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ACE angiotensin I converting enzyme (peptidyl-dipeptidase A) 1 [Homo sapiens (human)]


RefSeq Accession Definition Services Price Order
NM_000789 Homo sapiens angiotensin I converting enzyme (peptidyl-dipeptidase A) 1 (ACE), transcript variant 1, mRNA. ORF Sequence $1372.35
Peptide Services
Antibody Services
Protein Services
NM_001178057 Homo sapiens angiotensin I converting enzyme (peptidyl-dipeptidase A) 1 (ACE), transcript variant 3, mRNA. ORF Sequence $602.04
Peptide Services
Antibody Services
Protein Services
NM_152830 Homo sapiens angiotensin I converting enzyme (peptidyl-dipeptidase A) 1 (ACE), transcript variant 2, mRNA. ORF Sequence $637.71
Peptide Services
Antibody Services
Protein Services


Gene Symbol ACE
Entrez Gene ID 1636
Full Name angiotensin I converting enzyme (peptidyl-dipeptidase A) 1
Synonyms ACE1, CD143, DCP, DCP1, MGC26566, MVCD3
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

17

17q23.3

Summary This gene encodes an enzyme involved in catalyzing the conversion of angiotensin I into a physiologically active peptide angiotensin II. Angiotensin II is a potent vasopressor and aldosterone-stimulating peptide that controls blood pressure and fluid-electrolyte balance. This enzyme plays a key role in the renin-angiotensin system. Many studies have associated the presence or absence of a 287 bp Alu repeat element in this gene with the levels of circulating enzyme or cardiovascular pathophysiologies. Multiple alternatively spliced transcript variants encoding different isoforms have been identified, and two most abundant spliced variants encode the somatic form and the testicular form, respectively, that are equally active. [provided by RefSeq, May 2010].
Disorder

MIM: 106180

{Myocardial infarction, susceptibility to} (3); {Alzheimer disease,

mRNA Protein Product Sequence Price Select
NM_000789, 307691163 NP_000780, 4503273 angiotensin-converting enzyme isoform 1 precursor Full Length $1739.15
ORF Sequence $1372.35
NM_001178057, 295844836 NP_001171528, 295844837 angiotensin-converting enzyme isoform 3 precursor Full Length $1099.35
ORF Sequence $602.04
NM_152830, 307691164 NP_690043, 23238214 angiotensin-converting enzyme isoform 2 precursor Full Length $1142.40
ORF Sequence $637.71
KEGG
hsa05142Chagas disease (American trypanosomiasis)
hsa04614Renin-angiotensin system
hsa05410Hypertrophic cardiomyopathy (HCM)
WikiPathways
WP554ACE Inhibitor Pathway
Reactome
REACT_17015Metabolism of proteins
REACT_147707Metabolism of Angiotensinogen to Angiotensins
Homo sapiens (human)ACENP_000780.1
Pan troglodytes (chimpanzee)ACENP_001008995.1
Macaca mulatta (Rhesus monkey)LOC100428661XP_002800616.1
Canis lupus familiaris (dog)ACEXP_003639297.1
Bos taurus (cattle)ACENP_001193597.1
Mus musculus (house mouse)AceNP_997507.1
Rattus norvegicus (Norway rat)AceNP_036676.1
Gallus gallus (chicken)ACENP_001161204.1
Danio rerio (zebrafish)aceXP_694336.5
GeneCards ACE
PDB 2IUX, 4APJ, 1UZE, 4APH, 3L3N, 2OC2, 1UZF, 2YDM, 2C6N, 2IUL, 3NXQ, 3BKL, 2C6F, 3BKK, 1O8A, 2XYD, 2XY9, 1O86
UniProt P12821, B4DKH4
MIM 106180
Ensembl ENSG00000159640
HGNC 2707
HPRD 00108

GeneRIFs: Gene References Into Functions What's a GeneRIF?

General protein information

Preferred Names
angiotensin-converting enzyme
Names
angiotensin-converting enzyme
kininase II
peptidase P
CD143 antigen
testicular ECA
carboxycathepsin
dipeptidyl carboxypeptidase 1
dipeptidyl carboxypeptidase I
angiotensin converting enzyme, somatic isoform
angiotensin I converting enzyme (peptidyl-dipeptidase A) 1
angiotensin I converting enzyme peptidyl-dipeptidase A 1 transcript
NP_000780.1
NP_001171528.1
NP_690043.1

Interactant

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