• THAT   AND
  • THAT   AND


Sequence in raw or FASTA format:

Database:

Blast Method:

 
 


AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8) [Homo sapiens (human)]


RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_000029 Homo sapiens angiotensinogen (serpin peptidase inhibitor, clade A, member 8) (AGT), mRNA. GenEZ ORF Cloning On-demand $699.00 18

*Business Day

Related Services

Gene Symbol AGT
Entrez Gene ID 183
Full Name angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
Synonyms ANHU, SERPINA8
General protein information
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

1

1q42.2

Summary The protein encoded by this gene, pre-angiotensinogen or angiotensinogen precursor, is expressed in the liver and is cleaved by the enzyme renin in response to lowered blood pressure. The resulting product, angiotensin I, is then cleaved by angiotensin converting enzyme (ACE) to generate the physiologically active enzyme angiotensin II. The protein is involved in maintaining blood pressure and in the pathogenesis of essential hypertension and preeclampsia. Mutations in this gene are associated with susceptibility to essential hypertension, and can cause renal tubular dysgenesis, a severe disorder of renal tubular development. Defects in this gene have also been associated with non-familial structural atrial fibrillation, and inflammatory bowel disease. [provided by RefSeq, Jul 2008].
Disorder

MIM: 106150

{Hypertension, essential, susceptibility to}, 145500 (3);

