Sequence in raw or FASTA format:
EPHB4 EPH receptor B4 [
Homo sapiens (human)]
Gene Symbol EPHB4
Entrez Gene ID
Full Name EPH receptor B4
Synonyms HTK, MYK1, TYRO11
General protein information
ephrin type-B receptor 4
ephrin type-B receptor 4
ephrin receptor EphB4
soluble EPHB4 variant 1
soluble EPHB4 variant 2
soluble EPHB4 variant 3
hepatoma transmembrane kinase
tyrosine-protein kinase TYRO11
tyrosine-protein kinase receptor HTK
Gene Type protein-coding
Homo sapiens (human)
Chromosome:7 Map Location:7q22
Summary Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. The protein encoded by this gene binds to ephrin-B2 and plays an essential role in vascular development. [provided by RefSeq, Jul 2008].
Pathway Interaction Database
ID Name Evidence
GO:0005887 integral component of plasma membrane IDA
GO:0070062 extracellular vesicular exosome IDA
2E7H, 2HLE, 2X9F, 2BBA, 2VWU, 2VWZ, 2YN8, 2VWW, 2VX1, 2VWX, 2XVD, 4BB4, 3ZEW, 2VWV, 2VX0, 4AW5, 2VWY, 2QKQ
Q96L35, P54760, Q541P7, Q7Z635
Related articles in PubMed EphB4 is overexpressed in gliomas and promotes the growth of glioma cells. Chen T, et al. Tumour Biol, 2013 Feb. PMID 23138393. Critical role for the receptor tyrosine kinase EPHB4 in esophageal cancers. Hasina R, et al. Cancer Res, 2013 Jan 1. PMID 23100466. Clinical implications of EphB4 receptor expression in pancreatic cancer. Li M, et al. Mol Biol Rep, 2013 Feb. PMID 23079712. Copy number variation in ACHE/EPHB4 (7q22) and in BCHE/MME (3q26) genes in sporadic breast cancer. Boberg DR, et al. Chem Biol Interact, 2013 Mar 25. PMID 23063927. Genome-wide association study for circulating levels of PAI-1 provides novel insights into its regulation. Huang J, et al. Blood, 2012 Dec 6. PMID 22990020. See all (81) citations in PubMed See citations in PubMed for homologs of this gene provided by HomoloGene
GeneRIFs: Gene References Into Functions
What's a GeneRIF?
EphB4 receptor expresion is correlated to the initiation, progression and tumor angiogenesis.
Title: Clinical implications of EphB4 receptor expression in pancreatic cancer.
verify amplification and/or deletion in the ACHE, BCHE, EPHB4 and MME genes in 32 samples of sporadic breast cancer
Title: Copy number variation in ACHE/EPHB4 (7q22) and in BCHE/MME (3q26) genes in sporadic breast cancer.
expression of EphB4 was significantly upregulated in clinical glioma samples; overexpression of EphB4 in glioma cell lines accelerated cell growth and tumorigenesis; downregulation of EphB4 inhibited cell growth
Title: EphB4 is overexpressed in gliomas and promotes the growth of glioma cells.
EphB4 is robustly expressed and potentially serves as a novel biomarker for targeted therapy in esophageal cancers
Title: Critical role for the receptor tyrosine kinase EPHB4 in esophageal cancers.
EphB4 plays an important role in the progression of papillary thyroid carcinoma by stimulating cell migration and EphB4 might be a potential therapeutic target in papillary thyroid carcinoma.
Title: EphB4 is overexpressed in papillary thyroid carcinoma and promotes the migration of papillary thyroid cancer cells.
EphB4 protein expression is significantly increased in non-small- cell lung cancer and corresponds to progression and severity of the disease.
Title: EphB4 gene polymorphism and protein expression in non-small-cell lung cancer.
EphB4/EphrinB2 expression has closed related to gennesis and progression of hepatoblastoma.
Title: Relationships among differentiation degree, contrast-enhanced ultrasound and the expression of Ephb4/Ephrinb2 in primary hepatocarcinoma.
Data indicated for the first time that EphrinB2 and EphB4 expressions increase according to the histopathological grade and KPS score of glioma, and their expression levels are related to the progression-free survival of glioblastoma patients.
Title: Expression of EphrinB2 and EphB4 in glioma tissues correlated to the progression of glioma and the prognosis of glioblastoma patients.
The expressions of ephrinB2 and EphB4 were significantly higher in NSCLC tissue than in control tissues, and were positively correlated with lymphatic metastasis.
Title: [Relationship between multi-slice spiral CT pulmonary perfusion imaging and the expression of EphB4 and ephrinB2 in non-small cell lung cancer].
Data found significant correlations between ephA2, ephA4, ephA7, ephB4, and ephB6 and overall and/or recurrence-free survival in large microarray datasets.
Title: Eph/ephrin profiling in human breast cancer reveals significant associations between expression level and clinical outcome.
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