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DRD1 dopamine receptor D1 [Homo sapiens (human)]


RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_000794 Homo sapiens dopamine receptor D1 (DRD1), mRNA. GenEZ ORF Cloning In-stock $509.00 $460.00 12

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Related Services

Gene Symbol DRD1
Entrez Gene ID 1812
Full Name dopamine receptor D1
Synonyms DADR, DRD1A
General protein information
Preferred Names
D(1A) dopamine receptor
Names
D(1A) dopamine receptor
dopamine D1 receptor
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

5

5q35.1

Summary This gene encodes the D1 subtype of the dopamine receptor. The D1 subtype is the most abundant dopamine receptor in the central nervous system. This G-protein coupled receptor stimulates adenylyl cyclase and activates cyclic AMP-dependent protein kinases. D1 receptors regulate neuronal growth and development, mediate some behavioral responses, and modulate dopamine receptor D2-mediated events. Alternate transcription initiation sites result in two transcript variants of this gene. [provided by RefSeq, Jul 2008].
Disorder

MIM: 126449

mRNA Protein Product Sequence Price Select
NM_000794, 88758587 NP_000785, 4503383 D(1A) dopamine receptor ORF Sequence $360.00
KEGG
hsa04020Calcium signaling pathway
hsa04080Neuroactive ligand-receptor interaction
hsa05012Parkinson's disease
hsa04540Gap junction
hsa04728Dopaminergic synapse
hsa05030Cocaine addiction
hsa05031Amphetamine addiction
hsa05034Alcoholism
hsa05032Morphine addiction
WikiPathways
WP666Hypothetical Network for Drug Addiction
WP58Monoamine GPCRs
WP455GPCRs, Class A Rhodopsin-like
Reactome
REACT_19184GPCR downstream signaling
REACT_19327G alpha (s) signalling events
REACT_14828Class A/1 (Rhodopsin-like receptors)
REACT_14797Signaling by GPCR
REACT_16968Dopamine receptors
REACT_16983Amine ligand-binding receptors
REACT_21340GPCR ligand binding
REACT_111102Signal Transduction
Homo sapiens (human)DRD1NP_000785.1
Pan troglodytes (chimpanzee)DRD1XP_001149473.2
Canis lupus familiaris (dog)DRD1XP_005619252.1
Bos taurus (cattle)DRD1NP_776467.1
Mus musculus (house mouse)Drd1aNP_034206.1
Rattus norvegicus (Norway rat)Drd1NP_036678.2
Gallus gallus (chicken)DRD1NP_001138320.1
Danio rerio (zebrafish)drd1bNP_001129448.1
Xenopus (Silurana) tropicalis (western clawed frog)drd1XP_004912926.1
Process
IDNameEvidence
GO:0001659temperature homeostasisIEA
GO:0001661conditioned taste aversionIEA
GO:0001662behavioral fear responseIEA
GO:0001963synaptic transmission, dopaminergicIEA
GO:0001975response to amphetamineIEA
GO:0006606protein import into nucleusIEA
GO:0007187G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messengerIDA
GO:0007189adenylate cyclase-activating G-protein coupled receptor signaling pathwayIDA
GO:0007190activation of adenylate cyclase activityIDA
GO:0007191adenylate cyclase-activating dopamine receptor signaling pathwayIDA
GO:0007416synapse assemblyISS
GO:0007613memoryIEA
GO:0007617mating behaviorISS
GO:0007625grooming behaviorIEA
GO:0007628adult walking behaviorISS
GO:0008542visual learningISS
GO:0010579positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathwayIEA
GO:0014002astrocyte developmentIEA
GO:0015872dopamine transportIEA
GO:0019226transmission of nerve impulseISS
GO:0019228neuronal action potentialIEA
GO:0021542dentate gyrus developmentIEA
GO:0021756striatum developmentIEA
GO:0021853cerebral cortex GABAergic interneuron migrationISS
GO:0030335positive regulation of cell migrationISS
GO:0030432peristalsisIEA
GO:0030819positive regulation of cAMP biosynthetic processIDA
GO:0035106operant conditioningIEA
GO:0042053regulation of dopamine metabolic processIEA
GO:0042311vasodilationIEA
GO:0042417dopamine metabolic processIC
GO:0042493response to drugISS
GO:0042711maternal behaviorIEA
GO:0043268positive regulation of potassium ion transportISS
GO:0046323glucose importIEA
GO:0046959habituationIEA
GO:0046960sensitizationIEA
GO:0048148behavioral response to cocaineIEA
GO:0051281positive regulation of release of sequestered calcium ion into cytosolIDA
GO:0051482positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathwayIDA
GO:0051584regulation of dopamine uptake involved in synaptic transmissionIC
GO:0051968positive regulation of synaptic transmission, glutamatergicISS
GO:0060134prepulse inhibitionISS
GO:0060158phospholipase C-activating dopamine receptor signaling pathwayIDA
GO:0060158phospholipase C-activating dopamine receptor signaling pathwayIGI
GO:0060291long-term synaptic potentiationIEA
GO:0060292long term synaptic depressionIEA
GO:0071870cellular response to catecholamine stimulusIDA
Component
IDNameEvidence
GO:0005634nucleusIEA
GO:0005789endoplasmic reticulum membraneIEA
GO:0005886plasma membraneIDA
GO:0005886plasma membraneTAS
GO:0005887integral component of plasma membraneIC
Function
IDNameEvidence
GO:0001588dopamine neurotransmitter receptor activity, coupled via GsIDA
GO:0001588dopamine neurotransmitter receptor activity, coupled via GsIMP
GO:0004952dopamine neurotransmitter receptor activityIDA
GO:0005515protein bindingIPI
GO:0035240dopamine bindingIMP
GeneCards DRD1
PDB 1OZ5
UniProt P21728
Vega OTTHUMG00000130557
MIM 126449
Ensembl ENSG00000184845
HGNC 3020
HPRD 00538

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Interactant

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