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DCTN1 dynactin 1 [Homo sapiens (human)]

RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_001135040 Homo sapiens dynactin 1 (DCTN1), transcript variant 3, mRNA. GenEZ ORF Cloning On-demand $1699.00 25
NM_001135041 Homo sapiens dynactin 1 (DCTN1), transcript variant 4, mRNA. GenEZ ORF Cloning On-demand $1699.00 25
NM_001190836 Homo sapiens dynactin 1 (DCTN1), transcript variant 5, mRNA. GenEZ ORF Cloning On-demand $1699.00 25
NM_001190837 Homo sapiens dynactin 1 (DCTN1), transcript variant 6, mRNA. GenEZ ORF Cloning On-demand $1699.00 25
NM_004082 Homo sapiens dynactin 1 (DCTN1), transcript variant 1, mRNA. GenEZ ORF Cloning On-demand $1699.00 25
NM_023019 Homo sapiens dynactin 1 (DCTN1), transcript variant 2, mRNA. GenEZ ORF Cloning On-demand $1699.00 25

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Gene Symbol DCTN1
Entrez Gene ID 1639
Full Name dynactin 1
Synonyms DAP-150, DP-150, P135
General protein information
Preferred Names
dynactin subunit 1
dynactin subunit 1
150 kDa dynein-associated polypeptide
dynactin 1 (p150, glued homolog, Drosophila)
Gene Type protein-coding
Organism Homo sapiens (human)



Summary This gene encodes the largest subunit of dynactin, a macromolecular complex consisting of 10 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. Dynactin is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit interacts with dynein intermediate chain by its domains directly binding to dynein and binds to microtubules via a highly conserved glycine-rich cytoskeleton-associated protein (CAP-Gly) domain in its N-terminus. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms. Mutations in this gene cause distal hereditary motor neuronopathy type VIIB (HMN7B) which is also known as distal spinal and bulbar muscular atrophy (dSBMA). [provided by RefSeq, Oct 2008].

MIM: 601143

Neuropathy, distal hereditary motor, type VIIB, 607641 (3);

mRNA Protein Product Sequence Price Select
NM_001135040, 299890880 NP_001128512, 205277392 dynactin subunit 1 isoform 3 ORF Sequence $1500.00
NM_001135041, 299890882 NP_001128513, 205277396 dynactin subunit 1 isoform 4 ORF Sequence $1500.00
NM_001190836, 299890870 NP_001177765, 299890871 dynactin subunit 1 isoform 5 ORF Sequence $1500.00
NM_001190837, 299890874 NP_001177766, 299890875 dynactin subunit 1 isoform 6 ORF Sequence $1500.00
NM_004082, 299890881 NP_004073, 13259510 dynactin subunit 1 isoform 1 ORF Sequence $1500.00
NM_023019, 299890884 NP_075408, 13259508 dynactin subunit 1 isoform 2 ORF Sequence $1500.00
hsa05016Huntington's disease
hsa04962Vasopressin-regulated water reabsorption
Pathway Interaction Database
ncadherinpathwayN-cadherin signaling events
REACT_152Cell Cycle, Mitotic
REACT_2203G2/M Transition
REACT_15296Recruitment of mitotic centrosome proteins and complexes
REACT_15479Centrosome maturation
REACT_15364Loss of Nlp from mitotic centrosomes
REACT_15451Loss of proteins required for interphase microtubule organization####from the centrosome
REACT_18356Unfolded Protein Response (UPR)
REACT_18368IRE1alpha activates chaperones
REACT_17015Metabolism of proteins
REACT_6900Immune System
REACT_21391Mitotic G2-G2/M phases
REACT_75774Adaptive Immune System
REACT_115566Cell Cycle
REACT_18273XBP1(S) activates chaperone genes
REACT_121399MHC class II antigen presentation
REACT_160315Regulation of PLK1 Activity at G2/M Transition
Homo sapiens (human)DCTN1NP_004073.2
Pan troglodytes (chimpanzee)DCTN1XP_001156535.1
Macaca mulatta (Rhesus monkey)DCTN1XP_001108486.2
Canis lupus familiaris (dog)DCTN1XP_005630593.1
Bos taurus (cattle)DCTN1NP_001092404.1
Mus musculus (house mouse)Dctn1NP_031861.2
Rattus norvegicus (Norway rat)Dctn1NP_077044.1
Gallus gallus (chicken)DCTN1NP_001026538.1
Danio rerio (zebrafish)dctn1bXP_001342673.3
Drosophila melanogaster (fruit fly)GlNP_524061.1
Xenopus (Silurana) tropicalis (western clawed frog)dctn1XP_002936330.2
GO:0000086G2/M transition of mitotic cell cycleTAS
GO:0000278mitotic cell cycleTAS
GO:0006987activation of signaling protein activity involved in unfolded protein responseTAS
GO:0007067mitotic nuclear divisionNAS
GO:0007399nervous system developmentNAS
GO:0008219cell deathIEA
GO:0010970microtubule-based transportIEA
GO:0019886antigen processing and presentation of exogenous peptide antigen via MHC class IITAS
GO:0030968endoplasmic reticulum unfolded protein responseTAS
GO:0044267cellular protein metabolic processTAS
GO:0000922spindle poleIDA
GO:0005869dynactin complexIEA
GO:0030286dynein complexIEA
GO:0031252cell leading edgeIEA
GO:0003774motor activityIEA
GO:0005515protein bindingIPI
GO:0045502dynein bindingIEA
GeneCards DCTN1
UniProt Q6MZZ3, Q14203
Vega OTTHUMG00000129963
MIM 601143
Ensembl ENSG00000204843
HGNC 2711
HPRD 07206

GeneRIFs: Gene References Into Functions What's a GeneRIF?

What is the normal function of the DCTN1 gene?

The DCTN1 gene provides instructions for making a protein called dynactin-1. At least two different versions of this protein are produced in cells. The two versions differ in size; the larger version is called p150-glued, and the smaller version is called p135.

Both versions of the dynactin-1 protein interact with several other proteins to form a group (a complex) of proteins called dynactin. The p150-glued version of dynactin-1 is the largest component (subunit) of the dynactin complex. This complex plays a critical role in cell division and the transport of materials within cells. To carry out these roles, the complex's p150-glued subunit attaches (binds) to a protein called dynein, which acts as a motor, and also binds to a track-like system of small tubes called microtubules. The dynactin complex, dynein, and microtubules work together like a conveyer belt to move materials within cells.

Researchers believe that the dynactin complex is particularly important for the proper function of axons, which are specialized extensions of nerve cells (neurons). Axons transmit impulses from nerve to nerve and from nerves to muscles. Axons can be quite long; some are more than 3 feet in length. The dynactin complex is a critical part of a rapid transport system that supplies axons with materials to keep them healthy and functioning efficiently.


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