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AKT1 v-akt murine thymoma viral oncogene homolog 1 [Homo sapiens (human)]


RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_001014431 Homo sapiens v-akt murine thymoma viral oncogene homolog 1 (AKT1), transcript variant 3, mRNA. GenEZ ORF Cloning In-stock $509.00 $460.00 12
NM_001014432 Homo sapiens v-akt murine thymoma viral oncogene homolog 1 (AKT1), transcript variant 2, mRNA. GenEZ ORF Cloning In-stock $509.00 $460.00 12
NM_005163 Homo sapiens v-akt murine thymoma viral oncogene homolog 1 (AKT1), transcript variant 1, mRNA. GenEZ ORF Cloning In-stock $509.00 $460.00 12

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Gene Symbol AKT1
Entrez Gene ID 207
Full Name v-akt murine thymoma viral oncogene homolog 1
Synonyms AKT, MGC99656, PKB, PKB-ALPHA, PRKBA, RAC, RAC-ALPHA
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

14

14q32.32|14q32.32

Summary The serine-threonine protein kinase encoded by the AKT1 gene is catalytically inactive in serum-starved primary and immortalized fibroblasts. AKT1 and the related AKT2 are activated by platelet-derived growth factor. The activation is rapid and specific, and it is abrogated by mutations in the pleckstrin homology domain of AKT1. It was shown that the activation occurs through phosphatidylinositol 3-kinase. In the developing nervous system AKT is a critical mediator of growth factor-induced neuronal survival. Survival factors can suppress apoptosis in a transcription-independent manner by activating the serine/threonine kinase AKT1, which then phosphorylates and inactivates components of the apoptotic machinery. Mutations in this gene have been associated with the Proteus syndrome. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2011].
Disorder

