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Sequence in raw or FASTA format:

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FLCN folliculin [Homo sapiens (human)]


Clone ID RefSeq Accession Definition Vector Stock Status *Turnaround time Price Order
OHu18989 NM_144997 Homo sapiens folliculin (FLCN), transcript variant 1, mRNA. pcDNA3.1+-DYK On-demand 7-9 $219.00
OHu19027 NM_144606 Homo sapiens folliculin (FLCN), transcript variant 2, mRNA. pcDNA3.1+-DYK In-stock 5-7 $99.00
OHu18989 XM_005256515 PREDICTED: Homo sapiens folliculin (FLCN), transcript variant X2, mRNA. pcDNA3.1+-DYK On-demand 7-9 $219.00
OHu49747 XM_006721470 PREDICTED: Homo sapiens folliculin (FLCN), transcript variant X3, mRNA. pcDNA3.1+-DYK On-demand 7-9 $219.00
OHu18989C NM_144997 Homo sapiens folliculin (FLCN), transcript variant 1, mRNA. Customized vector On-demand 7-9 $269.00
OHu19027C NM_144606 Homo sapiens folliculin (FLCN), transcript variant 2, mRNA. Customized vector In-stock 5-7 $149.00
OHu18989C XM_005256515 PREDICTED: Homo sapiens folliculin (FLCN), transcript variant X2, mRNA. Customized vector On-demand 7-9 $269.00
OHu49747C XM_006721470 PREDICTED: Homo sapiens folliculin (FLCN), transcript variant X3, mRNA. Customized vector On-demand 7-9 $269.00

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Gene Symbol FLCN
Entrez Gene ID 201163
Full Name folliculin
Synonyms BHD, FLCL
General protein information
Preferred Names
folliculin
Names
folliculin
birt-Hogg-Dube syndrome protein
BHD skin lesion fibrofolliculoma protein
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

17

17p11.2

Summary This gene is located within the Smith-Magenis syndrome region on chromosome 17. Mutations in this gene are associated with Birt-Hogg-Dube syndrome, which is characterized by fibrofolliculomas, renal tumors, lung cysts, and pneumothorax. Alternative splicing of this gene results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008].
Disorder

MIM: 607273

Birt-Hogg-Dube syndrome, 135150 (3); Pneumothorax, primary

mRNA Protein Product Sequence Price Select
NM_144606, 186928862 NP_653207, 21389403 folliculin isoform 2 ORF Sequence $269.00
NM_144997, 186928861 NP_659434, 22907034 folliculin isoform 1 ORF Sequence $700.00
XM_005256515, 530410049 XP_005256572, 530410050 folliculin isoform X2 ORF Sequence $700.00
XM_006721470, 578829760 XP_006721533, 578829761 folliculin isoform X3 ORF Sequence $400.00
KEGG
hsa05211Renal cell carcinoma
Homo sapiens (human)FLCNNP_659434.2
Pan troglodytes (chimpanzee)FLCNXP_001161086.1
Macaca mulatta (Rhesus monkey)FLCNXP_001088928.1
Canis lupus familiaris (dog)FLCNNP_001121083.1
Bos taurus (cattle)FLCNNP_001030440.1
Mus musculus (house mouse)FlcnNP_001258285.1
Rattus norvegicus (Norway rat)FlcnNP_955422.1
Gallus gallus (chicken)FLCNXP_414807.2
Danio rerio (zebrafish)flcnNP_001035463.1
Drosophila melanogaster (fruit fly)BHDNP_648090.1
Caenorhabditis elegansF22D3.2NP_001022107.2
Xenopus (Silurana) tropicalis (western clawed frog)flcnNP_001011353.1
Process
IDNameEvidence
GO:0000122negative regulation of transcription from RNA polymerase II promoterIDA
GO:0000122negative regulation of transcription from RNA polymerase II promoterIMP
GO:0001701in utero embryonic developmentISS
GO:0001932regulation of protein phosphorylationIDA
GO:0001934positive regulation of protein phosphorylationISS
GO:0007043cell-cell junction assemblyISS
GO:0010628positive regulation of gene expressionISS
GO:0010629negative regulation of gene expressionISS
GO:0010823negative regulation of mitochondrion organizationISS
GO:0030097hemopoiesisISS
GO:0030308negative regulation of cell growthIDA
GO:0030336negative regulation of cell migrationIMP
GO:0030511positive regulation of transforming growth factor beta receptor signaling pathwayIDA
GO:0030511positive regulation of transforming growth factor beta receptor signaling pathwayISS
GO:0031929TOR signalingIMP
GO:0032006regulation of TOR signalingISS
GO:0032007negative regulation of TOR signalingISS
GO:0032008positive regulation of TOR signalingISS
GO:0032465regulation of cytokinesisIMP
GO:0035024negative regulation of Rho protein signal transductionIMP
GO:0035065regulation of histone acetylationISS
GO:0043065positive regulation of apoptotic processISS
GO:0045785positive regulation of cell adhesionIMP
GO:0045944positive regulation of transcription from RNA polymerase II promoterIDA
GO:0045944positive regulation of transcription from RNA polymerase II promoterIMP
GO:0051898negative regulation of protein kinase B signalingISS
GO:0070373negative regulation of ERK1 and ERK2 cascadeISS
GO:1900181negative regulation of protein localization to nucleusIDA
GO:1901723negative regulation of cell proliferation involved in kidney developmentISS
GO:2000506negative regulation of energy homeostasisISS
GO:2000973regulation of pro-B cell differentiationISS
GO:2001170negative regulation of ATP biosynthetic processISS
Component
IDNameEvidence
GO:0005634nucleusIDA
GO:0005737cytoplasmIDA
GO:0005886plasma membraneIDA
GO:0030496midbodyIDA
GO:0044291cell-cell contact zoneIDA
Function
IDNameEvidence
GO:0005515protein bindingIPI
GO:0032403protein complex bindingIDA
GeneCards FLCN
UniProt Q8NFG4
Vega OTTHUMG00000059275
MIM 607273
Ensembl ENSG00000154803
HGNC 27310
HPRD 06278

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