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Sequence in raw or FASTA format:

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DNMT1 DNA (cytosine-5-)-methyltransferase 1 [Homo sapiens (human)]


Clone ID RefSeq Accession Definition Vector Stock Status *Turnaround time Price Order
OHu26697 NM_001379 Homo sapiens DNA (cytosine-5-)-methyltransferase 1 (DNMT1), transcript variant 2, mRNA. pcDNA3.1+-DYK On-demand 30 $2699.00
OHu27021 NM_001130823 Homo sapiens DNA (cytosine-5-)-methyltransferase 1 (DNMT1), transcript variant 1, mRNA. pcDNA3.1+-DYK On-demand 30 $2699.00
OHu51480 XM_006722681 PREDICTED: Homo sapiens DNA (cytosine-5-)-methyltransferase 1 (DNMT1), transcript variant X1, mRNA. pcDNA3.1+-DYK On-demand 25 $1699.00
OHu26697C NM_001379 Homo sapiens DNA (cytosine-5-)-methyltransferase 1 (DNMT1), transcript variant 2, mRNA. Customized vector On-demand 30 $2699.00
OHu27021C NM_001130823 Homo sapiens DNA (cytosine-5-)-methyltransferase 1 (DNMT1), transcript variant 1, mRNA. Customized vector On-demand 30 $2699.00
OHu51480C XM_006722681 PREDICTED: Homo sapiens DNA (cytosine-5-)-methyltransferase 1 (DNMT1), transcript variant X1, mRNA. Customized vector On-demand 25 $1699.00

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Gene Symbol DNMT1
Entrez Gene ID 1786
Full Name DNA (cytosine-5-)-methyltransferase 1
Synonyms ADCADN, AIM, CXXC9, DNMT, HSN1E, MCMT
General protein information
Preferred Names
DNA (cytosine-5)-methyltransferase 1
Names
DNA (cytosine-5)-methyltransferase 1
m.HsaI
DNA MTase HsaI
DNA methyltransferase HsaI
CXXC-type zinc finger protein 9
NP_001124295.1
NP_001370.1
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

19

19p13.2

Summary DNA (cytosine-5-)-methyltransferase 1 has a role in the establishment and regulation of tissue-specific patterns of methylated cytosine residues. Aberrant methylation patterns are associated with certain human tumors and developmental abnormalities. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008].
Disorder

MIM: 126375

mRNA Protein Product Sequence Price Select
NM_001130823, 195927036 NP_001124295, 195927037 DNA (cytosine-5)-methyltransferase 1 isoform a ORF Sequence $2500.00
NM_001379, 195546895 NP_001370, 4503351 DNA (cytosine-5)-methyltransferase 1 isoform b ORF Sequence $2500.00
XM_006722681, 578833064 XP_006722744, 578833065 DNA (cytosine-5)-methyltransferase 1 isoform X1 ORF Sequence $1500.00
KEGG
hsa00270Cysteine and methionine metabolism
hsa_M00035Methionine degradation
hsa05206MicroRNAs in cancer
WikiPathways
WP241One Carbon Metabolism
WP2333Trans-sulfuration pathway
WP2525Trans-sulfuration and one carbon metabolism
WP2446RB in Cancer
Pathway Interaction Database
rb_1pathwayRegulation of retinoblastoma protein
Reactome
REACT_71Gene Expression
REACT_200857Epigenetic regulation of gene expression
REACT_200808PRC2 methylates histones and DNA
REACT_200834Negative epigenetic regulation of rRNA expression
REACT_200856NoRC negatively regulates rRNA expression
Homo sapiens (human)DNMT1NP_001124295.1
Pan troglodytes (chimpanzee)DNMT1XP_512361.3
Macaca mulatta (Rhesus monkey)DNMT1XP_001104704.2
Canis lupus familiaris (dog)DNMT1XP_533919.4
Bos taurus (cattle)DNMT1NP_872592.2
Mus musculus (house mouse)Dnmt1NP_001186360.2
Rattus norvegicus (Norway rat)Dnmt1NP_445806.3
Gallus gallus (chicken)DNMT1NP_996835.1
Danio rerio (zebrafish)dnmt1NP_571264.1
Arabidopsis thaliana (thale cress)DMT2NP_193150.1
Arabidopsis thaliana (thale cress)AT4G08990NP_192638.1
Arabidopsis thaliana (thale cress)MEE57NP_193097.1
Arabidopsis thaliana (thale cress)MET1NP_199727.1
Xenopus (Silurana) tropicalis (western clawed frog)dnmt1XP_002934384.1
Process
IDNameEvidence
GO:0000122negative regulation of transcription from RNA polymerase II promoterIEA
GO:0006306DNA methylationTAS
GO:0006351transcription, DNA-templatedIEA
GO:0010216maintenance of DNA methylationIDA
GO:0010628positive regulation of gene expressionIMP
GO:0016458gene silencingIEA
GO:0016568chromatin modificationIEA
GO:0042127regulation of cell proliferationIEA
GO:0051571positive regulation of histone H3-K4 methylationIMP
GO:0051573negative regulation of histone H3-K9 methylationIMP
GO:0071230cellular response to amino acid stimulusIEA
GO:0090116C-5 methylation of cytosineIEA
Component
IDNameEvidence
GO:0005634nucleusIEA
GO:0005657replication forkIEA
GO:0005721centromeric heterochromatinIEA
Function
IDNameEvidence
GO:0003677DNA bindingIDA
GO:0003682chromatin bindingIEA
GO:0003723RNA bindingIEA
GO:0003886DNA (cytosine-5-)-methyltransferase activityIDA
GO:0005515protein bindingIPI
GO:0008134transcription factor bindingIEA
GO:0008270zinc ion bindingIEA
GO:0008327methyl-CpG bindingIEA
GO:0009008DNA-methyltransferase activityIDA
GeneCards DNMT1
UniProt P26358, I6L9H2
Vega OTTHUMG00000180397
MIM 126375
Ensembl ENSG00000130816
HGNC 2976
HPRD 00532

GeneRIFs: Gene References Into Functions What's a GeneRIF?

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