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UBR1 ubiquitin protein ligase E3 component n-recognin 1 [Homo sapiens (human)]

RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_174916 Homo sapiens ubiquitin protein ligase E3 component n-recognin 1 (UBR1), mRNA. GenEZ ORF Cloning On-demand $2699.00 30

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Gene Symbol UBR1
Entrez Gene ID 197131
Full Name ubiquitin protein ligase E3 component n-recognin 1
Synonyms JBS, MGC142065, MGC142067
Gene Type protein-coding
Organism Homo sapiens (human)



Summary The N-end rule pathway is one proteolytic pathway of the ubiquitin system. The recognition component of this pathway, encoded by this gene, binds to a destabilizing N-terminal residue of a substrate protein and participates in the formation of a substrate-linked multiubiquitin chain. This leads to the eventual degradation of the substrate protein. The protein described in this record has a RING-type zinc finger and a UBR-type zinc finger. Mutations in this gene have been associated with Johanson-Blizzard syndrome. [provided by RefSeq, Jul 2008].

MIM: 605981

Johanson-Blizzard syndrome, 243800 (3)

mRNA Protein Product Sequence Price Select
NM_174916, 83656781 NP_777576, 28372497 E3 ubiquitin-protein ligase UBR1 ORF Sequence $2500.00
REACT_75842Antigen processing: Ubiquitination & Proteasome degradation
REACT_6900Immune System
REACT_75774Adaptive Immune System
REACT_75820Class I MHC mediated antigen processing & presentation
Homo sapiens (human)UBR1NP_777576.1
Pan troglodytes (chimpanzee)UBR1XP_510341.3
Macaca mulatta (Rhesus monkey)UBR1XP_001105721.2
Canis lupus familiaris (dog)UBR1XP_544645.2
Bos taurus (cattle)UBR1NP_001192826.1
Mus musculus (house mouse)Ubr1NP_033487.2
Gallus gallus (chicken)UBR1XP_421165.2
Danio rerio (zebrafish)ubr1XP_002665264.2
GeneCards UBR1
UniProt Q8IWV7
MIM 605981
Ensembl ENSG00000159459
HGNC 16808
HPRD 09342

GeneRIFs: Gene References Into Functions What's a GeneRIF?

General protein information


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