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ERBB3 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) [Homo sapiens (human)]


RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_001005915 Homo sapiens v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) (ERBB3), transcript variant s, mRNA. GenEZ ORF Cloning On-demand $399.00 14
NM_001982 Homo sapiens v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) (ERBB3), transcript variant 1, mRNA. GenEZ ORF Cloning In-stock $1198.00 $1149.00 16

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Gene Symbol ERBB3
Entrez Gene ID 2065
Full Name v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)
Synonyms ErbB-3, HER3, LCCS2, MDA-BF-1, MGC88033, c-erbB-3, c-erbB3, erbB3-S, p180-ErbB3, p45-sErbB3, p85-sErbB3
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

12

12q13

Summary This gene encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound protein has a neuregulin binding domain but not an active kinase domain. It therefore can bind this ligand but not convey the signal into the cell through protein phosphorylation. However, it does form heterodimers with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation of pathways which lead to cell proliferation or differentiation. Amplification of this gene and/or overexpression of its protein have been reported in numerous cancers, including prostate, bladder, and breast tumors. Alternate transcriptional splice variants encoding different isoforms have been characterized. One isoform lacks the intermembrane region and is secreted outside the cell. This form acts to modulate the activity of the membrane-bound form. Additional splice variants have also been reported, but they have not been thoroughly characterized. [provided by RefSeq, Jul 2008].
Disorder

MIM: 190151

Lethal congenital contractural syndrome 2, 607598 (3)

mRNA Protein Product Sequence Price Select
NM_001005915, 54792101 NP_001005915, 54792102 receptor tyrosine-protein kinase erbB-3 isoform s precursor ORF Sequence $250.00
NM_001982, 317171925 NP_001973, 54792100 receptor tyrosine-protein kinase erbB-3 isoform 1 precursor ORF Sequence $999.00
KEGG
hsa04012ErbB signaling pathway
hsa04020Calcium signaling pathway
hsa04144Endocytosis
Pathway Interaction Database
a6b1_a6b4_integrin_pathwaya6b1 and a6b4 Integrin signaling
erbb_network_pathwayErbB receptor signaling network
erbb2erbb3pathwayErbB2/ErbB3 signaling events
WikiPathways
WP364IL-6 Signaling Pathway
WP673ErbB signaling pathway
WP2261Signaling Pathways in Glioblastoma
WP1591Heart Development
Reactome
REACT_147723PI3K/AKT Signaling in Cancer
REACT_17025Downstream signal transduction
REACT_115871Signaling by EGFR in Cancer
REACT_6802Innate Immune System
REACT_75829PIP3 activates AKT signaling
REACT_115993SHC1 events in ERBB2 signaling
REACT_118773Signaling by the B Cell Receptor (BCR)
REACT_147814DAP12 signaling
REACT_118638Downstream Signaling Events Of B Cell Receptor (BCR)
REACT_115662Downregulation of ERBB2:ERBB3 signaling
REACT_9417Signaling by EGFR
REACT_21270PI-3K cascade
REACT_6900Immune System
REACT_147694DAP12 interactions
REACT_115755Signaling by ERBB2
REACT_111040Signaling by SCF-KIT
REACT_115961PI3K events in ERBB4 signaling
REACT_9470Signaling by FGFR
REACT_147727Constitutive PI3K/AKT Signaling in Cancer
REACT_115596Signaling by ERBB4
REACT_12464PI3K/AKT activation
REACT_12056NGF signalling via TRKA from the plasma membrane
REACT_116125Disease
REACT_111102Signal Transduction
REACT_120736Signaling by FGFR in disease
REACT_115896GRB7 events in ERBB2 signaling
REACT_11061Signalling by NGF
REACT_75774Adaptive Immune System
REACT_116008PI3K events in ERBB2 signaling
REACT_16888Signaling by PDGF
REACT_12578GAB1 signalosome
REACT_21272Downstream signaling of activated FGFR
Homo sapiens (human)ERBB3NP_001973.2
Pan troglodytes (chimpanzee)ERBB3XP_509131.2
Macaca mulatta (Rhesus monkey)ERBB3XP_001113953.2
Canis lupus familiaris (dog)ERBB3XP_538226.3
Bos taurus (cattle)ERBB3NP_001096575.1
Mus musculus (house mouse)Erbb3NP_034283.1
Rattus norvegicus (Norway rat)Erbb3NP_058914.2
Gallus gallus (chicken)ERBB3NP_001038134.1
Danio rerio (zebrafish)erbb3aNP_001005320.1
Danio rerio (zebrafish)erbb3bNP_001014826.1
GeneCards ERBB3
PDB 2L9U, 3KEX, 3LMG, 3P11, 1M6B
UniProt P21860
MIM 190151
Ensembl ENSG00000065361
HGNC 3431
HPRD 01820

GeneRIFs: Gene References Into Functions What's a GeneRIF?

General protein information

Preferred Names
receptor tyrosine-protein kinase erbB-3
Names
receptor tyrosine-protein kinase erbB-3
proto-oncogene-like protein c-ErbB-3
tyrosine kinase-type cell surface receptor HER3
NP_001005915.1
NP_001973.2

Interactant



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