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ERBB3 v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3 [Homo sapiens (human)]


Clone ID RefSeq Accession Definition Vector Stock Status *Turnaround time Price Order
OHu20847 NM_001005915 Homo sapiens v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3 (ERBB3), transcript variant s, mRNA. pcDNA3.1+-DYK On-demand 7-9 $159.00
OHu27015 NM_001982 Homo sapiens v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3 (ERBB3), transcript variant 1, mRNA. pcDNA3.1+-DYK In-stock 16 $1149.00
OHu20847C NM_001005915 Homo sapiens v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3 (ERBB3), transcript variant s, mRNA. Customized vector On-demand 7-9 $209.00
OHu27015C NM_001982 Homo sapiens v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3 (ERBB3), transcript variant 1, mRNA. Customized vector In-stock 16 $1149.00

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Gene Symbol ERBB3
Entrez Gene ID 2065
Full Name v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3
Synonyms ErbB-3, HER3, LCCS2, MDA-BF-1, c-erbB-3, c-erbB3, erbB3-S, p180-ErbB3, p45-sErbB3, p85-sErbB3
General protein information
Preferred Names
receptor tyrosine-protein kinase erbB-3
Names
receptor tyrosine-protein kinase erbB-3
proto-oncogene-like protein c-ErbB-3
tyrosine kinase-type cell surface receptor HER3
NP_001005915.1
NP_001973.2
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

12

12q13

Summary This gene encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound protein has a neuregulin binding domain but not an active kinase domain. It therefore can bind this ligand but not convey the signal into the cell through protein phosphorylation. However, it does form heterodimers with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation of pathways which lead to cell proliferation or differentiation. Amplification of this gene and/or overexpression of its protein have been reported in numerous cancers, including prostate, bladder, and breast tumors. Alternate transcriptional splice variants encoding different isoforms have been characterized. One isoform lacks the intermembrane region and is secreted outside the cell. This form acts to modulate the activity of the membrane-bound form. Additional splice variants have also been reported, but they have not been thoroughly characterized. [provided by RefSeq, Jul 2008].
Disorder

MIM: 190151

Lethal congenital contractural syndrome 2, 607598 (3)

