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AKT1 v-akt murine thymoma viral oncogene homolog 1 [Homo sapiens (human)]

RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_001014431 Homo sapiens v-akt murine thymoma viral oncogene homolog 1 (AKT1), transcript variant 3, mRNA. GenEZ ORF Cloning In-stock $509.00 $460.00 12
NM_001014432 Homo sapiens v-akt murine thymoma viral oncogene homolog 1 (AKT1), transcript variant 2, mRNA. GenEZ ORF Cloning In-stock $509.00 $460.00 12
NM_005163 Homo sapiens v-akt murine thymoma viral oncogene homolog 1 (AKT1), transcript variant 1, mRNA. GenEZ ORF Cloning In-stock $509.00 $460.00 12
XM_005267401 PREDICTED: Homo sapiens v-akt murine thymoma viral oncogene homolog 1 (AKT1), transcript variant X1, mRNA. GenEZ ORF Cloning On-demand $699.00 18

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Gene Symbol AKT1
Entrez Gene ID 207
Full Name v-akt murine thymoma viral oncogene homolog 1
General protein information
Gene Type protein-coding
Organism Homo sapiens (human)



Summary The serine-threonine protein kinase encoded by the AKT1 gene is catalytically inactive in serum-starved primary and immortalized fibroblasts. AKT1 and the related AKT2 are activated by platelet-derived growth factor. The activation is rapid and specific, and it is abrogated by mutations in the pleckstrin homology domain of AKT1. It was shown that the activation occurs through phosphatidylinositol 3-kinase. In the developing nervous system AKT is a critical mediator of growth factor-induced neuronal survival. Survival factors can suppress apoptosis in a transcription-independent manner by activating the serine/threonine kinase AKT1, which then phosphorylates and inactivates components of the apoptotic machinery. Mutations in this gene have been associated with the Proteus syndrome. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2011].

