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ERBB2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) [Homo sapiens (human)]


RefSeq Accession Definition Services Price Order
NM_001005862 Homo sapiens v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) (ERBB2), transcript variant 2, mRNA. ORF Sequence $1287.30
Peptide Services
Antibody Services
Protein Services
NM_004448 Homo sapiens v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) (ERBB2), transcript variant 1, mRNA. ORF Sequence $1318.80
Peptide Services
Antibody Services
Protein Services


Gene Symbol ERBB2
Entrez Gene ID 2064
Full Name v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)
Synonyms CD340, HER-2, HER-2/neu, HER2, MLN 19, NEU, NGL, TKR1
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

17

17q11.2-q12|17q21.1

Summary This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized. [provided by RefSeq, Jul 2008].
Disorder

MIM: 164870

Adenocarcinoma of lung, somatic, 211980 (3); Glioblastoma, somatic,

mRNA Protein Product Sequence Price Select
NM_001005862, 54792097 NP_001005862, 54792098 receptor tyrosine-protein kinase erbB-2 isoform b Full Length $1685.60
ORF Sequence $1287.30
NM_004448, 54792095 NP_004439, 54792096 receptor tyrosine-protein kinase erbB-2 isoform a Full Length $1618.40
ORF Sequence $1318.80
KEGG
hsa05213Endometrial cancer
hsa05215Prostate cancer
hsa04020Calcium signaling pathway
hsa04520Adherens junction
hsa05223Non-small cell lung cancer
hsa05200Pathways in cancer
hsa04012ErbB signaling pathway
hsa05219Bladder cancer
hsa05212Pancreatic cancer
hsa04066HIF-1 signaling pathway
hsa04510Focal adhesion
Pathway Interaction Database
erbb2erbb3pathwayErbB2/ErbB3 signaling events
erbb4_pathwayErbB4 signaling events
erbb_network_pathwayErbB receptor signaling network
a6b1_a6b4_integrin_pathwaya6b1 and a6b4 Integrin signaling
myc_represspathwayValidated targets of C-MYC transcriptional repression
WikiPathways
WP673ErbB signaling pathway
WP2261Signaling Pathways in Glioblastoma
WP710DNA damage response (only ATM dependent)
WP2377Integrated Pancreatic Cancer Pathway
WP364IL-6 Signaling Pathway
WP2037Prolactin Signaling Pathway
WP306Focal Adhesion
WP2256Integrated Pancreatic Cancer Pathway
WP244Alpha6-Beta4 Integrin Signaling Pathway
WP2034Leptin signaling pathway
Reactome
REACT_19271Semaphorin interactions
REACT_75829PIP3 activates AKT signaling
REACT_147814DAP12 signaling
REACT_120736Signaling by FGFR in disease
REACT_16888Signaling by PDGF
REACT_115896GRB7 events in ERBB2 signaling
REACT_11061Signalling by NGF
REACT_12464PI3K/AKT activation
REACT_12578GAB1 signalosome
REACT_21272Downstream signaling of activated FGFR
REACT_9470Signaling by FGFR
REACT_118773Signaling by the B Cell Receptor (BCR)
REACT_9417Signaling by EGFR
REACT_116008PI3K events in ERBB2 signaling
REACT_6802Innate Immune System
REACT_115720PLCG1 events in ERBB2 signaling
REACT_18266Axon guidance
REACT_19259Sema4D in semaphorin signaling
REACT_115662Downregulation of ERBB2:ERBB3 signaling
REACT_12056NGF signalling via TRKA from the plasma membrane
REACT_75774Adaptive Immune System
REACT_111102Signal Transduction
REACT_116125Disease
REACT_17025Downstream signal transduction
REACT_118638Downstream Signaling Events Of B Cell Receptor (BCR)
REACT_115993SHC1 events in ERBB2 signaling
REACT_147723PI3K/AKT Signaling in Cancer
REACT_111040Signaling by SCF-KIT
REACT_21270PI-3K cascade
REACT_115871Signaling by EGFR in Cancer
REACT_115755Signaling by ERBB2
REACT_147727Constitutive PI3K/AKT Signaling in Cancer
REACT_115596Signaling by ERBB4
REACT_147694DAP12 interactions
REACT_115961PI3K events in ERBB4 signaling
REACT_6900Immune System
REACT_115854GRB2 events in ERBB2 signaling
REACT_111045Developmental Biology
REACT_19277Sema4D induced cell migration and growth-cone collapse
Homo sapiens (human)ERBB2NP_004439.2
Pan troglodytes (chimpanzee)ERBB2XP_003315512.2
Macaca mulatta (Rhesus monkey)ERBB2XP_001090430.1
Canis lupus familiaris (dog)ERBB2NP_001003217.1
Bos taurus (cattle)LOC505709XP_003587474.1
Mus musculus (house mouse)Erbb2NP_001003817.1
Rattus norvegicus (Norway rat)Erbb2NP_058699.2
Gallus gallus (chicken)ERBB2NP_001038126.1
Danio rerio (zebrafish)erbb2NP_956413.2
GeneCards ERBB2
PDB 3N85, 3H3B, 3RCD, 2A91, 3PP0, 1MFL, 1N8Z, 2JWA, 1S78, 3MZW, 1QR1, 2KS1, 3BE1, 1MFG, 1OVC, 1MW4, 2L4K
UniProt P04626
MIM 164870
Ensembl ENSG00000141736
HGNC 3430
HPRD 01281

GeneRIFs: Gene References Into Functions What's a GeneRIF?

General protein information

Preferred Names
receptor tyrosine-protein kinase erbB-2
Names
receptor tyrosine-protein kinase erbB-2
herstatin
p185erbB2
proto-oncogene Neu
c-erb B2/neu protein
proto-oncogene c-ErbB-2
metastatic lymph node gene 19 protein
neuro/glioblastoma derived oncogene homolog
tyrosine kinase-type cell surface receptor HER2
neuroblastoma/glioblastoma derived oncogene homolog
v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog
NP_001005862.1
NP_004439.2

Interactant

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