Sequence in raw or FASTA format:
EPHA3 EPH receptor A3 [Homo sapiens (human)]
| Gene Symbol | EPHA3 |
| Entrez Gene ID | 2042 |
| Full Name | EPH receptor A3 |
| Synonyms | EK4, ETK, ETK1, HEK, HEK4, TYRO4 |
| Gene Type | protein-coding |
| Organism | Homo sapiens (human) |
| Genome |
3 3p11.2 |
| Summary | This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. This gene encodes a protein that binds ephrin-A ligands. Two alternatively spliced transcript variants have been described for this gene. [provided by RefSeq]. |
| Disorder | MIM: 179611 |
| mRNA | NM_005233, 156547090 |
| Protein | NP_005224, 21361241 |
| Product | ephrin type-A receptor 3 isoform a precursor |
| RefSeq Status | REVIEWED |
| mRNA | NM_182644, 156547125 |
| Protein | NP_872585, 32967314 |
| Product | ephrin type-A receptor 3 isoform b precursor |
| RefSeq Status | REVIEWED |
| hsa04360 | Axon guidance |
Pathway Interaction Database
| epha_fwdpathway | EPHA forward signaling |
| ephrina_ephapathway | EphrinA-EPHA pathway |
| Homo sapiens (human) | EPHA3 | NP_005224.2 |
| Pan troglodytes (chimpanzee) | EPHA3 | XP_001136396.1 |
| Canis lupus familiaris (dog) | EPHA3 | XP_545052.2 |
| Bos taurus (cattle) | EPHA3 | XP_618140.3 |
| Mus musculus (house mouse) | Epha3 | NP_034270.1 |
| Rattus norvegicus (Norway rat) | Epha3 | NP_113752.1 |
| Gallus gallus (chicken) | EPHA3 | NP_990761.1 |
| Danio rerio (zebrafish) | epha3l | XP_001336188.2 |
| ID | Name | Evidence |
| GO:0001660 | fever generation | IEA |
| GO:0006468 | protein phosphorylation | IEA |
| GO:0007165 | signal transduction | TAS |
| GO:0007169 | transmembrane receptor protein tyrosine kinase signaling pathway | IEA |
| GO:0032496 | response to lipopolysaccharide | IEA |
| GO:0034097 | response to cytokine stimulus | IEA |
Component
| ID | Name | Evidence |
| GO:0005576 | extracellular region | IEA |
| GO:0005886 | plasma membrane | IEA |
| GO:0005887 | integral to plasma membrane | IEA |
Function
| ID | Name | Evidence |
| GO:0000166 | nucleotide binding | IEA |
| GO:0004714 | transmembrane receptor protein tyrosine kinase activity | TAS |
| GO:0004872 | receptor activity | IEA |
| GO:0005003 | ephrin receptor activity | IEA |
| GO:0005524 | ATP binding | IEA |
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