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TYMP thymidine phosphorylase [Homo sapiens (human)]


Clone ID RefSeq Accession Definition Vector Stock Status *Turnaround time Price Order
OHu22602 NM_001257988 Homo sapiens thymidine phosphorylase (TYMP), transcript variant 4, mRNA. pcDNA3.1+-DYK On-demand 7-9 $219.00
OHu23077 NM_001257989 Homo sapiens thymidine phosphorylase (TYMP), transcript variant 5, mRNA. pcDNA3.1+-DYK On-demand 7-9 $219.00
OHu22602 NM_001113756 Homo sapiens thymidine phosphorylase (TYMP), transcript variant 3, mRNA. pcDNA3.1+-DYK On-demand 7-9 $219.00
OHu22602 NM_001113755 Homo sapiens thymidine phosphorylase (TYMP), transcript variant 1, mRNA. pcDNA3.1+-DYK On-demand 7-9 $219.00
OHu22602 NM_001953 Homo sapiens thymidine phosphorylase (TYMP), transcript variant 2, mRNA. pcDNA3.1+-DYK On-demand 7-9 $219.00
OHu22602C NM_001257988 Homo sapiens thymidine phosphorylase (TYMP), transcript variant 4, mRNA. Customized vector On-demand 7-9 $269.00
OHu23077C NM_001257989 Homo sapiens thymidine phosphorylase (TYMP), transcript variant 5, mRNA. Customized vector On-demand 7-9 $269.00
OHu22602C NM_001113756 Homo sapiens thymidine phosphorylase (TYMP), transcript variant 3, mRNA. Customized vector On-demand 7-9 $269.00
OHu22602C NM_001113755 Homo sapiens thymidine phosphorylase (TYMP), transcript variant 1, mRNA. Customized vector On-demand 7-9 $269.00
OHu22602C NM_001953 Homo sapiens thymidine phosphorylase (TYMP), transcript variant 2, mRNA. Customized vector On-demand 7-9 $269.00

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Gene Symbol TYMP
Entrez Gene ID 1890
Full Name thymidine phosphorylase
Synonyms ECGF, ECGF1, MEDPS1, MNGIE, MTDPS1, PDECGF, TP, hPD-ECGF
General protein information
Preferred Names
thymidine phosphorylase
Names
thymidine phosphorylase
tdRPase
gliostatin
NP_001107227.1
NP_001107228.1
NP_001244917.1
NP_001244918.1
NP_001944.1
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

22

22q13.33

Summary This gene encodes an angiogenic factor which promotes angiogenesis in vivo and stimulates the in vitro growth of a variety of endothelial cells. It has a highly restricted target cell specificity acting only on endothelial cells. Mutations in this gene have been associated with mitochondrial neurogastrointestinal encephalomyopathy. Multiple alternatively spliced transcript variants have been identified. [provided by RefSeq, Apr 2012].
Disorder

MIM: 131222

Mitochondrial DNA depletion syndrome 1 (MNGIE type), 603041 (3)

mRNA Protein Product Sequence Price Select
NM_001113755, 384229045 NP_001107227, 166158922 thymidine phosphorylase isoform 1 proprotein ORF Sequence $550.00
NM_001113756, 384229047 NP_001107228, 166158925 thymidine phosphorylase isoform 1 proprotein ORF Sequence $550.00
NM_001257988, 384229048 NP_001244917, 384229049 thymidine phosphorylase isoform 1 proprotein ORF Sequence $550.00
NM_001257989, 384229050 NP_001244918, 384229051 thymidine phosphorylase isoform 2 proprotein ORF Sequence $550.00
NM_001953, 384229046 NP_001944, 4503445 thymidine phosphorylase isoform 1 proprotein ORF Sequence $550.00
KEGG
hsa00240Pyrimidine metabolism
hsa00983Drug metabolism - other enzymes
hsa05219Bladder cancer
WikiPathways
WP1601Fluoropyrimidine Activity
BIOCYC
HUMAN_PWY0-181salvage pathways of pyrimidine deoxyribonucleotides
META_PWY-7181pyrimidine deoxyribonucleosides degradation
Reactome
REACT_1023Pyrimidine catabolism
REACT_655Pyrimidine salvage reactions
REACT_1698Metabolism of nucleotides
REACT_957Pyrimidine metabolism
REACT_111217Metabolism
Homo sapiens (human)TYMPNP_001107228.1
Pan troglodytes (chimpanzee)TYMPXP_515224.4
Macaca mulatta (Rhesus monkey)TYMPXP_001112945.1
Mus musculus (house mouse)TympNP_612175.1
Rattus norvegicus (Norway rat)TympNP_001012122.1
Xenopus (Silurana) tropicalis (western clawed frog)tympNP_001120427.1
Process
IDNameEvidence
GO:0000002mitochondrial genome maintenanceTAS
GO:0001525angiogenesisIEA
GO:0006206pyrimidine nucleobase metabolic processTAS
GO:0006220pyrimidine nucleotide metabolic processTAS
GO:0006260DNA replicationTAS
GO:0006935chemotaxisIEA
GO:0030154cell differentiationIEA
GO:0043097pyrimidine nucleoside salvageTAS
GO:0044281small molecule metabolic processTAS
GO:0046135pyrimidine nucleoside catabolic processTAS
GO:0055086nucleobase-containing small molecule metabolic processTAS
Component
IDNameEvidence
GO:0005829cytosolTAS
Function
IDNameEvidence
GO:0004645phosphorylase activityIEA
GO:0005161platelet-derived growth factor receptor bindingTAS
GO:0008083growth factor activityIEA
GO:0009032thymidine phosphorylase activityIEA
GO:0016154pyrimidine-nucleoside phosphorylase activityIEA
GO:0016763transferase activity, transferring pentosyl groupsEXP
GeneCards TYMP
UniProt E5KRG5, B2RBL3, P19971
Vega OTTHUMG00000150249
MIM 131222
Ensembl ENSG00000025708
HGNC 3148
HPRD 08833

GeneRIFs: Gene References Into Functions What's a GeneRIF?

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