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DCTN1 dynactin 1 [Homo sapiens (human)]

RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_001135040 Homo sapiens dynactin 1 (DCTN1), transcript variant 3, mRNA. GenEZ ORF Cloning On-demand $1699.00 25
NM_001135041 Homo sapiens dynactin 1 (DCTN1), transcript variant 4, mRNA. GenEZ ORF Cloning On-demand $1699.00 25
NM_001190836 Homo sapiens dynactin 1 (DCTN1), transcript variant 5, mRNA. GenEZ ORF Cloning On-demand $1699.00 25
NM_001190837 Homo sapiens dynactin 1 (DCTN1), transcript variant 6, mRNA. GenEZ ORF Cloning On-demand $1699.00 25
NM_004082 Homo sapiens dynactin 1 (DCTN1), transcript variant 1, mRNA. GenEZ ORF Cloning On-demand $1699.00 25
NM_023019 Homo sapiens dynactin 1 (DCTN1), transcript variant 2, mRNA. GenEZ ORF Cloning On-demand $1699.00 25

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Gene Symbol DCTN1
Entrez Gene ID 1639
Full Name dynactin 1
Synonyms DAP-150, DP-150, P135
Gene Type protein-coding
Organism Homo sapiens (human)



Summary This gene encodes the largest subunit of dynactin, a macromolecular complex consisting of 10 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. Dynactin is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit interacts with dynein intermediate chain by its domains directly binding to dynein and binds to microtubules via a highly conserved glycine-rich cytoskeleton-associated protein (CAP-Gly) domain in its N-terminus. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms. Mutations in this gene cause distal hereditary motor neuronopathy type VIIB (HMN7B) which is also known as distal spinal and bulbar muscular atrophy (dSBMA). [provided by RefSeq, Oct 2008].

MIM: 601143

Neuropathy, distal hereditary motor, type VIIB, 607641 (3);

mRNA Protein Product Sequence Price Select
NM_001135040, 299890880 NP_001128512, 205277392 dynactin subunit 1 isoform 3 ORF Sequence $1500.00
NM_001135041, 299890882 NP_001128513, 205277396 dynactin subunit 1 isoform 4 ORF Sequence $1500.00
NM_001190836, 299890870 NP_001177765, 299890871 dynactin subunit 1 isoform 5 ORF Sequence $1500.00
NM_001190837, 299890874 NP_001177766, 299890875 dynactin subunit 1 isoform 6 ORF Sequence $1500.00
NM_004082, 299890881 NP_004073, 13259510 dynactin subunit 1 isoform 1 ORF Sequence $1500.00
NM_023019, 299890884 NP_075408, 13259508 dynactin subunit 1 isoform 2 ORF Sequence $1500.00
hsa05016Huntington's disease
hsa04962Vasopressin-regulated water reabsorption
Pathway Interaction Database
ncadherinpathwayN-cadherin signaling events
REACT_121399MHC class II antigen presentation
REACT_115566Cell Cycle
REACT_18356Unfolded Protein Response
REACT_6900Immune System
REACT_15364Loss of Nlp from mitotic centrosomes
REACT_15451Loss of proteins required for interphase microtubule organization####from the centrosome
REACT_18273Activation of Chaperone Genes by XBP1(S)
REACT_75774Adaptive Immune System
REACT_15380Diabetes pathways
REACT_15479Centrosome maturation
REACT_18368Activation of Chaperones by IRE1alpha
REACT_21391Mitotic G2-G2/M phases
REACT_15296Recruitment of mitotic centrosome proteins and complexes
REACT_2203G2/M Transition
REACT_152Cell Cycle, Mitotic
Homo sapiens (human)DCTN1NP_001177766.1
Pan troglodytes (chimpanzee)DCTN1XP_001156479.1
Macaca mulatta (Rhesus monkey)DCTN1XP_001108486.2
Canis lupus familiaris (dog)DCTN1XP_866352.1
Bos taurus (cattle)DCTN1NP_001092404.1
Mus musculus (house mouse)Dctn1NP_031861.2
Rattus norvegicus (Norway rat)Dctn1NP_077044.1
Gallus gallus (chicken)DCTN1NP_001026538.1
Danio rerio (zebrafish)dctn1aNP_001070680.1
Danio rerio (zebrafish)dctn1bXP_001342673.2
Drosophila melanogaster (fruit fly)GlNP_524061.1
Caenorhabditis elegansdnc-1NP_502033.2
GeneCards DCTN1
PDB 2HL3, 2COY, 2HKQ, 2HL5, 1TXQ, 2HKN, 2HQH, 3TQ7, 3E2U
UniProt Q6MZZ3, Q14203, A8MY36
MIM 601143
Ensembl ENSG00000204843
HGNC 2711
HPRD 07206

GeneRIFs: Gene References Into Functions What's a GeneRIF?

General protein information

Preferred Names
dynactin subunit 1
dynactin subunit 1
150 kDa dynein-associated polypeptide
dynactin 1 (p150, glued homolog, Drosophila)


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