Sequence in raw or FASTA format:
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 [Homo sapiens (human)]
| Gene Symbol | EEF1A1 |
| Entrez Gene ID | 1915 |
| Full Name | eukaryotic translation elongation factor 1 alpha 1 |
| Synonyms | CCS-3, CCS3, EE1A1, EEF-1, EEF1A, EF-Tu, EF1A, FLJ25721, GRAF-1EF, HNGC:16303, LENG7, MGC102687, MGC131894, MGC16224, PTI1, eEF1A-1 |
| Gene Type | protein-coding |
| Organism | Homo sapiens (human) |
| Genome |
6 6q14.1 |
| Summary | This gene encodes an isoform of the alpha subunit of the elongation factor-1 complex, which is responsible for the enzymatic delivery of aminoacyl tRNAs to the ribosome. This isoform (alpha 1) is expressed in brain, placenta, lung, liver, kidney, and pancreas, and the other isoform (alpha 2) is expressed in brain, heart and skeletal muscle. This isoform is identified as an autoantigen in 66% of patients with Felty syndrome. This gene has been found to have multiple copies on many chromosomes, some of which, if not all, represent different pseudogenes. [provided by RefSeq]. |
| Disorder | MIM: 130590 |
| mRNA | NM_001402, 83367078 |
| Protein | NP_001393, 4503471 |
| Product | elongation factor 1-alpha 1 |
| RefSeq Status | REVIEWED |
| hsa03013 | RNA transport |
WikiPathways
| WP107 | Translation Factors |
| WP437 | EGFR1 Signaling Pathway |
Reactome
| REACT_1404 | Peptide chain elongation |
| REACT_1014 | Translation |
| REACT_71 | Gene Expression |
| REACT_1477 | Eukaryotic Translation Elongation |
| REACT_17015 | Metabolism of proteins |
| Homo sapiens (human) | EEF1A1 | NP_001393.1 |
| Pan troglodytes (chimpanzee) | EEF1A1 | NP_001009165.1 |
| Canis lupus familiaris (dog) | EEF1A1 | XP_532203.2 |
| Bos taurus (cattle) | EEF1A1 | NP_776960.1 |
| Rattus norvegicus (Norway rat) | Eef1a2l1 | NP_284925.1 |
| Gallus gallus (chicken) | EEF1A1 | NP_989488.2 |
| Danio rerio (zebrafish) | ef1a | NP_571338.1 |
| Danio rerio (zebrafish) | zgc:109885 | NP_001035074.1 |
| Drosophila melanogaster (fruit fly) | Ef1alpha48D | NP_477375.1 |
| Caenorhabditis elegans | eft-4 | NP_509323.1 |
| Caenorhabditis elegans | eft-3 | NP_498520.1 |
| ID | Name | Evidence |
| GO:0006412 | translation | TAS |
| GO:0006414 | translational elongation | EXP |
| GO:0006414 | translational elongation | TAS |
| GO:0010467 | gene expression | TAS |
| GO:0044267 | cellular protein metabolic process | TAS |
Component
| ID | Name | Evidence |
| GO:0005737 | cytoplasm | TAS |
| GO:0005829 | cytosol | EXP |
| GO:0005853 | eukaryotic translation elongation factor 1 complex | TAS |
Function
| ID | Name | Evidence |
| GO:0000166 | nucleotide binding | IEA |
| GO:0003746 | translation elongation factor activity | IEA |
| GO:0003924 | GTPase activity | IEA |
| GO:0005515 | protein binding | IPI |
| GO:0005525 | GTP binding | TAS |
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