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DRD4 dopamine receptor D4 [Homo sapiens (human)]


RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_000797 Homo sapiens dopamine receptor D4 (DRD4), mRNA. GenEZ ORF Cloning On-demand TBD TBD

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Gene Symbol DRD4
Entrez Gene ID 1815
Full Name dopamine receptor D4
Synonyms D4DR
General protein information
Preferred Names
D(4) dopamine receptor
Names
D(4) dopamine receptor
dopamine D4 receptor
D(2C) dopamine receptor
seven transmembrane helix receptor
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

11

11p15.5

Summary This gene encodes the D4 subtype of the dopamine receptor. The D4 subtype is a G-protein coupled receptor which inhibits adenylyl cyclase. It is a target for drugs which treat schizophrenia and Parkinson disease. Mutations in this gene have been associated with various behavioral phenotypes, including autonomic nervous system dysfunction, attention deficit/hyperactivity disorder, and the personality trait of novelty seeking. This gene contains a polymorphic number (2-10 copies) of tandem 48 nt repeats; the sequence shown contains four repeats. [provided by RefSeq, Jul 2008].
Disorder

MIM: 126452

Autonomic nervous system dysfunction (3); [Novelty seeking

mRNA Protein Product Sequence Price Select
NM_000797, 296010830 NP_000788, 32483397 D(4) dopamine receptor ORF Sequence $550.00
KEGG
hsa04080Neuroactive ligand-receptor interaction
hsa04728Dopaminergic synapse
WikiPathways
WP117GPCRs, Other
WP666Hypothetical Network for Drug Addiction
WP1602Nicotine Activity on Dopaminergic Neurons
WP58Monoamine GPCRs
WP455GPCRs, Class A Rhodopsin-like
Reactome
REACT_19184GPCR downstream signaling
REACT_19231G alpha (i) signalling events
REACT_14828Class A/1 (Rhodopsin-like receptors)
REACT_14797Signaling by GPCR
REACT_16968Dopamine receptors
REACT_16983Amine ligand-binding receptors
REACT_21340GPCR ligand binding
REACT_111102Signal Transduction
Homo sapiens (human)DRD4NP_000788.2
Macaca mulatta (Rhesus monkey)DRD4XP_001087197.1
Mus musculus (house mouse)Drd4NP_031904.1
Rattus norvegicus (Norway rat)Drd4NP_037076.1
Gallus gallus (chicken)DRD4NP_001136321.1
Danio rerio (zebrafish)drd4bNP_001012636.1
Danio rerio (zebrafish)drd4aNP_001012634.1
Xenopus (Silurana) tropicalis (western clawed frog)drd4XP_002937535.2
Process
IDNameEvidence
GO:0000187activation of MAPK activityIDA
GO:0001662behavioral fear responseNAS
GO:0001963synaptic transmission, dopaminergicIEA
GO:0001975response to amphetamineISS
GO:0006874cellular calcium ion homeostasisIC
GO:0007194negative regulation of adenylate cyclase activityIDA
GO:0007195adenylate cyclase-inhibiting dopamine receptor signaling pathwayIDA
GO:0007212dopamine receptor signaling pathwayIDA
GO:0007614short-term memoryIEA
GO:0007623circadian rhythmIEA
GO:0008344adult locomotory behaviorISS
GO:0008355olfactory learningIEA
GO:0009648photoperiodismIEA
GO:0030818negative regulation of cAMP biosynthetic processIDA
GO:0032417positive regulation of sodium:proton antiporter activityIDA
GO:0033674positive regulation of kinase activityIDA
GO:0034776response to histamineIDA
GO:0035176social behaviorNAS
GO:0042053regulation of dopamine metabolic processISS
GO:0042417dopamine metabolic processIC
GO:0042596fear responseISS
GO:0042752regulation of circadian rhythmISS
GO:0046928regulation of neurotransmitter secretionIEA
GO:0048148behavioral response to cocaineISS
GO:0048149behavioral response to ethanolTAS
GO:0048545response to steroid hormoneIEA
GO:0050482arachidonic acid secretionIDA
GO:0050709negative regulation of protein secretionIDA
GO:0050848regulation of calcium-mediated signalingIEA
GO:0051586positive regulation of dopamine uptake involved in synaptic transmissionIC
GO:0060041retina development in camera-type eyeIEA
GO:0060080regulation of inhibitory postsynaptic membrane potentialISS
GO:0060406positive regulation of penile erectionIEA
GO:1901386negative regulation of voltage-gated calcium channel activityIDA
GO:2000463positive regulation of excitatory postsynaptic membrane potentialIEA
Component
IDNameEvidence
GO:0005886plasma membraneTAS
GO:0005887integral component of plasma membraneIDA
GO:0005938cell cortexIEA
GO:0012506vesicle membraneIEA
GO:0016020membraneIDA
GO:0043025neuronal cell bodyIEA
GO:0043195terminal boutonIEA
GO:0043197dendritic spineIEA
Function
IDNameEvidence
GO:0001591dopamine neurotransmitter receptor activity, coupled via Gi/GoIDA
GO:0001591dopamine neurotransmitter receptor activity, coupled via Gi/GoISS
GO:0004952dopamine neurotransmitter receptor activityIDA
GO:0005515protein bindingIPI
GO:0008144drug bindingIDA
GO:0015459potassium channel regulator activityNAS
GO:0017124SH3 domain bindingIDA
GO:0035240dopamine bindingIDA
GO:0042802identical protein bindingIPI
GeneCards DRD4
UniProt P21917
Vega OTTHUMG00000133312
MIM 126452
Ensembl ENSG00000069696
HGNC 3025
HPRD 00541

GeneRIFs: Gene References Into Functions What's a GeneRIF?

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