AKT1 v-akt murine thymoma viral oncogene homolog 1 [Homo sapiens (human)]

Summary
mRNA and Protein
Pathway
Homologues
Gene Ontology
Links to Other Databases

Gene Symbol	AKT1
Entrez Gene ID	207
Full Name	v-akt murine thymoma viral oncogene homolog 1
Synonyms	AKT, MGC99656, PKB, PKB-ALPHA, PRKBA, RAC, RAC-ALPHA
Gene Type	protein-coding
Organism	Homo sapiens (human)
Genome	Chromosome:14 Map Location:14q32.32\|14q32.32
Summary	The serine-threonine protein kinase encoded by the AKT1 gene is catalytically inactive in serum-starved primary and immortalized fibroblasts. AKT1 and the related AKT2 are activated by platelet-derived growth factor. The activation is rapid and specific, and it is abrogated by mutations in the pleckstrin homology domain of AKT1. It was shown that the activation occurs through phosphatidylinositol 3-kinase. In the developing nervous system AKT is a critical mediator of growth factor-induced neuronal survival. Survival factors can suppress apoptosis in a transcription-independent manner by activating the serine/threonine kinase AKT1, which then phosphorylates and inactivates components of the apoptotic machinery. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq].
Disorder	MIM: 164730 Breast cancer, somatic, 114480 (3); Colorectal cancer, somatic,

mRNA	NM_005163, 62241010
Protein	NP_005154, 62241011
Product	RAC-alpha serine/threonine-protein kinase
RefSeq Status	REVIEWED
mRNA	NM_001014431, 62241012
Protein	NP_001014431, 62241013
Product	RAC-alpha serine/threonine-protein kinase
RefSeq Status	REVIEWED
mRNA	NM_001014432, 62241014
Protein	NP_001014432, 62241015
Product	RAC-alpha serine/threonine-protein kinase
RefSeq Status	REVIEWED

KEGG

hsa05211	Renal cell carcinoma
hsa05218	Melanoma
hsa04660	T cell receptor signaling pathway
hsa05215	Prostate cancer
hsa04370	VEGF signaling pathway
hsa05222	Small cell lung cancer
hsa04973	Carbohydrate digestion and absorption
hsa04630	Jak-STAT signaling pathway
hsa05160	Hepatitis C
hsa04380	Osteoclast differentiation
hsa04666	Fc gamma R-mediated phagocytosis
hsa04664	Fc epsilon RI signaling pathway
hsa04662	B cell receptor signaling pathway
hsa05142	Chagas disease (American trypanosomiasis)
hsa04910	Insulin signaling pathway
hsa04012	ErbB signaling pathway
hsa05210	Colorectal cancer
hsa05145	Toxoplasmosis
hsa04914	Progesterone-mediated oocyte maturation
hsa05212	Pancreatic cancer
hsa04920	Adipocytokine signaling pathway
hsa04722	Neurotrophin signaling pathway
hsa05200	Pathways in cancer
hsa05223	Non-small cell lung cancer
hsa04210	Apoptosis
hsa04062	Chemokine signaling pathway
hsa05214	Glioma
hsa04010	MAPK signaling pathway
hsa05221	Acute myeloid leukemia
hsa04150	mTOR signaling pathway
hsa05213	Endometrial cancer
hsa04510	Focal adhesion
hsa04620	Toll-like receptor signaling pathway
hsa05220	Chronic myeloid leukemia
hsa04530	Tight junction

WikiPathways

WP49	IL-2 Signaling Pathway
WP581	EPO Receptor Signaling
WP1559	TFs Regulate miRNAs related to cardiac hypertrophy
WP437	EGFR1 Signaling Pathway
WP61	Delta-Notch Signaling Pathway
WP395	IL-4 signaling Pathway
WP127	IL-5 Signaling Pathway
WP382	MAPK signaling pathway
WP231	TNF-alpha/NF-kB Signaling Pathway
WP1544	MicroRNAs in cardiomyocyte hypertrophy
WP69	T Cell Receptor Signaling Pathway
WP75	Toll-like receptor signaling pathway
WP22	IL-9 Signaling Pathway
WP254	Apoptosis
WP363	Wnt Signaling Pathway NetPath
WP712	Estrogen signaling pathway
WP138	Androgen Receptor Signaling Pathway
WP286	IL-3 Signaling Pathway
WP244	Alpha6-Beta4 Integrin Signaling Pathway
WP205	IL-7 Signaling Pathway
WP26	Signal Transduction of S1P Receptor
WP474	Endochondral Ossification
WP304	Kit Receptor Signaling Pathway
WP364	IL-6 Signaling Pathway
WP481	Insulin Signaling
WP23	B Cell Receptor Signaling Pathway
WP306	Focal Adhesion
WP185	Integrin-mediated cell adhesion

