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ELAVL1 ELAV like RNA binding protein 1 [Homo sapiens (human)]


Clone ID RefSeq Accession Definition Vector Stock Status *Turnaround time Price Order
OHu23723 NM_001419 Homo sapiens ELAV like RNA binding protein 1 (ELAVL1), mRNA. pcDNA3.1+-DYK In-stock 5-7 $99.00
OHu23723C NM_001419 Homo sapiens ELAV like RNA binding protein 1 (ELAVL1), mRNA. Customized vector In-stock 5-7 $149.00

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Gene Symbol ELAVL1
Entrez Gene ID 1994
Full Name ELAV like RNA binding protein 1
Synonyms ELAV1, HUR, Hua, MelG
General protein information
Preferred Names
ELAV-like protein 1
Names
ELAV-like protein 1
Hu antigen R
hu-antigen R
embryonic lethal, abnormal vision, drosophila, homolog-like 1
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

19

19p13.2

Summary The protein encoded by this gene is a member of the ELAVL family of RNA-binding proteins that contain several RNA recognition motifs, and selectively bind AU-rich elements (AREs) found in the 3' untranslated regions of mRNAs. AREs signal degradation of mRNAs as a means to regulate gene expression, thus by binding AREs, the ELAVL family of proteins play a role in stabilizing ARE-containing mRNAs. This gene has been implicated in a variety of biological processes and has been linked to a number of diseases, including cancer. It is highly expressed in many cancers, and could be potentially useful in cancer diagnosis, prognosis, and therapy. [provided by RefSeq, Sep 2012].
Disorder

MIM: 603466

mRNA Protein Product Sequence Price Select
NM_001419, 38201713 NP_001410, 38201714 ELAV-like protein 1 ORF Sequence $269.00
KEGG
hsa04152AMPK signaling pathway
WikiPathways
WP1403AMPK signaling
Reactome
REACT_71Gene Expression
REACT_24994Regulation of mRNA stability by proteins that bind AU-rich elements
REACT_25218HuR stabilizes mRNA
Homo sapiens (human)ELAVL1NP_001410.2
Pan troglodytes (chimpanzee)ELAVL1XP_001156587.2
Macaca mulatta (Rhesus monkey)ELAVL1XP_001092907.2
Canis lupus familiaris (dog)ELAVL1XP_854218.1
Bos taurus (cattle)ELAVL1NP_001069922.1
Mus musculus (house mouse)Elavl1NP_034615.2
Rattus norvegicus (Norway rat)Elavl1NP_001102318.1
Gallus gallus (chicken)ELAVL1NP_990164.1
Danio rerio (zebrafish)hugNP_570984.1
Xenopus (Silurana) tropicalis (western clawed frog)elavl1NP_001005461.1
Process
IDNameEvidence
GO:0007275multicellular organismal developmentTAS
GO:0010467gene expressionTAS
GO:0016070RNA metabolic processTAS
GO:0016071mRNA metabolic processTAS
GO:0045727positive regulation of translationIDA
GO:0048255mRNA stabilizationIDA
GO:0048255mRNA stabilizationIMP
GO:00709353'-UTR-mediated mRNA stabilizationIDA
GO:00709353'-UTR-mediated mRNA stabilizationIMP
GO:2000036regulation of stem cell maintenanceISS
Component
IDNameEvidence
GO:0005634nucleusIDA
GO:0005654nucleoplasmTAS
GO:0005737cytoplasmIDA
GO:0005829cytosolTAS
GO:0016020membraneIDA
Function
IDNameEvidence
GO:0000166nucleotide bindingIEA
GO:0003723RNA bindingIDA
GO:0003725double-stranded RNA bindingIDA
GO:0003729mRNA bindingTAS
GO:0003730mRNA 3'-UTR bindingISS
GO:0005515protein bindingIPI
GO:0017091AU-rich element bindingIDA
GO:0019901protein kinase bindingIPI
GO:0035925mRNA 3'-UTR AU-rich region bindingIDA
GO:0044822poly(A) RNA bindingIDA
GeneCards ELAVL1
PDB 4EGL, 4ED5, 4FXV, 3HI9
UniProt Q15717
Vega OTTHUMG00000182470
MIM 603466
Ensembl ENSG00000066044
HGNC 3312
HPRD 16025

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Interactant

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