitamin D3, the physiologically active form of vitamin D3, by hydroxylation of the side chain. In regulating the level of vitamin D3, this enzyme plays a role in calcium homeostasis and the vitamin D endocrine system. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
Disorder

MIM: 126065

mRNA Protein Product Sequence Price Select
NM_000782, 193083115 NP_000773, 55770850 1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial isoform 1 precursor ORF Sequence $550.00
NM_001128915, 193083116 NP_001122387, 193083117 1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial isoform 2 precursor ORF Sequence $550.00
XM_005260304, 578835802 XP_005260361, 530417885 1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial isoform X1 ORF Sequence $550.00
KEGG
hsa00100Steroid biosynthesis
hsa05206MicroRNAs in cancer
WikiPathways
WP1531Vitamin D synthesis
WP43cytochrome P450
WP702metapathway biotransformation
WP299Nuclear receptors in lipid metabolism and toxicity
Reactome
REACT_13433Biological oxidations
REACT_13567Cytochrome P450 - arranged by substrate type
REACT_13450Vitamins
REACT_13705Phase 1 - Functionalization of compounds
REACT_11057Metabolism of steroid hormones and vitamin D
REACT_13523Vitamin D (calciferol) metabolism
REACT_22258Metabolism of lipids and lipoproteins
REACT_111217Metabolism
Homo sapiens (human)CYP24A1NP_000773.2
Pan troglodytes (chimpanzee)LOC746729XP_001154704.2
Macaca mulatta (Rhesus monkey)LOC698937XP_002798136.1
Canis lupus familiaris (dog)CYP24A1XP_543059.2
Bos taurus (cattle)CYP24A1NP_001178346.1
Mus musculus (house mouse)Cyp24a1NP_034126.1
Rattus norvegicus (Norway rat)Cyp24a1NP_963966.1
Gallus gallus (chicken)CYP24A1NP_990310.1
Danio rerio (zebrafish)cyp24a1NP_001082927.1
Drosophila melanogaster (fruit fly)Cyp12b2NP_611370.2
Caenorhabditis eleganscyp-44A1NP_495052.1
Xenopus (Silurana) tropicalis (western clawed frog)LOC100496967XP_002941296.2
Process
IDNameEvidence
GO:0001649osteoblast differentiationIEP
GO:0006766vitamin metabolic processTAS
GO:0006805xenobiotic metabolic processTAS
GO:0008202steroid metabolic processTAS
GO:0033280response to vitamin DIDA
GO:0042359vitamin D metabolic processTAS
GO:0042369vitamin D catabolic processNAS
GO:0044281small molecule metabolic processTAS
GO:0055114oxidation-reduction processIDA
GO:0070561vitamin D receptor signaling pathwayNAS
Component
IDNameEvidence
GO:0005743mitochondrial inner membraneTAS
Function
IDNameEvidence
GO:0005506iron ion bindingIEA
GO:000840325-hydroxycholecalciferol-24-hydroxylase activityIEA
GO:0016491oxidoreductase activityNAS
GO:0020037heme bindingTAS
GO:00303421-alpha,25-dihydroxyvitamin D3 24-hydroxylase activityIDA
GeneCards CYP24A1
UniProt Q07973
Vega OTTHUMG00000032773
MIM 126065
Ensembl ENSG00000019186
HGNC 2602
HPRD 00522

GeneRIFs: Gene References Into Functions What's a GeneRIF?

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