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DPYD dihydropyrimidine dehydrogenase [Homo sapiens (human)]


RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_000110 Homo sapiens dihydropyrimidine dehydrogenase (DPYD), transcript variant 1, mRNA. GenEZ ORF Cloning On-demand $1699.00 25
NM_001160301 Homo sapiens dihydropyrimidine dehydrogenase (DPYD), transcript variant 2, mRNA. GenEZ ORF Cloning In-stock $308.00 $259.00 10
XM_005270562 PREDICTED: Homo sapiens dihydropyrimidine dehydrogenase (DPYD), transcript variant X2, mRNA. GenEZ ORF Cloning On-demand $899.00 20
XM_006710397 PREDICTED: Homo sapiens dihydropyrimidine dehydrogenase (DPYD), transcript variant X3, mRNA. GenEZ ORF Cloning On-demand $899.00 20

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Gene Symbol DPYD
Entrez Gene ID 1806
Full Name dihydropyrimidine dehydrogenase
Synonyms DHP, DHPDHASE, DPD
General protein information
Preferred Names
dihydropyrimidine dehydrogenase [NADP(+)]
Names
dihydropyrimidine dehydrogenase [NADP(+)]
dihydrouracil dehydrogenase
dihydrothymine dehydrogenase
NP_000101.2
NP_001153773.1
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

1

1p22

Summary The protein encoded by this gene is a pyrimidine catabolic enzyme and the initial and rate-limiting factor in the pathway of uracil and thymidine catabolism. Mutations in this gene result in dihydropyrimidine dehydrogenase deficiency, an error in pyrimidine metabolism associated with thymine-uraciluria and an increased risk of toxicity in cancer patients receiving 5-fluorouracil chemotherapy. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009].
Disorder

MIM: 612779

Dihydropyrimidine dehydrogenase deficiency, 274270 (3);

mRNA Protein Product Sequence Price Select
NM_000110, 119943097 NP_000101, 119943098 dihydropyrimidine dehydrogenase [NADP(+)] isoform 1 ORF Sequence $1500.00
NM_001160301, 237757299 NP_001153773, 237757300 dihydropyrimidine dehydrogenase [NADP(+)] isoform 2 ORF Sequence $159.00
XM_005270562, 578798493 XP_005270619, 578798494 dihydropyrimidine dehydrogenase [NADP(+)] isoform X2 ORF Sequence $750.00
XM_006710397, 578798495 XP_006710460, 578798496 dihydropyrimidine dehydrogenase [NADP(+)] isoform X3 ORF Sequence $750.00
KEGG
hsa00770Pantothenate and CoA biosynthesis
hsa00240Pyrimidine metabolism
hsa00410beta-Alanine metabolism
hsa00983Drug metabolism - other enzymes
hsa_M00046Pyrimidine degradation, uracil => beta-alanine, thymine => 3-aminoisobutanoate
WikiPathways
WP1601Fluoropyrimidine Activity
BIOCYC
HUMAN_PWY-3982uracil degradation II (reductive)
HUMAN_PWY-6430thymine degradation
Reactome
REACT_1023Pyrimidine catabolism
REACT_1698Metabolism of nucleotides
REACT_957Pyrimidine metabolism
REACT_111217Metabolism
Homo sapiens (human)DPYDNP_000101.2
Pan troglodytes (chimpanzee)DPYDXP_513583.3
Macaca mulatta (Rhesus monkey)DPYDXP_001106007.1
Canis lupus familiaris (dog)DPYDXP_005621932.1
Bos taurus (cattle)DPYDNP_776466.1
Mus musculus (house mouse)DpydNP_740748.1
Rattus norvegicus (Norway rat)DpydNP_112289.1
Gallus gallus (chicken)DPYDXP_426639.3
Danio rerio (zebrafish)dpydbNP_998058.1
Drosophila melanogaster (fruit fly)su(r)NP_572538.1
Caenorhabditis elegansdpyd-1NP_508927.2
Xenopus (Silurana) tropicalis (western clawed frog)dpydXP_002933845.2
Process
IDNameEvidence
GO:0006145purine nucleobase catabolic processIMP
GO:0006206pyrimidine nucleobase metabolic processTAS
GO:0006208pyrimidine nucleobase catabolic processIMP
GO:0006208pyrimidine nucleobase catabolic processISS
GO:0006210thymine catabolic processIDA
GO:0006212uracil catabolic processIDA
GO:0006214thymidine catabolic processIDA
GO:0006222UMP biosynthetic processIEA
GO:0019483beta-alanine biosynthetic processIEA
GO:0044281small molecule metabolic processTAS
GO:0046135pyrimidine nucleoside catabolic processTAS
GO:0055086nucleobase-containing small molecule metabolic processTAS
GO:0055114oxidation-reduction processIEA
Component
IDNameEvidence
GO:0005737cytoplasmIDA
GO:0005829cytosolIDA
GO:0005829cytosolTAS
Function
IDNameEvidence
GO:0004158dihydroorotate oxidase activityIEA
GO:0017113dihydropyrimidine dehydrogenase (NADP+) activityIDA
GO:0017113dihydropyrimidine dehydrogenase (NADP+) activityIMP
GO:0017113dihydropyrimidine dehydrogenase (NADP+) activityISS
GO:0017113dihydropyrimidine dehydrogenase (NADP+) activityTAS
GO:0042803protein homodimerization activityIDA
GO:0042803protein homodimerization activityISS
GO:0046872metal ion bindingIEA
GO:0050660flavin adenine dinucleotide bindingISS
GO:0050661NADP bindingISS
GO:00515394 iron, 4 sulfur cluster bindingIEA
GeneCards DPYD
UniProt Q12882
Vega OTTHUMG00000039683
MIM 612779
Ensembl ENSG00000188641
HGNC 3012
HPRD 02036

GeneRIFs: Gene References Into Functions What's a GeneRIF?

What is the normal function of the DPYD gene?

The DPYD gene provides instructions for making an enzyme called dihydropyrimidine dehydrogenase, which is involved in the breakdown of molecules called uracil and thymine when they are not needed. Uracil and thymine are pyrimidines, which are one type of nucleotide. Nucleotides are building blocks of DNA, its chemical cousin RNA, and molecules such as ATP and GTP that serve as energy sources in the cell.

Dihydropyrimidine dehydrogenase is involved in the first step of the breakdown of pyrimidines. This enzyme converts uracil to another molecule called 5,6-dihydrouracil and converts thymine to 5,6-dihydrothymine. The molecules created when pyrimidines are broken down are excreted by the body or used in other cellular processes.

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