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DPYD dihydropyrimidine dehydrogenase [Homo sapiens (human)]


Clone ID RefSeq Accession Definition Vector Stock Status *Turnaround time Price Order
OHu19551 NM_000110 Homo sapiens dihydropyrimidine dehydrogenase (DPYD), transcript variant 1, mRNA. pcDNA3.1+-DYK On-demand 25 $1699.00
OHu21185 NM_001160301 Homo sapiens dihydropyrimidine dehydrogenase (DPYD), transcript variant 2, mRNA. pcDNA3.1+-DYK In-stock 5-7 $99.00
OHu33082 XM_005270562 PREDICTED: Homo sapiens dihydropyrimidine dehydrogenase (DPYD), transcript variant X2, mRNA. pcDNA3.1+-DYK On-demand 12-14 $279.00
OHu33083 XM_006710397 PREDICTED: Homo sapiens dihydropyrimidine dehydrogenase (DPYD), transcript variant X3, mRNA. pcDNA3.1+-DYK On-demand 12-14 $279.00
OHu19551C NM_000110 Homo sapiens dihydropyrimidine dehydrogenase (DPYD), transcript variant 1, mRNA. Customized vector On-demand 25 $1699.00
OHu21185C NM_001160301 Homo sapiens dihydropyrimidine dehydrogenase (DPYD), transcript variant 2, mRNA. Customized vector In-stock 5-7 $149.00
OHu33082C XM_005270562 PREDICTED: Homo sapiens dihydropyrimidine dehydrogenase (DPYD), transcript variant X2, mRNA. Customized vector On-demand 12-14 $329.00
OHu33083C XM_006710397 PREDICTED: Homo sapiens dihydropyrimidine dehydrogenase (DPYD), transcript variant X3, mRNA. Customized vector On-demand 12-14 $329.00

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Gene Symbol DPYD
Entrez Gene ID 1806
Full Name dihydropyrimidine dehydrogenase
Synonyms DHP, DHPDHASE, DPD
General protein information
Preferred Names
dihydropyrimidine dehydrogenase [NADP(+)]
Names
dihydropyrimidine dehydrogenase [NADP(+)]
dihydrouracil dehydrogenase
dihydrothymine dehydrogenase
NP_000101.2
NP_001153773.1
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

1

1p22

Summary The protein encoded by this gene is a pyrimidine catabolic enzyme and the initial and rate-limiting factor in the pathway of uracil and thymidine catabolism. Mutations in this gene result in dihydropyrimidine dehydrogenase deficiency, an error in pyrimidine metabolism associated with thymine-uraciluria and an increased risk of toxicity in cancer patients receiving 5-fluorouracil chemotherapy. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009].
Disorder

MIM: 612779

Dihydropyrimidine dehydrogenase deficiency, 274270 (3);

mRNA Protein Product Sequence Price Select
NM_000110, 119943097 NP_000101, 119943098 dihydropyrimidine dehydrogenase [NADP(+)] isoform 1 ORF Sequence $1500.00
NM_001160301, 237757299 NP_001153773, 237757300 dihydropyrimidine dehydrogenase [NADP(+)] isoform 2 ORF Sequence $159.00
XM_005270562, 578798493 XP_005270619, 578798494 dihydropyrimidine dehydrogenase [NADP(+)] isoform X2 ORF Sequence $750.00
XM_006710397, 578798495 XP_006710460, 578798496 dihydropyrimidine dehydrogenase [NADP(+)] isoform X3 ORF Sequence $750.00
KEGG
hsa00770Pantothenate and CoA biosynthesis
hsa00240Pyrimidine metabolism
hsa00410beta-Alanine metabolism
hsa00983Drug metabolism - other enzymes
hsa_M00046Pyrimidine degradation, uracil => beta-alanine, thymine => 3-aminoisobutanoate
WikiPathways
WP1601Fluoropyrimidine Activity
BIOCYC
HUMAN_PWY-3982uracil degradation II (reductive)
HUMAN_PWY-6430thymine degradation
Reactome
REACT_1023Pyrimidine catabolism
REACT_1698Metabolism of nucleotides
REACT_957Pyrimidine metabolism
REACT_111217Metabolism
Homo sapiens (human)DPYDNP_000101.2
Pan troglodytes (chimpanzee)DPYDXP_513583.3
Macaca mulatta (Rhesus monkey)DPYDXP_001106007.1
Canis lupus familiaris (dog)DPYDXP_005621932.1
Bos taurus (cattle)DPYDNP_776466.1
Mus musculus (house mouse)DpydNP_740748.1
Rattus norvegicus (Norway rat)DpydNP_112289.1
Gallus gallus (chicken)DPYDXP_426639.3
Danio rerio (zebrafish)dpydbNP_998058.1
Drosophila melanogaster (fruit fly)su(r)NP_572538.1
Caenorhabditis elegansdpyd-1NP_508927.2
Xenopus (Silurana) tropicalis (western clawed frog)dpydXP_002933845.2
Process
IDNameEvidence
GO:0006145purine nucleobase catabolic processIMP
GO:0006206pyrimidine nucleobase metabolic processTAS
GO:0006208pyrimidine nucleobase catabolic processIMP
GO:0006208pyrimidine nucleobase catabolic processISS
GO:0006210thymine catabolic processIDA
GO:0006212uracil catabolic processIDA
GO:0006214thymidine catabolic processIDA
GO:0006222UMP biosynthetic processIEA
GO:0019483beta-alanine biosynthetic processIEA
GO:0044281small molecule metabolic processTAS
GO:0046135pyrimidine nucleoside catabolic processTAS
GO:0055086nucleobase-containing small molecule metabolic processTAS
GO:0055114oxidation-reduction processIEA
Component
IDNameEvidence
GO:0005737cytoplasmIDA
GO:0005829cytosolIDA
GO:0005829cytosolTAS
Function
IDNameEvidence
GO:0004158dihydroorotate oxidase activityIEA
GO:0017113dihydropyrimidine dehydrogenase (NADP+) activityIDA
GO:0017113dihydropyrimidine dehydrogenase (NADP+) activityIMP
GO:0017113dihydropyrimidine dehydrogenase (NADP+) activityISS
GO:0017113dihydropyrimidine dehydrogenase (NADP+) activityTAS
GO:0042803protein homodimerization activityIDA
GO:0042803protein homodimerization activityISS
GO:0046872metal ion bindingIEA
GO:0050660flavin adenine dinucleotide bindingISS
GO:0050661NADP bindingISS
GO:00515394 iron, 4 sulfur cluster bindingIEA
GeneCards DPYD
UniProt Q12882
Vega OTTHUMG00000039683
MIM 612779
Ensembl ENSG00000188641
HGNC 3012
HPRD 02036

GeneRIFs: Gene References Into Functions What's a GeneRIF?

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