Sequence in raw or FASTA format:
DNMT1 DNA (cytosine-5-)-methyltransferase 1 [
Homo sapiens (human)]
Gene Symbol DNMT1
Entrez Gene ID
Full Name DNA (cytosine-5-)-methyltransferase 1
Synonyms ADCADN, AIM, CXXC9, DNMT, HSN1E, MCMT
General protein information
DNA (cytosine-5)-methyltransferase 1
DNA (cytosine-5)-methyltransferase 1
DNA MTase HsaI
DNA methyltransferase HsaI
CXXC-type zinc finger protein 9
Gene Type protein-coding
Homo sapiens (human)
Chromosome:19 Map Location:19p13.2
Summary DNA (cytosine-5-)-methyltransferase 1 has a role in the establishment and regulation of tissue-specific patterns of methylated cytosine residues. Aberrant methylation patterns are associated with certain human tumors and developmental abnormalities. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008].
WP241 One Carbon Metabolism
WP2333 Trans-sulfuration pathway
WP2525 Trans-sulfuration and one carbon metabolism
WP2446 RB in Cancer
Pathway Interaction Database
Related articles in PubMed Phosphorylation Drives an Apoptotic Protein to Activate Antiapoptotic Genes: PARADIGM OF INFLUENZA A MATRIX 1 PROTEIN FUNCTION. Halder UC, et al. J Biol Chem, 2013 May 17. PMID 23548901. UHRF1 targets DNMT1 for DNA methylation through cooperative binding of hemi-methylated DNA and methylated H3K9. Liu X, et al. Nat Commun, 2013. PMID 23463006. DNA 5-methylcytosine demethylation activities of the mammalian DNA methyltransferases. Chen CC, et al. J Biol Chem, 2013 Mar 29. PMID 23393137. DNMT1 mutation hot spot causes varied phenotypes of HSAN1 with dementia and hearing loss. Klein CJ, et al. Neurology, 2013 Feb 26. PMID 23365052. HBP1-mediated transcriptional regulation of DNA methyltransferase 1 and its impact on cell senescence. Pan K, et al. Mol Cell Biol, 2013 Mar. PMID 23249948. See all (296) citations in PubMed See citations in PubMed for homologs of this gene provided by HomoloGene
GeneRIFs: Gene References Into Functions
What's a GeneRIF?
UHRF1 can target DNMT1 for DNA maintenance methylation through binding either histone 3 lysine 9 methylation 2/3 or hemi-methylated CpG.
Title: UHRF1 targets DNMT1 for DNA methylation through cooperative binding of hemi-methylated DNA and methylated H3K9.
A review of the various regulatory mechanisms and interactions of DNMT1.
Title: An insight into the various regulatory mechanisms modulating human DNA methyltransferase 1 stability and function.
Decreased expression levels of DNMT1, DNMT3a, and DNMT3b in the ectopic endometrium and eutopic endometrium may play a role in patients with abnormal epigenetics which may lead to endometriosis.
Title: [Expression of DNMT1, DNMT3a, and DNMT3b in eutopic endometrium].
Ciprofloxacin has antifibrotic actions in Systemic sclerosis dermal and lung fibroblasts via the downregulation of Dnmt1, the upregulation of Fli1.
Title: Ciprofloxacin has antifibrotic effects in scleroderma fibroblasts via downregulation of Dnmt1 and upregulation of Fli1.
mammalian DNMT1, DNMT3B, and, to a much less extent, DNMT3A, can also act in vitro as DNA demethylases in a Ca2+ ion- and redox state-dependent manner
Title: DNA 5-methylcytosine demethylation activities of the mammalian DNA methyltransferases.
results indicate DNMT1 is essential for maintenance of colon cancer stem-like cells/cancer-initiating cells and short-term suppression of DNMT1 might be sufficient to disrupt cancer stem-like cells/cancer-initiating cells
Title: DNA methyltransferase 1 is essential for initiation of the colon cancers.
DNMT1 mutations in patients presenting with familial frontotemporal dementia or primary memory decline may also have sensory neuropathy and hearing loss, or phenotype for narcolepsy.
Title: DNMT1 mutation hot spot causes varied phenotypes of HSAN1 with dementia and hearing loss.
Results suggested that SNPs of DNMT1 could be used as genotypic markers for predicting genetic susceptibilities to H.pylori infection and risks in gastric atrophy.
Title: Polymorphisms of the DNA methyltransferase 1 associated with reduced risks of Helicobacter pylori infection and increased risks of gastric atrophy.
HBP1 represses the DNMT1 gene through binding a high-affinity site in the DNMT1 promoter.
Title: HBP1-mediated transcriptional regulation of DNA methyltransferase 1 and its impact on cell senescence.
Upregulation of DNMT1 is associated with neoplastic transformation.
Title: MicroRNA-152 targets DNA methyltransferase 1 in NiS-transformed cells via a feedback mechanism.
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