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TYMP thymidine phosphorylase [Homo sapiens (human)]


RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_001113755 Homo sapiens thymidine phosphorylase (TYMP), transcript variant 1, mRNA. GenEZ ORF Cloning On-demand TBD TBD
NM_001113756 Homo sapiens thymidine phosphorylase (TYMP), transcript variant 3, mRNA. GenEZ ORF Cloning On-demand TBD TBD
NM_001257988 Homo sapiens thymidine phosphorylase (TYMP), transcript variant 4, mRNA. GenEZ ORF Cloning On-demand TBD TBD
NM_001257989 Homo sapiens thymidine phosphorylase (TYMP), transcript variant 5, mRNA. GenEZ ORF Cloning On-demand TBD TBD
NM_001953 Homo sapiens thymidine phosphorylase (TYMP), transcript variant 2, mRNA. GenEZ ORF Cloning On-demand TBD TBD

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Gene Symbol TYMP
Entrez Gene ID 1890
Full Name thymidine phosphorylase
Synonyms ECGF, ECGF1, MEDPS1, MNGIE, MTDPS1, PDECGF, TP, hPD-ECGF
General protein information
Preferred Names
thymidine phosphorylase
Names
thymidine phosphorylase
tdRPase
gliostatin
NP_001107227.1
NP_001107228.1
NP_001244917.1
NP_001244918.1
NP_001944.1
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

22

22q13.33

Summary This gene encodes an angiogenic factor which promotes angiogenesis in vivo and stimulates the in vitro growth of a variety of endothelial cells. It has a highly restricted target cell specificity acting only on endothelial cells. Mutations in this gene have been associated with mitochondrial neurogastrointestinal encephalomyopathy. Multiple alternatively spliced transcript variants have been identified. [provided by RefSeq, Apr 2012].
Disorder

MIM: 131222

Mitochondrial DNA depletion syndrome 1 (MNGIE type), 603041 (3)

mRNA Protein Product Sequence Price Select
NM_001113755, 384229045 NP_001107227, 166158922 thymidine phosphorylase isoform 1 proprotein ORF Sequence $550.00
NM_001113756, 384229047 NP_001107228, 166158925 thymidine phosphorylase isoform 1 proprotein ORF Sequence $550.00
NM_001257988, 384229048 NP_001244917, 384229049 thymidine phosphorylase isoform 1 proprotein ORF Sequence $550.00
NM_001257989, 384229050 NP_001244918, 384229051 thymidine phosphorylase isoform 2 proprotein ORF Sequence $550.00
NM_001953, 384229046 NP_001944, 4503445 thymidine phosphorylase isoform 1 proprotein ORF Sequence $550.00
KEGG
hsa00240Pyrimidine metabolism
hsa00983Drug metabolism - other enzymes
hsa05219Bladder cancer
WikiPathways
WP1601Fluoropyrimidine Activity
BIOCYC
HUMAN_PWY0-181salvage pathways of pyrimidine deoxyribonucleotides
META_PWY-7181pyrimidine deoxyribonucleosides degradation
Reactome
REACT_1023Pyrimidine catabolism
REACT_655Pyrimidine salvage reactions
REACT_1698Metabolism of nucleotides
REACT_957Pyrimidine metabolism
REACT_111217Metabolism
Homo sapiens (human)TYMPNP_001107228.1
Pan troglodytes (chimpanzee)TYMPXP_515224.4
Macaca mulatta (Rhesus monkey)TYMPXP_001112945.1
Mus musculus (house mouse)TympNP_612175.1
Rattus norvegicus (Norway rat)TympNP_001012122.1
Xenopus (Silurana) tropicalis (western clawed frog)tympNP_001120427.1
Process
IDNameEvidence
GO:0000002mitochondrial genome maintenanceTAS
GO:0001525angiogenesisIEA
GO:0006206pyrimidine nucleobase metabolic processTAS
GO:0006220pyrimidine nucleotide metabolic processTAS
GO:0006260DNA replicationTAS
GO:0006935chemotaxisIEA
GO:0030154cell differentiationIEA
GO:0043097pyrimidine nucleoside salvageTAS
GO:0044281small molecule metabolic processTAS
GO:0046135pyrimidine nucleoside catabolic processTAS
GO:0055086nucleobase-containing small molecule metabolic processTAS
Component
IDNameEvidence
GO:0005829cytosolTAS
Function
IDNameEvidence
GO:0004645phosphorylase activityIEA
GO:0005161platelet-derived growth factor receptor bindingTAS
GO:0008083growth factor activityIEA
GO:0009032thymidine phosphorylase activityIEA
GO:0016154pyrimidine-nucleoside phosphorylase activityIEA
GO:0016763transferase activity, transferring pentosyl groupsEXP
GeneCards TYMP
UniProt E5KRG5, B2RBL3, P19971
Vega OTTHUMG00000150249
MIM 131222
Ensembl ENSG00000025708
HGNC 3148
HPRD 08833

GeneRIFs: Gene References Into Functions What's a GeneRIF?

What is the normal function of the TYMP gene?

The TYMP gene (previously known as ECGF1) provides instructions for making an enzyme called thymidine phosphorylase. Thymidine is a molecule known as a nucleoside, which (after a chemical modification) is used as a building block of DNA. Thymidine phosphorylase converts thymidine into two smaller molecules, 2-deoxyribose 1-phosphate and thymine. This chemical reaction is an important step in the breakdown of thymidine, which helps regulate the level of nucleosides in cells.

Thymidine phosphorylase plays an important role in maintaining the appropriate amount of thymidine in cell structures called mitochondria. Mitochondria convert the energy from food into a form that cells can use. Although most DNA is packaged in chromosomes within the nucleus, mitochondria also have a small amount of their own DNA (called mitochondrial DNA or mtDNA). Mitochondria use nucleosides, including thymidine, to build new molecules of mtDNA as needed.

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