MIM: 164730

Breast cancer, somatic, 114480 (3); Colorectal cancer, somatic,

mRNA Protein Product Sequence Price Select
NM_001014431, 62241012 NP_001014431, 62241013 RAC-alpha serine/threonine-protein kinase ORF Sequence $360.00
NM_001014432, 62241014 NP_001014432, 62241015 RAC-alpha serine/threonine-protein kinase ORF Sequence $360.00
NM_005163, 62241010 NP_005154, 62241011 RAC-alpha serine/threonine-protein kinase ORF Sequence $360.00
XM_005267401, 530403239 XP_005267458, 530403240 RAC-alpha serine/threonine-protein kinase isoform X1 ORF Sequence $550.00
hsa04010MAPK signaling pathway
hsa04012ErbB signaling pathway
hsa04510Focal adhesion
hsa04662B cell receptor signaling pathway
hsa04630Jak-STAT signaling pathway
hsa04664Fc epsilon RI signaling pathway
hsa04150mTOR signaling pathway
hsa04620Toll-like receptor signaling pathway
hsa04530Tight junction
hsa04370VEGF signaling pathway
hsa04910Insulin signaling pathway
hsa05211Renal cell carcinoma
hsa04660T cell receptor signaling pathway
hsa05213Endometrial cancer
hsa05215Prostate cancer
hsa04920Adipocytokine signaling pathway
hsa05212Pancreatic cancer
hsa05221Acute myeloid leukemia
hsa05222Small cell lung cancer
hsa05220Chronic myeloid leukemia
hsa05200Pathways in cancer
hsa05210Colorectal cancer
hsa05223Non-small cell lung cancer
hsa04062Chemokine signaling pathway
hsa04722Neurotrophin signaling pathway
hsa04914Progesterone-mediated oocyte maturation
hsa04666Fc gamma R-mediated phagocytosis
hsa05142Chagas disease (American trypanosomiasis)
hsa04973Carbohydrate digestion and absorption
hsa05160Hepatitis C
hsa05166HTLV-I infection
hsa04380Osteoclast differentiation
hsa05164Influenza A
hsa04725Cholinergic synapse
hsa04728Dopaminergic synapse
hsa04151PI3K-Akt signaling pathway
hsa05161Hepatitis B
hsa04066HIF-1 signaling pathway
hsa05205Proteoglycans in cancer
hsa04915Estrogen signaling pathway
hsa05169Epstein-Barr virus infection
hsa04668TNF signaling pathway
hsa04261Adrenergic signaling in cardiomyocytes
hsa04917Prolactin signaling pathway
hsa04932Non-alcoholic fatty liver disease (NAFLD)
hsa04919Thyroid hormone signaling pathway
hsa04611Platelet activation
hsa04014Ras signaling pathway
hsa04015Rap1 signaling pathway
hsa04068FoxO signaling pathway
hsa04022cGMP-PKG signaling pathway
hsa04152AMPK signaling pathway
WP382MAPK signaling pathway
WP437EGFR1 Signaling Pathway
WP127IL-5 Signaling Pathway
WP138Androgen receptor signaling pathway
WP1471TOR signaling
WP1984Integrated Breast Cancer Pathway
WP395IL-4 signaling Pathway
WP1559TFs Regulate miRNAs related to cardiac hypertrophy
WP1544MicroRNAs in cardiomyocyte hypertrophy
WP185Integrin-mediated cell adhesion
WP244Alpha6-Beta4 Integrin Signaling Pathway
WP474Endochondral Ossification
WP75Toll-like receptor signaling pathway
WP1982SREBP signalling
WP363Wnt Signaling Pathway NetPath
WP481Insulin Signaling
WP304Kit Receptor Signaling Pathway
WP712Estrogen signaling pathway
WP61Delta-Notch Signaling Pathway
WP286IL-3 Signaling Pathway
WP710DNA damage response (only ATM dependent)
WP1403AMPK signaling
WP205IL-7 Signaling Pathway
WP364IL-6 Signaling Pathway
WP26Signal Transduction of S1P Receptor
WP22IL-9 Signaling Pathway
WP49IL-2 Signaling pathway
WP69TCR Signaling Pathway
WP23B Cell Receptor Signaling Pathway
WP231TNF-alpha/NF-kB Signaling Pathway
WP581EPO Receptor Signaling
WP2332Interleukin-11 Signaling Pathway
WP2324AGE/RAGE pathway
WP2377Integrated Pancreatic Cancer Pathway
WP2374Oncostatin M Signaling Pathway
WP2380BDNF signaling pathway
WP2036TWEAK Signaling Pathway
WP2034Leptin signaling pathway
WP2261Signaling Pathways in Glioblastoma
WP2032TSH signaling pathway
WP1971Integrated Cancer pathway
WP2035FSH signaling pathway
WP2037Prolactin Signaling Pathway
WP2018RANKL/RANK Signaling Pathway
WP2203TSLP Signaling Pathway
WP2038Regulation of Microtubule Cytoskeleton
WP2263Prostate Cancer
WP1449Regulation of toll-like receptor signaling pathway
WP2355Corticotropin-releasing hormone
WP2112IL17 signaling pathway
Pathway Interaction Database
lysophospholipid_pathwayLPA receptor mediated events
il6_7pathwayIL6-mediated signaling events
cxcr4_pathwayCXCR4-mediated signaling events
aurora_a_pathwayAurora A signaling
hnf3bpathwayFOXA2 and FOXA3 transcription factor networks
vegfr1_pathwayVEGFR1 specific signals
il2_pi3kpathwayIL2 signaling events mediated by PI3K
vegfr1_2_pathwaySignaling events mediated by VEGFR1 and VEGFR2
smad2_3nuclearpathwayRegulation of nuclear SMAD2/3 signaling
