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ERCC1 excision repair cross-complementation group 1 [Homo sapiens (human)]


Clone ID RefSeq Accession Definition Vector Stock Status *Turnaround time Price Order
OHu22115 NM_001983 Homo sapiens excision repair cross-complementation group 1 (ERCC1), transcript variant 2, mRNA. pcDNA3.1+-DYK In-stock 5-7 $99.00
OHu22964 NM_001166049 Homo sapiens excision repair cross-complementation group 1 (ERCC1), transcript variant 3, mRNA. pcDNA3.1+-DYK In-stock 5-7 $99.00
OHu24783 NM_202001 Homo sapiens excision repair cross-complementation group 1 (ERCC1), transcript variant 1, mRNA. pcDNA3.1+-DYK In-stock 5-7 $99.00
OHu24783 XM_005258634 PREDICTED: Homo sapiens excision repair cross-complementing rodent repair deficiency, complementation group 1 (includes overlapping antisense sequence) (ERCC1), transcript variant X1, mRNA. pcDNA3.1+-DYK On-demand 7-9 $159.00
OHu24783 XM_005258635 PREDICTED: Homo sapiens excision repair cross-complementing rodent repair deficiency, complementation group 1 (includes overlapping antisense sequence) (ERCC1), transcript variant X2, mRNA. pcDNA3.1+-DYK On-demand 7-9 $159.00
OHu24783 XM_005258636 PREDICTED: Homo sapiens excision repair cross-complementing rodent repair deficiency, complementation group 1 (includes overlapping antisense sequence) (ERCC1), transcript variant X3, mRNA. pcDNA3.1+-DYK On-demand 7-9 $159.00
OHu52101 XM_005258637 PREDICTED: Homo sapiens excision repair cross-complementing rodent repair deficiency, complementation group 1 (includes overlapping antisense sequence) (ERCC1), transcript variant X4, mRNA. pcDNA3.1+-DYK On-demand 7-9 $159.00
OHu22115C NM_001983 Homo sapiens excision repair cross-complementation group 1 (ERCC1), transcript variant 2, mRNA. Customized vector In-stock 5-7 $149.00
OHu22964C NM_001166049 Homo sapiens excision repair cross-complementation group 1 (ERCC1), transcript variant 3, mRNA. Customized vector In-stock 5-7 $149.00
OHu24783C NM_202001 Homo sapiens excision repair cross-complementation group 1 (ERCC1), transcript variant 1, mRNA. Customized vector In-stock 5-7 $149.00
OHu24783C XM_005258634 PREDICTED: Homo sapiens excision repair cross-complementing rodent repair deficiency, complementation group 1 (includes overlapping antisense sequence) (ERCC1), transcript variant X1, mRNA. Customized vector On-demand 7-9 $209.00
OHu24783C XM_005258635 PREDICTED: Homo sapiens excision repair cross-complementing rodent repair deficiency, complementation group 1 (includes overlapping antisense sequence) (ERCC1), transcript variant X2, mRNA. Customized vector On-demand 7-9 $209.00
OHu24783C XM_005258636 PREDICTED: Homo sapiens excision repair cross-complementing rodent repair deficiency, complementation group 1 (includes overlapping antisense sequence) (ERCC1), transcript variant X3, mRNA. Customized vector On-demand 7-9 $209.00
OHu52101C XM_005258637 PREDICTED: Homo sapiens excision repair cross-complementing rodent repair deficiency, complementation group 1 (includes overlapping antisense sequence) (ERCC1), transcript variant X4, mRNA. Customized vector On-demand 7-9 $209.00

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Gene Symbol ERCC1
Entrez Gene ID 2067
Full Name excision repair cross-complementation group 1
Synonyms COFS4, RAD10, UV20
General protein information
Preferred Names
DNA excision repair protein ERCC-1
Names
DNA excision repair protein ERCC-1
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

19

19q13.32

Summary The product of this gene functions in the nucleotide excision repair pathway, and is required for the repair of DNA lesions such as those induced by UV light or formed by electrophilic compounds including cisplatin. The encoded protein forms a heterodimer with the XPF endonuclease (also known as ERCC4), and the heterodimeric endonuclease catalyzes the 5' incision in the process of excising the DNA lesion. The heterodimeric endonuclease is also involved in recombinational DNA repair and in the repair of inter-strand crosslinks. Mutations in this gene result in cerebrooculofacioskeletal syndrome, and polymorphisms that alter expression of this gene may play a role in carcinogenesis. Multiple transcript variants encoding different isoforms have been found for this gene. The last exon of this gene overlaps with the CD3e molecule, epsilon associated protein gene on the opposite strand. [provided by RefSeq, Oct 2009].
Disorder

