DLX5 distal-less homeobox 5 [Homo sapiens (human)]
| Gene Symbol | DLX5 |
| Entrez Gene ID | 1749 |
| Full Name | distal-less homeobox 5 |
| Synonyms | |
| Gene Type | protein-coding |
| Organism | Homo sapiens (human) |
| Genome |
7 7q22 |
| Summary | This gene encodes a member of a homeobox transcription factor gene family similiar to the Drosophila distal-less gene. The encoded protein may play a role in bone development and fracture healing. Mutation in this gene, which is located in a tail-to-tail configuration with another member of the family on the long arm of chromosome 7, may be associated with split-hand/split-foot malformation. [provided by RefSeq]. |
| Disorder | MIM: 600028 |
| mRNA | NM_005221, 84043959 |
| Protein | NP_005212, 4885187 |
| Product | homeobox protein DLX-5 |
| RefSeq Status | REVIEWED |
| Homo sapiens (human) | DLX5 | NP_005212.1 |
| Pan troglodytes (chimpanzee) | DLX5 | XP_519218.2 |
| Canis lupus familiaris (dog) | DLX5 | XP_539430.2 |
| Bos taurus (cattle) | DLX5 | NP_001068781.1 |
| Mus musculus (house mouse) | Dlx5 | NP_034186.2 |
| Rattus norvegicus (Norway rat) | Dlx5 | NP_037075.1 |
| Gallus gallus (chicken) | DLX5 | NP_989490.1 |
| Danio rerio (zebrafish) | dlx5a | NP_571381.1 |
| Caenorhabditis elegans | ceh-43 | NP_497904.1 |
| ID | Name | Evidence |
| GO:0001501 | skeletal system development | TAS |
| GO:0001649 | osteoblast differentiation | ISS |
| GO:0001958 | endochondral ossification | ISS |
| GO:0006355 | regulation of transcription, DNA-dependent | IEA |
| GO:0007275 | multicellular organismal development | IEA |
| GO:0007399 | nervous system development | IEA |
| GO:0007411 | axon guidance | IEA |
| GO:0008283 | cell proliferation | IDA |
| GO:0030326 | embryonic limb morphogenesis | IEA |
| GO:0030855 | epithelial cell differentiation | IEA |
| GO:0042472 | inner ear morphogenesis | IEA |
| GO:0045669 | positive regulation of osteoblast differentiation | IEA |
| GO:0048646 | anatomical structure formation involved in morphogenesis | IEA |
| GO:0050679 | positive regulation of epithelial cell proliferation | IEA |
| GO:0090263 | positive regulation of canonical Wnt receptor signaling pathway | IEA |
Component
| ID | Name | Evidence |
| GO:0005634 | nucleus | IDA |
| GO:0005730 | nucleolus | IDA |
| GO:0005737 | cytoplasm | IEA |
Function
| ID | Name | Evidence |
| GO:0003700 | sequence-specific DNA binding transcription factor activity | IEA |
| GO:0043565 | sequence-specific DNA binding | IEA |
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