mRNA Protein Product Sequence Price Select
NM_000029, 188595658 NP_000020, 4557287 angiotensinogen preproprotein ORF Sequence $550.00
KEGG
hsa04614Renin-angiotensin system
WikiPathways
WP554ACE Inhibitor Pathway
WP1544MicroRNAs in cardiomyocyte hypertrophy
WP236Adipogenesis
WP727Monoamine Transport
WP1528Physiological and Pathological Hypertrophy of the Heart
Pathway Interaction Database
prlsignalingeventspathwaySignaling events mediated by PRL
Reactome
REACT_19241Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
REACT_19184GPCR downstream signaling
REACT_19231G alpha (i) signalling events
REACT_18283G alpha (q) signalling events
REACT_17015Metabolism of proteins
REACT_14828Class A/1 (Rhodopsin-like receptors)
REACT_14797Signaling by GPCR
REACT_14819Peptide ligand-binding receptors
REACT_22279Fatty acid, triacylglycerol, and ketone body metabolism
REACT_22258Metabolism of lipids and lipoproteins
REACT_21340GPCR ligand binding
REACT_111102Signal Transduction
REACT_111217Metabolism
REACT_147707Metabolism of Angiotensinogen to Angiotensins
REACT_116145PPARA activates gene expression
REACT_120966Gastrin-CREB signalling pathway via PKC and MAPK
REACT_160078Peptide hormone metabolism
Homo sapiens (human)AGTNP_000020.1
Pan troglodytes (chimpanzee)AGTNP_001009032.1
Macaca mulatta (Rhesus monkey)AGTXP_001107374.2
Canis lupus familiaris (dog)AGTXP_005618890.1
Mus musculus (house mouse)AgtNP_031454.3
Rattus norvegicus (Norway rat)AgtNP_602308.1
Gallus gallus (chicken)AGTXP_004935548.1
Danio rerio (zebrafish)agtNP_932329.1
Xenopus (Silurana) tropicalis (western clawed frog)agtXP_002931552.2
Process
IDNameEvidence
GO:0001543ovarian follicle ruptureIEA
GO:0001558regulation of cell growthNAS
GO:0001568blood vessel developmentIEA
GO:0001658branching involved in ureteric bud morphogenesisIEA
GO:0001819positive regulation of cytokine productionTAS
GO:0001822kidney developmentIMP
GO:0001974blood vessel remodelingTAS
GO:0001998angiotensin mediated vasoconstriction involved in regulation of systemic arterial blood pressureIEA
GO:0001999renal response to blood flow involved in circulatory renin-angiotensin regulation of systemic arterial blood pressureIEA
GO:0002003angiotensin maturationTAS
GO:0002016regulation of blood volume by renin-angiotensinNAS
GO:0002018renin-angiotensin regulation of aldosterone productionNAS
GO:0002019regulation of renal output by angiotensinNAS
GO:0002034regulation of blood vessel size by renin-angiotensinTAS
GO:0003014renal system processIDA
GO:0003051angiotensin-mediated drinking behaviorIEA
GO:0003331positive regulation of extracellular matrix constituent secretionIEA
GO:0006883cellular sodium ion homeostasisIEA
GO:0007160cell-matrix adhesionIEA
GO:0007186G-protein coupled receptor signaling pathwayIDA
GO:0007199G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messengerTAS
GO:0007200phospholipase C-activating G-protein coupled receptor signaling pathwayNAS
GO:0007202activation of phospholipase C activityIEA
GO:0007250activation of NF-kappaB-inducing kinase activityIEA
GO:0007263nitric oxide mediated signal transductionTAS
GO:0007267cell-cell signalingTAS
GO:0007568agingIEA
GO:0007588excretionIEA
GO:0008065establishment of blood-nerve barrierIEA
GO:0008285negative regulation of cell proliferationIEA
GO:0009409response to coldIEA
GO:0009651response to salt stressIEA
GO:0010535positive regulation of activation of JAK2 kinase activityIMP
GO:0010595positive regulation of endothelial cell migrationIDA
GO:0010613positive regulation of cardiac muscle hypertrophyISS
GO:0010744positive regulation of macrophage derived foam cell differentiationIC
GO:0010873positive regulation of cholesterol esterificationIDA
GO:0010951negative regulation of endopeptidase activityIBA
GO:0014061regulation of norepinephrine secretionIEA
GO:0014068positive regulation of phosphatidylinositol 3-kinase signalingIDA
GO:0014824artery smooth muscle contractionIEA
GO:0014873response to muscle activity involved in regulation of muscle adaptationISS
GO:0016525negative regulation of angiogenesisIEA
GO:0019229regulation of vasoconstrictionNAS
GO:0030162regulation of proteolysisIBA
GO:0030198extracellular matrix organizationIEA
GO:0030308negative regulation of cell growthIEA
GO:0030432peristalsisIEA
GO:0032270positive regulation of cellular protein metabolic processIDA
GO:0032930positive regulation of superoxide anion generationIEA
GO:0033864positive regulation of NAD(P)H oxidase activityTAS
GO:0034104negative regulation of tissue remodelingIEA
GO:0034374low-density lipoprotein particle remodelingNAS
GO:0035411catenin import into nucleusIEA
GO:0035813regulation of renal sodium excretionNAS
GO:0035815positive regulation of renal sodium excretionIEA
GO:0040018positive regulation of multicellular organism growthIEA
GO:0042127regulation of cell proliferationNAS
GO:0042311vasodilationIEA
GO:0043410positive regulation of MAPK cascadeIEA
GO:0043524negative regulation of neuron apoptotic processIEA
GO:0044255cellular lipid metabolic processTAS
GO:0044267cellular protein metabolic processTAS
GO:0044281small molecule metabolic processTAS
GO:0045723positive regulation of fatty acid biosynthetic processIEA
GO:0045742positive regulation of epidermal growth factor receptor signaling pathwayIDA
GO:0045893positive regulation of transcription, DNA-templatedIDA
GO:0046622positive regulation of organ growthIEA
GO:0048143astrocyte activationIEA
GO:0048144fibroblast proliferationIEA
GO:0048146positive regulation of fibroblast proliferationISS
GO:0048169regulation of long-term neuronal synaptic plasticityIEA
GO:0048659smooth muscle cell proliferationIEA
GO:0050663cytokine secretionIEA
GO:0050729positive regulation of inflammatory responseTAS
GO:0050731positive regulation of peptidyl-tyrosine phosphorylationIDA
GO:0051092positive regulation of NF-kappaB transcription factor activityTAS
GO:0051145smooth muscle cell differentiationIEA
GO:0051387negative regulation of neurotrophin TRK receptor signaling pathwayIDA
GO:0051403stress-activated MAPK cascadeIEA
GO:0051924regulation of calcium ion transportIEA
GO:0061049cell growth involved in cardiac muscle cell developmentIEA
GO:0061098positive regulation of protein tyrosine kinase activityIMP
GO:0070371ERK1 and ERK2 cascadeIEA
GO:0070471uterine smooth muscle contractionIEA
GO:0071260cellular response to mechanical stimulusIEA
GO:0090190positive regulation of branching involved in ureteric bud morphogenesisIDA
GO:2000379positive regulation of reactive oxygen species metabolic processTAS
GO:2001238positive regulation of extrinsic apoptotic signaling pathwayIDA
Component
IDNameEvidence
GO:0005576extracellular regionNAS
GO:0005576extracellular regionTAS
GO:0005615extracellular spaceIC
GO:0005615extracellular spaceIDA
GO:0005615extracellular spaceISS
GO:0070062extracellular vesicular exosomeIDA
GO:0072562blood microparticleIDA
Function
IDNameEvidence
GO:0004867serine-type endopeptidase inhibitor activityIBA
GO:0005179hormone activityIC
GO:0005179hormone activityISS
GO:0005515protein bindingIPI
GO:0008083growth factor activityTAS
GO:0031702type 1 angiotensin receptor bindingIPI
GO:0031703type 2 angiotensin receptor bindingIPI
GeneCards AGT
PDB 1N9U, 4FYS, 2X0B, 4APH, 2WXW, 3CK0, 2JP8, 1N9V, 4AA1
UniProt B0ZBE2, P01019, B2R5S1
Vega OTTHUMG00000037757
MIM 106150
Ensembl ENSG00000135744
HGNC 333
HPRD 00106

GeneRIFs: Gene References Into Functions What's a GeneRIF?

What is the normal function of the AGT gene?

The AGT gene provides instructions for making a protein called angiotensinogen. This protein is part of the renin-angiotensin system, which regulates blood pressure and the balance of fluids and salts in the body. In the first step of this process, angiotensinogen is converted to angiotensin I. Through an additional step, angiotensin I is converted to angiotensin II. Angiotensin II causes blood vessels to narrow (constrict), which results in increased blood pressure. This molecule also stimulates production of the hormone aldosterone, which triggers the absorption of salt and water by the kidneys. The increased amount of fluid in the body also increases blood pressure. Proper blood pressure during fetal growth, which delivers oxygen to the developing tissues, is required for normal development of the kidneys, particularly of structures called the proximal tubules, and other tissues. In addition, angiotensin II may play a more direct role in kidney development, perhaps by affecting growth factors involved in the development of kidney structures.

Interactant

Our customer service representatives are available 24 hours a day, Monday through Friday; please contact us anytime for assistance.