hedgehog_glipathwayHedgehog signaling events mediated by Gli proteins
met_pathwaySignaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
angiopoietinreceptor_pathwayAngiopoietin receptor Tie2-mediated signaling
hedgehog_2pathwaySignaling events mediated by the Hedgehog family
avb3_integrin_pathwayIntegrins in angiogenesis
erbb2erbb3pathwayErbB2/ErbB3 signaling events
reelinpathwayReelin signaling pathway
telomerasepathwayRegulation of Telomerase
tcr_pathwayTCR signaling in naive CD4+ T cells
amb2_neutrophils_pathwayamb2 Integrin signaling
fgf_pathwayFGF signaling pathway
lymphangiogenesis_pathwayVEGFR3 signaling in lymphatic endothelium
reg_gr_pathwayGlucocorticoid receptor regulatory network
igf1_pathwayIGF1 pathway
er_nongenomic_pathwayPlasma membrane estrogen receptor signaling
insulin_glucose_pathwayInsulin-mediated glucose transport
pi3kciaktpathwayClass I PI3K signaling events mediated by Akt
pi3kplctrkpathwayTrk receptor signaling mediated by PI3K and PLC-gamma
ptp1bpathwaySignaling events mediated by PTP1B
foxopathwayFoxO family signaling
il4_2pathwayIL4-mediated signaling events
retinoic_acid_pathwayRetinoic acid receptors-mediated signaling
erbb1_downstream_pathwayErbB1 downstream signaling
hif1_tfpathwayHIF-1-alpha transcription factor network
faspathwayFAS (CD95) signaling pathway
ecadherin_nascentaj_pathwayE-cadherin signaling in the nascent adherens junction
ceramide_pathwayCeramide signaling pathway
ar_nongenomic_pathwayNongenotropic Androgen signaling
cd8tcrpathwayTCR signaling in naive CD8+ T cells
cxcr3pathwayCXCR3-mediated signaling events
insulin_pathwayInsulin Pathway
bcr_5pathwayBCR signaling pathway
txa2pathwayThromboxane A2 receptor signaling
ifngpathwayIFN-gamma pathway
s1p_s1p3_pathwayS1P3 pathway
nephrin_neph1_pathwayNephrin/Neph1 signaling in the kidney podocyte
a6b1_a6b4_integrin_pathwaya6b1 and a6b4 Integrin signaling
cd40_pathwayCD40/CD40L signaling
fcer1pathwayFc-epsilon receptor I signaling in mast cells
p53regulationpathwayp53 pathway
kitpathwaySignaling events mediated by Stem cell factor receptor (c-Kit)
ar_pathwayCoregulation of Androgen receptor activity
pdgfrbpathwayPDGFR-beta signaling pathway
mtor_4pathwaymTOR signaling pathway
ecadherin_keratinocyte_pathwayE-cadherin signaling in keratinocytes
p75ntrpathwayp75(NTR)-mediated signaling
REACT_549Activation of BAD and translocation to mitochondria
REACT_964Intrinsic Pathway for Apoptosis
REACT_697Activation of BH3-only proteins
REACT_19184GPCR downstream signaling
REACT_19290G beta:gamma signalling through PI3Kgamma
REACT_19388G-protein beta:gamma signalling
REACT_19183CD28 co-stimulation
REACT_19344Costimulation by the CD28 family
REACT_19358CD28 dependent PI3K/Akt signaling
REACT_19405CTLA4 inhibitory signaling
REACT_71Gene Expression
REACT_798Platelet activation, signaling and aggregation
REACT_1695GPVI-mediated activation cascade
REACT_278Platelet Aggregation (Plug Formation)
REACT_11123Membrane Trafficking
REACT_15523Integrin alphaIIb beta3 signaling
REACT_12508Metabolism of nitric oxide
REACT_12477eNOS activation
REACT_12389eNOS activation and regulation
REACT_9470Signaling by FGFR
REACT_12578GAB1 signalosome
REACT_14797Signaling by GPCR
REACT_9417Signaling by EGFR
REACT_16888Signaling by PDGF
REACT_6900Immune System
REACT_6802Innate Immune System
REACT_13698Regulation of beta-cell development
REACT_17025Downstream signal transduction
REACT_13655AKT-mediated inactivation of FOXO1A
REACT_11061Signalling by NGF
REACT_12464PI3K/AKT activation
REACT_12056NGF signalling via TRKA from the plasma membrane
REACT_11045Signaling by Wnt
REACT_12442AKT phosphorylates targets in the nucleus
REACT_12447Negative regulation of the PI3K/AKT network
REACT_13819Regulation of gene expression in beta cells
REACT_12564AKT phosphorylates targets in the cytosol
REACT_21272Downstream signaling of activated FGFR
REACT_21270PI-3K cascade
REACT_75774Adaptive Immune System
REACT_75829PIP3 activates AKT signaling
REACT_24994Regulation of mRNA stability by proteins that bind AU-rich elements
REACT_24915Butyrate Response Factor 1 (BRF1) destabilizes mRNA
REACT_25042KSRP destabilizes mRNA
REACT_111102Signal Transduction
REACT_111045Developmental Biology
REACT_111176Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
REACT_111040Signaling by SCF-KIT
REACT_147727Constitutive PI3K/AKT Signaling in Cancer
REACT_147723PI3K/AKT Signaling in Cancer
REACT_147694DAP12 interactions
REACT_147867Translocation of GLUT4 to the plasma membrane
