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EDN3 endothelin 3 [Homo sapiens (human)]

RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_000114 Homo sapiens endothelin 3 (EDN3), transcript variant 1, mRNA. GenEZ ORF Cloning In-stock $308.00 $259.00 TBD
NM_207032 Homo sapiens endothelin 3 (EDN3), transcript variant 2, mRNA. GenEZ ORF Cloning In-stock $308.00 $259.00 TBD
NM_207033 Homo sapiens endothelin 3 (EDN3), transcript variant 3, mRNA. GenEZ ORF Cloning On-demand TBD TBD
NM_207034 Homo sapiens endothelin 3 (EDN3), transcript variant 4, mRNA. GenEZ ORF Cloning In-stock $308.00 $259.00 TBD

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Related Services

Gene Symbol EDN3
Entrez Gene ID 1908
Full Name endothelin 3
Synonyms ET3, HSCR4, MGC15067, MGC61498, WS4B
Gene Type protein-coding
Organism Homo sapiens (human)



Summary The protein encoded by this gene is a member of the endothelin family. Endothelins are endothelium-derived vasoactive peptides involved in a variety of biological functions. The active form of this protein is a 21 amino acid peptide processed from the precursor protein. The active peptide is a ligand for endothelin receptor type B (EDNRB). The interaction of this endothelin with EDNRB is essential for development of neural crest-derived cell lineages, such as melanocytes and enteric neurons. Mutations in this gene and EDNRB have been associated with Hirschsprung disease (HSCR) and Waardenburg syndrome (WS), which are congenital disorders involving neural crest-derived cells. Four alternatively spliced transcript variants encoding three distinct isoforms have been observed. [provided by RefSeq, Jul 2008].

MIM: 131242

Waardenburg syndrome, type 4B, 613265 (3); Central hypoventilation

mRNA Protein Product Sequence Price Select
NM_000114, 46370058 NP_000105, 4557545 endothelin-3 isoform 1 preproprotein ORF Sequence $159.00
NM_207032, 46370059 NP_996915, 46370060 endothelin-3 isoform 2 preproprotein ORF Sequence $159.00
NM_207033, 46370061 NP_996916, 46370062 endothelin-3 isoform 3 preproprotein ORF Sequence $250.00
NM_207034, 46370063 NP_996917, 46370064 endothelin-3 isoform 1 preproprotein ORF Sequence $159.00
Pathway Interaction Database
REACT_18283G alpha (q) signalling events
REACT_120966Gastrin-CREB signalling pathway via PKC and MAPK
REACT_21340GPCR ligand binding
REACT_14819Peptide ligand-binding receptors
REACT_14797Signaling by GPCR
REACT_111102Signal Transduction
REACT_14828Class A/1 (Rhodopsin-like receptors)
REACT_19184GPCR downstream signaling
Homo sapiens (human)EDN3NP_000105.1
Pan troglodytes (chimpanzee)EDN3XP_001140677.1
Macaca mulatta (Rhesus monkey)EDN3XP_001082213.1
Canis lupus familiaris (dog)EDN3NP_001002942.1
Bos taurus (cattle)EDN3NP_001095449.1
Mus musculus (house mouse)Edn3NP_031929.1
Rattus norvegicus (Norway rat)Edn3NP_001071118.1
Gallus gallus (chicken)EDN3XP_001231488.2
Danio rerio (zebrafish)edn3bXP_001919586.1
GeneCards EDN3
UniProt P14138
MIM 131242
Ensembl ENSG00000124205
HGNC 3178
HPRD 00570

GeneRIFs: Gene References Into Functions What's a GeneRIF?

General protein information

Preferred Names


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