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DRD2 dopamine receptor D2 [Homo sapiens (human)]


RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_000795 Homo sapiens dopamine receptor D2 (DRD2), transcript variant 1, mRNA. GenEZ ORF Cloning In-stock $509.00 $460.00 12
NM_016574 Homo sapiens dopamine receptor D2 (DRD2), transcript variant 2, mRNA. GenEZ ORF Cloning In-stock $418.00 $369.00 10
XM_005271425 PREDICTED: Homo sapiens dopamine receptor D2 (DRD2), transcript variant X1, mRNA. GenEZ ORF Cloning On-demand $699.00 18
XM_006718774 PREDICTED: Homo sapiens dopamine receptor D2 (DRD2), transcript variant X2, mRNA. GenEZ ORF Cloning On-demand $549.00 14

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Gene Symbol DRD2
Entrez Gene ID 1813
Full Name dopamine receptor D2
Synonyms D2DR, D2R
General protein information
Preferred Names
D(2) dopamine receptor
Names
D(2) dopamine receptor
dopamine D2 receptor
dopamine receptor D2 isoform
seven transmembrane helix receptor
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

11

11q23

Summary This gene encodes the D2 subtype of the dopamine receptor. This G-protein coupled receptor inhibits adenylyl cyclase activity. A missense mutation in this gene causes myoclonus dystonia; other mutations have been associated with schizophrenia. Alternative splicing of this gene results in two transcript variants encoding different isoforms. A third variant has been described, but it has not been determined whether this form is normal or due to aberrant splicing. [provided by RefSeq, Jul 2008].
Disorder

MIM: 126450

Dystonia, myoclonic, 159900 (3)

