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SPRED1 sprouty-related, EVH1 domain containing 1 [Homo sapiens (human)]


RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_152594 Homo sapiens sprouty-related, EVH1 domain containing 1 (SPRED1), mRNA. GenEZ ORF Cloning On-demand $699.00 18
XM_005254202 PREDICTED: Homo sapiens sprouty-related, EVH1 domain containing 1 (SPRED1), transcript variant X1, mRNA. GenEZ ORF Cloning On-demand $699.00 18
XM_005254203 PREDICTED: Homo sapiens sprouty-related, EVH1 domain containing 1 (SPRED1), transcript variant X2, mRNA. GenEZ ORF Cloning On-demand $549.00 14

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Related Services

Gene Symbol SPRED1
Entrez Gene ID 161742
Full Name sprouty-related, EVH1 domain containing 1
Synonyms NFLS, PPP1R147, hSpred1, spred-1
General protein information
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

15

15q14

Summary The protein encoded by this gene is a member of the Sprouty family of proteins and is phosphorylated by tyrosine kinase in response to several growth factors. The encoded protein can act as a homodimer or as a heterodimer with SPRED2 to regulate activation of the MAP kinase cascade. Defects in this gene are a cause of neurofibromatosis type 1-like syndrome (NFLS). [provided by RefSeq, Jul 2008].
Disorder

MIM: 609291

Legius syndrome, 611431 (3)

mRNA Protein Product Sequence Price Select
NM_152594, 187169267 NP_689807, 22749221 sprouty-related, EVH1 domain-containing protein 1 ORF Sequence $550.00
XM_005254202, 530405472 XP_005254259, 530405473 sprouty-related, EVH1 domain-containing protein 1 isoform X1 ORF Sequence $550.00
XM_005254203, 578826670 XP_005254260, 530405475 sprouty-related, EVH1 domain-containing protein 1 isoform X2 ORF Sequence $400.00
KEGG
hsa04630Jak-STAT signaling pathway
WikiPathways
WP304Kit Receptor Signaling Pathway
WP2038Regulation of Microtubule Cytoskeleton
Pathway Interaction Database
kitpathwaySignaling events mediated by Stem cell factor receptor (c-Kit)
Homo sapiens (human)SPRED1NP_689807.1
Pan troglodytes (chimpanzee)SPRED1XP_001138171.1
Canis lupus familiaris (dog)SPRED1XP_544609.3
Bos taurus (cattle)SPRED1NP_001179445.1
Mus musculus (house mouse)Spred1NP_277059.1
Rattus norvegicus (Norway rat)Spred1NP_001040554.1
Gallus gallus (chicken)SPRED1NP_001186638.1
Danio rerio (zebrafish)spred1NP_998397.1
Xenopus (Silurana) tropicalis (western clawed frog)spred1NP_001008037.1
Process
IDNameEvidence
GO:0000188inactivation of MAPK activityISS
GO:0007275multicellular organismal developmentIEA
GO:0010801negative regulation of peptidyl-threonine phosphorylationIMP
GO:0010923negative regulation of phosphatase activityIDA
GO:0043517positive regulation of DNA damage response, signal transduction by p53 class mediatorISS
GO:0090311regulation of protein deacetylationISS
Component
IDNameEvidence
GO:0005634nucleusIDA
GO:0005730nucleolusIDA
GO:0005737cytoplasmIDA
GO:0005901caveolaIEA
Function
IDNameEvidence
GO:0005173stem cell factor receptor bindingISS
GO:0005515protein bindingIPI
GO:0019901protein kinase bindingIPI
GO:0019902phosphatase bindingIDA
GO:0030291protein serine/threonine kinase inhibitor activityISS
GeneCards SPRED1
PDB 3SYX
UniProt Q7Z699
Vega OTTHUMG00000172377
MIM 609291
Ensembl ENSG00000166068
HGNC 20249
HPRD 11601

What is the normal function of the SPRED1 gene?

The SPRED1 gene provides instructions for making the Spred-1 protein, which helps control (regulate) the Ras/MAPK signaling pathway. The Ras/MAPK pathway is involved in the growth and division of cells (proliferation), the process by which cells mature to carry out specific functions (differentiation), cell movement, and the self-destruction of cells (apoptosis).

The Spred-1 protein attaches (binds) to a protein called Raf, which is part of the Ras/MAPK pathway. The binding of the Spred-1 protein blocks the activation of Raf, stopping the signaling through the remainder of the Ras/MAPK pathway.

Interactant

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