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EPAS1 endothelial PAS domain protein 1 [Homo sapiens (human)]

RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_001430 Homo sapiens endothelial PAS domain protein 1 (EPAS1), mRNA. GenEZ ORF Cloning On-demand $899.00 20

*Business Day

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Gene Symbol EPAS1
Entrez Gene ID 2034
Full Name endothelial PAS domain protein 1
Synonyms ECYT4, HIF2A, HLF, MOP2, PASD2, bHLHe73
Gene Type protein-coding
Organism Homo sapiens (human)



Summary This gene encodes a transcription factor involved in the induction of genes regulated by oxygen, which is induced as oxygen levels fall. The encoded protein contains a basic-helix-loop-helix domain protein dimerization domain as well as a domain found in proteins in signal transduction pathways which respond to oxygen levels. Mutations in this gene are associated with erythrocytosis familial type 4. [provided by RefSeq, Nov 2009].

MIM: 603349

Erythrocytosis, familial, 4, 611783 (3)

mRNA Protein Product Sequence Price Select
NM_001430, 262527236 NP_001421, 40254439 endothelial PAS domain-containing protein 1 ORF Sequence $750.00
hsa05211Renal cell carcinoma
hsa05200Pathways in cancer
Pathway Interaction Database
vegfr1_2_pathwaySignaling events mediated by VEGFR1 and VEGFR2
hif2pathwayHIF-2-alpha transcription factor network
REACT_121311Cellular response to hypoxia
REACT_120956Cellular responses to stress
REACT_120916Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha
REACT_120815Regulation of Hypoxia-inducible Factor (HIF) by Oxygen
REACT_121226Oxygen-dependent Asparagine Hydroxylation of Hypoxia-inducible Factor Alpha
REACT_121092Regulation of Gene Expression by Hypoxia-inducible Factor
Homo sapiens (human)EPAS1NP_001421.2
Pan troglodytes (chimpanzee)EPAS1XP_001147219.1
Macaca mulatta (Rhesus monkey)EPAS1XP_001112947.2
Canis lupus familiaris (dog)EPAS1XP_531807.2
Bos taurus (cattle)EPAS1NP_777150.1
Mus musculus (house mouse)Epas1NP_034267.3
Rattus norvegicus (Norway rat)Epas1NP_075578.1
Gallus gallus (chicken)EPAS1NP_990138.1
Danio rerio (zebrafish)epas1bNP_001034895.1
GeneCards EPAS1
PDB 3F1P, 1P97, 4GHI, 3F1O, 2A24, 3H82, 3F1N, 3H7W
UniProt B3KW07, Q99814
MIM 603349
Ensembl ENSG00000116016
HGNC 3374
HPRD 06787

GeneRIFs: Gene References Into Functions What's a GeneRIF?

General protein information

Preferred Names
endothelial PAS domain-containing protein 1
endothelial PAS domain-containing protein 1
HIF-1alpha-like factor
HIF-1-alpha-like factor
member of PAS protein 2
PAS domain-containing protein 2
hypoxia-inducible factor 2 alpha
hypoxia-inducible factor 2-alpha
basic-helix-loop-helix-PAS protein MOP2
class E basic helix-loop-helix protein 73


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