Pathway Interaction Database

cd8tcrpathway	TCR signaling in naive CD8+ T cells
txa2pathway	Thromboxane A2 receptor signaling
tcr_pathway	TCR signaling in naive CD4+ T cells
ar_nongenomic_pathway	Nongenotropic Androgen signaling
cxcr4_pathway	CXCR4-mediated signaling events
hedgehog_glipathway	Hedgehog signaling events mediated by Gli proteins
hif1_tfpathway	HIF-1-alpha transcription factor network
insulin_pathway	Insulin Pathway
foxopathway	FoxO family signaling
erbb2erbb3pathway	ErbB2/ErbB3 signaling events
fcer1pathway	Fc-epsilon receptor I signaling in mast cells
ecadherin_nascentaj_pathway	E-cadherin signaling in the nascent adherens junction
erbb1_downstream_pathway	ErbB1 downstream signaling
amb2_neutrophils_pathway	amb2 Integrin signaling
pi3kplctrkpathway	Trk receptor signaling mediated by PI3K and PLC-gamma
angiopoietinreceptor_pathway	Angiopoietin receptor Tie2-mediated signaling
hedgehog_2pathway	Signaling events mediated by the Hedgehog family
er_nongenomic_pathway	Plasma membrane estrogen receptor signaling
pdgfrbpathway	PDGFR-beta signaling pathway
lysophospholipid_pathway	LPA receptor mediated events
reg_gr_pathway	Glucocorticoid receptor regulatory network
cd40_pathway	CD40/CD40L signaling
p75ntrpathway	p75(NTR)-mediated signaling
ceramide_pathway	Ceramide signaling pathway
ar_pathway	Coregulation of Androgen receptor activity
ecadherin_keratinocyte_pathway	E-cadherin signaling in keratinocytes
avb3_integrin_pathway	Integrins in angiogenesis
s1p_s1p3_pathway	S1P3 pathway
bcr_5pathway	BCR signaling pathway
smad2_3nuclearpathway	Regulation of nuclear SMAD2/3 signaling
endothelinpathway	Endothelins
nephrin_neph1_pathway	Nephrin/Neph1 signaling in the kidney podocyte
a6b1_a6b4_integrin_pathway	a6b1 and a6b4 Integrin signaling
ptp1bpathway	Signaling events mediated by PTP1B
p53regulationpathway	p53 pathway
faspathway	FAS (CD95) signaling pathway
vegfr1_pathway	VEGFR1 specific signals
insulin_glucose_pathway	Insulin-mediated glucose transport
il4_2pathway	IL4-mediated signaling events
ifngpathway	IFN-gamma pathway
il2_pi3kpathway	IL2 signaling events mediated by PI3K
vegfr1_2_pathway	Signaling events mediated by VEGFR1 and VEGFR2
igf1_pathway	IGF1 pathway
kitpathway	Signaling events mediated by Stem cell factor receptor (c-Kit)
cxcr3pathway	CXCR3-mediated signaling events
reelinpathway	Reelin signaling pathway
hnf3bpathway	FOXA2 and FOXA3 transcription factor networks
met_pathway	Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
aurora_a_pathway	Aurora A signaling
mtor_4pathway	mTOR signaling pathway
pi3kciaktpathway	Class I PI3K signaling events mediated by Akt
telomerasepathway	Regulation of Telomerase
retinoic_acid_pathway	Retinoic acid receptors-mediated signaling
lymphangiogenesis_pathway	VEGFR3 signaling in lymphatic endothelium
fgf_pathway	FGF signaling pathway
il6_7pathway	IL6-mediated signaling events

Reactome

REACT_12389	eNOS activation and regulation
REACT_14797	Signaling by GPCR
REACT_11061	Signalling by NGF
REACT_19344	Costimulation by the CD28 family
REACT_697	Activation of BH3-only proteins
REACT_622	Platelet activation triggers
REACT_24994	Regulation of mRNA Stability by Proteins that Bind AU-rich Elements
REACT_604	Hemostasis
REACT_13819	Regulation of gene expression in beta cells
REACT_12464	PI3K/AKT signalling
REACT_12508	Metabolism of nitric oxide
REACT_578	Apoptosis
REACT_12442	AKT phosphorylates targets in the nucleus
REACT_20605	Metabolism of mRNA
REACT_19388	G-protein beta:gamma signalling
REACT_19183	CD28 co-stimulation
REACT_798	Platelet Activation
REACT_1695	GPVI-mediated activation cascade
REACT_20	Formation of Platelet plug
REACT_19290	G beta:gamma signalling through PI3Kgamma
REACT_25042	Destabilization of mRNA by KSRP
REACT_12447	Negative regulation of the PI3K/AKT network
REACT_19405	CTLA4 inhibitory signaling
REACT_15523	Integrin alphaIIb beta3 signaling
REACT_19358	CD28 dependent PI3K/Akt signaling
REACT_6900	Signaling in Immune system
REACT_549	Activation of BAD and translocation to mitochondria
REACT_12477	eNOS activation
REACT_13552	Integrin cell surface interactions
REACT_12056	NGF signalling via TRKA from the plasma membrane
REACT_278	Platelet Aggregation (Plug Formation)
REACT_13655	AKT-mediated inactivation of FOXO1A
REACT_13698	Regulation of beta-cell development
REACT_964	Intrinsic Pathway for Apoptosis
REACT_12564	AKT phosphorylates targets in the cytosol
REACT_24915	Destabilization of mRNA by Butyrate Response Factor 1 (BRF1)
REACT_19184	GPCR downstream signaling
REACT_21257	Metabolism of RNA

