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DRD4 dopamine receptor D4 [Homo sapiens (human)]

RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_000797 Homo sapiens dopamine receptor D4 (DRD4), mRNA. GenEZ ORF Cloning On-demand TBD TBD

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Gene Symbol DRD4
Entrez Gene ID 1815
Full Name dopamine receptor D4
Synonyms D4DR
Gene Type protein-coding
Organism Homo sapiens (human)



Summary This gene encodes the D4 subtype of the dopamine receptor. The D4 subtype is a G-protein coupled receptor which inhibits adenylyl cyclase. It is a target for drugs which treat schizophrenia and Parkinson disease. Mutations in this gene have been associated with various behavioral phenotypes, including autonomic nervous system dysfunction, attention deficit/hyperactivity disorder, and the personality trait of novelty seeking. This gene contains a polymorphic number (2-10 copies) of tandem 48 nt repeats; the sequence shown contains four repeats. [provided by RefSeq, Jul 2008].

MIM: 126452

Autonomic nervous system dysfunction (3); [Novelty seeking

mRNA Protein Product Sequence Price Select
NM_000797, 296010830 NP_000788, 32483397 D(4) dopamine receptor ORF Sequence $550.00
hsa04080Neuroactive ligand-receptor interaction
hsa04728Dopaminergic synapse
WP58Monoamine GPCRs
WP455GPCRs, Class A Rhodopsin-like
WP1602Nicotine Activity on Dopaminergic Neurons
WP117GPCRs, Other
WP666Hypothetical Network for Drug Addiction
REACT_16983Amine ligand-binding receptors
REACT_14797Signaling by GPCR
REACT_14828Class A/1 (Rhodopsin-like receptors)
REACT_16968Dopamine receptors
REACT_21340GPCR ligand binding
REACT_111102Signal Transduction
REACT_19231G alpha (i) signalling events
REACT_19184GPCR downstream signaling
Homo sapiens (human)DRD4NP_000788.2
Pan troglodytes (chimpanzee)DRD4XP_001149749.1
Macaca mulatta (Rhesus monkey)DRD4XP_001087197.1
Mus musculus (house mouse)Drd4NP_031904.1
Rattus norvegicus (Norway rat)Drd4NP_037076.1
Gallus gallus (chicken)DRD4NP_001136321.1
Danio rerio (zebrafish)drd4aNP_001012634.1
Danio rerio (zebrafish)drd4bNP_001012636.1
GeneCards DRD4
UniProt P21917
MIM 126452
Ensembl ENSG00000069696
HGNC 3025
HPRD 00541

GeneRIFs: Gene References Into Functions What's a GeneRIF?

General protein information

Preferred Names
D(4) dopamine receptor
D(4) dopamine receptor
dopamine D4 receptor
D(2C) dopamine receptor
seven transmembrane helix receptor


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