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EPO erythropoietin [Homo sapiens (human)]


RefSeq Accession Definition Services Price Order
NM_000799 Homo sapiens erythropoietin (EPO), mRNA. ORF Sequence $168.78
Peptide Services
Antibody Services
Protein Services


Gene Symbol EPO
Entrez Gene ID 2056
Full Name erythropoietin
Synonyms EP, MGC138142, MVCD2
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

7

7q22

Summary This gene is a member of the EPO/TPO family and encodes a secreted, glycosylated cytokine composed of four alpha helical bundles. The protein is found in the plasma and regulates red cell production by promoting erythroid differentiation and initiating hemoglobin synthesis. This protein also has neuroprotective activity against a variety of potential brain injuries and antiapoptotic functions in several tissue types. [provided by RefSeq, Jul 2008].
Disorder

MIM: 133170

{Microvascular complications of diabetes 2}, 612623 (3)

mRNA Protein Product Sequence Price Select
NM_000799, 62240996 NP_000790, 62240997 erythropoietin precursor Full Length $388.60
ORF Sequence $168.78
KEGG
hsa04066HIF-1 signaling pathway
hsa04640Hematopoietic cell lineage
hsa04060Cytokine-cytokine receptor interaction
hsa04630Jak-STAT signaling pathway
hsa04151PI3K-Akt signaling pathway
WikiPathways
WP581EPO Receptor Signaling
Pathway Interaction Database
hif2pathwayHIF-2-alpha transcription factor network
epopathwayEPO signaling pathway
a4b1_paxindep_pathwayPaxillin-independent events mediated by a4b1 and a4b7
hif1_tfpathwayHIF-1-alpha transcription factor network
kitpathwaySignaling events mediated by Stem cell factor receptor (c-Kit)
Reactome
REACT_121311Cellular response to hypoxia
REACT_120815Regulation of Hypoxia-inducible Factor (HIF) by Oxygen
REACT_121092Regulation of Gene Expression by Hypoxia-inducible Factor
REACT_120956Cellular responses to stress
Homo sapiens (human)EPONP_000790.2
Pan troglodytes (chimpanzee)EPOXP_519268.2
Macaca mulatta (Rhesus monkey)EPONP_001036201.1
Canis lupus familiaris (dog)EPONP_001006647.1
Bos taurus (cattle)EPONP_776334.1
Mus musculus (house mouse)EpoNP_031968.1
Rattus norvegicus (Norway rat)EpoNP_058697.1
Danio rerio (zebrafish)epoNP_001108600.1
Danio rerio (zebrafish)LOC100002479XP_001342254.1
GeneCards EPO
PDB 1CN4, 1EER, 1BUY
UniProt G9JKG7, P01588
MIM 133170
Ensembl ENSG00000130427
HGNC 3415
HPRD 00586

GeneRIFs: Gene References Into Functions What's a GeneRIF?

General protein information

Preferred Names
erythropoietin
Names
erythropoietin
epoetin

Interactant

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