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DRD5 dopamine receptor D5 [Homo sapiens (human)]


RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_000798 Homo sapiens dopamine receptor D5 (DRD5), mRNA. GenEZ ORF Cloning In-stock $509.00 $460.00 12

*Business Day

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Gene Symbol DRD5
Entrez Gene ID 1816
Full Name dopamine receptor D5
Synonyms DBDR, DRD1B, DRD1L2
General protein information
Preferred Names
D(1B) dopamine receptor
Names
D(1B) dopamine receptor
dopamine D5 receptor
dopamine receptor D1B
d(5) dopamine receptor
D1beta dopamine receptor
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

4

4p16.1

Summary This gene encodes the D5 subtype of the dopamine receptor. The D5 subtype is a G-protein coupled receptor which stimulates adenylyl cyclase. This receptor is expressed in neurons in the limbic regions of the brain. It has a 10-fold higher affinity for dopamine than the D1 subtype. Pseudogenes related to this gene reside on chromosomes 1 and 2. [provided by RefSeq, Jul 2008].
Disorder

MIM: 126453

{Blepharospasm, primary benign}, 606798 (3); Dystonia, primary

mRNA Protein Product Sequence Price Select
NM_000798, 171919773 NP_000789, 4503391 D(1B) dopamine receptor ORF Sequence $360.00
KEGG
hsa04020Calcium signaling pathway
hsa04080Neuroactive ligand-receptor interaction
hsa04728Dopaminergic synapse
WikiPathways
WP58Monoamine GPCRs
WP455GPCRs, Class A Rhodopsin-like
Reactome
REACT_19184GPCR downstream signaling
REACT_19327G alpha (s) signalling events
REACT_14828Class A/1 (Rhodopsin-like receptors)
REACT_14797Signaling by GPCR
REACT_16968Dopamine receptors
REACT_16983Amine ligand-binding receptors
REACT_21340GPCR ligand binding
REACT_111102Signal Transduction
Homo sapiens (human)DRD5NP_000789.1
Pan troglodytes (chimpanzee)DRD5XP_528711.2
Macaca mulatta (Rhesus monkey)DRD5XP_001097117.1
Canis lupus familiaris (dog)DRD5XP_005618635.1
Bos taurus (cattle)DRD5NP_001193558.1
Mus musculus (house mouse)Drd5NP_038531.1
Rattus norvegicus (Norway rat)Drd5NP_036900.1
Gallus gallus (chicken)SPATA2LXP_004936358.1
Danio rerio (zebrafish)drd7NP_001107115.1
Xenopus (Silurana) tropicalis (western clawed frog)LOC100495174XP_004911296.1
Process
IDNameEvidence
GO:0001963synaptic transmission, dopaminergicNAS
GO:0001975response to amphetamineIEA
GO:0001992regulation of systemic arterial blood pressure by vasopressinIEA
GO:0001994norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressureIEA
GO:0006874cellular calcium ion homeostasisTAS
GO:0007189adenylate cyclase-activating G-protein coupled receptor signaling pathwayIDA
GO:0007190activation of adenylate cyclase activityTAS
GO:0007191adenylate cyclase-activating dopamine receptor signaling pathwayIDA
GO:0007268synaptic transmissionNAS
GO:0008306associative learningIEA
GO:0010579positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathwayIEA
GO:0019226transmission of nerve impulseIEA
GO:0033861negative regulation of NAD(P)H oxidase activityIDA
GO:0042060wound healingIEA
GO:0042220response to cocaineIEA
GO:0045762positive regulation of adenylate cyclase activityIDA
GO:0045762positive regulation of adenylate cyclase activityNAS
GO:0045776negative regulation of blood pressureIEA
GO:0045924regulation of female receptivityIEA
GO:0046960sensitizationIEA
GO:0060158phospholipase C-activating dopamine receptor signaling pathwayTAS
GO:0060292long term synaptic depressionIEA
GO:0071870cellular response to catecholamine stimulusIDA
GO:0072593reactive oxygen species metabolic processIDA
Component
IDNameEvidence
GO:0005886plasma membraneIDA
GO:0005886plasma membraneTAS
GO:0005887integral component of plasma membraneNAS
GO:0005887integral component of plasma membraneTAS
GO:0031526brush border membraneIEA
Function
IDNameEvidence
GO:0001588dopamine neurotransmitter receptor activity, coupled via GsTAS
GO:0004952dopamine neurotransmitter receptor activityIDA
GO:0035240dopamine bindingIDA
GeneCards DRD5
UniProt P21918
Vega OTTHUMG00000128489
MIM 126453
Ensembl ENSG00000169676
HGNC 3026
HPRD 00542

GeneRIFs: Gene References Into Functions What's a GeneRIF?

What is the normal function of the DRD5 gene?

The DRD5 gene provides instructions for making a protein called dopamine receptor D5, which is found in the brain. This protein works together with a chemical messenger (neurotransmitter) called dopamine. Dopamine fits into the D5 receptor like a key in a lock, which triggers chemical reactions within nerve cells. Dopamine signaling has many critical functions in the brain, including regulation of attention, mood, memory, learning, and movement.

Interactant

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