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DRD2 dopamine receptor D2 [Homo sapiens (human)]


RefSeq Accession Definition Services Price Order
NM_000795 Homo sapiens dopamine receptor D2 (DRD2), transcript variant 1, mRNA. ORF Sequence $386.28
Peptide Services
Antibody Services
Protein Services
NM_016574 Homo sapiens dopamine receptor D2 (DRD2), transcript variant 2, mRNA. ORF Sequence $361.05
Peptide Services
Antibody Services
Protein Services


Gene Symbol DRD2
Entrez Gene ID 1813
Full Name dopamine receptor D2
Synonyms D2DR, D2R
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

11

11q23

Summary This gene encodes the D2 subtype of the dopamine receptor. This G-protein coupled receptor inhibits adenylyl cyclase activity. A missense mutation in this gene causes myoclonus dystonia; other mutations have been associated with schizophrenia. Alternative splicing of this gene results in two transcript variants encoding different isoforms. A third variant has been described, but it has not been determined whether this form is normal or due to aberrant splicing. [provided by RefSeq, Jul 2008].
Disorder

MIM: 126450

Dystonia, myoclonic, 159900 (3)

mRNA Protein Product Sequence Price Select
NM_000795, 181336946 NP_000786, 4503385 D(2) dopamine receptor isoform long Full Length $786.77
ORF Sequence $386.28
NM_016574, 181337009 NP_057658, 17986270 D(2) dopamine receptor isoform short Full Length $761.54
ORF Sequence $361.05
KEGG
hsa04080Neuroactive ligand-receptor interaction
hsa05030Cocaine addiction
hsa04540Gap junction
hsa04728Dopaminergic synapse
hsa05034Alcoholism
WikiPathways
WP58Monoamine GPCRs
WP455GPCRs, Class A Rhodopsin-like
WP666Hypothetical Network for Drug Addiction
WP1602Nicotine Activity on Dopaminergic Neurons
Reactome
REACT_14828Class A/1 (Rhodopsin-like receptors)
REACT_16968Dopamine receptors
REACT_19184GPCR downstream signaling
REACT_21340GPCR ligand binding
REACT_111102Signal Transduction
REACT_19231G alpha (i) signalling events
REACT_14797Signaling by GPCR
REACT_16983Amine ligand-binding receptors
Homo sapiens (human)DRD2NP_000786.1
Pan troglodytes (chimpanzee)DRD2NP_001029100.1
Macaca mulatta (Rhesus monkey)DRD2XP_001085571.1
Canis lupus familiaris (dog)DRD2NP_001003110.1
Bos taurus (cattle)DRD2NP_776468.1
Mus musculus (house mouse)Drd2NP_034207.2
Rattus norvegicus (Norway rat)Drd2NP_036679.1
Gallus gallus (chicken)DRD2NP_001106761.1
Danio rerio (zebrafish)drd2bNP_922918.1
Danio rerio (zebrafish)drd2aNP_898891.1
Caenorhabditis elegansdop-3NP_001024908.2
GeneCards DRD2
PDB 1I15
UniProt P14416
MIM 126450
Ensembl ENSG00000149295
HGNC 3023
HPRD 00539

GeneRIFs: Gene References Into Functions What's a GeneRIF?

General protein information

Preferred Names
D(2) dopamine receptor
Names
D(2) dopamine receptor
dopamine D2 receptor
dopamine receptor D2 isoform
seven transmembrane helix receptor

Interactant

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