Homo sapiens (human)	AKT1	NP_001014431.1
Canis lupus familiaris (dog)	AKT1	XP_548000.2
Bos taurus (cattle)	AKT1	NP_776411.1
Mus musculus (house mouse)	Akt1	NP_033782.1
Rattus norvegicus (Norway rat)	Akt1	NP_150233.1
Gallus gallus (chicken)	AKT1	NP_990386.1
Danio rerio (zebrafish)	akt2l	NP_997980.1
Caenorhabditis elegans	akt-1	NP_001023645.1
Caenorhabditis elegans	akt-2	NP_510357.3

Process

ID	Name	Evidence
GO:0000060	protein import into nucleus, translocation	IMP
GO:0001649	osteoblast differentiation	IEA
GO:0001893	maternal placenta development	IEA
GO:0001934	positive regulation of protein phosphorylation	IDA
GO:0005975	carbohydrate metabolic process	IEA
GO:0005979	regulation of glycogen biosynthetic process	IMP
GO:0006417	regulation of translation	IEA
GO:0006464	protein modification process	TAS
GO:0006468	protein phosphorylation	IDA
GO:0006469	negative regulation of protein kinase activity	IMP
GO:0006469	negative regulation of protein kinase activity	ISS
GO:0006809	nitric oxide biosynthetic process	TAS
GO:0006810	transport	IEA
GO:0006915	apoptosis	TAS
GO:0006916	anti-apoptosis	TAS
GO:0006924	activation-induced cell death of T cells	IMP
GO:0006954	inflammatory response	IEA
GO:0007165	signal transduction	TAS
GO:0007186	G-protein coupled receptor protein signaling pathway	TAS
GO:0007281	germ cell development	IEA
GO:0007399	nervous system development	IEA
GO:0007596	blood coagulation	TAS
GO:0008286	insulin receptor signaling pathway	IMP
GO:0008629	induction of apoptosis by intracellular signals	TAS
GO:0008633	activation of pro-apoptotic gene products	EXP
GO:0008633	activation of pro-apoptotic gene products	TAS
GO:0008637	apoptotic mitochondrial changes	IEA
GO:0008643	carbohydrate transport	IEA
GO:0009408	response to heat	TAS
GO:0009725	response to hormone stimulus	IEA
GO:0010748	negative regulation of plasma membrane long-chain fatty acid transport	IMP
GO:0010765	positive regulation of sodium ion transport	IEA
GO:0010907	positive regulation of glucose metabolic process	IMP
GO:0010975	regulation of neuron projection development	ISS
GO:0015758	glucose transport	IEA
GO:0016070	RNA metabolic process	TAS
GO:0016071	mRNA metabolic process	TAS
GO:0016310	phosphorylation	EXP
GO:0016310	phosphorylation	IDA
GO:0016567	protein ubiquitination	IEA
GO:0018105	peptidyl-serine phosphorylation	IDA
GO:0030030	cell projection organization	IEA
GO:0030163	protein catabolic process	IEA
GO:0030168	platelet activation	TAS
GO:0030307	positive regulation of cell growth	IDA
GO:0030334	regulation of cell migration	IMP
GO:0031018	endocrine pancreas development	TAS
GO:0031295	T cell costimulation	TAS
GO:0031659	positive regulation of cyclin-dependent protein kinase activity involved in G1/S	IDA
GO:0031999	negative regulation of fatty acid beta-oxidation	IMP
GO:0032094	response to food	IEA
GO:0032270	positive regulation of cellular protein metabolic process	ISS
GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process	IEA
GO:0032869	cellular response to insulin stimulus	IMP
GO:0032869	cellular response to insulin stimulus	ISS
GO:0032880	regulation of protein localization	IEA
GO:0033138	positive regulation of peptidyl-serine phosphorylation	IDA
GO:0034405	response to fluid shear stress	IMP
GO:0035556	intracellular signal transduction	IDA
GO:0042593	glucose homeostasis	IEA
GO:0042640	anagen	IEA
GO:0043066	negative regulation of apoptosis	IDA
GO:0043066	negative regulation of apoptosis	NAS
GO:0043491	protein kinase B signaling cascade	IEA
GO:0043536	positive regulation of blood vessel endothelial cell migration	IDA
GO:0045429	positive regulation of nitric oxide biosynthetic process	IMP
GO:0045600	positive regulation of fat cell differentiation	IMP
GO:0045725	positive regulation of glycogen biosynthetic process	IMP
GO:0045725	positive regulation of glycogen biosynthetic process	NAS
GO:0045792	negative regulation of cell size	IEA
GO:0045884	regulation of survival gene product expression	IEA
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	IEA
GO:0046209	nitric oxide metabolic process	TAS
GO:0046326	positive regulation of glucose import	IMP
GO:0046329	negative regulation of JNK cascade	IEA
GO:0046777	protein autophosphorylation	TAS
GO:0046889	positive regulation of lipid biosynthetic process	IMP
GO:0048009	insulin-like growth factor receptor signaling pathway	IMP
GO:0048011	nerve growth factor receptor signaling pathway	TAS
GO:0048015	phosphatidylinositol-mediated signaling	TAS
GO:0050999	regulation of nitric-oxide synthase activity	TAS
GO:0051000	positive regulation of nitric-oxide synthase activity	IMP
GO:0051091	positive regulation of sequence-specific DNA binding transcription factor activity	IDA
GO:0051146	striated muscle cell differentiation	IEA
GO:0060709	glycogen cell development involved in embryonic placenta development	IEA
GO:0060716	labyrinthine layer blood vessel development	IEA
GO:0070141	response to UV-A	IDA
GO:0071363	cellular response to growth factor stimulus	IEA
GO:0090004	positive regulation of establishment of protein localization in plasma membrane	IMP

