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DPYD dihydropyrimidine dehydrogenase [Homo sapiens (human)]


RefSeq Accession Definition Services Price Order
NM_000110 Homo sapiens dihydropyrimidine dehydrogenase (DPYD), transcript variant 1, mRNA. ORF Sequence $1077.30
Peptide Services
Antibody Services
Protein Services
NM_001160301 Homo sapiens dihydropyrimidine dehydrogenase (DPYD), transcript variant 2, mRNA. ORF Sequence $159.00
Peptide Services
Antibody Services
Protein Services


Gene Symbol DPYD
Entrez Gene ID 1806
Full Name dihydropyrimidine dehydrogenase
Synonyms DHP, DHPDHASE, DPD, MGC132008, MGC70799
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

1

1p22

Summary The protein encoded by this gene is a pyrimidine catabolic enzyme and the initial and rate-limiting factor in the pathway of uracil and thymidine catabolism. Mutations in this gene result in dihydropyrimidine dehydrogenase deficiency, an error in pyrimidine metabolism associated with thymine-uraciluria and an increased risk of toxicity in cancer patients receiving 5-fluorouracil chemotherapy. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009].
Disorder

MIM: 612779

Dihydropyrimidine dehydrogenase deficiency, 274270 (3);

mRNA Protein Product Sequence Price Select
NM_000110, 119943097 NP_000101, 119943098 dihydropyrimidine dehydrogenase [NADP(+)] isoform 1 Full Length $1557.85
ORF Sequence $1077.30
NM_001160301, 237757299 NP_001153773, 237757300 dihydropyrimidine dehydrogenase [NADP(+)] isoform 2 Full Length $518.81
ORF Sequence $159.00
KEGG
hsa00983Drug metabolism - other enzymes
hsa00410beta-Alanine metabolism
hsa_M00046Pyrimidine degradation, uracil => beta-alanine, thymine => 3-aminoisobutanoate
hsa00770Pantothenate and CoA biosynthesis
hsa00240Pyrimidine metabolism
WikiPathways
WP1601Fluoropyrimidine Activity
BIOCYC
HUMAN_PWY-3982uracil degradation II (reductive)
HUMAN_PWY-6430thymine degradation
Reactome
REACT_1698Metabolism of nucleotides
REACT_957Pyrimidine metabolism
REACT_1023Pyrimidine catabolism
REACT_111217Metabolism
Homo sapiens (human)DPYDNP_000101.2
Pan troglodytes (chimpanzee)DPYDXP_513583.3
Macaca mulatta (Rhesus monkey)DPYDXP_001106007.1
Canis lupus familiaris (dog)DPYDXP_537061.3
Bos taurus (cattle)DPYDNP_776466.1
Mus musculus (house mouse)DpydNP_740748.1
Rattus norvegicus (Norway rat)DpydNP_112289.1
Gallus gallus (chicken)DPYDXP_426639.3
Danio rerio (zebrafish)dpydbNP_998058.1
Drosophila melanogaster (fruit fly)su(r)NP_572538.1
Caenorhabditis elegansdpyd-1NP_508927.2
Arabidopsis thaliana (thale cress)PYD1NP_188408.1
GeneCards DPYD
UniProt Q12882
MIM 612779
Ensembl ENSG00000188641
HGNC 3012
HPRD 02036

GeneRIFs: Gene References Into Functions What's a GeneRIF?

General protein information

Preferred Names
dihydropyrimidine dehydrogenase [NADP(+)]
Names
dihydropyrimidine dehydrogenase [NADP(+)]
dihydrouracil dehydrogenase
dihydrothymine dehydrogenase
NP_000101.2
NP_001153773.1

Interactant

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