DNMT1 DNA (cytosine-5-)-methyltransferase 1 [Homo sapiens (human)]

Gene Symbol	DNMT1
Entrez Gene ID	1786
Full Name	DNA (cytosine-5-)-methyltransferase 1
Synonyms	AIM, CXXC9, DNMT, FLJ16293, MCMT, MGC104992
Gene Type	protein-coding
Organism	Homo sapiens (human)
Genome	Chromosome:19 Map Location:19p13.2
Summary	DNA (cytosine-5-)-methyltransferase 1 has a role in the establishment and regulation of tissue-specific patterns of methylated cytosine residues. Aberrant methylation patterns are associated with certain human tumors and developmental abnormalities. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq].
Disorder	MIM: 126375

mRNA	NM_001379, 195546895
Protein	NP_001370, 4503351
Product	DNA (cytosine-5)-methyltransferase 1 isoform b
RefSeq Status	REVIEWED
mRNA	NM_001130823, 195927036
Protein	NP_001124295, 195927037
Product	DNA (cytosine-5)-methyltransferase 1 isoform a
RefSeq Status	REVIEWED

KEGG

hsa01100	Metabolic pathways
hsa00270	Cysteine and methionine metabolism

WikiPathways

WP241

One Carbon Metabolism

Pathway Interaction Database

rb_1pathway

Regulation of retinoblastoma protein

Homo sapiens (human)	DNMT1	NP_001124295.1
Pan troglodytes (chimpanzee)	DNMT1	XP_001163764.1
Canis lupus familiaris (dog)	DNMT1	XP_533919.2
Bos taurus (cattle)	DNMT1	NP_872592.1
Mus musculus (house mouse)	Dnmt1	NP_034196.3
Rattus norvegicus (Norway rat)	Dnmt1	NP_445806.1

Process

ID	Name	Evidence
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	TAS
GO:0006306	DNA methylation	TAS
GO:0010216	maintenance of DNA methylation	IDA
GO:0010628	positive regulation of gene expression	IMP
GO:0016458	gene silencing	IEA
GO:0016568	chromatin modification	IEA
GO:0042127	regulation of cell proliferation	IEA
GO:0051571	positive regulation of histone H3-K4 methylation	IMP
GO:0051573	negative regulation of histone H3-K9 methylation	IMP
GO:0090116	C-5 methylation of cytosine	TAS

Component

ID	Name	Evidence
GO:0005634	nucleus	IEA
GO:0005657	replication fork	IEA
GO:0005721	centromeric heterochromatin	IEA

Function

ID	Name	Evidence
GO:0003677	DNA binding	IDA
GO:0003886	DNA (cytosine-5-)-methyltransferase activity	IEA
GO:0005515	protein binding	IPI
GO:0008134	transcription factor binding	IEA
GO:0008270	zinc ion binding	IEA
GO:0009008	DNA-methyltransferase activity	IDA
GO:0016740	transferase activity	IEA
GO:0046872	metal ion binding	IEA

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RefSeq Accession	Definition	Sequence	Price	Select
NM_001379	Homo sapiens DNA (cytosine-5-)-methyltransferase 1 (DNMT1), transcript variant 2, mRNA.	Full Length	$2419.65
NM_001379		ORF Sequence	$1697.85
NM_001130823	Homo sapiens DNA (cytosine-5-)-methyltransferase 1 (DNMT1), transcript variant 1, mRNA.	Full Length	$2441.25
NM_001130823		ORF Sequence	$1714.65