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DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 [Homo sapiens (human)]

RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_001376 Homo sapiens dynein, cytoplasmic 1, heavy chain 1 (DYNC1H1), mRNA. GenEZ ORF Cloning On-demand TBD TBD

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Gene Symbol DYNC1H1
Entrez Gene ID 1778
Full Name dynein, cytoplasmic 1, heavy chain 1
Synonyms DHC1, DHC1a, DNCH1, DNCL, DNECL, DYHC, Dnchc1, HL-3, SMALED1, p22
General protein information
Preferred Names
cytoplasmic dynein 1 heavy chain 1
cytoplasmic dynein 1 heavy chain 1
dynein heavy chain, cytosolic
dynein, cytoplasmic, heavy polypeptide 1
Gene Type protein-coding
Organism Homo sapiens (human)



Summary Dyneins are a group of microtubule-activated ATPases that function as molecular motors. They are divided into two subgroups of axonemal and cytoplasmic dyneins. The cytoplasmic dyneins function in intracellular motility, including retrograde axonal transport, protein sorting, organelle movement, and spindle dynamics. Molecules of conventional cytoplasmic dynein are comprised of 2 heavy chain polypeptides and a number of intermediate and light chains.This gene encodes a member of the cytoplasmic dynein heavy chain family. [provided by RefSeq, Oct 2008].

MIM: 600112

mRNA Protein Product Sequence Price Select
NM_001376, 209413718 NP_001367, 33350932 cytoplasmic dynein 1 heavy chain 1 ORF Sequence $-1.00
hsa04962Vasopressin-regulated water reabsorption
hsa05132Salmonella infection
Pathway Interaction Database
lis1pathwayLissencephaly gene (LIS1) in neuronal migration and development
REACT_152Cell Cycle, Mitotic
REACT_2203G2/M Transition
REACT_15296Recruitment of mitotic centrosome proteins and complexes
REACT_15479Centrosome maturation
REACT_15364Loss of Nlp from mitotic centrosomes
REACT_15451Loss of proteins required for interphase microtubule organization####from the centrosome
REACT_6900Immune System
REACT_21391Mitotic G2-G2/M phases
REACT_75774Adaptive Immune System
REACT_115566Cell Cycle
REACT_121399MHC class II antigen presentation
REACT_160315Regulation of PLK1 Activity at G2/M Transition
Homo sapiens (human)DYNC1H1NP_001367.2
Pan troglodytes (chimpanzee)DYNC1H1XP_003314564.1
Macaca mulatta (Rhesus monkey)LOC718989XP_001112455.2
Canis lupus familiaris (dog)DYNC1H1XP_537556.2
Bos taurus (cattle)DYNC1H1NP_001193067.1
Mus musculus (house mouse)Dync1h1NP_084514.2
Rattus norvegicus (Norway rat)Dync1h1NP_062099.3
Gallus gallus (chicken)DYNC1H1XP_421371.3
Danio rerio (zebrafish)dync1h1NP_001036210.1
Drosophila melanogaster (fruit fly)Dhc64CNP_523929.2
Caenorhabditis elegansdhc-1NP_491363.1
GO:0000086G2/M transition of mitotic cell cycleTAS
GO:0000278mitotic cell cycleTAS
GO:0006200ATP catabolic processIEA
GO:0007018microtubule-based movementIEA
GO:0007052mitotic spindle organizationNAS
GO:0008219cell deathIEA
GO:0019886antigen processing and presentation of exogenous peptide antigen via MHC class IITAS
GO:0033962cytoplasmic mRNA processing body assemblyISS
GO:0034063stress granule assemblyISS
GO:0005868cytoplasmic dynein complexNAS
GO:0070062extracellular vesicular exosomeIDA
GO:0003777microtubule motor activityIEA
GO:0005515protein bindingIPI
GO:0005524ATP bindingIEA
GO:0016887ATPase activityIEA
GO:0044822poly(A) RNA bindingIDA
GeneCards DYNC1H1
UniProt Q14204
Vega OTTHUMG00000171644
MIM 600112
Ensembl ENSG00000197102
HGNC 2961
HPRD 02524

GeneRIFs: Gene References Into Functions What's a GeneRIF?

What is the normal function of the DYNC1H1 gene?

The DYNC1H1 gene provides instructions for making a protein that is part of a group (complex) of proteins called dynein. This complex is found in the fluid inside cells (cytoplasm). Dynein is turned on (activated) by attaching (binding) to another complex called dynactin. This dynein-dynactin complex binds to various materials within cells. Using energy provided by molecules called ATP, the dynein-dynactin complex moves material along a track-like system of small tubes called microtubules, similar to a conveyer belt. The dynein-dynactin complex is necessary for protein transport, positioning of cell compartments, mobility of structures within the cell, and many other cell processes. In nerve cells (neurons), dynein helps neighboring cells communicate by transporting sac-like structures called synaptic vesicles that contain chemical messengers. When synaptic vesicles are passed from one neuron to another, the dynein-dynactin complex transports the vesicle from the edge of the cell to the center where the chemical message is received.

The parts (subunits) of a dynein complex are classified by weight as heavy, intermediate, light intermediate, or light chains. Two heavy chain proteins bind together to form the core of the dynein complex. Combinations of intermediate, light intermediate, and light chains make up the rest of the complex. The protein produced from the DYNC1H1 gene is a heavy chain. Other subunits are produced from different genes.


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