mRNA Protein Product Sequence Price Select
NM_001005915, 54792101 NP_001005915, 54792102 receptor tyrosine-protein kinase erbB-3 isoform s precursor ORF Sequence $250.00
NM_001982, 317171925 NP_001973, 54792100 receptor tyrosine-protein kinase erbB-3 isoform 1 precursor ORF Sequence $999.00
KEGG
hsa04012ErbB signaling pathway
hsa04020Calcium signaling pathway
hsa04144Endocytosis
hsa05205Proteoglycans in cancer
hsa05206MicroRNAs in cancer
WikiPathways
WP1591Heart Development
WP673ErbB signaling pathway
WP364IL-6 Signaling Pathway
WP2261Signaling Pathways in Glioblastoma
Pathway Interaction Database
erbb2erbb3pathwayErbB2/ErbB3 signaling events
a6b1_a6b4_integrin_pathwaya6b1 and a6b4 Integrin signaling
erbb_network_pathwayErbB receptor signaling network
Reactome
REACT_9470Signaling by FGFR
REACT_12578GAB1 signalosome
REACT_9417Signaling by EGFR
REACT_16888Signaling by PDGF
REACT_6900Immune System
REACT_6802Innate Immune System
REACT_17025Downstream signal transduction
REACT_11061Signalling by NGF
REACT_12464PI3K/AKT activation
REACT_12056NGF signalling via TRKA from the plasma membrane
REACT_21272Downstream signaling of activated FGFR
REACT_21270PI-3K cascade
REACT_75774Adaptive Immune System
REACT_75829PIP3 activates AKT signaling
REACT_111102Signal Transduction
REACT_111040Signaling by SCF-KIT
REACT_147727Constitutive PI3K/AKT Signaling in Cancer
REACT_147723PI3K/AKT Signaling in Cancer
REACT_147694DAP12 interactions
REACT_147814DAP12 signaling
REACT_115896GRB7 events in ERBB2 signaling
REACT_115596Signaling by ERBB4
REACT_115755Signaling by ERBB2
REACT_115993SHC1 events in ERBB2 signaling
REACT_116008PI3K events in ERBB2 signaling
REACT_116125Disease
REACT_115662Downregulation of ERBB2:ERBB3 signaling
REACT_115871Signaling by EGFR in Cancer
REACT_115961PI3K events in ERBB4 signaling
REACT_118773Signaling by the B Cell Receptor (BCR)
REACT_118638Downstream signaling events of B Cell Receptor (BCR)
REACT_120736Signaling by FGFR in disease
REACT_163936Fc epsilon receptor (FCERI) signaling
REACT_163769Role of LAT2/NTAL/LAB on calcium mobilization
Homo sapiens (human)ERBB3NP_001973.2
Pan troglodytes (chimpanzee)ERBB3XP_509131.2
Macaca mulatta (Rhesus monkey)ERBB3XP_001113953.2
Canis lupus familiaris (dog)ERBB3XP_538226.4
Bos taurus (cattle)ERBB3NP_001096575.1
Mus musculus (house mouse)Erbb3NP_034283.1
Rattus norvegicus (Norway rat)Erbb3NP_058914.2
Gallus gallus (chicken)ERBB3NP_001038134.1
Xenopus (Silurana) tropicalis (western clawed frog)erbb3XP_002934562.2
Process
IDNameEvidence
GO:0003197endocardial cushion developmentIEA
GO:0006468protein phosphorylationIEA
GO:0007162negative regulation of cell adhesionIDA
GO:0007165signal transductionIDA
GO:0007169transmembrane receptor protein tyrosine kinase signaling pathwayISS
GO:0007173epidermal growth factor receptor signaling pathwayTAS
GO:0007422peripheral nervous system developmentISS
GO:0007507heart developmentISS
GO:0008543fibroblast growth factor receptor signaling pathwayTAS
GO:0009968negative regulation of signal transductionIDA
GO:0014037Schwann cell differentiationISS
GO:0014065phosphatidylinositol 3-kinase signalingIDA
GO:0014068positive regulation of phosphatidylinositol 3-kinase signalingTAS
GO:0021545cranial nerve developmentISS
GO:0038095Fc-epsilon receptor signaling pathwayTAS
GO:0042060wound healingNAS
GO:0042127regulation of cell proliferationIDA
GO:0043524negative regulation of neuron apoptotic processISS
GO:0045087innate immune responseTAS
GO:0048011neurotrophin TRK receptor signaling pathwayTAS
GO:0048015phosphatidylinositol-mediated signalingTAS
GO:0051048negative regulation of secretionIDA
GO:0051402neuron apoptotic processIMP
GO:0061098positive regulation of protein tyrosine kinase activityIMP
GO:0097192extrinsic apoptotic signaling pathway in absence of ligandIMP
Component
IDNameEvidence
GO:0005615extracellular spaceIDA
GO:0005886plasma membraneTAS
GO:0005887integral component of plasma membraneTAS
GO:0016323basolateral plasma membraneIDA
GO:0016324apical plasma membraneIEA
GO:0016328lateral plasma membraneIEA
GO:0043235receptor complexIDA
GO:0043235receptor complexISS
Function
IDNameEvidence
GO:0004713protein tyrosine kinase activityIDA
GO:0004888transmembrane signaling receptor activityISS
GO:0005515protein bindingIPI
GO:0005524ATP bindingIEA
GO:0019838growth factor bindingIPI
GO:0019838growth factor bindingISS
GO:0030296protein tyrosine kinase activator activityIDA
GO:0042803protein homodimerization activityNAS
GO:0046982protein heterodimerization activityIDA
GO:0046982protein heterodimerization activityIPI
GeneCards ERBB3
UniProt P21860
Vega OTTHUMG00000170140
MIM 190151
Ensembl ENSG00000065361
HGNC 3431
HPRD 01820

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Interactant

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