ACE angiotensin I converting enzyme (peptidyl-dipeptidase A) 1 [Homo sapiens (human)]

Gene Symbol	ACE
Entrez Gene ID	1636
Full Name	angiotensin I converting enzyme (peptidyl-dipeptidase A) 1
Synonyms	ACE1, CD143, DCP, DCP1, MGC26566, MVCD3
Gene Type	protein-coding
Organism	Homo sapiens (human)
Genome	Chromosome:17 Map Location:17q23.3
Summary	This gene encodes an enzyme involved in catalyzing the conversion of angiotensin I into a physiologically active peptide angiotensin II. Angiotensin II is a potent vasopressor and aldosterone-stimulating peptide that controls blood pressure and fluid-electrolyte balance. This enzyme plays a key role in the renin-angiotensin system. Many studies have associated the presence or absence of a 287 bp Alu repeat element in this gene with the levels of circulating enzyme or cardiovascular pathophysiologies. Multiple alternatively spliced transcript variants encoding different isoforms have been identified, and two most abundant spliced variants encode the somatic form and the testicular form, respectively, that are equally active. [provided by RefSeq].
Disorder	MIM: 106180 {Myocardial infarction, susceptibility to} (3); {Alzheimer disease,

mRNA	NM_000789, 307691163
Protein	NP_000780, 4503273
Product	angiotensin-converting enzyme isoform 1 precursor
RefSeq Status	REVIEWED
mRNA	NM_152830, 307691164
Protein	NP_690043, 23238214
Product	angiotensin-converting enzyme isoform 2 precursor
RefSeq Status	REVIEWED
mRNA	NM_001178057, 295844836
Protein	NP_001171528, 295844837
Product	angiotensin-converting enzyme isoform 3 precursor
RefSeq Status	REVIEWED

KEGG

hsa05410	Hypertrophic cardiomyopathy (HCM)
hsa04614	Renin-angiotensin system
hsa05142	Chagas disease (American trypanosomiasis)

WikiPathways

WP554

ACE Inhibitor Pathway

Homo sapiens (human)	ACE	NP_000780.1
Pan troglodytes (chimpanzee)	ACE	NP_001008995.1
Canis lupus familiaris (dog)	ACE	XP_548035.2
Mus musculus (house mouse)	Ace	NP_997507.1
Rattus norvegicus (Norway rat)	Ace	NP_036676.1
Gallus gallus (chicken)	ACE	XP_418074.2
Danio rerio (zebrafish)	wu:fb81h03	XP_694336.4

Process

ID	Name	Evidence
GO:0001666	response to hypoxia	IEA
GO:0001822	kidney development	IMP
GO:0001974	blood vessel remodeling	IC
GO:0002005	angiotensin catabolic process in blood	IC
GO:0002019	regulation of renal output by angiotensin	IC
GO:0002446	neutrophil mediated immunity	IEA
GO:0003081	regulation of systemic arterial blood pressure by renin-angiotensin	IC
GO:0006508	proteolysis	IEA
GO:0008217	regulation of blood pressure	ISS
GO:0014910	regulation of smooth muscle cell migration	ISS
GO:0019229	regulation of vasoconstriction	IC
GO:0019233	sensory perception of pain	IEA
GO:0031667	response to nutrient levels	IEA
GO:0032496	response to lipopolysaccharide	IEA
GO:0032943	mononuclear cell proliferation	IC
GO:0042312	regulation of vasodilation	IC
GO:0042447	hormone catabolic process	IDA
GO:0042447	hormone catabolic process	ISS
GO:0042755	eating behavior	IEA
GO:0043065	positive regulation of apoptosis	IEA
GO:0043171	peptide catabolic process	IDA
GO:0050482	arachidonic acid secretion	IDA
GO:0050729	positive regulation of inflammatory response	IEA
GO:0050769	positive regulation of neurogenesis	IEA
GO:0060218	hemopoietic stem cell differentiation	IC

Component

ID	Name	Evidence
GO:0005576	extracellular region	IEA
GO:0005615	extracellular space	IDA
GO:0005624	membrane fraction	IDA
GO:0005768	endosome	IDA
GO:0005886	plasma membrane	IDA
GO:0009897	external side of plasma membrane	IDA
GO:0016021	integral to membrane	IEA

Function

ID	Name	Evidence
GO:0003779	actin binding	IDA
GO:0004180	carboxypeptidase activity	IEA
GO:0005515	protein binding	IPI
GO:0008144	drug binding	IDA
GO:0008233	peptidase activity	IEA
GO:0008237	metallopeptidase activity	IDA
GO:0008237	metallopeptidase activity	ISS
GO:0008241	peptidyl-dipeptidase activity	IDA
GO:0008241	peptidyl-dipeptidase activity	ISS
GO:0008270	zinc ion binding	IDA
GO:0031404	chloride ion binding	IDA
GO:0031711	bradykinin receptor binding	IPI
GO:0042277	peptide binding	IEA
GO:0046872	metal ion binding	IEA

GeneCards	ACE
PDB	2IUL, 3NXQ, 2IUX, 3BKL, 1UZE, 3L3N, 3BKK, 2OC2, 2C6F, 1UZF, 1O8A, 2C6N, 1O86
UniProt	P12821, B4DXI3, B4DKH4
MIM	106180
Ensembl	ENSG00000159640
HGNC	2707
HPRD	00108

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RefSeq Accession	Definition	Sequence	Price	Select
NM_000789	Homo sapiens angiotensin I converting enzyme (peptidyl-dipeptidase A) 1 (ACE), transcript variant 1, mRNA.	Full Length	$1739.15
NM_000789		ORF Sequence	$1372.35
NM_152830	Homo sapiens angiotensin I converting enzyme (peptidyl-dipeptidase A) 1 (ACE), transcript variant 2, mRNA.	Full Length	$1142.40
NM_152830		ORF Sequence	$637.71
NM_001178057	Homo sapiens angiotensin I converting enzyme (peptidyl-dipeptidase A) 1 (ACE), transcript variant 3, mRNA.	Full Length	$1099.35
NM_001178057		ORF Sequence	$602.04

Sequence in raw or FASTA format: