ERBB2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) [Homo sapiens (human)]

Summary
mRNA and Protein
Pathway
Homologues
Gene Ontology
Links to Other Databases

Gene Symbol	ERBB2
Entrez Gene ID	2064
Full Name	v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)
Synonyms	CD340, HER-2, HER-2/neu, HER2, MLN 19, NEU, NGL, TKR1
Gene Type	protein-coding
Organism	Homo sapiens (human)
Genome	Chromosome:17 Map Location:17q11.2-q12\|17q21.1
Summary	This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized. [provided by RefSeq].
Disorder	MIM: 164870 Adenocarcinoma of lung, somatic, 211980 (3); Glioblastoma, somatic,

mRNA	NM_004448, 54792095
Protein	NP_004439, 54792096
Product	receptor tyrosine-protein kinase erbB-2 isoform a
RefSeq Status	REVIEWED
mRNA	NM_001005862, 54792097
Protein	NP_001005862, 54792098
Product	receptor tyrosine-protein kinase erbB-2 isoform b
RefSeq Status	REVIEWED

KEGG

hsa04520	Adherens junction
hsa05223	Non-small cell lung cancer
hsa05200	Pathways in cancer
hsa04012	ErbB signaling pathway
hsa05219	Bladder cancer
hsa05212	Pancreatic cancer
hsa04510	Focal adhesion
hsa05213	Endometrial cancer
hsa04020	Calcium signaling pathway
hsa05215	Prostate cancer

WikiPathways

WP364	IL-6 Signaling Pathway
WP306	Focal Adhesion
WP244	Alpha6-Beta4 Integrin Signaling Pathway
WP673	ErbB signaling pathway

Pathway Interaction Database

erbb2erbb3pathway	ErbB2/ErbB3 signaling events
erbb_network_pathway	ErbB receptor signaling network
a6b1_a6b4_integrin_pathway	a6b1 and a6b4 Integrin signaling
myc_represspathway	Validated targets of C-MYC transcriptional repression
erbb4_pathway	ErbB4 signaling events

Reactome

REACT_18266	Axon guidance
REACT_19259	Sema4D in semaphorin signaling
REACT_19277	Sema4D induced cell migration and growth-cone collapse
REACT_19271	Semaphorin interactions

Homo sapiens (human)	ERBB2	NP_004439.2
Canis lupus familiaris (dog)	ERBB2	NP_001003217.1
Mus musculus (house mouse)	Erbb2	NP_001003817.1
Rattus norvegicus (Norway rat)	Erbb2	NP_058699.2
Gallus gallus (chicken)	ERBB2	NP_001038126.1
Danio rerio (zebrafish)	erbb2	NP_956413.2

Process

ID	Name	Evidence
GO:0001889	liver development	IEA
GO:0006355	regulation of transcription, DNA-dependent	IEA
GO:0006468	protein phosphorylation	TAS
GO:0007165	signal transduction	IDA
GO:0007166	cell surface receptor linked signaling pathway	IDA
GO:0007167	enzyme linked receptor protein signaling pathway	TAS
GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	IDA
GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	TAS
GO:0007173	epidermal growth factor receptor signaling pathway	NAS
GO:0007399	nervous system development	TAS
GO:0007411	axon guidance	TAS
GO:0007422	peripheral nervous system development	IEA
GO:0007507	heart development	TAS
GO:0007519	skeletal muscle tissue development	IEA
GO:0007528	neuromuscular junction development	IEA
GO:0008045	motor axon guidance	IEA
GO:0008283	cell proliferation	TAS
GO:0010001	glial cell differentiation	IEA
GO:0014065	phosphatidylinositol 3-kinase cascade	IDA
GO:0014068	positive regulation of phosphatidylinositol 3-kinase cascade	IEA
GO:0030879	mammary gland development	TAS
GO:0032570	response to progesterone stimulus	IEA
GO:0032886	regulation of microtubule-based process	IDA
GO:0033088	negative regulation of immature T cell proliferation in thymus	IEA
GO:0042060	wound healing	IDA
GO:0042493	response to drug	IEA
GO:0042552	myelination	IEA
GO:0043066	negative regulation of apoptosis	IEA
GO:0043406	positive regulation of MAP kinase activity	IDA
GO:0043410	positive regulation of MAPKKK cascade	IEA
GO:0043586	tongue development	IEA
GO:0045765	regulation of angiogenesis	NAS
GO:0045785	positive regulation of cell adhesion	IDA
GO:0046579	positive regulation of Ras protein signal transduction	IEA
GO:0046777	protein autophosphorylation	IDA
GO:0048015	phosphatidylinositol-mediated signaling	NAS
GO:0048485	sympathetic nervous system development	IEA
GO:0048678	response to axon injury	IEA
GO:0050679	positive regulation of epithelial cell proliferation	IDA
GO:0060056	mammary gland involution	IEA
GO:0060209	estrus	IEA

