Sequence in raw or FASTA format:

EDN2 endothelin 2 [Homo sapiens (human)]

Gene Symbol	EDN2
Entrez Gene ID	1907
Full Name	endothelin 2
Synonyms	ET2, PPET2
Gene Type	protein-coding
Organism	Homo sapiens (human)
Genome	Chromosome:1 Map Location:1p34
Summary	This gene encodes a member of the endothelin protein family of secretory vasoconstrictive peptides. The preproprotein is processed to a short mature form which functions as a ligand for the endothelin receptors that initiate intracellular signaling events. This gene product is involved in a wide range of biological processes, such as hypertension and ovulation. [provided by RefSeq].
Disorder	MIM: 131241

Pathway Interaction Database

endothelinpathway	Endothelins
p53downstreampathway	Direct p53 effectors

Reactome

REACT_14828	Class A/1 (Rhodopsin-like receptors)
REACT_19184	GPCR downstream signaling
REACT_18283	G alpha (q) signalling events
REACT_21340	GPCR ligand binding
REACT_14797	Signaling by GPCR
REACT_14819	Peptide ligand-binding receptors

Homo sapiens (human)	EDN2	NP_001947.1
Pan troglodytes (chimpanzee)	EDN2	XP_524683.2
Canis lupus familiaris (dog)	EDN2	NP_001003002.1
Bos taurus (cattle)	EDN2	NP_783645.1
Mus musculus (house mouse)	Edn2	NP_031928.2
Rattus norvegicus (Norway rat)	Edn2	NP_036681.1
Gallus gallus (chicken)	EDN2	XP_417707.1

Process

ID	Name	Evidence
GO:0001516	prostaglandin biosynthetic process	IDA
GO:0001543	ovarian follicle rupture	IEA
GO:0002690	positive regulation of leukocyte chemotaxis	IDA
GO:0003058	hormonal regulation of the force of heart contraction	TAS
GO:0003099	positive regulation of the force of heart contraction by chemical signal	TAS
GO:0003100	regulation of systemic arterial blood pressure by endothelin	IDA
GO:0007166	cell surface receptor linked signaling pathway	IC
GO:0007204	elevation of cytosolic calcium ion concentration	IDA
GO:0007205	activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway	IEA
GO:0008217	regulation of blood pressure	IEA
GO:0008284	positive regulation of cell proliferation	IDA
GO:0010460	positive regulation of heart rate	IDA
GO:0014824	artery smooth muscle contraction	IDA
GO:0014826	vein smooth muscle contraction	IDA
GO:0019221	cytokine-mediated signaling pathway	IDA
GO:0019229	regulation of vasoconstriction	IEA
GO:0019722	calcium-mediated signaling	IDA
GO:0030593	neutrophil chemotaxis	IDA
GO:0042116	macrophage activation	IDA
GO:0042310	vasoconstriction	IDA
GO:0045987	positive regulation of smooth muscle contraction	IEA
GO:0046887	positive regulation of hormone secretion	IEA
GO:0046888	negative regulation of hormone secretion	IEA
GO:0048016	inositol phosphate-mediated signaling	IDA
GO:0048246	macrophage chemotaxis	IDA
GO:0060585	positive regulation of prostaglandin-endoperoxide synthase activity	IMP

Component

Function

ID	Name	Evidence
GO:0005179	hormone activity	IDA
GO:0031708	endothelin B receptor binding	IPI

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RefSeq Accession	Definition	Sequence	Price	Select
NM_001956	Homo sapiens endothelin 2 (EDN2), mRNA.	Full Length	$364.82
NM_001956	Homo sapiens endothelin 2 (EDN2), mRNA.	ORF Sequence	$159.00