mRNA Protein Product Sequence Price Select
NM_000795, 181336946 NP_000786, 4503385 D(2) dopamine receptor isoform long ORF Sequence $360.00
NM_016574, 181337009 NP_057658, 17986270 D(2) dopamine receptor isoform short ORF Sequence $269.00
XM_005271425, 578822010 XP_005271482, 530397832 D(2) dopamine receptor isoform X1 ORF Sequence $550.00
XM_006718774, 578822011 XP_006718837, 578822012 D(2) dopamine receptor isoform X2 ORF Sequence $400.00
KEGG
hsa04080Neuroactive ligand-receptor interaction
hsa05012Parkinson's disease
hsa04540Gap junction
hsa04728Dopaminergic synapse
hsa05030Cocaine addiction
hsa05034Alcoholism
hsa04015Rap1 signaling pathway
WikiPathways
WP666Hypothetical Network for Drug Addiction
WP1602Nicotine Activity on Dopaminergic Neurons
WP58Monoamine GPCRs
WP455GPCRs, Class A Rhodopsin-like
Reactome
REACT_19184GPCR downstream signaling
REACT_19231G alpha (i) signalling events
REACT_14828Class A/1 (Rhodopsin-like receptors)
REACT_14797Signaling by GPCR
REACT_16968Dopamine receptors
REACT_16983Amine ligand-binding receptors
REACT_21340GPCR ligand binding
REACT_111102Signal Transduction
Homo sapiens (human)DRD2NP_000786.1
Pan troglodytes (chimpanzee)DRD2NP_001029100.1
Macaca mulatta (Rhesus monkey)DRD2XP_001085571.1
Canis lupus familiaris (dog)DRD2NP_001003110.1
Bos taurus (cattle)DRD2NP_776468.1
Mus musculus (house mouse)Drd2NP_034207.2
Rattus norvegicus (Norway rat)Drd2NP_036679.1
Gallus gallus (chicken)DRD2NP_001106761.1
Danio rerio (zebrafish)drd2bNP_922918.1
Danio rerio (zebrafish)drd2aNP_898891.1
Caenorhabditis elegansdop-3NP_001024908.2
Xenopus (Silurana) tropicalis (western clawed frog)LOC100493063XP_002937871.2
Process
IDNameEvidence
GO:0001659temperature homeostasisISS
GO:0001666response to hypoxiaIEA
GO:0001963synaptic transmission, dopaminergicIEA
GO:0001975response to amphetamineISS
GO:0001976neurological system process involved in regulation of systemic arterial blood pressureISS
GO:0002027regulation of heart rateISS
GO:0002028regulation of sodium ion transportISS
GO:0002031G-protein coupled receptor internalizationIEA
GO:0002052positive regulation of neuroblast proliferationISS
GO:0002092positive regulation of receptor internalizationIEA
GO:0006874cellular calcium ion homeostasisIC
GO:0007194negative regulation of adenylate cyclase activityIDA
GO:0007194negative regulation of adenylate cyclase activityIEA
GO:0007195adenylate cyclase-inhibiting dopamine receptor signaling pathwayIDA
GO:0007195adenylate cyclase-inhibiting dopamine receptor signaling pathwayIEA
GO:0007270neuron-neuron synaptic transmissionISS
GO:0007409axonogenesisISS
GO:0007416synapse assemblyISS
GO:0007608sensory perception of smellISS
GO:0007616long-term memoryIEA
GO:0007625grooming behaviorIEA
GO:0007626locomotory behaviorISS
GO:0007628adult walking behaviorISS
GO:0007631feeding behaviorIEA
GO:0008104protein localizationISS
GO:0008285negative regulation of cell proliferationISS
GO:0008306associative learningISS
GO:0008542visual learningISS
GO:0009416response to light stimulusISS
GO:0009636response to toxic substanceIEA
GO:0010039response to iron ionIEA
GO:0014854response to inactivityIEA
GO:0016055Wnt signaling pathwayIEA
GO:0021756striatum developmentIEA
GO:0021769orbitofrontal cortex developmentIEA
GO:0021853cerebral cortex GABAergic interneuron migrationISS
GO:0021984adenohypophysis developmentISS
GO:0030336negative regulation of cell migrationISS
GO:0030432peristalsisISS
GO:0030814regulation of cAMP metabolic processIDA
GO:0031223auditory behaviorIEA
GO:0032147activation of protein kinase activityIEA
GO:0032228regulation of synaptic transmission, GABAergicISS
GO:0032467positive regulation of cytokinesisIMP
GO:0032922circadian regulation of gene expressionISS
GO:0033602negative regulation of dopamine secretionIEA
GO:0034776response to histamineIDA
GO:0035094response to nicotineIEA
GO:0035556intracellular signal transductionIDA
GO:0035810positive regulation of urine volumeIEA
GO:0035815positive regulation of renal sodium excretionIEA
GO:0040018positive regulation of multicellular organism growthIEA
GO:0042220response to cocaineISS
GO:0042321negative regulation of circadian sleep/wake cycle, sleepIEA
GO:0042417dopamine metabolic processIC
GO:0042493response to drugISS
GO:0043266regulation of potassium ion transportISS
GO:0043278response to morphineISS
GO:0043473pigmentationIEA
GO:0043666regulation of phosphoprotein phosphatase activityIEA
GO:0045745positive regulation of G-protein coupled receptor protein signaling pathwayIEA
GO:0045776negative regulation of blood pressureISS
GO:0045944positive regulation of transcription from RNA polymerase II promoterIEA
GO:0046488phosphatidylinositol metabolic processISS
GO:0046676negative regulation of insulin secretionIEA
GO:0048148behavioral response to cocaineISS
GO:0048149behavioral response to ethanolISS
GO:0048169regulation of long-term neuronal synaptic plasticityISS
GO:0048678response to axon injuryIEA
GO:0048755branching morphogenesis of a nerveISS
GO:0050482arachidonic acid secretionIDA
GO:0050709negative regulation of protein secretionIDA
GO:0051209release of sequestered calcium ion into cytosolISS
GO:0051481negative regulation of cytosolic calcium ion concentrationIEA
GO:0051482positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathwayIDA
GO:0051584regulation of dopamine uptake involved in synaptic transmissionIC
GO:0051586positive regulation of dopamine uptake involved in synaptic transmissionISS
GO:0051823regulation of synapse structural plasticityIEA
GO:0051898negative regulation of protein kinase B signalingISS
GO:0051967negative regulation of synaptic transmission, glutamatergicISS
GO:0060124positive regulation of growth hormone secretionISS
GO:0060134prepulse inhibitionISS
GO:0060158phospholipase C-activating dopamine receptor signaling pathwayIGI
GO:0060160negative regulation of dopamine receptor signaling pathwayISS
GO:0070374positive regulation of ERK1 and ERK2 cascadeIEA
GO:0090325regulation of locomotion involved in locomotory behaviorIEA
GO:1900273positive regulation of long-term synaptic potentiationIEA
GO:1901386negative regulation of voltage-gated calcium channel activityIDA
GO:1901386negative regulation of voltage-gated calcium channel activityIEA
Component
IDNameEvidence
GO:0001669acrosomal vesicleIEA
GO:0005886plasma membraneTAS
GO:0005887integral component of plasma membraneIC
GO:0005887integral component of plasma membraneIDA
GO:0014069postsynaptic densityIEA
GO:0016328lateral plasma membraneIEA
GO:0030139endocytic vesicleIEA
GO:0030424axonISS
GO:0030425dendriteISS
GO:0030672synaptic vesicle membraneIEA
GO:0036126sperm flagellumIEA
GO:0043197dendritic spineIEA
GO:0043204perikaryonIEA
GO:0043679axon terminusIEA
Function
IDNameEvidence
GO:0001591dopamine neurotransmitter receptor activity, coupled via Gi/GoIDA
GO:0005515protein bindingIPI
GO:0008144drug bindingIDA
GO:0015459potassium channel regulator activityNAS
GO:0035240dopamine bindingIEA
GO:0035255ionotropic glutamate receptor bindingIEA
GO:0042802identical protein bindingIPI
GO:0042803protein homodimerization activityIEA
GO:0046982protein heterodimerization activityIEA
GeneCards DRD2
UniProt P14416
Vega OTTHUMG00000167717
MIM 126450
Ensembl ENSG00000149295
HGNC 3023
HPRD 00539

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