EEF1A2 eukaryotic translation elongation factor 1 alpha 2 [Homo sapiens (human)]
| Gene Symbol | EEF1A2 |
| Entrez Gene ID | 1917 |
| Full Name | eukaryotic translation elongation factor 1 alpha 2 |
| Synonyms | EEF1AL, EF-1-alpha-2, EF1A, FLJ41696, HS1, STN, STNL |
| Gene Type | protein-coding |
| Organism | Homo sapiens (human) |
| Genome |
20 20q13.3 |
| Summary | This gene encodes an isoform of the alpha subunit of the elongation factor-1 complex, which is responsible for the enzymatic delivery of aminoacyl tRNAs to the ribosome. This isoform (alpha 2) is expressed in brain, heart and skeletal muscle, and the other isoform (alpha 1) is expressed in brain, placenta, lung, liver, kidney, and pancreas. This gene may be critical in the development of ovarian cancer. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]. |
| Disorder | MIM: 602959 |
| mRNA | NM_001958, 25453470 |
| Protein | NP_001949, 4503475 |
| Product | elongation factor 1-alpha 2 |
| RefSeq Status | REVIEWED |
| Homo sapiens (human) | EEF1A2 | NP_001949.1 |
| Pan troglodytes (chimpanzee) | EEF1A2 | XP_001138897.1 |
| Canis lupus familiaris (dog) | EEF1A2 | XP_849749.1 |
| Bos taurus (cattle) | EEF1A2 | NP_001032541.1 |
| Mus musculus (house mouse) | Eef1a2 | NP_031932.1 |
| Rattus norvegicus (Norway rat) | Eef1a2 | NP_036792.2 |
| Gallus gallus (chicken) | EEF1A2 | XP_001233518.1 |
| Danio rerio (zebrafish) | zgc:92085 | NP_001002371.1 |
| Drosophila melanogaster (fruit fly) | Ef1alpha100E | NP_524611.1 |
| ID | Name | Evidence |
| GO:0006412 | translation | NAS |
| GO:0006916 | anti-apoptosis | IEA |
| GO:0010035 | response to inorganic substance | IEA |
Component
| ID | Name | Evidence |
| GO:0005634 | nucleus | IEA |
| GO:0005737 | cytoplasm | IEA |
| GO:0005853 | eukaryotic translation elongation factor 1 complex | IEA |
| GO:0043025 | neuronal cell body | IEA |
Function
| ID | Name | Evidence |
| GO:0000166 | nucleotide binding | IEA |
| GO:0003746 | translation elongation factor activity | IEA |
| GO:0003924 | GTPase activity | IEA |
| GO:0005515 | protein binding | IPI |
| GO:0005525 | GTP binding | IEA |
| GO:0008135 | translation factor activity, nucleic acid binding | NAS |
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