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Sequence in raw or FASTA format:

Database:

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ERBB2 v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 [Homo sapiens (human)]


Clone ID RefSeq Accession Definition Vector Stock Status *Turnaround time Price Order
OHu23956 NM_001289936 Homo sapiens v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 (ERBB2), transcript variant 3, mRNA. pcDNA3.1+-DYK On-demand 25 $1699.00
OHu24035 NM_001289937 Homo sapiens v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 (ERBB2), transcript variant 4, mRNA. pcDNA3.1+-DYK On-demand 25 $1699.00
OHu27526 NM_001289938 Homo sapiens v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 (ERBB2), transcript variant 5, mRNA. pcDNA3.1+-DYK On-demand 7-9 $219.00
OHu27580 NM_001005862 Homo sapiens v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 (ERBB2), transcript variant 2, mRNA. pcDNA3.1+-DYK On-demand 25 $1699.00
OHu27656 NM_004448 Homo sapiens v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 (ERBB2), transcript variant 1, mRNA. pcDNA3.1+-DYK On-demand 25 $1699.00
OHu50199 XM_006721765 PREDICTED: Homo sapiens v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 (ERBB2), transcript variant X3, mRNA. pcDNA3.1+-DYK On-demand TBD TBD
OHu27580 XM_005257140 PREDICTED: Homo sapiens v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 (ERBB2), transcript variant X2, mRNA. pcDNA3.1+-DYK On-demand 25 $1699.00
OHu50200 XM_006721767 PREDICTED: Homo sapiens v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 (ERBB2), transcript variant X5, mRNA. pcDNA3.1+-DYK On-demand TBD TBD
OHu50201 XM_006721768 PREDICTED: Homo sapiens v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 (ERBB2), transcript variant X6, mRNA. pcDNA3.1+-DYK On-demand TBD TBD
OHu23956C NM_001289936 Homo sapiens v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 (ERBB2), transcript variant 3, mRNA. Customized vector On-demand 25 $1699.00
OHu24035C NM_001289937 Homo sapiens v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 (ERBB2), transcript variant 4, mRNA. Customized vector On-demand 25 $1699.00
OHu27526C NM_001289938 Homo sapiens v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 (ERBB2), transcript variant 5, mRNA. Customized vector On-demand 7-9 $269.00
OHu27580C NM_001005862 Homo sapiens v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 (ERBB2), transcript variant 2, mRNA. Customized vector On-demand 25 $1699.00
OHu27656C NM_004448 Homo sapiens v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 (ERBB2), transcript variant 1, mRNA. Customized vector On-demand 25 $1699.00
OHu50199C XM_006721765 PREDICTED: Homo sapiens v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 (ERBB2), transcript variant X3, mRNA. Customized vector On-demand TBD $1699.00
OHu27580C XM_005257140 PREDICTED: Homo sapiens v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 (ERBB2), transcript variant X2, mRNA. Customized vector On-demand 25 $1699.00
OHu50200C XM_006721767 PREDICTED: Homo sapiens v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 (ERBB2), transcript variant X5, mRNA. Customized vector On-demand TBD $329.00
OHu50201C XM_006721768 PREDICTED: Homo sapiens v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 (ERBB2), transcript variant X6, mRNA. Customized vector On-demand TBD $329.00

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Gene Symbol ERBB2
Entrez Gene ID 2064
Full Name v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2
Synonyms CD340, HER-2, HER-2/neu, HER2, MLN 19, NEU, NGL, TKR1
General protein information
Preferred Names
receptor tyrosine-protein kinase erbB-2
Names
receptor tyrosine-protein kinase erbB-2
herstatin
p185erbB2
proto-oncogene Neu
c-erb B2/neu protein
proto-oncogene c-ErbB-2
metastatic lymph node gene 19 protein
neuro/glioblastoma derived oncogene homolog
tyrosine kinase-type cell surface receptor HER2
neuroblastoma/glioblastoma derived oncogene homolog
v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog
NP_001005862.1
NP_004439.2
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

17

17q12

Summary This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized. [provided by RefSeq, Jul 2008].
Disorder