Component

ID	Name	Evidence
GO:0005634	nucleus	IEA
GO:0005737	cytoplasm	IEA
GO:0005886	plasma membrane	NAS
GO:0005886	plasma membrane	TAS
GO:0005902	microvillus	IEA
GO:0009925	basal plasma membrane	IEA
GO:0016021	integral to membrane	NAS
GO:0016323	basolateral plasma membrane	IDA
GO:0016324	apical plasma membrane	IEA
GO:0043219	lateral loop	IEA
GO:0043235	receptor complex	IDA
GO:0043235	receptor complex	TAS
GO:0045121	membrane raft	IEA
GO:0045211	postsynaptic membrane	IEA
GO:0048471	perinuclear region of cytoplasm	IEA

Function

ID	Name	Evidence
GO:0000166	nucleotide binding	IEA
GO:0001948	glycoprotein binding	IEA
GO:0003677	DNA binding	IEA
GO:0004713	protein tyrosine kinase activity	IDA
GO:0004713	protein tyrosine kinase activity	IGI
GO:0004713	protein tyrosine kinase activity	TAS
GO:0004714	transmembrane receptor protein tyrosine kinase activity	IDA
GO:0004716	receptor signaling protein tyrosine kinase activity	IEA
GO:0004888	transmembrane receptor activity	IDA
GO:0005006	epidermal growth factor receptor activity	NAS
GO:0005515	protein binding	IPI
GO:0005524	ATP binding	IEA
GO:0008022	protein C-terminus binding	IPI
GO:0019838	growth factor binding	IDA
GO:0019903	protein phosphatase binding	IPI
GO:0031625	ubiquitin protein ligase binding	IEA
GO:0042802	identical protein binding	IPI
GO:0043125	ErbB-3 class receptor binding	TAS
GO:0046982	protein heterodimerization activity	IDA
GO:0046982	protein heterodimerization activity	IPI
GO:0046982	protein heterodimerization activity	NAS
GO:0046983	protein dimerization activity	NAS
GO:0051879	Hsp90 protein binding	IEA

GeneCards	ERBB2
PDB	3N85, 3H3B, 1N8Z, 2JWA, 1S78, 3MZW, 2A91, 3BE1, 2KS1, 1QR1, 1MFG, 1OVC, 1MW4, 2L4K, 1MFL
UniProt	P04626
MIM	164870
Ensembl	ENSG00000141736
HGNC	3430
HPRD	01281

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RefSeq Accession	Definition	Sequence	Price	Select
NM_004448	Homo sapiens v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) (ERBB2), transcript variant 1, mRNA.	Full Length	$1618.40
NM_004448		ORF Sequence	$1318.80
NM_001005862	Homo sapiens v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) (ERBB2), transcript variant 2, mRNA.	Full Length	$1685.60
NM_001005862		ORF Sequence	$1287.30