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Sequence in raw or FASTA format:

Database:

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SPRED1 sprouty-related, EVH1 domain containing 1 [Homo sapiens (human)]


Clone ID RefSeq Accession Definition Vector Stock Status *Turnaround time Price Order
OHu18529 NM_152594 Homo sapiens sprouty-related, EVH1 domain containing 1 (SPRED1), mRNA. pcDNA3.1+-DYK On-demand 7-9 $219.00
OHu48143 XM_005254202 PREDICTED: Homo sapiens sprouty-related, EVH1 domain containing 1 (SPRED1), transcript variant X1, mRNA. pcDNA3.1+-DYK On-demand 7-9 $219.00
OHu48144 XM_005254203 PREDICTED: Homo sapiens sprouty-related, EVH1 domain containing 1 (SPRED1), transcript variant X2, mRNA. pcDNA3.1+-DYK On-demand 7-9 $219.00
OHu18529C NM_152594 Homo sapiens sprouty-related, EVH1 domain containing 1 (SPRED1), mRNA. Customized vector On-demand 7-9 $269.00
OHu48143C XM_005254202 PREDICTED: Homo sapiens sprouty-related, EVH1 domain containing 1 (SPRED1), transcript variant X1, mRNA. Customized vector On-demand 7-9 $269.00
OHu48144C XM_005254203 PREDICTED: Homo sapiens sprouty-related, EVH1 domain containing 1 (SPRED1), transcript variant X2, mRNA. Customized vector On-demand 7-9 $269.00

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Gene Symbol SPRED1
Entrez Gene ID 161742
Full Name sprouty-related, EVH1 domain containing 1
Synonyms NFLS, PPP1R147, hSpred1, spred-1
General protein information
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

15

15q14

Summary The protein encoded by this gene is a member of the Sprouty family of proteins and is phosphorylated by tyrosine kinase in response to several growth factors. The encoded protein can act as a homodimer or as a heterodimer with SPRED2 to regulate activation of the MAP kinase cascade. Defects in this gene are a cause of neurofibromatosis type 1-like syndrome (NFLS). [provided by RefSeq, Jul 2008].
Disorder

MIM: 609291

Legius syndrome, 611431 (3)

mRNA Protein Product Sequence Price Select
NM_152594, 187169267 NP_689807, 22749221 sprouty-related, EVH1 domain-containing protein 1 ORF Sequence $550.00
XM_005254202, 530405472 XP_005254259, 530405473 sprouty-related, EVH1 domain-containing protein 1 isoform X1 ORF Sequence $550.00
XM_005254203, 578826670 XP_005254260, 530405475 sprouty-related, EVH1 domain-containing protein 1 isoform X2 ORF Sequence $400.00
KEGG
hsa04630Jak-STAT signaling pathway
WikiPathways
WP304Kit Receptor Signaling Pathway
WP2038Regulation of Microtubule Cytoskeleton
Pathway Interaction Database
kitpathwaySignaling events mediated by Stem cell factor receptor (c-Kit)
Homo sapiens (human)SPRED1NP_689807.1
Pan troglodytes (chimpanzee)SPRED1XP_001138171.1
Canis lupus familiaris (dog)SPRED1XP_544609.3
Bos taurus (cattle)SPRED1NP_001179445.1
Mus musculus (house mouse)Spred1NP_277059.1
Rattus norvegicus (Norway rat)Spred1NP_001040554.1
Gallus gallus (chicken)SPRED1NP_001186638.1
Danio rerio (zebrafish)spred1NP_998397.1
Xenopus (Silurana) tropicalis (western clawed frog)spred1NP_001008037.1
Process
IDNameEvidence
GO:0000188inactivation of MAPK activityISS
GO:0007275multicellular organismal developmentIEA
GO:0010801negative regulation of peptidyl-threonine phosphorylationIMP
GO:0010923negative regulation of phosphatase activityIDA
GO:0043517positive regulation of DNA damage response, signal transduction by p53 class mediatorISS
GO:0090311regulation of protein deacetylationISS
Component
IDNameEvidence
GO:0005634nucleusIDA
GO:0005730nucleolusIDA
GO:0005737cytoplasmIDA
GO:0005901caveolaIEA
Function
IDNameEvidence
GO:0005173stem cell factor receptor bindingISS
GO:0005515protein bindingIPI
GO:0019901protein kinase bindingIPI
GO:0019902phosphatase bindingIDA
GO:0030291protein serine/threonine kinase inhibitor activityISS
GeneCards SPRED1
PDB 3SYX
UniProt Q7Z699
Vega OTTHUMG00000172377
MIM 609291
Ensembl ENSG00000166068
HGNC 20249
HPRD 11601

Interactant

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