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Sequence in raw or FASTA format:


Blast Method:


DNMT1 DNA (cytosine-5-)-methyltransferase 1 [Homo sapiens (human)]

RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_001130823 Homo sapiens DNA (cytosine-5-)-methyltransferase 1 (DNMT1), transcript variant 1, mRNA. GenEZ ORF Cloning On-demand $2699.00 30
NM_001379 Homo sapiens DNA (cytosine-5-)-methyltransferase 1 (DNMT1), transcript variant 2, mRNA. GenEZ ORF Cloning On-demand $2699.00 30
XM_006722681 PREDICTED: Homo sapiens DNA (cytosine-5-)-methyltransferase 1 (DNMT1), transcript variant X1, mRNA. GenEZ ORF Cloning On-demand $1699.00 25

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Gene Symbol DNMT1
Entrez Gene ID 1786
Full Name DNA (cytosine-5-)-methyltransferase 1
General protein information
Preferred Names
DNA (cytosine-5)-methyltransferase 1
DNA (cytosine-5)-methyltransferase 1
DNA MTase HsaI
DNA methyltransferase HsaI
CXXC-type zinc finger protein 9
Gene Type protein-coding
Organism Homo sapiens (human)



Summary DNA (cytosine-5-)-methyltransferase 1 has a role in the establishment and regulation of tissue-specific patterns of methylated cytosine residues. Aberrant methylation patterns are associated with certain human tumors and developmental abnormalities. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008].

MIM: 126375

mRNA Protein Product Sequence Price Select
NM_001130823, 195927036 NP_001124295, 195927037 DNA (cytosine-5)-methyltransferase 1 isoform a ORF Sequence $2500.00
NM_001379, 195546895 NP_001370, 4503351 DNA (cytosine-5)-methyltransferase 1 isoform b ORF Sequence $2500.00
XM_006722681, 578833064 XP_006722744, 578833065 DNA (cytosine-5)-methyltransferase 1 isoform X1 ORF Sequence $1500.00
hsa00270Cysteine and methionine metabolism
hsa_M00035Methionine degradation
hsa05206MicroRNAs in cancer
WP241One Carbon Metabolism
WP2333Trans-sulfuration pathway
WP2525Trans-sulfuration and one carbon metabolism
WP2446RB in Cancer
Pathway Interaction Database
rb_1pathwayRegulation of retinoblastoma protein
REACT_71Gene Expression
REACT_200857Epigenetic regulation of gene expression
REACT_200808PRC2 methylates histones and DNA
REACT_200834Negative epigenetic regulation of rRNA expression
REACT_200856NoRC negatively regulates rRNA expression
Homo sapiens (human)DNMT1NP_001124295.1
Pan troglodytes (chimpanzee)DNMT1XP_512361.3
Macaca mulatta (Rhesus monkey)DNMT1XP_001104704.2
Canis lupus familiaris (dog)DNMT1XP_533919.4
Bos taurus (cattle)DNMT1NP_872592.2
Mus musculus (house mouse)Dnmt1NP_001186360.2
Rattus norvegicus (Norway rat)Dnmt1NP_445806.3
Gallus gallus (chicken)DNMT1NP_996835.1
Danio rerio (zebrafish)dnmt1NP_571264.1
Arabidopsis thaliana (thale cress)DMT2NP_193150.1
Arabidopsis thaliana (thale cress)AT4G08990NP_192638.1
Arabidopsis thaliana (thale cress)MEE57NP_193097.1
Arabidopsis thaliana (thale cress)MET1NP_199727.1
Xenopus (Silurana) tropicalis (western clawed frog)dnmt1XP_002934384.1
GO:0000122negative regulation of transcription from RNA polymerase II promoterIEA
GO:0006306DNA methylationTAS
GO:0006351transcription, DNA-templatedIEA
GO:0010216maintenance of DNA methylationIDA
GO:0010628positive regulation of gene expressionIMP
GO:0016458gene silencingIEA
GO:0016568chromatin modificationIEA
GO:0042127regulation of cell proliferationIEA
GO:0051571positive regulation of histone H3-K4 methylationIMP
GO:0051573negative regulation of histone H3-K9 methylationIMP
GO:0071230cellular response to amino acid stimulusIEA
GO:0090116C-5 methylation of cytosineIEA
GO:0005657replication forkIEA
GO:0005721centromeric heterochromatinIEA
GO:0003677DNA bindingIDA
GO:0003682chromatin bindingIEA
GO:0003723RNA bindingIEA
GO:0003886DNA (cytosine-5-)-methyltransferase activityIDA
GO:0005515protein bindingIPI
GO:0008134transcription factor bindingIEA
GO:0008270zinc ion bindingIEA
GO:0008327methyl-CpG bindingIEA
GO:0009008DNA-methyltransferase activityIDA
GeneCards DNMT1
UniProt P26358, I6L9H2
Vega OTTHUMG00000180397
MIM 126375
Ensembl ENSG00000130816
HGNC 2976
HPRD 00532

GeneRIFs: Gene References Into Functions What's a GeneRIF?

What is the normal function of the DNMT1 gene?

The DNMT1 gene provides instructions for making an enzyme called DNA (cytosine-5)-methyltransferase 1. This enzyme is involved in DNA methylation, which is the addition of methyl groups, consisting of one carbon atom and three hydrogen atoms (methylation), to DNA molecules. In particular, the enzyme helps add methyl groups to DNA building blocks (nucleotides) called cytosines.

DNA methylation is important in many cellular functions. These include determining whether the instructions in a particular segment of DNA are carried out or suppressed (gene silencing), regulating reactions involving proteins and fats (lipids), and controlling the processing of chemicals that relay signals in the nervous system (neurotransmitters). DNA (cytosine-5)-methyltransferase 1 is active in the adult nervous system. Although its specific function is not well understood, the enzyme may help regulate nerve cell (neuron) maturation and specialization (differentiation), the ability of neurons to migrate where needed and connect with each other, and neuron survival.


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