EPHA5 EPH receptor A5 [Homo sapiens (human)]
| Gene Symbol | EPHA5 |
| Entrez Gene ID | 2044 |
| Full Name | EPH receptor A5 |
| Synonyms | CEK7, EHK1, HEK7, TYRO4 |
| Gene Type | protein-coding |
| Organism | Homo sapiens (human) |
| Genome |
4 4q13.1 |
| Summary | This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]. |
| Disorder | MIM: 600004 |
| mRNA | NM_004439, 221625400 |
| Protein | NP_004430, 221625401 |
| Product | ephrin type-A receptor 5 isoform a precursor |
| RefSeq Status | REVIEWED |
| mRNA | NM_182472, 221625421 |
| Protein | NP_872272, 221625422 |
| Product | ephrin type-A receptor 5 isoform b precursor |
| RefSeq Status | REVIEWED |
| hsa04360 | Axon guidance |
Pathway Interaction Database
| ephrina_ephapathway | EphrinA-EPHA pathway |
| ephrinarevpathway | Ephrin A reverse signaling |
| epha_fwdpathway | EPHA forward signaling |
| Homo sapiens (human) | EPHA5 | NP_004430.4 |
| Pan troglodytes (chimpanzee) | EPHA5 | XP_001164976.1 |
| Mus musculus (house mouse) | Epha5 | NP_031963.2 |
| Gallus gallus (chicken) | EPHA5 | NP_990436.1 |
| Danio rerio (zebrafish) | ek1 | NP_571170.1 |
| Danio rerio (zebrafish) | epha4b | NP_705944.1 |
| ID | Name | Evidence |
| GO:0006468 | protein phosphorylation | IEA |
| GO:0019933 | cAMP-mediated signaling | ISS |
| GO:0048013 | ephrin receptor signaling pathway | ISS |
| GO:0048666 | neuron development | IEP |
Component
| ID | Name | Evidence |
| GO:0005791 | rough endoplasmic reticulum | IDA |
| GO:0005886 | plasma membrane | IDA |
| GO:0005887 | integral to plasma membrane | IEA |
| GO:0009897 | external side of plasma membrane | IDA |
| GO:0030425 | dendrite | IDA |
| GO:0043025 | neuronal cell body | IDA |
| GO:0048471 | perinuclear region of cytoplasm | IDA |
Function
| ID | Name | Evidence |
| GO:0000166 | nucleotide binding | IEA |
| GO:0004872 | receptor activity | IEA |
| GO:0005003 | ephrin receptor activity | ISS |
| GO:0005005 | transmembrane-ephrin receptor activity | NAS |
| GO:0005524 | ATP binding | IEA |
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