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EN2 engrailed homeobox 2 [Homo sapiens (human)]


RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_001427 Homo sapiens engrailed homeobox 2 (EN2), mRNA. GenEZ ORF Cloning On-demand TBD TBD

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Gene Symbol EN2
Entrez Gene ID 2020
Full Name engrailed homeobox 2
Synonyms
General protein information
Preferred Names
homeobox protein engrailed-2
Names
homeobox protein engrailed-2
hu-En-2
engrailed-2
engrailed homolog 2
homeobox protein en-2
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

7

7q36

Summary Homeobox-containing genes are thought to have a role in controlling development. In Drosophila, the 'engrailed' (en) gene plays an important role during development in segmentation, where it is required for the formation of posterior compartments. Different mutations in the mouse homologs, En1 and En2, produced different developmental defects that frequently are lethal. The human engrailed homologs 1 and 2 encode homeodomain-containing proteins and have been implicated in the control of pattern formation during development of the central nervous system. [provided by RefSeq, Jul 2008].
Disorder

MIM: 131310

{Autism susceptibility 10}, 611016 (3)

mRNA Protein Product Sequence Price Select
NM_001427, 126090912 NP_001418, 7710121 homeobox protein engrailed-2 ORF Sequence $400.00
Homo sapiens (human)EN2NP_001418.2
Pan troglodytes (chimpanzee)EN2XP_001146034.2
Macaca mulatta (Rhesus monkey)EN2XP_001106130.1
Mus musculus (house mouse)En2NP_034264.1
Rattus norvegicus (Norway rat)En2NP_001102684.1
Gallus gallus (chicken)LOC100859435NP_001254648.1
Danio rerio (zebrafish)eng2bNP_571115.1
Danio rerio (zebrafish)eng2aNP_571119.2
Xenopus (Silurana) tropicalis (western clawed frog)LOC100498251XP_002932525.1
Process
IDNameEvidence
GO:0007275multicellular organismal developmentTAS
GO:0030901midbrain developmentIEA
GO:0030902hindbrain developmentIEA
GO:0045944positive regulation of transcription from RNA polymerase II promoterIEA
GO:0048666neuron developmentIEA
Component
IDNameEvidence
GO:0005634nucleusIEA
GO:0016020membraneIEA
Function
IDNameEvidence
GO:0003700sequence-specific DNA binding transcription factor activityIEA
GO:0043565sequence-specific DNA bindingIEA
GeneCards EN2
UniProt P19622
Vega OTTHUMG00000151354
MIM 131310
Ensembl ENSG00000164778
HGNC 3343
HPRD 08836

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Interactant

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