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ACE angiotensin I converting enzyme [Homo sapiens (human)]

RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_000789 Homo sapiens angiotensin I converting enzyme (ACE), transcript variant 1, mRNA. GenEZ ORF Cloning On-demand TBD TBD
NM_001178057 Homo sapiens angiotensin I converting enzyme (ACE), transcript variant 3, mRNA. GenEZ ORF Cloning On-demand $849.00 20
NM_152830 Homo sapiens angiotensin I converting enzyme (ACE), transcript variant 2, mRNA. GenEZ ORF Cloning On-demand $849.00 20
XM_005257110 PREDICTED: Homo sapiens angiotensin I converting enzyme (ACE), transcript variant X1, mRNA. GenEZ ORF Cloning On-demand TBD TBD
XM_006721737 PREDICTED: Homo sapiens angiotensin I converting enzyme (ACE), transcript variant X2, mRNA. GenEZ ORF Cloning On-demand $849.00 20

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Gene Symbol ACE
Entrez Gene ID 1636
Full Name angiotensin I converting enzyme
Synonyms ACE1, CD143, DCP, DCP1, ICH, MVCD3
General protein information
Preferred Names
angiotensin-converting enzyme
angiotensin-converting enzyme
kininase II
peptidase P
CD143 antigen
testicular ECA
dipeptidyl carboxypeptidase 1
dipeptidyl carboxypeptidase I
angiotensin converting enzyme, somatic isoform
angiotensin I converting enzyme (peptidyl-dipeptidase A) 1
angiotensin I converting enzyme peptidyl-dipeptidase A 1 transcript
Gene Type protein-coding
Organism Homo sapiens (human)



Summary This gene encodes an enzyme involved in catalyzing the conversion of angiotensin I into a physiologically active peptide angiotensin II. Angiotensin II is a potent vasopressor and aldosterone-stimulating peptide that controls blood pressure and fluid-electrolyte balance. This enzyme plays a key role in the renin-angiotensin system. Many studies have associated the presence or absence of a 287 bp Alu repeat element in this gene with the levels of circulating enzyme or cardiovascular pathophysiologies. Multiple alternatively spliced transcript variants encoding different isoforms have been identified, and two most abundant spliced variants encode the somatic form and the testicular form, respectively, that are equally active. [provided by RefSeq, May 2010].

MIM: 106180

{Myocardial infarction, susceptibility to} (3); {Alzheimer disease,

mRNA Protein Product Sequence Price Select
NM_000789, 307691163 NP_000780, 4503273 angiotensin-converting enzyme isoform 1 precursor ORF Sequence $1500.00
NM_001178057, 295844836 NP_001171528, 295844837 angiotensin-converting enzyme isoform 3 precursor ORF Sequence $700.00
NM_152830, 307691164 NP_690043, 23238214 angiotensin-converting enzyme isoform 2 precursor ORF Sequence $700.00
XM_005257110, 530411693 XP_005257167, 530411694 angiotensin-converting enzyme isoform X1 ORF Sequence $1500.00
XM_006721737, 578830519 XP_006721800, 578830520 angiotensin-converting enzyme isoform X2 ORF Sequence $700.00
hsa04614Renin-angiotensin system
hsa05410Hypertrophic cardiomyopathy (HCM)
hsa05142Chagas disease (American trypanosomiasis)
WP554ACE Inhibitor Pathway
REACT_17015Metabolism of proteins
REACT_147707Metabolism of Angiotensinogen to Angiotensins
REACT_160078Peptide hormone metabolism
Homo sapiens (human)ACENP_000780.1
Pan troglodytes (chimpanzee)ACENP_001008995.1
Macaca mulatta (Rhesus monkey)LOC100428661XP_002800616.1
Canis lupus familiaris (dog)LOC610668XP_003639297.1
Bos taurus (cattle)ACENP_001193597.1
Mus musculus (house mouse)AceNP_997507.1
Rattus norvegicus (Norway rat)AceNP_036676.1
Gallus gallus (chicken)ACENP_001161204.1
Danio rerio (zebrafish)aceXP_694336.5
Xenopus (Silurana) tropicalis (western clawed frog)aceNP_001116882.1
GO:0001822kidney developmentIMP
GO:0001974blood vessel remodelingIC
GO:0002003angiotensin maturationTAS
GO:0002005angiotensin catabolic process in bloodIC
GO:0002019regulation of renal output by angiotensinIC
GO:0003081regulation of systemic arterial blood pressure by renin-angiotensinIC
GO:0008217regulation of blood pressureISS
GO:0014910regulation of smooth muscle cell migrationISS
GO:0019229regulation of vasoconstrictionIC
GO:0032943mononuclear cell proliferationIC
GO:0042312regulation of vasodilationIC
GO:0042447hormone catabolic processIDA
GO:0042447hormone catabolic processISS
GO:0043171peptide catabolic processIDA
GO:0044267cellular protein metabolic processTAS
GO:0050482arachidonic acid secretionIDA
GO:0060218hematopoietic stem cell differentiationIC
GO:0005576extracellular regionTAS
GO:0005615extracellular spaceIDA
GO:0005886plasma membraneIDA
GO:0005886plasma membraneTAS
GO:0009897external side of plasma membraneIDA
GO:0016021integral component of membraneIEA
GO:0070062extracellular vesicular exosomeIDA
GO:0003779actin bindingIDA
GO:0004175endopeptidase activityIDA
GO:0004180carboxypeptidase activityIEA
GO:0005515protein bindingIPI
GO:0008144drug bindingIDA
GO:0008237metallopeptidase activityIDA
GO:0008237metallopeptidase activityISS
GO:0008241peptidyl-dipeptidase activityIDA
GO:0008241peptidyl-dipeptidase activityISS
GO:0008270zinc ion bindingIDA
GO:0031404chloride ion bindingIDA
GO:0031711bradykinin receptor bindingIPI
GeneCards ACE
UniProt D3DU13, P12821, B4DKH4
Vega OTTHUMG00000154927
MIM 106180
Ensembl ENSG00000159640
HGNC 2707
HPRD 00108

GeneRIFs: Gene References Into Functions What's a GeneRIF?

What is the normal function of the ACE gene?

The ACE gene provides instructions for making the angiotensin-converting enzyme. This enzyme is able to cut (cleave) proteins. It is part of the renin-angiotensin system, which regulates blood pressure and the balance of fluids and salts in the body. By cutting a protein called angiotensin I at a particular location, the angiotensin-converting enzyme converts this protein to angiotensin II. Angiotensin II causes blood vessels to narrow (constrict), which results in increased blood pressure. This protein also stimulates production of the hormone aldosterone, which triggers the absorption of salt and water by the kidneys. The increased amount of fluid in the body also increases blood pressure. Proper blood pressure during fetal growth, which delivers oxygen to the developing tissues, is required for normal development of the kidneys, particularly of structures called the proximal tubules, and other tissues. In addition, angiotensin II may play a more direct role in kidney development, perhaps by affecting growth factors involved in the development of kidney structures.

The angiotensin-converting enzyme can cleave other proteins, including bradykinin. Bradykinin causes blood vessels to widen (dilate), which decreases blood pressure. Cleavage by the angiotensin-converting enzyme inactivates bradykinin, helping to increase blood pressure.


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