MIM: 164870

Adenocarcinoma of lung, somatic, 211980 (3); Glioblastoma, somatic,

mRNA Protein Product Sequence Price Select
NM_001005862, 584277101 NP_001005862, 54792098 receptor tyrosine-protein kinase erbB-2 isoform b ORF Sequence $1500.00
NM_001289936, 584277102 NP_001276865, 584277103 receptor tyrosine-protein kinase erbB-2 isoform c ORF Sequence $1500.00
NM_001289937, 584277105 NP_001276866, 584277106 receptor tyrosine-protein kinase erbB-2 isoform d precursor ORF Sequence $1500.00
NM_001289938, 584277108 NP_001276867, 584277109 receptor tyrosine-protein kinase erbB-2 isoform e ORF Sequence $700.00
NM_004448, 584277099 NP_004439, 54792096 receptor tyrosine-protein kinase erbB-2 isoform a precursor ORF Sequence $1500.00
XM_005257140, 530411753 XP_005257197, 530411754 receptor tyrosine-protein kinase erbB-2 isoform X2 ORF Sequence $1500.00
XM_006721765, 578830589 XP_006721828, 578830590 receptor tyrosine-protein kinase erbB-2 isoform X3 ORF Sequence $1500.00
XM_006721767, 578830593 XP_006721830, 578830594 receptor tyrosine-protein kinase erbB-2 isoform X5 ORF Sequence $700.00
XM_006721768, 578830595 XP_006721831, 578830596 receptor tyrosine-protein kinase erbB-2 isoform X6 ORF Sequence $700.00
KEGG
hsa04012ErbB signaling pathway
hsa04020Calcium signaling pathway
hsa04510Focal adhesion
hsa04520Adherens junction
hsa05213Endometrial cancer
hsa05215Prostate cancer
hsa05212Pancreatic cancer
hsa05219Bladder cancer
hsa05200Pathways in cancer
hsa05223Non-small cell lung cancer
hsa04066HIF-1 signaling pathway
hsa05205Proteoglycans in cancer
hsa05206MicroRNAs in cancer
WikiPathways
WP244Alpha6-Beta4 Integrin Signaling Pathway
WP710DNA damage response (only ATM dependent)
WP673ErbB signaling pathway
WP364IL-6 Signaling Pathway
WP2377Integrated Pancreatic Cancer Pathway
WP2034Leptin signaling pathway
WP2261Signaling Pathways in Glioblastoma
WP2037Prolactin Signaling Pathway
Pathway Interaction Database
erbb4_pathwayErbB4 signaling events
erbb2erbb3pathwayErbB2/ErbB3 signaling events
a6b1_a6b4_integrin_pathwaya6b1 and a6b4 Integrin signaling
erbb_network_pathwayErbB receptor signaling network
myc_represspathwayValidated targets of C-MYC transcriptional repression
Reactome
REACT_18266Axon guidance
REACT_19259Sema4D in semaphorin signaling
REACT_19277Sema4D induced cell migration and growth-cone collapse
REACT_19271Semaphorin interactions
REACT_9470Signaling by FGFR
REACT_12578GAB1 signalosome
REACT_9417Signaling by EGFR
REACT_16888Signaling by PDGF
REACT_6900Immune System
REACT_6802Innate Immune System
REACT_17025Downstream signal transduction
REACT_11061Signalling by NGF
REACT_12464PI3K/AKT activation
REACT_12056NGF signalling via TRKA from the plasma membrane
REACT_21272Downstream signaling of activated FGFR
REACT_21270PI-3K cascade
REACT_75774Adaptive Immune System
REACT_75829PIP3 activates AKT signaling
REACT_111102Signal Transduction
REACT_111045Developmental Biology
REACT_111040Signaling by SCF-KIT
REACT_147727Constitutive PI3K/AKT Signaling in Cancer
REACT_147723PI3K/AKT Signaling in Cancer
REACT_147694DAP12 interactions
REACT_147814DAP12 signaling
REACT_115896GRB7 events in ERBB2 signaling
REACT_115596Signaling by ERBB4
REACT_115755Signaling by ERBB2
REACT_115854GRB2 events in ERBB2 signaling
REACT_115993SHC1 events in ERBB2 signaling
REACT_116008PI3K events in ERBB2 signaling
REACT_116125Disease
REACT_115662Downregulation of ERBB2:ERBB3 signaling
REACT_115720PLCG1 events in ERBB2 signaling
REACT_115871Signaling by EGFR in Cancer
REACT_115961PI3K events in ERBB4 signaling
REACT_118773Signaling by the B Cell Receptor (BCR)
REACT_118638Downstream signaling events of B Cell Receptor (BCR)
REACT_120736Signaling by FGFR in disease
REACT_163936Fc epsilon receptor (FCERI) signaling
REACT_163769Role of LAT2/NTAL/LAB on calcium mobilization
Homo sapiens (human)ERBB2NP_004439.2
Pan troglodytes (chimpanzee)ERBB2XP_003315512.2
Macaca mulatta (Rhesus monkey)ERBB2XP_001090430.1
Canis lupus familiaris (dog)ERBB2NP_001003217.1
Bos taurus (cattle)ERBB2XP_003587474.1
Mus musculus (house mouse)Erbb2NP_001003817.1
