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SLC26A3 solute carrier family 26 (anion exchanger), member 3 [Homo sapiens (human)]


Clone ID RefSeq Accession Definition Vector Stock Status *Turnaround time Price Order
OHu26676 NM_000111 Homo sapiens solute carrier family 26 (anion exchanger), member 3 (SLC26A3), mRNA. pcDNA3.1+-DYK On-demand 12-14 $279.00
OHu26676 XM_006715873 PREDICTED: Homo sapiens solute carrier family 26 (anion exchanger), member 3 (SLC26A3), transcript variant X1, mRNA. pcDNA3.1+-DYK On-demand 12-14 $279.00
OHu26676C NM_000111 Homo sapiens solute carrier family 26 (anion exchanger), member 3 (SLC26A3), mRNA. Customized vector On-demand 12-14 $329.00
OHu26676C XM_006715873 PREDICTED: Homo sapiens solute carrier family 26 (anion exchanger), member 3 (SLC26A3), transcript variant X1, mRNA. Customized vector On-demand 12-14 $329.00

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Gene Symbol SLC26A3
Entrez Gene ID 1811
Full Name solute carrier family 26 (anion exchanger), member 3
Synonyms CLD, DRA
General protein information
Preferred Names
chloride anion exchanger
Names
chloride anion exchanger
down-regulated in adenoma protein
solute carrier family 26, member 3
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

7

7q31

Summary The protein encoded by this gene is a transmembrane glycoprotein that transports chloride ions across the cell membrane in exchange for bicarbonate ions. It is localized to the mucosa of the lower intestinal tract, particularly to the apical membrane of columnar epithelium and some goblet cells. The protein is essential for intestinal chloride absorption, and mutations in this gene have been associated with congenital chloride diarrhea. [provided by RefSeq, Oct 2008].
Disorder

MIM: 126650

?Colon cancer (1); Chloride diarrhea, congenital, Finnish type,

mRNA Protein Product Sequence Price Select
NM_000111, 171543859 NP_000102, 4557535 chloride anion exchanger ORF Sequence $700.00
XM_006715873, 578813972 XP_006715936, 578813973 chloride anion exchanger isoform X1 ORF Sequence $700.00
KEGG
hsa04972Pancreatic secretion
hsa04978Mineral absorption
Reactome
REACT_19118SLC-mediated transmembrane transport
REACT_19357Multifunctional anion exchangers
REACT_19397Transport of inorganic cations/anions and amino acids/oligopeptides
REACT_15518Transmembrane transport of small molecules
Homo sapiens (human)SLC26A3NP_000102.1
Pan troglodytes (chimpanzee)SLC26A3XP_527858.2
Macaca mulatta (Rhesus monkey)SLC26A3XP_001090155.2
Canis lupus familiaris (dog)SLC26A3XP_540380.3
Bos taurus (cattle)SLC26A3NP_001077145.1
Mus musculus (house mouse)Slc26a3NP_067328.1
Rattus norvegicus (Norway rat)Slc26a3NP_446207.1
Gallus gallus (chicken)SLC26A3NP_001186373.1
Danio rerio (zebrafish)si:dkey-31f5.1NP_001035265.1
Danio rerio (zebrafish)slc26a3NP_001129155.1
Caenorhabditis eleganssulp-6NP_491138.2
Xenopus (Silurana) tropicalis (western clawed frog)LOC101731072XP_004913063.1
Process
IDNameEvidence
GO:0006355regulation of transcription, DNA-templatedTAS
GO:0006811ion transportTAS
GO:0006820anion transportTAS
GO:0007588excretionTAS
GO:0015701bicarbonate transportIEA
GO:0048240sperm capacitationISS
GO:0051454intracellular pH elevationISS
GO:0055085transmembrane transportTAS
GO:0060081membrane hyperpolarizationISS
GO:0071320cellular response to cAMPISS
GO:1902358sulfate transmembrane transportIEA
GO:1902476chloride transmembrane transportIEA
GO:1902476chloride transmembrane transportISS
GO:2001141regulation of RNA biosynthetic processTAS
Component
IDNameEvidence
GO:0005886plasma membraneTAS
GO:0016020membraneISS
GO:0016021integral component of membraneIEA
GO:0016324apical plasma membraneIEA
GO:0031526brush border membraneIEA
GO:0097225sperm midpieceISS
Function
IDNameEvidence
GO:0003700sequence-specific DNA binding transcription factor activityTAS
GO:0003712transcription cofactor activityTAS
GO:0005215transporter activityTAS
GO:0005515protein bindingIPI
GO:0008271secondary active sulfate transmembrane transporter activityIEA
GO:0015106bicarbonate transmembrane transporter activityISS
GO:0015108chloride transmembrane transporter activityISS
GO:0015301anion:anion antiporter activityIEA
GeneCards SLC26A3
UniProt P40879
Vega OTTHUMG00000154812
MIM 126650
Ensembl ENSG00000091138
HGNC 3018
HPRD 00544

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Interactant

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