MIM: 164730

Breast cancer, somatic, 114480 (3); Colorectal cancer, somatic,

mRNA Protein Product Sequence Price Select
NM_001014431, 62241012 NP_001014431, 62241013 RAC-alpha serine/threonine-protein kinase ORF Sequence $360.00
NM_001014432, 62241014 NP_001014432, 62241015 RAC-alpha serine/threonine-protein kinase ORF Sequence $360.00
NM_005163, 62241010 NP_005154, 62241011 RAC-alpha serine/threonine-protein kinase ORF Sequence $360.00
KEGG
hsa05214Glioma
hsa04510Focal adhesion
hsa04150mTOR signaling pathway
hsa05221Acute myeloid leukemia
hsa04010MAPK signaling pathway
hsa05200Pathways in cancer
hsa05213Endometrial cancer
hsa04620Toll-like receptor signaling pathway
hsa04062Chemokine signaling pathway
hsa04722Neurotrophin signaling pathway
hsa05223Non-small cell lung cancer
hsa04920Adipocytokine signaling pathway
hsa05169Epstein-Barr virus infection
hsa05166HTLV-I infection
hsa04210Apoptosis
hsa04151PI3K-Akt signaling pathway
hsa05215Prostate cancer
hsa05220Chronic myeloid leukemia
hsa05222Small cell lung cancer
hsa04530Tight junction
hsa05218Melanoma
hsa04630Jak-STAT signaling pathway
hsa05211Renal cell carcinoma
hsa04380Osteoclast differentiation
hsa05161Hepatitis B
hsa05162Measles
hsa04666Fc gamma R-mediated phagocytosis
hsa04660T cell receptor signaling pathway
hsa04725Cholinergic synapse
hsa04973Carbohydrate digestion and absorption
hsa05160Hepatitis C
hsa04370VEGF signaling pathway
hsa05164Influenza A
hsa04728Dopaminergic synapse
hsa04664Fc epsilon RI signaling pathway
hsa05142Chagas disease (American trypanosomiasis)
hsa04662B cell receptor signaling pathway
hsa04066HIF-1 signaling pathway
hsa04910Insulin signaling pathway
hsa04012ErbB signaling pathway
hsa05210Colorectal cancer
hsa05152Tuberculosis
hsa05145Toxoplasmosis
hsa04914Progesterone-mediated oocyte maturation
hsa05212Pancreatic cancer
WikiPathways
WP205IL-7 Signaling Pathway
WP2203TSLP Signaling Pathway
WP49IL-2 Signaling Pathway
WP2036TWEAK Signaling Pathway
WP1403AMPK signaling
WP474Endochondral Ossification
WP304Kit Receptor Signaling Pathway
WP481Insulin Signaling
WP1471TOR signaling
WP26Signal Transduction of S1P Receptor
WP23B Cell Receptor Signaling Pathway
WP306Focal Adhesion
WP244Alpha6-Beta4 Integrin Signaling Pathway
WP364IL-6 Signaling Pathway
WP2324AGE/RAGE pathway
WP1971Integrated Cancer pathway
WP2374Oncostatin M Signaling Pathway
WP185Integrin-mediated cell adhesion
WP61Delta-Notch Signaling Pathway
WP2261Signaling Pathways in Glioblastoma
WP395IL-4 signaling Pathway
WP382MAPK signaling pathway
WP1984Integrated Breast Cancer Pathway
WP127IL-5 Signaling Pathway
WP231TNF-alpha/NF-kB Signaling Pathway
WP1544MicroRNAs in cardiomyocyte hypertrophy
WP69TCR Signaling Pathway
WP581EPO Receptor Signaling
WP2035FSH signaling pathway
WP1559TFs Regulate miRNAs related to cardiac hypertrophy
WP2037Prolactin Signaling Pathway
WP437EGFR1 Signaling Pathway
WP2032TSH signaling pathway
WP75Toll-like receptor signaling pathway
WP2034Leptin signaling pathway
WP22IL-9 Signaling Pathway
WP254Apoptosis
WP2018RANKL/RANK Signaling Pathway
WP363Wnt Signaling Pathway NetPath
WP712Estrogen signaling pathway
WP138Androgen receptor signaling pathway
WP2332Interleukin-11 Signaling Pathway
WP2256Integrated Pancreatic Cancer Pathway
WP2377Integrated Pancreatic Cancer Pathway
WP1539Angiogenesis
WP286IL-3 Signaling Pathway
Pathway Interaction Database
hnf3bpathwayFOXA2 and FOXA3 transcription factor networks
lymphangiogenesis_pathwayVEGFR3 signaling in lymphatic endothelium
telomerasepathwayRegulation of Telomerase
retinoic_acid_pathwayRetinoic acid receptors-mediated signaling
aurora_a_pathwayAurora A signaling
txa2pathwayThromboxane A2 receptor signaling
foxopathwayFoxO family signaling
met_pathwaySignaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
cxcr4_pathwayCXCR4-mediated signaling events
cxcr3pathwayCXCR3-mediated signaling events
igf1_pathwayIGF1 pathway
kitpathwaySignaling events mediated by Stem cell factor receptor (c-Kit)
reelinpathwayReelin signaling pathway
mtor_4pathwaymTOR signaling pathway
pi3kciaktpathwayClass I PI3K signaling events mediated by Akt
angiopoietinreceptor_pathwayAngiopoietin receptor Tie2-mediated signaling
hedgehog_glipathwayHedgehog signaling events mediated by Gli proteins
hif1_tfpathwayHIF-1-alpha transcription factor network
insulin_pathwayInsulin Pathway
il6_7pathwayIL6-mediated signaling events
pi3kplctrkpathwayTrk receptor signaling mediated by PI3K and PLC-gamma
fgf_pathwayFGF signaling pathway
cd8tcrpathwayTCR signaling in naive CD8+ T cells
pdgfrbpathwayPDGFR-beta signaling pathway
er_nongenomic_pathwayPlasma membrane estrogen receptor signaling
amb2_neutrophils_pathwayamb2 Integrin signaling
tcr_pathwayTCR signaling in naive CD4+ T cells
lysophospholipid_pathwayLPA receptor mediated events
p75ntrpathwayp75(NTR)-mediated signaling