REACT_147814DAP12 signaling
REACT_115596Signaling by ERBB4
REACT_115755Signaling by ERBB2
REACT_116008PI3K events in ERBB2 signaling
REACT_115662Downregulation of ERBB2:ERBB3 signaling
REACT_115871Signaling by EGFR in Cancer
REACT_115961PI3K events in ERBB4 signaling
REACT_118773Signaling by the B Cell Receptor (BCR)
REACT_118638Downstream signaling events of B Cell Receptor (BCR)
REACT_120736Signaling by FGFR in disease
REACT_163936Fc epsilon receptor (FCERI) signaling
REACT_163769Role of LAT2/NTAL/LAB on calcium mobilization
REACT_200731deactivation of the beta-catenin transactivating complex
REACT_200777TCF dependent signaling in response to WNT
Homo sapiens (human)AKT1NP_001014431.1
Pan troglodytes (chimpanzee)AKT1XP_001143158.2
Macaca mulatta (Rhesus monkey)AKT1XP_001085265.2
Canis lupus familiaris (dog)AKT1XP_548000.3
Bos taurus (cattle)AKT1NP_776411.1
Mus musculus (house mouse)Akt1NP_033782.1
Rattus norvegicus (Norway rat)Akt1NP_150233.1
Gallus gallus (chicken)AKT1NP_990386.1
Danio rerio (zebrafish)LOC100331515XP_003200336.2
Caenorhabditis elegansakt-1NP_001023646.1
Caenorhabditis elegansakt-2NP_510357.3
Xenopus (Silurana) tropicalis (western clawed frog)akt1XP_004917249.1
GO:0000060protein import into nucleus, translocationIMP
GO:0001649osteoblast differentiationIEA
GO:0001893maternal placenta developmentIEA
GO:0001934positive regulation of protein phosphorylationIDA
GO:0001938positive regulation of endothelial cell proliferationIMP
GO:0005978glycogen biosynthetic processIEA
GO:0005979regulation of glycogen biosynthetic processIMP
GO:0006006glucose metabolic processIEA
GO:0006417regulation of translationIEA
GO:0006464cellular protein modification processTAS
GO:0006468protein phosphorylationIDA
GO:0006469negative regulation of protein kinase activityIMP
GO:0006469negative regulation of protein kinase activityISS
GO:0006809nitric oxide biosynthetic processTAS
GO:0006915apoptotic processTAS
GO:0006924activation-induced cell death of T cellsIMP
GO:0006954inflammatory responseIEA
GO:0007165signal transductionTAS
GO:0007173epidermal growth factor receptor signaling pathwayTAS
GO:0007186G-protein coupled receptor signaling pathwayTAS
GO:0007281germ cell developmentIEA
GO:0007596blood coagulationTAS
GO:0008283cell proliferationTAS
GO:0008286insulin receptor signaling pathwayIMP
GO:0008543fibroblast growth factor receptor signaling pathwayTAS
GO:0008637apoptotic mitochondrial changesIEA
GO:0009408response to heatTAS
GO:0010467gene expressionTAS
GO:0010507negative regulation of autophagyIMP
GO:0010748negative regulation of plasma membrane long-chain fatty acid transportIMP
GO:0010765positive regulation of sodium ion transportIEA
GO:0010907positive regulation of glucose metabolic processIMP
GO:0010951negative regulation of endopeptidase activityIMP
GO:0010975regulation of neuron projection developmentISS
GO:0015758glucose transportIEA
GO:0016070RNA metabolic processTAS
GO:0016071mRNA metabolic processTAS
GO:0016567protein ubiquitinationIEA
GO:0018105peptidyl-serine phosphorylationIDA
GO:0030030cell projection organizationIEA
GO:0030154cell differentiationTAS
GO:0030163protein catabolic processIEA
GO:0030168platelet activationTAS
GO:0030212hyaluronan metabolic processIEA
GO:0030307positive regulation of cell growthIDA
GO:0030334regulation of cell migrationIMP
GO:0030334regulation of cell migrationTAS
GO:0031018endocrine pancreas developmentTAS
GO:0031295T cell costimulationTAS
GO:0031659positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycleIDA
GO:0031999negative regulation of fatty acid beta-oxidationIMP
GO:0032094response to foodIEA
GO:0032270positive regulation of cellular protein metabolic processISS
GO:0032287peripheral nervous system myelin maintenanceIEA
GO:0032436positive regulation of proteasomal ubiquitin-dependent protein catabolic processIEA
GO:0032869cellular response to insulin stimulusIMP
GO:0032869cellular response to insulin stimulusISS
GO:0033138positive regulation of peptidyl-serine phosphorylationIDA
GO:0034405response to fluid shear stressIMP
GO:0035556intracellular signal transductionIDA
GO:0038095Fc-epsilon receptor signaling pathwayTAS
GO:0042593glucose homeostasisIEA
GO:0043065positive regulation of apoptotic processIEA
GO:0043066negative regulation of apoptotic processIDA
GO:0043154negative regulation of cysteine-type endopeptidase activity involved in apoptotic processISS
GO:0043491protein kinase B signalingIEA
