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AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8) [Homo sapiens (human)]


RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_000029 Homo sapiens angiotensinogen (serpin peptidase inhibitor, clade A, member 8) (AGT), mRNA. GenEZ ORF Cloning On-demand $699.00 18

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Gene Symbol AGT
Entrez Gene ID 183
Full Name angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
Synonyms ANHU, FLJ92595, FLJ97926, SERPINA8
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

1

1q42-q43

Summary The protein encoded by this gene, pre-angiotensinogen or angiotensinogen precursor, is expressed in the liver and is cleaved by the enzyme renin in response to lowered blood pressure. The resulting product, angiotensin I, is then cleaved by angiotensin converting enzyme (ACE) to generate the physiologically active enzyme angiotensin II. The protein is involved in maintaining blood pressure and in the pathogenesis of essential hypertension and preeclampsia. Mutations in this gene are associated with susceptibility to essential hypertension, and can cause renal tubular dysgenesis, a severe disorder of renal tubular development. Defects in this gene have also been associated with non-familial structural atrial fibrillation, and inflammatory bowel disease. [provided by RefSeq, Jul 2008].
Disorder

MIM: 106150

{Hypertension, essential, susceptibility to}, 145500 (3);

mRNA Protein Product Sequence Price Select
NM_000029, 188595658 NP_000020, 4557287 angiotensinogen preproprotein ORF Sequence $550.00
KEGG
hsa04614Renin-angiotensin system
Pathway Interaction Database
prlsignalingeventspathwaySignaling events mediated by PRL
WikiPathways
WP727Monoamine Transport
WP1544MicroRNAs in cardiomyocyte hypertrophy
WP554ACE Inhibitor Pathway
WP236Adipogenesis
Reactome
REACT_14819Peptide ligand-binding receptors
REACT_19241Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
REACT_17015Metabolism of proteins
REACT_14797Signaling by GPCR
REACT_14828Class A/1 (Rhodopsin-like receptors)
REACT_19231G alpha (i) signalling events
REACT_111102Signal Transduction
REACT_22279Fatty acid, triacylglycerol, and ketone body metabolism
REACT_18283G alpha (q) signalling events
REACT_21340GPCR ligand binding
REACT_22258Metabolism of lipids and lipoproteins
REACT_120966Gastrin-CREB signalling pathway via PKC and MAPK
REACT_19184GPCR downstream signaling
REACT_111217Metabolism
REACT_116145PPARA Activates Gene Expression
REACT_147707Metabolism of Angiotensinogen to Angiotensins
Homo sapiens (human)AGTNP_000020.1
Pan troglodytes (chimpanzee)AGTNP_001009032.1
Macaca mulatta (Rhesus monkey)AGTXP_001107374.2
Canis lupus familiaris (dog)AGTXP_536348.3
Mus musculus (house mouse)AgtNP_031454.3
Rattus norvegicus (Norway rat)AgtNP_602308.1
Gallus gallus (chicken)AGTXP_419584.2
Danio rerio (zebrafish)agtNP_932329.1
GeneCards AGT
PDB 1N9U, 4FYS, 2X0B, 4APH, 2WXW, 2JP8, 1N9V, 4AA1
UniProt B0ZBE2, P01019, B2R5S1
MIM 106150
Ensembl ENSG00000135744
HGNC 333
HPRD 00106

GeneRIFs: Gene References Into Functions What's a GeneRIF?

General protein information

Interactant



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