MIM: 126380

Cerebrooculofacioskeletal syndrome 4, 610758 (3)

mRNA Protein Product Sequence Price Select
NM_001166049, 260593724 NP_001159521, 260593725 DNA excision repair protein ERCC-1 isoform 3 ORF Sequence $199.00
NM_001983, 260593722 NP_001974, 4503599 DNA excision repair protein ERCC-1 isoform 2 ORF Sequence $199.00
NM_202001, 260593723 NP_973730, 42544169 DNA excision repair protein ERCC-1 isoform 1 ORF Sequence $269.00
XM_005258634, 530415959 XP_005258691, 530415960 DNA excision repair protein ERCC-1 isoform X1 ORF Sequence $400.00
XM_005258635, 530415961 XP_005258692, 530415962 DNA excision repair protein ERCC-1 isoform X2 ORF Sequence $400.00
XM_005258636, 578834109 XP_005258693, 530415964 DNA excision repair protein ERCC-1 isoform X3 ORF Sequence $400.00
XM_005258637, 530415965 XP_005258694, 530415966 DNA excision repair protein ERCC-1 isoform X4 ORF Sequence $300.00
KEGG
hsa03420Nucleotide excision repair
hsa03460Fanconi anemia pathway
Reactome
REACT_216DNA Repair
REACT_1826Nucleotide Excision Repair
REACT_311Dual incision reaction in GG-NER
REACT_1628Transcription-coupled NER (TC-NER)
REACT_1941Formation of transcription-coupled NER (TC-NER) repair complex
REACT_2253Global Genomic NER (GG-NER)
REACT_257Formation of incision complex in GG-NER
REACT_2222Dual incision reaction in TC-NER
Homo sapiens (human)ERCC1NP_001974.1
Pan troglodytes (chimpanzee)ERCC1NP_001181860.1
Canis lupus familiaris (dog)ERCC1XP_005616504.1
Bos taurus (cattle)ERCC1NP_001069853.1
Mus musculus (house mouse)Ercc1NP_031974.2
Rattus norvegicus (Norway rat)Ercc1NP_001099698.1
Danio rerio (zebrafish)ercc1NP_001096608.1
Drosophila melanogaster (fruit fly)Ercc1NP_477468.1
Arabidopsis thaliana (thale cress)ERCC1NP_187172.1
Xenopus (Silurana) tropicalis (western clawed frog)ercc1NP_001107393.1
Process
IDNameEvidence
GO:0000718nucleotide-excision repair, DNA damage removalTAS
GO:0000720pyrimidine dimer repair by nucleotide-excision repairIEA
GO:0000737DNA catabolic process, endonucleolyticIDA
GO:0001302replicative cell agingIEA
GO:0006281DNA repairTAS
GO:0006283transcription-coupled nucleotide-excision repairTAS
GO:0006289nucleotide-excision repairIDA
GO:0006289nucleotide-excision repairIGI
GO:0006289nucleotide-excision repairTAS
GO:0006295nucleotide-excision repair, DNA incision, 3'-to lesionIMP
GO:0006296nucleotide-excision repair, DNA incision, 5'-to lesionIMP
GO:0006302double-strand break repairIEA
GO:0006310DNA recombinationIGI
GO:0006312mitotic recombinationIMP
GO:0006949syncytium formationIEA
GO:0006979response to oxidative stressIMP
GO:0007283spermatogenesisIEA
GO:0007584response to nutrientIEA
GO:0008283cell proliferationIEA
GO:0008584male gonad developmentIEA
GO:0009650UV protectionIEA
GO:0009744response to sucroseIEA
GO:0010165response to X-rayIEA
GO:0010259multicellular organismal agingIEA
GO:0032205negative regulation of telomere maintenanceIMP
GO:0035166post-embryonic hemopoiesisIEA
GO:0035264multicellular organism growthIEA
GO:0045190isotype switchingIEA
GO:0048477oogenesisIEA
GO:0048568embryonic organ developmentIEA
GO:0051276chromosome organizationIEA
Component
IDNameEvidence
GO:0000109nucleotide-excision repair complexIDA
GO:0000784nuclear chromosome, telomeric regionIDA
GO:0005634nucleusIDA
GO:0005654nucleoplasmTAS
GO:0005669transcription factor TFIID complexIEA
GO:0005730nucleolusIDA
GO:0005737cytoplasmIDA
Function
IDNameEvidence
GO:0000014single-stranded DNA endodeoxyribonuclease activityIDA
GO:0001094TFIID-class transcription factor bindingIEA
GO:0003684damaged DNA bindingIDA
GO:0003697single-stranded DNA bindingIDA
GO:0005515protein bindingIPI
GO:0008022protein C-terminus bindingIPI
GO:0017025TBP-class protein bindingIEA
GO:0019904protein domain specific bindingIPI
GO:0043566structure-specific DNA bindingIDA
GeneCards ERCC1
UniProt P07992
Vega OTTHUMG00000182121
MIM 126380
Ensembl ENSG00000012061
HGNC 3433
HPRD 00533

GeneRIFs: Gene References Into Functions What's a GeneRIF?

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