GO:0043536positive regulation of blood vessel endothelial cell migrationIDA
GO:0044281small molecule metabolic processTAS
GO:0045087innate immune responseTAS
GO:0045429positive regulation of nitric oxide biosynthetic processIMP
GO:0045600positive regulation of fat cell differentiationIMP
GO:0045725positive regulation of glycogen biosynthetic processIMP
GO:0045725positive regulation of glycogen biosynthetic processNAS
GO:0045792negative regulation of cell sizeIEA
GO:0045861negative regulation of proteolysisIMP
GO:0045907positive regulation of vasoconstrictionIEA
GO:0045944positive regulation of transcription from RNA polymerase II promoterIEA
GO:0046209nitric oxide metabolic processTAS
GO:0046326positive regulation of glucose importIMP
GO:0046329negative regulation of JNK cascadeIEA
GO:0046777protein autophosphorylationTAS
GO:0046889positive regulation of lipid biosynthetic processIMP
GO:0048009insulin-like growth factor receptor signaling pathwayIMP
GO:0048011neurotrophin TRK receptor signaling pathwayTAS
GO:0048015phosphatidylinositol-mediated signalingTAS
GO:0050999regulation of nitric-oxide synthase activityTAS
GO:0051000positive regulation of nitric-oxide synthase activityIMP
GO:0051091positive regulation of sequence-specific DNA binding transcription factor activityIDA
GO:0051146striated muscle cell differentiationIEA
GO:0060644mammary gland epithelial cell differentiationTAS
GO:0060709glycogen cell differentiation involved in embryonic placenta developmentIEA
GO:0060716labyrinthine layer blood vessel developmentIEA
GO:0061024membrane organizationTAS
GO:0070141response to UV-AIDA
GO:0071260cellular response to mechanical stimulusIEA
GO:0071364cellular response to epidermal growth factor stimulusIEA
GO:0071456cellular response to hypoxiaIEA
GO:0090004positive regulation of establishment of protein localization to plasma membraneIMP
GO:0090201negative regulation of release of cytochrome c from mitochondriaISS
GO:0097193intrinsic apoptotic signaling pathwayTAS
GO:0097194execution phase of apoptosisIEA
GO:1900740positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathwayTAS
GO:1901976regulation of cell cycle checkpointTAS
GO:1902176negative regulation of intrinsic apoptotic signaling pathway in response to oxidative stressNAS
GO:2001240negative regulation of extrinsic apoptotic signaling pathway in absence of ligandTAS
GO:0005886plasma membraneIDA
GO:0005886plasma membraneTAS
GO:0015630microtubule cytoskeletonIDA
GO:0004672protein kinase activityTAS
GO:0004674protein serine/threonine kinase activityIDA
GO:0004674protein serine/threonine kinase activityTAS
GO:0004712protein serine/threonine/tyrosine kinase activityIDA
GO:0005080protein kinase C bindingIEA
GO:0005515protein bindingIPI
GO:0005524ATP bindingIC
GO:0005524ATP bindingIDA
GO:0005547phosphatidylinositol-3,4,5-trisphosphate bindingIDA
GO:0016301kinase activityIDA
GO:0019899enzyme bindingISS
GO:0030235nitric-oxide synthase regulator activityIMP
GO:0042802identical protein bindingIPI
GO:0043325phosphatidylinositol-3,4-bisphosphate bindingIDA
GO:007188914-3-3 protein bindingIPI
GeneCards AKT1
PDB 1UNR, 3OCB, 4EKL, 3MVH, 3MV5, 1H10, 3OW4, 4EKK, 4GV1, 3O96, 3QKM, 1UNQ, 2UZR, 2UZS, 4EJN, 3CQU, 3CQW, 2UVM, 3QKL, 1UNP, 3QKK
UniProt B3KVH4, B0LPE5, P31749
Vega OTTHUMG00000170795
MIM 164730
Ensembl ENSG00000142208
HGNC 391
HPRD 01261

GeneRIFs: Gene References Into Functions What's a GeneRIF?

What is the normal function of the AKT1 gene?

The AKT1 gene provides instructions for making a protein called AKT1 kinase. This protein is found in various cell types throughout the body, where it plays a critical role in many signaling pathways. For example, AKT1 kinase helps regulate cell growth and division (proliferation), the process by which cells mature to carry out specific functions (differentiation), and cell survival. AKT1 kinase also helps control apoptosis, which is the self-destruction of cells when they become damaged or are no longer needed.

Signaling involving AKT1 kinase appears to be essential for the normal development and function of the nervous system. Studies have suggested a role for AKT1 kinase in cell-to-cell communication among nerve cells (neurons), neuronal survival, and the formation of memories.

The AKT1 gene belongs to a class of genes known as oncogenes. When mutated, oncogenes have the potential to cause normal cells to become cancerous.


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