Component

ID	Name	Evidence
GO:0005625	soluble fraction	IEA
GO:0005634	nucleus	IDA
GO:0005654	nucleoplasm	EXP
GO:0005654	nucleoplasm	TAS
GO:0005737	cytoplasm	IDA
GO:0005737	cytoplasm	ISS
GO:0005819	spindle	IEA
GO:0005829	cytosol	EXP
GO:0005829	cytosol	IDA
GO:0005829	cytosol	TAS
GO:0005886	plasma membrane	EXP
GO:0005886	plasma membrane	IDA
GO:0005886	plasma membrane	TAS
GO:0015630	microtubule cytoskeleton	IDA
GO:0030027	lamellipodium	IEA

Function

ID	Name	Evidence
GO:0000166	nucleotide binding	IEA
GO:0004672	protein kinase activity	TAS
GO:0004674	protein serine/threonine kinase activity	EXP
GO:0004674	protein serine/threonine kinase activity	IDA
GO:0004674	protein serine/threonine kinase activity	TAS
GO:0005515	protein binding	IPI
GO:0005524	ATP binding	IC
GO:0005547	phosphatidylinositol-3,4,5-trisphosphate binding	IDA
GO:0016301	kinase activity	EXP
GO:0016301	kinase activity	IDA
GO:0019899	enzyme binding	ISS
GO:0030235	nitric-oxide synthase regulator activity	IMP
GO:0042802	identical protein binding	IPI
GO:0043325	phosphatidylinositol-3,4-bisphosphate binding	IDA

GeneCards	AKT1
PDB	3O96, 1UNR, 2UZR, 1UNQ, 3OCB, 2UZS, 3CQU, 3MVH, 3MV5, 1H10, 3OW4, 3CQW, 2UVM, 1UNP
UniProt	B3KVH4, B0LPE5, P31749
MIM	164730
Ensembl	ENSG00000142208
HGNC	391
HPRD	01261

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RefSeq Accession	Definition	Sequence	Price	Select
NM_005163	Homo sapiens v-akt murine thymoma viral oncogene homolog 1 (AKT1), transcript variant 1, mRNA.	Full Length	$1052.80
NM_005163		ORF Sequence	$418.47
NM_001014431	Homo sapiens v-akt murine thymoma viral oncogene homolog 1 (AKT1), transcript variant 3, mRNA.	Full Length	$810.26
NM_001014431		ORF Sequence	$418.47
NM_001014432	Homo sapiens v-akt murine thymoma viral oncogene homolog 1 (AKT1), transcript variant 2, mRNA.	Full Length	$834.62
NM_001014432		ORF Sequence	$418.47