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ERCC1 excision repair cross-complementing rodent repair deficiency, complementation group 1 (includes overlapping antisense sequence) [Homo sapiens (human)]


RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_001166049 Homo sapiens excision repair cross-complementing rodent repair deficiency, complementation group 1 (includes overlapping antisense sequence) (ERCC1), transcript variant 3, mRNA. GenEZ ORF Cloning In-stock $348.00 $299.00 10
NM_001983 Homo sapiens excision repair cross-complementing rodent repair deficiency, complementation group 1 (includes overlapping antisense sequence) (ERCC1), transcript variant 2, mRNA. GenEZ ORF Cloning In-stock $348.00 $299.00 10
NM_202001 Homo sapiens excision repair cross-complementing rodent repair deficiency, complementation group 1 (includes overlapping antisense sequence) (ERCC1), transcript variant 1, mRNA. GenEZ ORF Cloning In-stock $418.00 $369.00 10

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Related Services

Gene Symbol ERCC1
Entrez Gene ID 2067
Full Name excision repair cross-complementing rodent repair deficiency, complementation group 1 (includes overlapping antisense sequence)
Synonyms COFS4, RAD10, UV20
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

19

19q13.32

Summary The product of this gene functions in the nucleotide excision repair pathway, and is required for the repair of DNA lesions such as those induced by UV light or formed by electrophilic compounds including cisplatin. The encoded protein forms a heterodimer with the XPF endonuclease (also known as ERCC4), and the heterodimeric endonuclease catalyzes the 5' incision in the process of excising the DNA lesion. The heterodimeric endonuclease is also involved in recombinational DNA repair and in the repair of inter-strand crosslinks. Mutations in this gene result in cerebrooculofacioskeletal syndrome, and polymorphisms that alter expression of this gene may play a role in carcinogenesis. Multiple transcript variants encoding different isoforms have been found for this gene. The last exon of this gene overlaps with the CD3e molecule, epsilon associated protein gene on the opposite strand. [provided by RefSeq, Oct 2009].
Disorder

MIM: 126380

Cerebrooculofacioskeletal syndrome 4, 610758 (3)

mRNA Protein Product Sequence Price Select
NM_001166049, 260593724 NP_001159521, 260593725 DNA excision repair protein ERCC-1 isoform 3 ORF Sequence $199.00
NM_001983, 260593722 NP_001974, 4503599 DNA excision repair protein ERCC-1 isoform 2 ORF Sequence $199.00
NM_202001, 260593723 NP_973730, 42544169 DNA excision repair protein ERCC-1 isoform 1 ORF Sequence $269.00
KEGG
hsa03460Fanconi anemia pathway
hsa03420Nucleotide excision repair
Reactome
REACT_1628Transcription-coupled NER (TC-NER)
REACT_1826Nucleotide Excision Repair
REACT_1941Formation of transcription-coupled NER (TC-NER) repair complex
REACT_2222Dual incision reaction in TC-NER
REACT_2253Global Genomic NER (GG-NER)
REACT_311Dual incision reaction in GG-NER
REACT_216DNA Repair
REACT_257Formation of incision complex in GG-NER
Homo sapiens (human)ERCC1NP_001974.1
Pan troglodytes (chimpanzee)ERCC1NP_001181860.1
Canis lupus familiaris (dog)ERCC1XP_855116.1
Bos taurus (cattle)ERCC1NP_001069853.1
Mus musculus (house mouse)Ercc1NP_031974.2
Rattus norvegicus (Norway rat)Ercc1NP_001099698.1
Danio rerio (zebrafish)ercc1NP_001096608.1
Drosophila melanogaster (fruit fly)Ercc1NP_477468.1
Arabidopsis thaliana (thale cress)ERCC1NP_187172.1
GeneCards ERCC1
PDB 2A1J, 1Z00, 2JPD, 2JNW, 2A1I
UniProt P07992, B2RC01
MIM 126380
Ensembl ENSG00000012061
HGNC 3433
HPRD 00533

GeneRIFs: Gene References Into Functions What's a GeneRIF?

General protein information

Preferred Names
DNA excision repair protein ERCC-1
Names
DNA excision repair protein ERCC-1

Interactant



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