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EN1 engrailed homeobox 1 [Homo sapiens (human)]


RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_001426 Homo sapiens engrailed homeobox 1 (EN1), mRNA. GenEZ ORF Cloning On-demand TBD TBD

*Business Day

Related Services

Gene Symbol EN1
Entrez Gene ID 2019
Full Name engrailed homeobox 1
Synonyms
General protein information
Preferred Names
homeobox protein engrailed-1
Names
homeobox protein engrailed-1
hu-En-1
engrailed homolog 1
homeobox protein en-1
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

2

2q14.2

Summary Homeobox-containing genes are thought to have a role in controlling development. In Drosophila, the 'engrailed' (en) gene plays an important role during development in segmentation, where it is required for the formation of posterior compartments. Different mutations in the mouse homologs, En1 and En2, produced different developmental defects that frequently are lethal. The human engrailed homologs 1 and 2 encode homeodomain-containing proteins and have been implicated in the control of pattern formation during development of the central nervous system. [provided by RefSeq, Jul 2008].
Disorder

MIM: 131290

mRNA Protein Product Sequence Price Select
NM_001426, 126090908 NP_001417, 126090909 homeobox protein engrailed-1 ORF Sequence $400.00
WikiPathways
WP706SIDS Susceptibility Pathways
Homo sapiens (human)EN1NP_001417.3
Pan troglodytes (chimpanzee)EN1XP_001172516.1
Bos taurus (cattle)EN1XP_003585804.1
Mus musculus (house mouse)En1NP_034263.2
Rattus norvegicus (Norway rat)En1XP_001056699.2
Danio rerio (zebrafish)eng1bNP_001013516.1
Process
IDNameEvidence
GO:0001501skeletal system developmentTAS
GO:0009653anatomical structure morphogenesisTAS
GO:0009953dorsal/ventral pattern formationIEA
GO:0009954proximal/distal pattern formationIEA
GO:0030901midbrain developmentIEA
GO:0030902hindbrain developmentIEA
GO:0030917midbrain-hindbrain boundary developmentIEA
GO:0035115embryonic forelimb morphogenesisIEA
GO:0042220response to cocaineIEA
GO:0043473pigmentationIEA
GO:0045944positive regulation of transcription from RNA polymerase II promoterIEA
GO:0048666neuron developmentIEA
Component
IDNameEvidence
GO:0005634nucleusIEA
GO:0016020membraneIEA
Function
IDNameEvidence
GO:0003700sequence-specific DNA binding transcription factor activityIEA
GO:0043565sequence-specific DNA bindingIEA
GeneCards EN1
UniProt Q05925
Vega OTTHUMG00000131401
MIM 131290
Ensembl ENSG00000163064
HGNC 3342
HPRD 08835

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Interactant

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