ar_nongenomic_pathwayNongenotropic Androgen signaling
cd40_pathwayCD40/CD40L signaling
ar_pathwayCoregulation of Androgen receptor activity
ecadherin_keratinocyte_pathwayE-cadherin signaling in keratinocytes
erbb2erbb3pathwayErbB2/ErbB3 signaling events
fcer1pathwayFc-epsilon receptor I signaling in mast cells
ecadherin_nascentaj_pathwayE-cadherin signaling in the nascent adherens junction
hedgehog_2pathwaySignaling events mediated by the Hedgehog family
erbb1_downstream_pathwayErbB1 downstream signaling
reg_gr_pathwayGlucocorticoid receptor regulatory network
ceramide_pathwayCeramide signaling pathway
s1p_s1p3_pathwayS1P3 pathway
avb3_integrin_pathwayIntegrins in angiogenesis
bcr_5pathwayBCR signaling pathway
smad2_3nuclearpathwayRegulation of nuclear SMAD2/3 signaling
endothelinpathwayEndothelins
nephrin_neph1_pathwayNephrin/Neph1 signaling in the kidney podocyte
a6b1_a6b4_integrin_pathwaya6b1 and a6b4 Integrin signaling
ptp1bpathwaySignaling events mediated by PTP1B
p53regulationpathwayp53 pathway
faspathwayFAS (CD95) signaling pathway
vegfr1_pathwayVEGFR1 specific signals
insulin_glucose_pathwayInsulin-mediated glucose transport
il4_2pathwayIL4-mediated signaling events
ifngpathwayIFN-gamma pathway
il2_pi3kpathwayIL2 signaling events mediated by PI3K
vegfr1_2_pathwaySignaling events mediated by VEGFR1 and VEGFR2
Reactome
REACT_116125Disease
REACT_21272Downstream signaling of activated FGFR
REACT_13552Integrin cell surface interactions
REACT_116008PI3K events in ERBB2 signaling
REACT_147723PI3K/AKT Signaling in Cancer
REACT_278Platelet Aggregation (Plug Formation)
REACT_24915Destabilization of mRNA by Butyrate Response Factor 1 (BRF1)
REACT_12564AKT phosphorylates targets in the cytosol
REACT_13698Regulation of beta-cell development
REACT_19184GPCR downstream signaling
REACT_11061Signalling by NGF
REACT_17025Downstream signal transduction
REACT_19344Costimulation by the CD28 family
REACT_12389eNOS activation and regulation
REACT_111102Signal Transduction
REACT_14797Signaling by GPCR
REACT_13655AKT-mediated inactivation of FOXO1A
REACT_111217Metabolism
REACT_12477eNOS activation
REACT_115662Downregulation of ERBB2:ERBB3 signaling
REACT_12056NGF signalling via TRKA from the plasma membrane
REACT_964Intrinsic Pathway for Apoptosis
REACT_6802Innate Immune System
REACT_118773Signaling by the B Cell Receptor (BCR)
REACT_578Apoptosis
REACT_16888Signaling by PDGF
REACT_24994Regulation of mRNA Stability by Proteins that Bind AU-rich Elements
REACT_12578GAB1 signalosome
REACT_147867Translocation of GLUT4 to the Plasma Membrane
REACT_12464PI3K/AKT activation
REACT_147727Constitutive PI3K/AKT Signaling in Cancer
REACT_13819Regulation of gene expression in beta cells
REACT_120736Signaling by FGFR in disease
REACT_147814DAP12 signaling
REACT_12442AKT phosphorylates targets in the nucleus
REACT_12508Metabolism of nitric oxide
REACT_75774Adaptive Immune System
REACT_9417Signaling by EGFR
REACT_19183CD28 co-stimulation
REACT_697Activation of BH3-only proteins
REACT_118638Downstream Signaling Events Of B Cell Receptor (BCR)
REACT_604Hemostasis
REACT_19388G-protein beta:gamma signalling
REACT_11123Membrane Trafficking
REACT_71Gene Expression
REACT_798Platelet activation, signaling and aggregation
REACT_1695GPVI-mediated activation cascade
REACT_19290G beta:gamma signalling through PI3Kgamma
REACT_12447Negative regulation of the PI3K/AKT network
REACT_25042Destabilization of mRNA by KSRP
REACT_115871Signaling by EGFR in Cancer
REACT_75829PIP3 activates AKT signaling
REACT_115755Signaling by ERBB2
REACT_15523Integrin alphaIIb beta3 signaling
REACT_111045Developmental Biology
REACT_19405CTLA4 inhibitory signaling
REACT_115596Signaling by ERBB4
REACT_111176Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
REACT_147694DAP12 interactions
REACT_19358CD28 dependent PI3K/Akt signaling
REACT_115961PI3K events in ERBB4 signaling
REACT_111040Signaling by SCF-KIT
REACT_6900Immune System
REACT_21270PI-3K cascade
REACT_549Activation of BAD and translocation to mitochondria
REACT_9470Signaling by FGFR
Homo sapiens (human)AKT1NP_001014431.1
Macaca mulatta (Rhesus monkey)AKT1XP_001085265.2
Canis lupus familiaris (dog)AKT1XP_548000.3
Bos taurus (cattle)AKT1NP_776411.1
Mus musculus (house mouse)Akt1NP_033782.1
Rattus norvegicus (Norway rat)Akt1NP_150233.1
Gallus gallus (chicken)AKT1NP_990386.1
Danio rerio (zebrafish)akt2lNP_997980.1
Caenorhabditis elegansakt-1NP_001023645.1
Caenorhabditis elegansakt-2NP_510357.3
GeneCards AKT1
PDB 1UNR, 3OCB, 4EKL, 3MVH, 3MV5, 1H10, 3OW4, 4EKK, 4GV1, 3O96, 3QKM, 1UNQ, 2UZR, 2UZS, 4EJN, 3CQU, 3CQW, 2UVM, 3QKL, 1UNP, 3QKK
UniProt B3KVH4, B0LPE5, P31749
MIM 164730
Ensembl ENSG00000142208
HGNC 391
HPRD 01261

GeneRIFs: Gene References Into Functions What's a GeneRIF?

General protein information

Interactant



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