EPHB4 EPH receptor B4 [Homo sapiens (human)]
| Gene Symbol | EPHB4 |
| Entrez Gene ID | 2050 |
| Full Name | EPH receptor B4 |
| Synonyms | HTK, MYK1, TYRO11 |
| Gene Type | protein-coding |
| Organism | Homo sapiens (human) |
| Genome |
7 7q22 |
| Summary | Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. The protein encoded by this gene binds to ephrin-B2 and plays an essential role in vascular development. [provided by RefSeq]. |
| Disorder | MIM: 600011 |
| mRNA | NM_004444, 55774978 |
| Protein | NP_004435, 32528301 |
| Product | ephrin type-B receptor 4 precursor |
| RefSeq Status | REVIEWED |
| hsa04360 | Axon guidance |
Pathway Interaction Database
| ephrinbrevpathway | Ephrin B reverse signaling |
| ephbfwdpathway | EPHB forward signaling |
| ephrinb_ephbpathway | EphrinB-EPHB pathway |
| Homo sapiens (human) | EPHB4 | NP_004435.3 |
| Pan troglodytes (chimpanzee) | EPHB4 | XP_519269.2 |
| Canis lupus familiaris (dog) | EPHB4 | XP_546948.2 |
| Bos taurus (cattle) | EPHB4 | XP_874493.3 |
| Mus musculus (house mouse) | Ephb4 | NP_034274.3 |
| Danio rerio (zebrafish) | ephb4a | NP_571489.1 |
| Danio rerio (zebrafish) | ephb4b | NP_571492.1 |
| ID | Name | Evidence |
| GO:0006468 | protein phosphorylation | IEA |
| GO:0007169 | transmembrane receptor protein tyrosine kinase signaling pathway | IEA |
| GO:0008283 | cell proliferation | TAS |
| GO:0009887 | organ morphogenesis | TAS |
| GO:0045765 | regulation of angiogenesis | NAS |
Component
| ID | Name | Evidence |
| GO:0005887 | integral to plasma membrane | IEA |
| GO:0009986 | cell surface | IDA |
| GO:0016020 | membrane | IEA |
Function
| ID | Name | Evidence |
| GO:0000166 | nucleotide binding | IEA |
| GO:0004714 | transmembrane receptor protein tyrosine kinase activity | TAS |
| GO:0004872 | receptor activity | IEA |
| GO:0005003 | ephrin receptor activity | IEA |
| GO:0005524 | ATP binding | IEA |
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