Rattus norvegicus (Norway rat)Erbb2NP_058699.2
Gallus gallus (chicken)ERBB2NP_001038126.1
Danio rerio (zebrafish)erbb2NP_956413.2
Xenopus (Silurana) tropicalis (western clawed frog)erbb2XP_002940420.2
Process
IDNameEvidence
GO:0001934positive regulation of protein phosphorylationISS
GO:0006351transcription, DNA-templatedIEA
GO:0006468protein phosphorylationTAS
GO:0007165signal transductionIDA
GO:0007166cell surface receptor signaling pathwayIDA
GO:0007167enzyme linked receptor protein signaling pathwayTAS
GO:0007169transmembrane receptor protein tyrosine kinase signaling pathwayIDA
GO:0007169transmembrane receptor protein tyrosine kinase signaling pathwayTAS
GO:0007173epidermal growth factor receptor signaling pathwayTAS
GO:0007399nervous system developmentTAS
GO:0007411axon guidanceTAS
GO:0007422peripheral nervous system developmentIEA
GO:0007507heart developmentTAS
GO:0007528neuromuscular junction developmentIEA
GO:0008045motor neuron axon guidanceIEA
GO:0008283cell proliferationTAS
GO:0008543fibroblast growth factor receptor signaling pathwayTAS
GO:0014065phosphatidylinositol 3-kinase signalingIDA
GO:0018108peptidyl-tyrosine phosphorylationIDA
GO:0018108peptidyl-tyrosine phosphorylationIEA
GO:0018108peptidyl-tyrosine phosphorylationIGI
GO:0018108peptidyl-tyrosine phosphorylationTAS
GO:0023014signal transduction by phosphorylationIEA
GO:0023014signal transduction by phosphorylationTAS
GO:0030307positive regulation of cell growthIMP
GO:0030879mammary gland developmentTAS
GO:0032321positive regulation of Rho GTPase activityISS
GO:0032886regulation of microtubule-based processIDA
GO:0033088negative regulation of immature T cell proliferation in thymusIEA
GO:0038095Fc-epsilon receptor signaling pathwayTAS
GO:0042060wound healingIDA
GO:0042552myelinationIEA
GO:0043406positive regulation of MAP kinase activityIDA
GO:0045087innate immune responseTAS
GO:0045727positive regulation of translationIMP
GO:0045765regulation of angiogenesisNAS
GO:0045785positive regulation of cell adhesionIDA
GO:0045943positive regulation of transcription from RNA polymerase I promoterIMP
GO:0045945positive regulation of transcription from RNA polymerase III promoterIDA
GO:0046777protein autophosphorylationIDA
GO:0048011neurotrophin TRK receptor signaling pathwayTAS
GO:0048015phosphatidylinositol-mediated signalingNAS
GO:0048015phosphatidylinositol-mediated signalingTAS
GO:0050679positive regulation of epithelial cell proliferationIDA
GO:0070372regulation of ERK1 and ERK2 cascadeIMP
Component
IDNameEvidence
GO:0005634nucleusIDA
GO:0005737cytoplasmIDA
GO:0005886plasma membraneIDA
GO:0005886plasma membraneNAS
GO:0005886plasma membraneTAS
GO:0010008endosome membraneIDA
GO:0016021integral component of membraneNAS
GO:0016323basolateral plasma membraneIDA
GO:0016324apical plasma membraneIEA
GO:0031410cytoplasmic vesicleIEA
GO:0043235receptor complexIDA
GO:0043235receptor complexTAS
GO:0048471perinuclear region of cytoplasmIEA
Function
IDNameEvidence
GO:0001042RNA polymerase I core bindingIDA
GO:0004713protein tyrosine kinase activityIDA
GO:0004713protein tyrosine kinase activityIGI
GO:0004713protein tyrosine kinase activityTAS
GO:0004714transmembrane receptor protein tyrosine kinase activityIDA
GO:0004716receptor signaling protein tyrosine kinase activityIEA
GO:0004888transmembrane signaling receptor activityIDA
GO:0005006epidermal growth factor-activated receptor activityNAS
GO:0005515protein bindingIPI
GO:0005524ATP bindingIEA
GO:0008022protein C-terminus bindingIPI
GO:0019838growth factor bindingIDA
GO:0019903protein phosphatase bindingIPI
GO:0042802identical protein bindingIPI
GO:0043125ErbB-3 class receptor bindingTAS
GO:0046982protein heterodimerization activityIDA
GO:0046982protein heterodimerization activityIPI
GO:0046982protein heterodimerization activityNAS
GO:0046983protein dimerization activityNAS
GeneCards ERBB2
UniProt X5DNK3, F5H1T4, J3QLU9, P04626
Vega OTTHUMG00000179300
MIM 164870
Ensembl ENSG00000141736
HGNC 3430
HPRD 01281

GeneRIFs: Gene References Into Functions What's a GeneRIF?

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