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EPO erythropoietin [Homo sapiens (human)]


RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_000799 Homo sapiens erythropoietin (EPO), mRNA. GenEZ ORF Cloning In-stock $308.00 $259.00 10

*Business Day

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Gene Symbol EPO
Entrez Gene ID 2056
Full Name erythropoietin
Synonyms EP, MVCD2
General protein information
Preferred Names
erythropoietin
Names
erythropoietin
epoetin
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

7

7q22

Summary This gene is a member of the EPO/TPO family and encodes a secreted, glycosylated cytokine composed of four alpha helical bundles. The protein is found in the plasma and regulates red cell production by promoting erythroid differentiation and initiating hemoglobin synthesis. This protein also has neuroprotective activity against a variety of potential brain injuries and antiapoptotic functions in several tissue types. [provided by RefSeq, Jul 2008].
Disorder

MIM: 133170

{Microvascular complications of diabetes 2}, 612623 (3)

mRNA Protein Product Sequence Price Select
NM_000799, 62240996 NP_000790, 62240997 erythropoietin precursor ORF Sequence $159.00
KEGG
hsa04060Cytokine-cytokine receptor interaction
hsa04630Jak-STAT signaling pathway
hsa04640Hematopoietic cell lineage
hsa04151PI3K-Akt signaling pathway
hsa04066HIF-1 signaling pathway
WikiPathways
WP581EPO Receptor Signaling
Pathway Interaction Database
hif2pathwayHIF-2-alpha transcription factor network
a4b1_paxindep_pathwayPaxillin-independent events mediated by a4b1 and a4b7
hif1_tfpathwayHIF-1-alpha transcription factor network
kitpathwaySignaling events mediated by Stem cell factor receptor (c-Kit)
epopathwayEPO signaling pathway
Reactome
REACT_121311Cellular response to hypoxia
REACT_121092Regulation of gene expression by Hypoxia-inducible Factor
REACT_120956Cellular responses to stress
REACT_120815Regulation of Hypoxia-inducible Factor (HIF) by oxygen
Homo sapiens (human)EPONP_000790.2
Pan troglodytes (chimpanzee)EPOXP_519268.2
Macaca mulatta (Rhesus monkey)EPONP_001036201.1
Canis lupus familiaris (dog)EPONP_001006647.1
Bos taurus (cattle)EPONP_776334.1
Mus musculus (house mouse)EpoNP_031968.1
Rattus norvegicus (Norway rat)EpoNP_058697.1
Danio rerio (zebrafish)epoNP_001033098.1
Danio rerio (zebrafish)LOC100002479XP_001342254.1
Xenopus (Silurana) tropicalis (western clawed frog)epoNP_001233194.1
Process
IDNameEvidence
GO:0006915apoptotic processIEA
GO:0007165signal transductionNAS
GO:0007566embryo implantationIEA
GO:0007568agingIEA
GO:0008015blood circulationNAS
GO:0008284positive regulation of cell proliferationIDA
GO:0009651response to salt stressIEA
GO:0010523negative regulation of calcium ion transport into cytosolIDA
GO:0018105peptidyl-serine phosphorylationIEA
GO:0032496response to lipopolysaccharideIEA
GO:0033189response to vitamin AIEA
GO:0033574response to testosteroneIEA
GO:0042523positive regulation of tyrosine phosphorylation of Stat5 proteinIDA
GO:0042541hemoglobin biosynthetic processIEA
GO:0043249erythrocyte maturationIEA
GO:0043627response to estrogenIEA
GO:0045666positive regulation of neuron differentiationIEA
GO:0045740positive regulation of DNA replicationIDA
GO:0045860positive regulation of protein kinase activityIEA
GO:0045893positive regulation of transcription, DNA-templatedIDA
GO:0046579positive regulation of Ras protein signal transductionIDA
GO:0048678response to axon injuryIEA
GO:0051602response to electrical stimulusIEA
GO:0055093response to hyperoxiaIEA
GO:0061418regulation of transcription from RNA polymerase II promoter in response to hypoxiaTAS
GO:0070555response to interleukin-1IEA
GO:0071456cellular response to hypoxiaTAS
GO:0071474cellular hyperosmotic responseIDA
GO:1902219negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stressIDA
GO:1902251negative regulation of erythrocyte apoptotic processIDA
GO:2001258negative regulation of cation channel activityIDA
Component
IDNameEvidence
GO:0005576extracellular regionTAS
GO:0005615extracellular spaceIDA
GO:0009986cell surfaceIDA
Function
IDNameEvidence
GO:0005128erythropoietin receptor bindingIEA
GO:0005179hormone activityIEA
GO:0005515protein bindingIPI
GO:0030295protein kinase activator activityIEA
GeneCards EPO
PDB 1CN4, 1EER, 1BUY
UniProt G9JKG7, P01588
Vega OTTHUMG00000152121
MIM 133170
Ensembl ENSG00000130427
HGNC 3415
HPRD 00586

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Interactant

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