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Sequence in raw or FASTA format:

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EPHB4 EPH receptor B4 [Homo sapiens (human)]


Clone ID RefSeq Accession Definition Vector Stock Status *Turnaround time Price Order
OHu13402 NM_004444 Homo sapiens EPH receptor B4 (EPHB4), mRNA. pcDNA3.1+-DYK On-demand 12-14 $279.00
OHu13402C NM_004444 Homo sapiens EPH receptor B4 (EPHB4), mRNA. Customized vector On-demand 12-14 $329.00

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Gene Symbol EPHB4
Entrez Gene ID 2050
Full Name EPH receptor B4
Synonyms HTK, MYK1, TYRO11
General protein information
Preferred Names
ephrin type-B receptor 4
Names
ephrin type-B receptor 4
ephrin receptor EphB4
soluble EPHB4 variant 1
soluble EPHB4 variant 2
soluble EPHB4 variant 3
hepatoma transmembrane kinase
tyrosine-protein kinase TYRO11
tyrosine-protein kinase receptor HTK
NP_004435.3
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

7

7q22

Summary Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. The protein encoded by this gene binds to ephrin-B2 and plays an essential role in vascular development. [provided by RefSeq, Jul 2008].
Disorder

MIM: 600011

mRNA Protein Product Sequence Price Select
NM_004444, 55774978 NP_004435, 32528301 ephrin type-B receptor 4 precursor ORF Sequence $750.00
KEGG
hsa04360Axon guidance
Pathway Interaction Database
ephrinb_ephbpathwayEphrinB-EPHB pathway
ephbfwdpathwayEPHB forward signaling
ephrinbrevpathwayEphrin B reverse signaling
Homo sapiens (human)EPHB4NP_004435.3
Pan troglodytes (chimpanzee)EPHB4XP_519269.3
Macaca mulatta (Rhesus monkey)EPHB4XP_002803271.1
Canis lupus familiaris (dog)EPHB4XP_546948.3
Bos taurus (cattle)EPHB4NP_001193197.1
Mus musculus (house mouse)Ephb4NP_001153043.1
Rattus norvegicus (Norway rat)Ephb4XP_003751205.1
Danio rerio (zebrafish)ephb4aNP_571489.1
Danio rerio (zebrafish)ephb4bNP_571492.1
Process
IDNameEvidence
GO:0001525angiogenesisISS
GO:0002042cell migration involved in sprouting angiogenesisIDA
GO:0003007heart morphogenesisISS
GO:0007155cell adhesionIDA
GO:0018108peptidyl-tyrosine phosphorylationIDA
GO:0018108peptidyl-tyrosine phosphorylationIEA
GO:0046777protein autophosphorylationIDA
GO:0048013ephrin receptor signaling pathwayIDA
Component
IDNameEvidence
GO:0005887integral component of plasma membraneIDA
GO:0070062extracellular vesicular exosomeIDA
Function
IDNameEvidence
GO:0004714transmembrane receptor protein tyrosine kinase activityIDA
GO:0005003ephrin receptor activityIDA
GO:0005515protein bindingIPI
GO:0005524ATP bindingIEA
GeneCards EPHB4
PDB 2E7H, 2HLE, 2X9F, 2BBA, 2VWU, 2VWZ, 2YN8, 2VWW, 2VX1, 2VWX, 2XVD, 4BB4, 3ZEW, 2VWV, 2VX0, 4AW5, 2VWY, 2QKQ
UniProt Q96L35, P54760, Q541P7, Q7Z635
Vega OTTHUMG00000157040
MIM 600011
Ensembl ENSG00000196411
HGNC 3395
HPRD 02481

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Interactant

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