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DAZL deleted in azoospermia-like [Homo sapiens (human)]


RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_001190811 Homo sapiens deleted in azoospermia-like (DAZL), transcript variant 1, mRNA. GenEZ ORF Cloning On-demand $449.00 14
NM_001351 Homo sapiens deleted in azoospermia-like (DAZL), transcript variant 2, mRNA. GenEZ ORF Cloning In-stock $348.00 $299.00 10

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Related Services

Gene Symbol DAZL
Entrez Gene ID 1618
Full Name deleted in azoospermia-like
Synonyms DAZH, DAZL1, DAZLA, SPGYLA
General protein information
Preferred Names
deleted in azoospermia-like
Names
deleted in azoospermia-like
DAZ homolog
DAZ-like autosomal
SPGY-like-autosomal
deleted in azoospermia-like 1
germline specific RNA binding protein
spermatogenesis gene on the Y-like autosomal
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

3

3p24.3

Summary The DAZ (Deleted in AZoospermia) gene family encodes potential RNA binding proteins that are expressed in prenatal and postnatal germ cells of males and females. The protein encoded by this gene is localized to the nucleus and cytoplasm of fetal germ cells and to the cytoplasm of developing oocytes. In the testis, this protein is localized to the nucleus of spermatogonia but relocates to the cytoplasm during meiosis where it persists in spermatids and spermatozoa. Transposition and amplification of this autosomal gene during primate evolution gave rise to the DAZ gene cluster on the Y chromosome. Mutations in this gene have been linked to severe spermatogenic failure and infertility in males. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010].
Disorder

MIM: 601486

{Spermatogenic failure, susceptibility to} (3)

mRNA Protein Product Sequence Price Select
NM_001190811, 299829261 NP_001177740, 299829262 deleted in azoospermia-like isoform 1 ORF Sequence $300.00
NM_001351, 299829260 NP_001342, 25121978 deleted in azoospermia-like isoform 2 ORF Sequence $199.00
WikiPathways
WP34Ovarian Infertility Genes
Homo sapiens (human)DAZLNP_001177740.1
Pan troglodytes (chimpanzee)DAZLXP_516314.3
Canis lupus familiaris (dog)DAZLXP_534251.3
Bos taurus (cattle)DAZLNP_001075194.1
Process
IDNameEvidence
GO:0007275multicellular organismal developmentIEA
GO:0007281germ cell developmentIEA
GO:0007283spermatogenesisIEA
GO:0045836positive regulation of meiosisIEA
GO:0045948positive regulation of translational initiationIDA
Component
IDNameEvidence
GO:0005634nucleusIEA
GO:0005737cytoplasmIEA
GO:0005844polysomeIEA
Function
IDNameEvidence
GO:0000166nucleotide bindingIEA
GO:0003723RNA bindingTAS
GO:0003730mRNA 3'-UTR bindingIEA
GO:0005515protein bindingIPI
GO:0008494translation activator activityIDA
GO:0042802identical protein bindingIEA
GeneCards DAZL
UniProt Q92904
Vega OTTHUMG00000157050
MIM 601486
Ensembl ENSG00000092345
HGNC 2685
HPRD 09029

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Interactant

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